scholarly journals Effect of Exercise and Zoledronic Acid on Lipid Profile and Bone Remodeling in Ovariectomized Rats

2018 ◽  
Vol 3 (12) ◽  
Author(s):  
Ahmed Sayed Khashaba, M.B.B.CH. MD. PhD ◽  
Fawaz Salem Al Batati ◽  
Abdulrhman Al Saffan BDS, MSc
Keyword(s):  
Physical Activity ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Free Access ◽  
Beneficial Effects ◽  
Prevention Of Osteoporosis ◽  
Cardio Vascular ◽  
Osteoporosis Fracture

Exercise (EXE) and amino-bisphosphonates (BP) are both considered as useful strategies in the prevention of post-menopausal bone loss. Exercise reduces lipid levels, and BP may induce increase in high-density lipoprotein cholesterol (HDL-C). We hypothesized that combined effects of BP and exercise would produce a better improvement of lipid profile. (Dolléans, 2010)  Non pharmacological prevention of osteoporosis fracture by physical activity and particularly regular exercises (EXE) characterized by impact or loading is currently recommended.The effect of regular exercise on the Lipid profile has been developed in a lot of studies It has been recently demonstrated that increasing steps walked may have beneficial effects on serum lipids and thus may decrease the cardio vascular disease risks. Conversely, physical activity, and more specifically mechanical stress, has been shown to induce an osteogenic effect mediated by osteocytes and osteoblasts. (Howe, 2011)  Sixty 6-month old Wistar female rats were maintained under the standard environmental conditions of light and temperature, (12 h light: 12 h dark photoperiod, at 24 ±2 oC) with free access to water. They were divided into 3 groups according to methods of induction

Beneficial effects of an intradialytic cycling training program in patients with end-stage kidney disease

2015 ◽  
Vol 40 (6) ◽  
pp. 550-556 ◽  
Author(s):  
Carole Groussard ◽  
Myriam Rouchon-Isnard ◽  
Céline Coutard ◽  
Fanny Romain ◽  
Ludivine Malardé ◽  
...  
Keyword(s):  
Body Composition ◽  
Kidney Disease ◽  
Physical Fitness ◽  
Lipid Profile ◽  
Antioxidant Status ◽  
Density Lipoprotein ◽  
Control Group ◽  
Beneficial Effects ◽  
Cycling Training ◽  
Training Protocol

In chronic kidney disease (CKD), oxidative stress (OS) plays a central role in the development of cardiovascular diseases. This pilot program aimed to determine whether an intradialytic aerobic cycling training protocol, by increasing physical fitness, could reduce OS and improve other CKD-related disorders such as altered body composition and lipid profile. Eighteen hemodialysis patients were randomly assigned to either an intradialytic training (cycling: 30 min, 55%–60% peak power, 3 days/week) group (EX; n = 8) or a control group (CON; n = 10) for 3 months. Body composition (from dual-energy X-ray absorptiometry), physical fitness (peak oxygen uptake and the 6-minute walk test (6MWT)), lipid profile (triglycerides (TG), total cholesterol, high-density lipoprotein, and low-density lipoprotein (LDL)), and pro/antioxidant status (15-F2α-isoprostanes (F2-IsoP) and oxidized LDL in plasma; superoxide dismutase, glutathione peroxidase, and reduced/oxidized glutathione in erythrocytes) were determined at baseline and 3 months later. The intradialytic training protocol did not modify body composition but had significant effects on physical fitness, lipid profile, and pro/antioxidant status. Indeed, at 3 months: (i) performance on the 6MWT was increased in EX (+23.4%, p < 0.001) but did not change in CON, (ii) plasma TG were reduced in EX (–23%, p < 0.03) but were not modified in CON, and (iii) plasma F2-IsoP concentrations were lower in EX than in CON (–35.7%, p = 0.02). In conclusion, our results show that 30 min of intradialytic training, 3 times per week for 3 months, are enough to exert beneficial effects on the most sensitive and reliable marker of lipid peroxidation (IsoP) while improving CKD-associated disorders (lipid profile and physical fitness). Intradialytic aerobic cycling training represents a useful and easy strategy to reduce CKD-associated disorders. These results need to be confirmed with a larger randomized study.

scholarly journals Lipid profile and cardiovascular risk indices of women on various types of contraceptives in the Ho Municipality of Ghana

2018 ◽  
Vol 7 (11) ◽  
pp. 4342
Author(s):  
Ahmed Tijani Bawah ◽  
Michael Asamoah Boateng ◽  
Francis A. Osei Kuffour ◽  
Mohammed Mustapha Seini ◽  
Paul Amoah ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Hormonal Contraceptives ◽  
Risk Indices ◽  
Cardio Vascular Disease ◽  
Negative Effect ◽  
Cardio Vascular

Background: Hormonal contraceptives (HCs) have been successfully used worldwide to prevent pregnancy by inhibiting ovulation and implantation. These contraceptives have effects on lipid metabolism, body fat and blood pressure which are all risk factors for cardio vascular disease (CVD). Some studies have reported that prolonged use of these hormone-based contraceptives have negative effect on cardiovascular risk indices, however, few of such studies have been done in Ghana, hence this study sought to examine the effect of various forms of contraceptives on cardio vascular risk indices in the Volta Region of Ghana.Methods: Purposive random sampling was employed in selecting women on various forms of contraceptives and aged-matched controls into the study. Fasting blood sample was collected from each participant after overnight fast for 10-16 hours into plain tubes and the sera used to determine lipid profile. Socio-demographic and BMI variables were also analyzed in this case-control study.Results: Statistically significant differences were observed for Diastolic Blood Pressure (DBP) (p=0.0153), High Density Lipoprotein levels (HDL) (p=0.001), and the atherogenic index (p=0.0101) between the cases and the controls.Conclusions: The use of HC significantly affects the DBP, HDL and atherogenic index and these could pose substantial risk for the development of CVD.

Intense electroacupuncture normalizes insulin sensitivity, increases muscle GLUT4 content, and improves lipid profile in a rat model of polycystic ovary syndrome

2010 ◽  
Vol 299 (4) ◽  
pp. E551-E559 ◽  
Author(s):  
Julia Johansson ◽  
Yi Feng ◽  
Ruijin Shao ◽  
Malin Lönn ◽  
Håkan Billig ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Lipid Profile ◽  
Muscle Protein ◽  
Polycystic Ovary ◽  
Low Frequency ◽  
Density Lipoprotein ◽  
Female Rats ◽  
Ovary Syndrome

Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and insulin resistance, possibly reflecting defects in skeletal muscle and adipocyte insulin signaling. Low-frequency (2 Hz) electroacupuncture (EA) increases insulin sensitivity in female rats with dihydrotestosterone (DHT)-induced PCOS, but the mechanism is unclear. We hypothesized that low-frequency EA regulates mediators involved in skeletal muscle glucose uptake and metabolism and alters the lipid profile in rats with DHT-induced PCOS. To test this hypothesis, we implanted in prepubescent female rats 90-day continuous-release pellets containing DHT (PCOS). At 70 days of age, the rats were randomly subdivided into two groups: one received low-frequency EA (evoking muscle twitches) for 20–25 min five times/wk for 4–5 wk; the other did not. Controls were implanted with pellets containing vehicle only. All three groups were otherwise handled similarly. Lipid profile was measured in fasting blood samples. Insulin sensitivity was determined by euglycemic hyperinsulinemic clamp, soleus muscle protein expression of glucose transporter 4 (GLUT4), and phosphorylated and nonphosphorylated Akt, and Akt substrate of 160 kDa was determined by Western blot analysis and GLUT4 location by immunofluorescence staining. PCOS EA rats had normalized insulin sensitivity, lower levels of total high-density lipoprotein and low-density lipoprotein cholesterol, and increased expression of GLUT4 in different compartments of skeletal muscle compared with PCOS rats. Total weight and body composition did not differ in the groups. Thus, in rats with DHT-induced PCOS, low-frequency EA has systemic and local effects involving intracellular signaling pathways in muscle that may, at least in part, account for the marked improved insulin sensitivity.

scholarly journals Lipid profile, apolipoprotein A-I and oxidative stress in professional footballers, sedentary individuals, and their relatives

2011 ◽  
Vol 55 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Aline Margioti Zanella ◽  
Marcelo Arruda Nakazone ◽  
Marcela Augusta Souza Pinhel ◽  
Dorotéia Rossi Silva Souza
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Physical Exercise ◽  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Beneficial Effects ◽  
Apolipoprotein A ◽  
And Oxidative Stress ◽  
Cholesterol Fraction

OBJECTIVE: To evaluate whether lipid profile (LP), apolipoprotein A-1 (apo A-I) and malondialdehyde (MDA) have any relationship with physical exercise by comparing the groups of footballers (FG) with sedentary individuals (CG) and their relatives (RFG and RCG). SUBJECTS AND METHODS: Twenty individuals from FG and CG, 60 from RFG, and 57 from RCG were studied. RESULTS: FG showed lower levels of total cholesterol (119.5 ± 37.9 mg/dL), LDL-cholesterol fraction (53.6 ± 30.3), apo A-I (116.7 ± 11.9), and higher level of HDL-cholesterol fraction (HDLc) (49.7 ± 8.5) compared to RFG (148.3 ± 36.9, P = 0.02; 82.4 ± 37.7, P < 0.01; 124.6 ± 10.2, P = 0.03; and 42.7 ± 7.7, P < 0.01; respectively). Moreover, FG had reduced levels of MDA (101.0 ± 77.0 ng/mL) compared to CG (290.0 ± 341.0, P = 0.03) and RFG (209.9 ± 197.5, P = 0.04). CONCLUSIONS: These results suggest an association between physical exercise and lower levels of MDA in FG. Physical activity seems to promote beneficial effects on the LP regardless of the genetic influence considering HDLc levels.

High-impact exercise strengthens bone in osteopenic ovariectomized rats with the same outcome as Sham rats

2003 ◽  
Vol 95 (3) ◽  
pp. 1032-1037 ◽  
Author(s):  
Akiko Honda ◽  
Naota Sogo ◽  
Seigo Nagasawa ◽  
Takuya Shimizu ◽  
Yoshihisa Umemura
Keyword(s):  
Bone Mass ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Middle Aged ◽  
Mineral Density ◽  
Beneficial Effects ◽  
Ovx Rats ◽  
Jump Exercise ◽  
Body Weights ◽  
The Right

The effect of jump exercise on middle-aged osteopenic rats was investigated. Forty-two 9-mo-old female rats were either sham-operated (Sham) or ovariectomized (OVX). Three months after surgery, the rats were divided into the following groups: Sham sedentary, Sham exercised, OVX sedentary, and OVX exercised. Rats in the exercise groups jumped 10 times/day, 5 days/wk, for 8 wk, with a jumping height of 40 cm. Less than 1 min was required for the jump training. After the experiment, the right tibia and femur were dissected, and blood was obtained from each rat. OVX rats were observed to have increased body weights and decreased bone mass in their tibiae and femurs. Jump-exercised rats, on the other hand, had significantly increased tibial bone mass, strength, and cortical areas. The bone mass and strength of OVX exercised rats increased to approximately the same extent as Sham exercised rats, despite estrogen deficiency or osteopenia. Our data suggest that jump exercise has beneficial effects on lower limb bone mass, strength, bone mineral density, and morphometry in middle-aged osteopenic rats, as well as in Sham rats.

scholarly journals A study on correlation of lipid profile with body mass index in young adults (18-20 years)

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 102-107
Author(s):  
Gurupavan Kumar Ganta ◽  
Divya D ◽  
Kedari G S R
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Young Adults ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Overweight And Obesity ◽  
Low Density

Overweight and obesity in youth is a worldwide public health problem. Predisposition to obesity starts during the first or second decade of life. Overweight and obesity in adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidaemia, hypertension and type 2 diabetes mellitus. Our study was done to find the relation between body mass index (BMI) and lipid profile in young adults (18-20 years) and for the correlation between the various parameters. 150 young adults between 18-20 years of age, who gave written voluntary consent were included in the study. BMI was calculated after measuring height and weight along with fasting blood samples for estimation of blood glucose and lipid profile [Total cholesterol, High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) and triacylglycerol (TGL)] were measured. The data collected was analysed using Statistical package for the social sciences (SPSS) statistics software version 20. A linear correlation regression analysis was done to know the correlation between the anthropometric measurements and biochemical parameters. ANOVA test was performed to know the significance and a p value of < 0.01 was taken as significant. All the biochemical parameters showed a positive correlation with BMI. Total cholesterol had the highest positive correlation with BMI. There was a prevalence of 39.3% overweight/obesity as per BMI cut-off. Individuals who were in the obese category had a higher prevalence of abnormal lipid profile especially total cholesterol. Stress and lack of physical activity have a detrimental effect on health and are a major risk factor for development of obesity. 90% of the students in this study did not have any regular physical activity. Educating the students about effects of obesity and dyslipidaemia on quality of health can help in bringing life style modifications which can help them in the long run.

scholarly journals Cannabis sativa and/or melatonin do not alter brain lipid but alter oxidative mechanisms in female rats

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Halimat Amin Abdulrahim ◽  
Isiaka Abdullateef Alagbonsi ◽  
Oluwasola Amuda ◽  
Noah Adavize Omeiza ◽  
Abdul-Rahuf Aderemi Feyitimi ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Rat Brain ◽  
Cannabis Sativa ◽  
Density Lipoprotein ◽  
Redox Status ◽  
Female Rats ◽  
Control Group ◽  
Brain Lipid ◽  
Significant Difference ◽  
The Brain

Abstract Background Lipid profile and redox status play a role in brain (dys)functions. Cannabinoid and melatonergic systems operate in the brain and contribute to brain (patho)physiology, but their roles in the modulation of brain lipid and redox status are not well-known. We studied the effect of ethanol extract of Cannabis sativa (CS) and/or melatonin (M) on the lipid profile and anti-oxidant system of the rat brain. Methods We randomly divided twenty-four (24) female Wistar rats into 4 groups (n = 6 rats each). Group 1 (control) received distilled water mixed with DMSO. Groups II–IV received CS (2 mg/kg), M (4 mg/kg), and co-administration of CS and M (CS + M) respectively via oral gavage between 8:00 am and 10:00 am once daily for 14 days. Animals underwent 12-h fasting after the last day of treatment and sacrificed under ketamine anesthesia (20 mg/kg; i.m). The brain tissues were excised and homogenized for assay of the concentrations of the total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), nitric oxide (NO), malondialdehyde (MDA), and the activities of glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase (GR), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and acetylcholinesterase (AChE). One-way analysis of variance (ANOVA) was used to compare means across groups, followed by the least significant difference (LSD) post-hoc test. Results CS and/or M did not affect the lipid profile parameters. However, CS increased the G6PD (from 15.58 ± 1.09 to 21.02 ± 1.45 U/L; p = 0.047), GPx (from 10.47 ± 0.86 to 17.71 ± 1.04 U/L; p = 0.019), and SOD (from 0.81 ± 0.02 to 0.90 ± 0.01 μM; p = 0.007), but decreased NO (from 9.40 ± 0.51 to 6.75 ± 0.21 μM; p = 0.010) and had no effect on MDA (p = 0.905), CAT (p = 0.831), GR (p = 0.639), and AChE (p = 0.571) in comparison with the control group. M augmented the increase in G6PD (from 21.02 ± 1.45 U/L to 27.18 ± 1.81 U/L; p = 0.032) and decrease in NO (from 6.75 ± 0.21 to 4.86 ± 0.13 μM; p = 0.034) but abolished the increase in GPx (from 17.71 ± 1.04 to 8.59 ± 2.06 U/L; p = 0.006) and SOD (from 0.90 ± 0.01 to 0.70 ± 0.00 μM; p = 0.000) elicited by CS in the rat brain in comparison with the CS group. Conclusions CS and M do not alter brain lipid profile. Our data support the contention that CS elicits an anti-oxidative effect on the brain tissue and that CS + M elicits a pro-oxidant effect in rat brain.

scholarly journals The Splenectomy Effects on Lipid Profile and Glucose Metabolism in the Major Thalassemia Patients

2021 ◽  
Author(s):  
Zohreh Sajadi Hezaveh ◽  
Mahsa Hadidi ◽  
Farzad Shidfar
Keyword(s):  
Physical Activity ◽  
Glucose Metabolism ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Beta Thalassemia ◽  
Oral Glucose ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

Background: Splenectomy is a common treatment for beta thalassemia. It not only eliminates many complications by reducing the need for blood transfusion, but also causes new complications that threaten the patients' health. The aim of this study was to determine if splenectomy could alter the lipid profile and glucose metabolism in beta thalassemia major patients. Methods: In this case-control study, 41 splenectomized and 42 non-splenectomized eligible beta thalassemia patients were selected from Zafar Thalassemia Clinic, Tehran, Iran. Anthropometric, demographic, and biochemical data were collected using standard methods. Physical activity and food intake were measured using International Physical Activity Questionnaire (IPAQ) and food frequency questionnaires (FFQ), respectively. Results: Demographic characteristics and dietary intake were not significantly different between the two groups. However, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), very low density lipoprotein cholesterol (VLDL-C), TC/HDL-C, LDL-C/TG, and LDL-C/HDL-C ratios were significantly higher, but HDL-C was significantly lower in splenectomized patients (P < 0.05). Furthermore, fasting blood glucose (P < 0.39) and oral glucose tolerance test (P < 0.53) did not significantly differ between the two groups. Conclusions: Reduced activity of the reticuloendothelial system and reduced removal of cholesterol might be the reason for higher plasma lipid profile and greater risk of cardiovascular diseases in splenectomized patients. On the other hand, glucose metabolism was not affected by splenectomy in adult patients. To clarify this relationship, prospective studies are suggested.

Effect of Cashew Nut on Lipid Profile: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 27 (5) ◽  
pp. 348-356 ◽  
Author(s):  
Mojgan Morvaridzadeh ◽  
Mahdi Sepidarkish ◽  
Farnaz Farsi ◽  
Abolfazl Akbari ◽  
Roghayeh Mostafai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lipid Profile ◽  
Fixed Effects ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Cochrane Library ◽  
Analysis Model ◽  
Beneficial Effects ◽  
Cashew Nut

Introduction: Nuts are one of the dietary components which appear to have beneficial effects on cardiovascular disease biomarkers. Studies demonstrate beneficial effects of cash­ews on serum lipids concentration, but results in the literature remain inconclusive. We conducted a review to examine the effects of cashew nut supplementation on serum lipid profile. Methods: Two reviewers independently searched PubMed, Web of Science, Cochrane Library, Scopus, and EMBASE electronic databases from inception until June 2019 without language limitation. Random- and fixed-effects models were used to calculate 95% confidence intervals (CI) for studies. Results: Six randomized clinical trials comprising 531 participants were included in this systematic review. Three studies were included in the meta-analysis model. There were no significant changes for total cholesterol (TC) (standardized mean difference [SMD]: –0.02, 95% CI: –0.32, 0.28), triglycerides (TG) (SMD: –0.01, 95% CI: –0.22, 0.20), high-density lipoprotein (HDL) cholesterol (SMD: 0.09, 95% CI: –0.16, 0.34), or low-density lipoprotein (LDL) cholesterol (SMD: –0.18, 95% CI: –0.75, 0.39). Conclusion: The results of this analysis demonstrate that treatment with cashew nut supplementation alone did not significantly change serum levels of LDL, HDL, TC, or TG.

The Effects of Yellow Soybean, Black Soybean, and Sword Bean on Lipid Levels and Oxidative Stress in Ovariectomized Rats

2010 ◽  
Vol 80 (2) ◽  
pp. 97-106 ◽  
Author(s):  
Jae Soon Byun ◽  
Young Sun Han ◽  
Sang Sun Lee
Keyword(s):  
Oxidative Stress ◽  
Postmenopausal Women ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Lipid Levels ◽  
Black Soybean ◽  
And Oxidative Stress

Soy isoflavones have been reported to decrease the risk of atherosclerosis in postmenopausal women. However, the effects of dietary consumption of soybean have not been explored. In this study, we evaluated the effects of consuming yellow soybeans, black soybeans (Glycine max), or sword beans (Canavalia gladiate) on lipid and oxidative stress levels in an ovariectomized rat model. Forty-seven nine-week-old female rats were ovariectomized, randomly divided into four groups, and fed one of the following diets for 10 weeks: a diet supplemented with casein (NC, n = 12), a diet supplemented with yellow soybean (YS, n = 12), a diet supplemented with black soybean (BS, n = 12), or a diet supplemented with sword bean (SB, n = 11). Plasma triglyceride (TG) levels in the BS and SB groups were significantly lower than that in the NC group. Notably, the BS group had significantly lower plasma total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels than the other groups. Hepatic total lipid levels were significantly lower in the YS and SB groups, and cholesterol levels were significantly lower in the SB group than in the NC group. Superoxide dismutase (SOD) and catalase (CAT) activities were significantly higher in the groups fed beans compared to the NC group. Hepatic thiobarbituric acid reactive substances (TBARS) levels were also significantly lower in the BS and SB groups than the NC group. In conclusion, our results suggest that consumption of various types of beans may inhibit oxidative stress in postmenopausal women by increasing antioxidant activity and improving lipid profiles. Notably, intake of black soybean resulted in the greatest improvement in risk factors associated with cardiovascular disease.

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