scholarly journals Serum lncRNA XIST has the Capacity to Serve as a Diagnostic Biomarker for Nasopharyngeal Carcinoma

2020 ◽  
Author(s):  
Lili Wang ◽  
Hongguang Song ◽  
Shiming Yang
Keyword(s):  
Clinical Stage ◽  
Diagnostic Biomarker ◽  
Healthy Individuals ◽  
Chi Square ◽  
Gender And Age ◽  
Lncrna Xist ◽  
Elevated Expression ◽  
Chi Square Test ◽  
Auc Value ◽  
The Relationship

Abstract BackgroundLncRNA XIST (X-inactive specific transcript) is involved in various tumors. In this study, we aimed to investigate the diagnostic performance of serum lncRNA XIST in NPC.MethodsSerum samples were collected from 117 NPC patients and 80 gender and age matched healthy individuals. The relative expression of serum lncRNA XIST was detected by qRT-PCR. Chi-square test was applied to evaluate the relationship between lncRNA XIST expression and clinical characteristics. ROC analysis was performed to identify the feasibility of serum XIST as a diagnostic biomarker for NPC.ResultsSerum lncRNA XIST was higher in NPC patients than that in healthy volunteers (P<0.001). Furthermore, its elevated expression showed positive link with clinical stage (P=0.013), TNM stage (P=0.024), and lymph node metastasis (P=0.003). ROC curve demonstrated that lncRNA XIST could discriminate between NPC patients and healthy individuals, with the AUC value of 0.827. The cut-off value of serum XIST for NPC diagnosis was 3.735, with the sensitivity of 75.2% and specificity of 83.7%.ConclusionLncRNA XIST as an oncogene plays promoting roles in aggressive progression of NPC. Serum lncRNA XIST may be employed as a diagnostic biomarker for NPC.

scholarly journals MiR-210 has the capacity to serve as a diagnostic biomarker for laryngeal carcinoma patient

2020 ◽  
Author(s):  
Lili Wang ◽  
Hongguang Song ◽  
Shiming Yang
Keyword(s):  
Laryngeal Carcinoma ◽  
Clinical Characteristics ◽  
Roc Analysis ◽  
Diagnostic Value ◽  
Diagnostic Biomarker ◽  
Chi Square ◽  
Qrt Pcr ◽  
Elevated Expression ◽  
Chi Square Test ◽  
Auc Value

Abstract Background Early diagnosis represents a great challenge for laryngeal carcinoma patients. MiR-210 is involved in various human cancers. In this study, we aimed to investigate the diagnostic performance of serum miR-210 in laryngeal carcinoma. Methods In our study, qRT-PCR was performed to determine the serum miR-210 level in 137 laryngeal carcinoma patients and 79 healthy volunteers. The association of serum miR-210 level with clinical characteristics of the patients was estimated by chi-square test. ROC analysis was applied to evaluate the diagnostic value of miR-210 in laryngeal carcinoma. Results Serum miR-210 level was higher in laryngeal carcinoma patients than that in healthy group (P < 0.001). Moreover, its elevated expression was positively associated with TNM stage (P = 0.000) and distant metastasis (P = 0.001). The AUC value of the ROC curve was 0.893, suggesting the possibility of serum miR-210 as a diagnostic biomarker for the disease. The cut-off value was 4.685, with the sensitivity of 83.2% and the specificity of 84.8%. Conclusion MiR-210 serves as an oncogene in progression of laryngeal carcinoma. Serum miR-210 may be a potential diagnostic biomarker for laryngeal carcinoma.

scholarly journals MiR-106B Represents an Innovative Bio-marker in Cholangiocarcinoma Detection

2020 ◽  
Author(s):  
Ning Wang ◽  
Yanni Li ◽  
Yanfang Zheng ◽  
Huoming Chen ◽  
Xiaolong Wen ◽  
...  
Keyword(s):  
Roc Curve ◽  
Clinical Stage ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Diagnostic Biomarker ◽  
Chi Square ◽  
Chi Square Test ◽  
Healthy Control ◽  
Important Regulator ◽  
Polymerase Chain

Abstract Background Cholangiocarcinoma (CCA) is one of the most aggressive malignancies. Late diagnosis may be responsible for the high mortality. MicroRNA-106b (MiR-106b) is accepted as an important regulator in various human malignancies. The current study was aimed to investigate the diagnostic value of miR-106b in CCA. Methods Serum levels of miR-106b in CCA patients and healthy control were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Chi-square test was used to analyze the association of miR-106b with the clinicopathological features. To evaluate the diagnostic value of miR-106b in CCA, the ROC curve was constructed. Results The expression of miR-106b was significantly increased in CCA samples compared with the healthy controls (P < 0.001). The overexpression of miR-106b was remarkable correlated with the lymphatic node metastasis (P = 0.038), clinical stage (P = 0.017) and differentiation (P = 0.009). ROC curve suggested that miR-106b was an effective diagnostic biomarker in CCA with the AUC of 0.913. The optimal cutoff value was 2.525, with the sensitivity of 89.7% and the specificity of 79.3%. Conclusions MiR-106b functions as an oncogene in CCA, which may be an potential diagnostic biomarker for CCA.

scholarly journals Investigation of Anti-Toxocaraand Anti-ToxoplasmaAntibodies in Patients with Schizophrenia Disorder

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Shahram Khademvatan ◽  
Niloufar Khajeddin ◽  
Sakineh Izadi ◽  
Elham Yousefi
Keyword(s):  
Clinical Course ◽  
Age Groups ◽  
Elevated Risk ◽  
Healthy Individuals ◽  
Chi Square ◽  
Exact Test ◽  
Chi Square Test ◽  
Males And Females ◽  
Study Participants ◽  
The Relationship

Objective. The aim of the present study was to examine the relationship betweenToxoplasma gondiiandToxocaraspp. infections in patients with schizophrenia disorder.Method. A total of 100 patients with schizophrenia disorder and 95 healthy individuals participated in the study. Participants were tested for the presence of anti-T. gondiiand anti-Toxocaraspp. antibodies by ELISA and Western blotting. Data were analyzed using Chi-square test and Fisher9s exact test.Results. There were no differences inT. gondiiIgG seroprevalence between patients with schizophrenia and healthy individuals (P=0.1), but there were differences in seroprevalence between males and females with schizophrenia (P=0.009). In contrast,Toxocaraspp. IgG seroprevalence was greater in patients with schizophrenia disorder than in healthy individuals (P=0.02), but there were no differences in seroprevalence between men and women with schizophrenia (P=0.5). Finally, there were no differences in seroprevalence ofT. gondiiorToxocaraspp. IgG among different subtypes of schizophrenia, various age groups, residential area, or clinical course of treatment (P>0.05).Conclusion. The present study suggests that patients with schizophrenia disorder are at elevated risk ofToxocaraspp. infection. Moreover, contamination withT. gondiiis a risk factor for schizophrenia in women.

scholarly journals Korelasi Faktor Demografi terhadap Kepercayaan Diri Menghadapi Pensiun Karyawan Padma Resort Legian

2020 ◽  
Vol 9 (1) ◽  
pp. 35-44
Author(s):  
I Putu Esa Widaharthana ◽  
Ni Made Dwi Oktavianthi ◽  
Made Artajaya
Keyword(s):  
Positive Relationship ◽  
Hotel Industry ◽  
Demographic Factors ◽  
Test Program ◽  
Chi Square ◽  
Important Thing ◽  
Gender And Age ◽  
Chi Square Test ◽  
The Relationship ◽  
Product Department

The main aim of the study is to analyze the correlation between demographic factors in determining the employee’s retirement confidence in hotel industry especially Padma Resort Legian. While the objectives of the study are to determine the relationship between demographic factors consist of gender, age, education, income and family dependent towards employee’s retirement confidence. The methods of collecting data is through the 98 questionnaires distribution to the pre-retiree employees from Housekeeping, Engineering and Food & Beverage Service and Product Department in Padma Resort Legian.. The techniques of analyzing data that used in this research are Crosstabs and Chi-Square test program. The findings of this research shows that two of demographic factors which are gender and age did not show any positive relationship with the retirement confidence. Otherwise, the three other factors which are income, education and family dependent show strong and positive relationship with the retirement confidence. The study also finds that income is the most important thing in building the retirement confidence of the employees.

IDENTIFIKASI SERTA HUBUNGAN KONSTRUKSI SUMUR GALI TERHADAP KANDUNGAN COLIFORM PADA AIR SUMUR GALI DI DUSUN JIKEN KABUPATEN LOMBOK TIMUR

2019 ◽  
Vol 7 (2) ◽  
pp. 115
Author(s):  
Dini Yuliansari
Keyword(s):  
Cross Sectional Study ◽  
Coliform Bacteria ◽  
Well Water ◽  
Chi Square ◽  
Cross Sectional ◽  
Content Variable ◽  
Chi Square Test ◽  
Dug Wells ◽  
Dug Well ◽  
The Relationship

The well is one of the source water used for bathing, washing, and drinking by the citizens in Jiken Hamlet, Rarang Village, Terara Sub-District. Poor dug well construction conditions can affect the amount of coliform bacteria contained in the dug well water. The purpose of this study is to identify the construction of dug wells and the content of coliform bacteria in dug well water and determine the relationship between dug well construction and the content of coliform bacteria. This research is analytic with a cross sectional study design. The results were obtained from 11 samples of dug wells which were observed in construction and the coliform content was known that all samples did not requirements as good dug well construction. Coliform content test results showed that as many as 5 dug well water samples did not pass the clean water quality standards. The results of data analysis with the chi-square test variable construction of dug wells with coliform content variable  showed 0,172 > 0,05, then the concluded is the dug well not suitable to use by people in that area as a source of water for daily needs.

Hubungan antara Luas Lesi pada Foto Toraks Penderita TB Paru Dewasa yang Memiliki Riwayat Diabetes Melitus dengan Indeks Massa Tubuh di Rumah Sakit Hasan Sadikin Bandung

2016 ◽  
Vol 1 (3) ◽  
pp. 138-144
Author(s):  
Ina Edwina ◽  
Rista D Soetikno ◽  
Irma H Hikmat
Keyword(s):  
Chest Radiograph ◽  
Chi Square ◽  
Pulmonary Tb ◽  
X Ray ◽  
Consecutive Sampling ◽  
Close Relationship ◽  
Chi Square Test ◽  
Chest X Ray ◽  
The Relationship ◽  
Diabetes Melitus

Background: Tuberculosis (TB) and diabetes mellitus (DM) prevalence rates are increasing rapidly, especially in developing countries like Indonesia. There is a relationship between TB and DM that are very prominent, which is the prevalence of pulmonary TB with DM increased by 20 times compared with pulmonary TB without diabetes. Chest X-ray picture of TB patients with DM is atypical lesion. However, there are contradictories of pulmonary TB lesion on chest radiograph of DM patients. Nutritional status has a close relationship with the morbidity of DM, as well as TB.Objectives: The purpose of this study was to determine the relationship between the lesions of TB on the chest radiograph of patients who su?er from DM with their Body Mass Index (BMI) in Hasan Sadikin Hospital Bandung.Material and Methods: The study was conducted in Department of Radiology RSHS Bandung between October 2014 - February 2015. We did a consecutive sampling of chest radiograph and IMT of DM patients with clinical diagnosis of TB, then the data was analysed by Chi Square test to determine the relationship between degree of lesions on chest radiograph of pulmonary TB on patients who have DM with their BMI.Results: The results showed that adult patients with active pulmonary TB with DM mostly in the range of age 51-70 years old, equal to 62.22%, with the highest gender in men, equal to 60%. Chest radiograph of TB in patients with DM are mostly seen in people who are obese, which is 40% and the vast majority of lesions are minimal lesions that is equal to 40%.Conclusions: There is a signifcant association between pulmonary TB lesion degree with BMI, with p = 0.03

Usia Resiko Tinggi dan Perdarahan Post Partum

2018 ◽  
Vol 3 (2) ◽  
pp. 91
Author(s):  
Ani Media Harumi ◽  
Kasiati Kasiati
Keyword(s):  
High Risk ◽  
Post Partum ◽  
Chi Square ◽  
Sample Number ◽  
Chi Square Test ◽  
Study Population ◽  
Relationship Of ◽  
The Relationship

Abstract: The purpose of this study is to analyze the relationship of age high risk with the incidence ofbleeding post partum in dr. M. Soewandhie Surabaya hospital. This research is analytic with an approachof a sectional cross. The study population was all post partum mothers in the Dr. M. Soewandhie Surabayahospital in January 2016 to March 2017, which amounts to an average of 1840respondents while theresearch sample number 182. Measuring collection sheet data obtained by systematic random sampling.The Study was conducted Chi-Square test obtained mean count X2 (0,00) is less than á (0.05) thenH0 is rejected and H1 accepted it means that there is a relationship between the age of high risk withbleeding post partum. Conclusion, there is a relationship between the age of high risk with the incidenceof bleeding post partum in the Spaceof the Maternity room Dr. Moch. Soewandhie Surabayahospital.

Association between tumor mutational burden (TMB) and immune-related adverse events (irAEs) in patients (pts) with metastatic urothelial carcinoma (mUC) during checkpoint immunotherapy.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 489-489
Author(s):  
Elie W. Akl ◽  
Pier Vitale Nuzzo ◽  
Elio Adib ◽  
Amin Nassar ◽  
Sarah Abou Alaiwi ◽  
...  
Keyword(s):  
Sequencing Data ◽  
Chi Square ◽  
P Values ◽  
Exact Test ◽  
Radiological Data ◽  
Tumor Mutational Burden ◽  
Chi Square Test ◽  
Metastatic Urothelial Carcinoma ◽  
Multivariable Regression ◽  
The Relationship

489 Background: Immune checkpoint inhibition (ICI) has greatly improved clinical outcomes for pts with mUC and other cancers. ICI is associated with a class of AEs, deemed irAEs due to immune activation. Nonetheless, biomarkers associated with irAE are still lacking. We hypothesized that the immune response against neoantigens is partly responsible for irAEs and investigated the association between irAEs, TMB and response to ICI. Methods: We identified patients with mUC at Dana Farber Cancer Institute who were treated with ICI (monotherapy or combination) and had available tumor sequencing data through Oncopanel. TMB was calculated using the number of non-synonymous exonic mutations per megabase. The severity of irAEs was graded using CTCAE v.5.0. Mann-Whitney U test was performed to identify association between TMB, incidence and grade of irAEs. A cut-off of 10/mb was assigned for TMB. Fisher’s exact test was used to evaluate the radiologic response between pts with and without irAEs and low vs. high TMB. Multivariable linear regression was used to assess the relationship between TMB, irAEs and response. p-values were adjusted using Benjamini-Hochberg method. Results: Of 101 pts with mUC who met the inclusion criteria, 32 (32%) reported irAEs. 6 (6%) were grade (G)1, 20 (20%) were G2, and 6 (6%) were G3. Median(m) time on therapy was 84 days for pts without irAEs and 88 days for pts with irAEs. Pts with irAEs had higher mTMB (15.4/mb) compared to pts with no irAEs (9.8) ( p = 0.01). In pts on monotherapy (93), those with irAEs (n=27) had a higher mTMB (15.13/mb) compared to pts with no irAEs (n=66) (mTMB = 10.20/mb) ( p = 0.01). Out of 94 pts with radiological data, response was achieved in 16 (50%) pts with irAE vs 10 (16%) pts with no irAE ( p < 0.001). When both irAE and response were included in a multivariable regression, the association between irAE and TMB was not significant ( p = 0.4). Pts with both irAE and high TMB had a response rate of 56% which was significantly higher than those with either irAE but low TMB (28.6%) or high TMB but no irAE (21.2 %) or low TMB and no irAE (10.3%) (Chi-square test p = 0.002; FDR corrected p-values for individual comparisons in Table). There was no association between TMB and irAE grade. Conclusions: Higher TMB was associated with higher incidence of irAEs in pts with mUC on ICIs. Moreover, pts with both high TMB and irAEs exhibited better response rates than those with only high TMB or irAEs, suggesting that they may provide complementary tumor and host characteristics. Further evaluation in mUC is needed to confirm this relationship between TMB, irAEs and response in a larger cohort and explore specific mutational signatures that may be associated with irAEs. [Table: see text]

A Cross Sectional Analysis of Tourism Development and Social Development

2021 ◽  
Vol 12 (2) ◽  
pp. 487
Author(s):  
Tauseef AMAN ◽  
Mussawar SHAH ◽  
Humera JAMAL ◽  
Younas KHAN ◽  
Muhammad ARIF ◽  
...  
Keyword(s):  
Social Development ◽  
Local Community ◽  
Tourism Development ◽  
Chi Square ◽  
Cross Sectional ◽  
Close Proximity ◽  
Chi Square Test ◽  
The Government ◽  
Sectional Analysis ◽  
The Relationship

The major objective of this study was to measure the association between various interventions and Chitral Gole National Park (CGNP) role in preservation of bio-diversity and socio-economic uplift. A sample size of 346 respondents was randomly selected from total population of 3326 from the 4 selected villages on the basis of close proximity. A conceptual framework including dependent variable social development and independent variable tourism development were taken. The data were analyzed through frequency and percentage distribution. Moreover, Chi-square test was applied to know the relationship between dependent and independent variables at bi-variate level. In bi-variate analysis a highly significant (P=0.000) relation was found between CGNP is main source of promoting tourism in Chitral,tourists do any impacts upon local community in terms of increased business activities, local culture is safeguarded despite influx of tourists in the area, tourism produced employment opportunities, and social development. Qualitative data supported the empirical findings, however tourism brings economic opportunities at micro and macro level, but unfortunately CGNP is not as satisfactory regarding generating income since its establishment. The government should ensure to make such polices pertaining to the entrance fee, provides accommodation services on payment to the tourists and to reserve the entrance fee or any other form of taxes to ensure CGNP to spend on self-sustaining basis by ensuring refinement in the procedures as well.

Analysis of the Relationship between Currency Redenomination and Financial Transaction Costs in Nigeria

2021 ◽  
Vol 7 (18) ◽  
pp. 59-68
Author(s):  
Hassana Aliyu MOHAMMED ◽  
◽  
Abdurrahman ISIK ◽  
Paul Terhemba IOREMBER ◽  
◽  
...  
Keyword(s):  
Transaction Costs ◽  
Financial Institutions ◽  
Financial Sector ◽  
Chi Square ◽  
User Costs ◽  
Inflationary Pressure ◽  
Cash Payment ◽  
Chi Square Test ◽  
The Cost ◽  
The Relationship

The study analyses the relationship between currency redenomination and financial sector transaction costs in Nigeria using a sample of 200 respondents from ten financial institutions. Applying the Chi-square test, the study reveals that high currency redenomination removes wasteful transactions removes user costs (difficulties arising from memorizing, calculating and carrying large sum of lowest denominations: coins and smaller notes). The results also show that currency redenomination influences inflationary pressure and currency liberalization in Nigeria. Based on the findings the study recommends the introduction of currency redenomination to facilitate the consumers' cash payment and reduce the cost incurred by producers and issuing authorities, and also make payment system more efficient and effective.

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