scholarly journals Program «Smart ECG – ranolazin» - own experience and world approach

2020 ◽  
Vol 24 (4 (96)) ◽  
pp. 110-116
Author(s):  
V. Tashchuk ◽  
O. Malinevska-Biliichuk ◽  
D. Onofreichuk ◽  
P. Ivanchuk ◽  
M. Tashchuk
Keyword(s):  
Clinical Trials ◽  
Exercise Tolerance ◽  
Control Group ◽  
Level Of Evidence ◽  
Aldosterone Antagonists ◽  
Basic Therapy ◽  
Group I ◽  
Improve Exercise Tolerance ◽  
Angina Frequency ◽  
Positive Effect

Purpose - comprehensive analysis of the world approach of the use of ranolazine in various clinical trials and the introduction of the program "Smart ECG" to assess the effectiveness of ranolazine.Matherial and methods. Evaluation of European guidelines, analysis of global randomized clinical trials of the ranolazine use, presentation of our own trial: we examined 40 patients with Q wave myocardial infarction (STEMI), were instituted basic therapy according to the modern recommendations which contained interventional treatment with restoration of patency of a heart attack-conditioned coronary artery, double antiplatelet therapy, statins, β-adrenergic blocker, angiotensin-converting enzyme inhibitors, aldosterone antagonists with addition of ranolazine (group I, 30 patients diagnosed STEMI), control - group II, 10 patients with STEMI, who received basic therapy without addition of ranolazine. Results. Analysis of clinical trials (CARISA, MARISA, ERICA, TERISA, MERLIN-TIMI, RIVER-PCI, RIMINI-TRIAL) proved the effectiveness of ranolazine as an antianginal and anti-ischemic drugs. The use of own program «Smart ECG» demonstrates the positive effect of ranolazine on STEMI and requires further implementation.Conclusion. In the European Society of Cardiology guidelines of the management of stable angina pectoris, ranolazine is given a class IIa (level of evidence B) recommendation as a second-line treatment to reduce angina frequency and improve exercise tolerance in subjects who cannot tolerate, have contraindications to, or whose symptoms are not adequately controlled by β- adrenergic blockers, calcium channel blockers and long-acting nitrates. In subjects with baseline low heart rate and low blood pressure, ranolazine may be considered as a first-line drug to reduce angina frequency and improve exercise tolerance - class IIa (level of evidence C) recommendation. Own study, which partially reflects the global approach according to the analyzed clinical studies, demonstrates the positive effect of ranolazine for patients with STEMI - analogue scale EQ–VAS indicates a positive effect, positive influence on the markers of electrical myocardial instability: decreasing of the probability of cases of SDNN decrease, depression of QT and maybe increase of ratio of maximum velocity for differentiated T wave.

scholarly journals EFFICACY OF SPIRULINA FOR ALLERGIC RHINITIS

2021 ◽  
Author(s):  
Iury Gomes Batista ◽  
Osmar Cleyton Person ◽  
Fernando Veiga Angelico Junior ◽  
Priscila Bogar
Keyword(s):  
Clinical Trials ◽  
Allergic Rhinitis ◽  
Randomized Clinical Trials ◽  
Nasal Congestion ◽  
Control Group ◽  
Cochrane Central Register ◽  
Level Of Evidence ◽  
Runny Nose ◽  
Trial Quality ◽  
Central Register

Introduction: Allergic rhinitis is a condition of high prevalence in the population and widely studied, with several treatments being consecrated for its control. Spirulina is a dietary supplement that modulates immune function, and has been shown to modulate the inflammatory response of allergic rhinitis. Purpose: To evaluate spirulina in the treatment and control of allergic rhinitis. Material and Methods: This is a systematic review of randomized clinical trials. Searches were performed for randomized clinical trials relating spirulina to allergic rhinitis in five electronic databases: Cochrane - Central Register of Controlled Trials - CENTRAL (2021), PUBMED (1966-2021), EMBASE (1974-2021), LILACS (1982-2021) AND SCOPUS (2021). Two investigators independently extracted data and assessed trial quality. Results: Two clinical trials involving a total of 215 patients were included. Both studies assessed the efficacy of spirulina in improving allergic rhinitis as the primary outcome. The first study described a significant reduction in runny nose, nasal congestion and itching over time of medication use (p 0.001) and in the second study the prevalence of rhinorrhea (P = 0.021), nasal congestion or obstruction (P = 0.039) and decreased smell (P = 0.030) were significantly less in the experimental group than in the control group. Conclusions: The included studies were in favor of the use of spirrulina. However, the level of evidence is very low and limited. We should have caution due to the small number of clinical trials and participants in these studies. It is recommended to carry out new RCTs following the CONSORT standardization.

scholarly journals INDUCTION OF EFFECTORS OF INNATE AND ADAPTIVE IMMUNITY IN THE PROCESS OF THERAPY OF TOPIC FORM OF RECOMBINANT INTERFERON-a2b DURING RESPIRATORY INFECTIONS IN PREGNANT

2017 ◽  
pp. 38-45 ◽  
Author(s):  
M. P. Kostinov ◽  
I. V. Lukachev ◽  
A. K. Mescheryakova ◽  
E. V. Dmitrieva ◽  
N. K. Akhmatova ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Adaptive Immunity ◽  
Respiratory Infections ◽  
Lymphocyte Subpopulations ◽  
Control Group ◽  
Recombinant Interferon ◽  
Innate And Adaptive Immunity ◽  
Basic Therapy ◽  
Cell Immunity ◽  
Group I

Aim. Study immunologic phenotype of lymphocytes in the process of therapy of topic form of recombinant interferon-a2b during respiratory infections in pregnant. Materials aih. methods. 74 pregnant women from 14 weeks of gestation took part in the study, among their 55 - within 24 hours with symptoms of acute respiratory infection (ARI) of light and medium, severe course of infection, who do not need hospitalization. Group I - 34 pregnan omen with ARI receiving basic therapy with human recombinant interferon-a2b in gel form. Group 11 - 21 pregnant with ARI receiving only basic therapy. Control group had 19 pregnant omen without signs of ARI. Relative content of principle lymphocyte subpopulations was -:udied by flow cytofluorimetry: CD3+, CD3+CD4+, CD3+CD8+, CD3-CD19+, CD3-CD16+56+, CD3-CD8+; immune regulatory index was calculated in blood within 24 hours 'om the onset of the disease and 8 - 10 days later. Results. A disbalance of lymphocyte subpopulations was noted in pregnant women with light or medium severity course of acute 'espiratory infections, that was characterized by an increased content of CD3-CD16+56+ .nd CD3+CD8+, as well as a reduced content of CD3+ and CD3+CD8+. Inclusion of a :opical form of recombinant interferon-oc2b during the first days of development of the disease .as a systemic effect on cell immunity and results in normalization of subpopulation compoition of blood lymphocytes that is characteristic for physiological course of pregnancy. Conclusion. Administration of topic form of recombinant interferon in pregnant with light or medium severity of ARI can be accompanied by activation of factors of innate and adaptive immunity.

scholarly journals BULLS CONSUMPTION AND USE OF DIET SUBSTANCES BY PROBIOTICS VETOSPORIN SUSPENSION

2018 ◽  
pp. 43-48
Author(s):  
Фаргат Вагапов ◽  
Fargat Vagapov ◽  
Наталья Гизатова ◽  
Natalya Gizatova
Keyword(s):  
Feed Intake ◽  
Live Weight ◽  
The Body ◽  
Control Group ◽  
Feed Supplement ◽  
Group I ◽  
Bull Calves ◽  
Positive Effect ◽  
Young Growth ◽  
Different Doses

The purpose of research is increase the efficiency of the use of nutrients for rations by Simmental breed bulls with various doses of Vetosporin Suspension. Bulls were fed by probiotic in the amount of 0.1; 1 and 2 ml per 10 kg of live weight. It has been established that the use of rations including the feed supplement studied, in the feeding of experimental groups, promoted an increase in feed intake. Thus, the young growth of the three experimental groups exceeded the analogues of the control group for the consumption of hay grass by 37-118 kg (1.47-4.68%), green weight – by 31-71 kg (1.74-3.98%). Concentrates, molas-ses, fodder, and salt were given to the animals in the same amount. It can be stated that feeding to the Simmental bulls of different doses of the Vetosporin drug suspension had a positive effect on the digestibil-ity of the nutrients of the diet and their assimilation by the body. It is evident that in animals of experimental groups there is a certain superiority in certain indices over analogues of the control group. In this case, the animals of group I were inferior to the experimental groups by a digestibility factor of 1.03-2.24%, raw fat by 0.43-0.77%. For the rest of the indicators, there was a similar trend. When fattening Simmental bull calves, full-fledged and, importantly, balanced feeding was organized. Taking this into account, the use of probiotic fodder supplement, Vetosporin Suspension, contributed to greater consumption of all types of feed, nutrients and energy by animal test groups. In this case, the greatest effect was observed with the use of an approved additive in a dose of 1.0 ml per 10 kg of alive weight.

scholarly journals Effects of Pulmonary Rehabilitation on Exercise Tolerance in Patients with COPD

2015 ◽  
Vol 9 (2) ◽  
pp. 65-71
Author(s):  
Mohammad Nesar Uddin Ahmed ◽  
Shelina Begum ◽  
Taskina Ali
Keyword(s):  
Drug Treatment ◽  
Pulmonary Rehabilitation ◽  
Exercise Tolerance ◽  
T Test ◽  
Control Group ◽  
Test Results ◽  
Standard Drug ◽  
Breathing Exercises ◽  
Copd Patients ◽  
Improve Exercise Tolerance

Background: Pulmonary rehabilitation (PR) is known to be therapeutically useful for COPD patients. Objective: To evaluate the effects of combination of breathing exercises (pursed lip breathing and diaphragmatic breathing) and lower extremity endurance training (LEET) as part of PR program on six minute walk distance (6MWD), on oxygen saturation (SpO2%), on the level of dyspnea and fatigue in patients with moderate stable COPD. Methods: This prospective study was conducted in the Department of Physiology, BSMMU, Dhaka from July 2010 to June 2011 on 116 male stable moderate COPD patients aged 50 to 65 years. They were enrolled from the out patient department (OPD) of the Department of Medicine of BSMMU and NIDCH Dhaka. 56 patients without PR constituted control group and experimental group included 60 patients intervened with PR. The experimental patients were advised to perform the PR program for 30 minutes duration per session at home twice daily, for consecutive 60 days along with the standard drug treatment of COPD. The control patients were advised to continue their standard drug treatment alone for consecutive 60 days. For the assessment of exercise tolerance, 6MWD, SpO2%, the level of dyspnea and fatigue of all subjects were recorded on day 0 and day 60 for both the groups. SpO2% was recorded by portable Pulse Oximeter and the level of dyspnea as well as fatigue were recorded by Modified Borg Scale. Statistical analysis was done by independent sample ‘t’ test and paired sample ‘t’ test. Results: Significant improvement were observed in 6MWD, SpO2%, the level of dyspnea and fatigue in patients who performed PR program. In addition, significant improvement in these parameters were observed after completing PR program compared to the beginning of the intervention. Conclusion: The study concludes that regular exercise of all components of PR program significantly improve exercise tolerance in COPD patients DOI: http://dx.doi.org/10.3329/jbsp.v9i2.22799 Bangladesh Soc Physiol. 2014, December; 9(2): 65-71

scholarly journals The Safety and Efficacy of Stem Cell Therapy as an Emerging Therapy for ALS: A Systematic Review of Controlled Clinical Trials

2021 ◽  
Vol 12 ◽  
Author(s):  
Ammar Aljabri ◽  
Alhussain Halawani ◽  
Ghassan Bin Lajdam ◽  
Suhail Labban ◽  
Samah Alshehri ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Stem Cell ◽  
Control Group ◽  
Safety And Efficacy ◽  
Positive Effects ◽  
Significant Difference ◽  
Marrow Mesenchymal Stem Cells ◽  
New Treatments ◽  
Positive Effect ◽  
Emerging Therapy

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a heterogeneous course that ultimately leads to death. Currently, there is no cure, and new treatments that can slow the progression of the disease are needed. Stem cell (SC) transplantation is an emerging therapy that has shown a lot of potential in recent clinical trials. This review is aimed to examine the results of various clinical trials on this topic, thus assessing the safety and efficacy of SC transplantation as a potential treatment for ALS. We identified 748 studies in our search, of which 134 full-text studies were assessed for eligibility. Six studies met the inclusion criteria and were included in this review. Although some of the included studies showed the positive effect of SC transplantation, other studies found that there was no significant difference compared to the control group. We observed more positive effects with bone marrow mesenchymal stem cells (BM-MSC) treatments than Granulocyte colony-stimulating factor (G-CSF) ones. However, other factors, such as route of administration, number of doses, and number of cells per dose, could also play a role in this discrepancy. Based on this information, we conclude that more properly conducted clinical trials are needed to appreciate the benefit of this treatment.

scholarly journals IATROGENIC CHANGES IN THYROID GLAND OF PATIENTS WITH ATRIAL FIBRILLATION AFTER THERAPY WITH AMIODARON

2021 ◽  
Vol 21 (1) ◽  
pp. 11-16
Author(s):  
O.I. Danyliuk
Keyword(s):  
Atrial Fibrillation ◽  
Thyroid Gland ◽  
Free Thyroxine ◽  
Antiarrhythmic Therapy ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Antiarrhythmic Action ◽  
Basic Therapy ◽  
Functional Changes ◽  
Group I

Objective of the study: to analyze the frequency of structural and functional changes in the thyroid gland of the patients with atrial fibrillation who took amiodarone for 12 months on regular basis. The study was based on findings obtained by examining 80 patients (28 women and 52 men) with cardiosclerosis (diffuse and postinfarction), atrial fibrillation and heart failure IIA at the age of 63.5 ± 1.3 years and 15 healthy individuals of the relevant age (62,4 ± 2,4 years) and relevant sex proportions. The main inclusion criterion was the euthyroid state of the thyroid gland before the beginning of antiarrhythmic therapy. To assess the functional state of the thyroid gland, we studied the content of free thyroxine, triiodothyronine, and antibodies to thyroid peroxidase. The examination was carried out before the therapy, and in 3, 6, 9 and 12 months after the beginning of the study during the course of antiarrhythmic therapy. To detect structural changes in the thyroid gland, we used ultrasound scanning. Depending on the prescribed treatment, the participants were divided into the following groups: group I included the patients who received amiodarone in a dosage of 200 mg per day and basic therapy (n = 60); control group involved the patients who received the basic therapy with antiarrhythmic drugs, digoxin and bisoprolol (n = 20). Results. The therapy with amiodarone for a year resulted in thyroid dysfunction in 33.3% of the patients. Hypothyroidism (20.0%) is leading in the structure of amiodarone-associated thyroid dysfunctions; this condition is subclinically manifested in 11.7% of the patients. The development of amiodarone-induced thyrotoxicosis was observed in 13.3% of the patients, and the first cases of hyperthyroidism were detected not earlier than six months. Under the effect of amiodarone in the first months of the therapy, serum levels of free thyroxine may increase, while free triiodothyronine may decrease, therefore there may be a tendency to slightly increased levels of thyroid-stimulating hormone in the first weeks of the therapy. The above changes in laboratory parameters are transient and are not accompanied by the deterioration of the antiarrhythmic action of amiodarone.

scholarly journals The influence of propylene glycol on body condition and milk yield of cows as well as colostrum and milk composition

2005 ◽  
Vol 53 (4) ◽  
pp. 51-60
Author(s):  
Robert Kupczyński ◽  
Maciej Adamski ◽  
Gustav Chládek
Keyword(s):  
Propylene Glycol ◽  
Milk Yield ◽  
Body Condition ◽  
Milk Composition ◽  
High Yield ◽  
Control Group ◽  
Group Iii ◽  
Group I ◽  
Before And After ◽  
Positive Effect

The research was executed on 24 high yield dairy cows divided into three groups (n = 8). There was the control group (I) that the propylene glycol wasn’t given to cows, group II – the cows received 250 ml/day/per head of the propylene glycol, and the group III ─ the cows received 500 ml/day per head of the propylene glycol. The preparation was administered to cows per os beginning from 2 weeks before parturition to the end of the third week of lactation. During the research the condition of animals was estimated by BCS method, the daily yield was recorded, and analyses of the milk and colostrum composition were performed. The propylene glycol lightened the decrease of cows’ condition during entering at the peak of lactation. The higher dose (500  ml) was more profitable, because it had an influence on the content of the colostrum components, low urea level in milk as well as on daily yield, which was higher of about 3.64  kg while the preparation was given, in comparison to the control group. In the 3rd week of lactation the low level of somatic cells in milk of cows that received the preparation was stated. In conclusion, our study revealed a great positive effect of propylene glycol given to the cows shortly before and after parturition on their body condition and a less significant effect on colostrum quality and milk yield.

Abstract 2390: Düsseldorfer-ABCD Trial (Autologous Bone Marrow Cells in Dilated Cardiomyopathy)

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Christiana M Schannwell ◽  
Muhammad Yousef ◽  
Carmen M Basalyk ◽  
Tobias Zeus ◽  
Michael Brehm ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Clinical Trials ◽  
Side Effects ◽  
Bone Marrow Cells ◽  
Autologous Bone Marrow ◽  
Left Ventricular ◽  
Control Group ◽  
Group I ◽  
Autologous Bone ◽  
Marrow Cells

Heart failure is a dangerous disease with an increasing frequency. Although conventional drug therapy may delay remodeling, there is no basic therapeutic regime available for preventing or even reversing this process. Several preclinical as well as clinical trials have shown that transplantation of autologous bone marrow cells improved cardiac function after myocardial infarction and chronic heart disease (CAD). We investigated the effects of intracoronary (ic) autologous stem cell transplantation (STX) at patients with non-ischemic dilated cardiomyopathy (DCM). Methods: A total of 10 patients with DCM were included in this study (group I). The control group also consists of 10 age and sex-matched patients with comparable ejection fraction (group II). CAD and myocarditis were excluded. All patients of group I received an ic autologous STX with mononuclear cells. Cell transplantation was performed via the ic administration route. All cells were infused directly into the dominant coronary vessel. To achieve a maximal ischemic stimulus all patients received Dobutamine intravenously and Dipipyridamol by ic application. All 20 patients were re-investigated after 3 months. Results: Three months after ic STX, the global left ventricular ejection fraction increased in patients from 18 ± 1 up to 26 ± 3% (p < 0.01). In parallel the physical ability (functional capacity) rose from 25 to 75 watt (p < 0.01). In addition, we found an improvement of maximum oxygen uptake under stress from 1236 ± 217 up to 1473 ± 198 ml/min (p < 0.01). Furthermore we documented a reduction of arrythmia. An unchanged or even impaired left ventricular function was not observed in any patient of group I. In the control group (group II) no significant changes were documented. No side effects of ic autologous STX were found, particularly no arrythmias, no heart insufficiency, no dyspnoea and no palpitations. Conclusion: These results show that transplantation of autologous bone marrow cells, as well as the ic approach, represents a novel and effective therapeutic procedure for the therapy of DCM. For this method of therapy, no ethical problems exist, and no side effects were observed. However, further experimental studies and controlled prospective clinical trials have to follow.

scholarly journals Assessment of exercise tolerance of older men practicing Nordic Walking

2015 ◽  
Vol 29 (3) ◽  
pp. 29-34 ◽  
Author(s):  
Edyta Michalak ◽  
Magdalena Zygmańska
Keyword(s):  
Physical Activity ◽  
Exercise Tolerance ◽  
Older Men ◽  
Control Group ◽  
Nordic Walking ◽  
Walking Test ◽  
Group I ◽  
Fitness Index ◽  
The Impact ◽  
Experimental Group

Abstract Introduction: The aim of the study was to determine the impact of systematic individual Nordic Walking training on physical performance in older men. Material and methods: The study included 18 men (aged 52 to 73), divided into two groups. Group I (the experimental group) underwent an 8-week Nordic Walking training, while group II (the control group) did not perform any physical activity during the analyzed period. The level of physical exercise tolerance was assessed twice: at the beginning and after eight weeks of the study period using the Finnish walking test and the 30-minute walking test. The results were analyzed with the use of Statistica 10. software. Results: The results of the initial Finnish walking test show that the average values of the Fitness Index, time of a 2-kilometer distance coverage and HR were similar in both study groups. After 8 weeks, a statistically significant improvement in exercise tolerance was observed in the experimental group. Aerobic endurance evaluated on the basis of the Fitness Index increased (p <0.01). A reduction in time of 2 kilometer distance coverage (p <0.01) was accompanied by a reduction (p <0.05) in the level of HR. In the men qualified to the control group, all of the tested parameters remained unchanged. Within the study group, after 8. weeks of training, a significant improvement was also noted in the distance covered during the 30-minute walking test (p <0.01). Conclusions: Regular aerobic physical activity improves exercise tolerance in older men and may contribute to improving the comfort of their living.

scholarly journals The initial experience of using the drain implant to eliminate epiphora in patients with rhinogenous pathology

2018 ◽  
Vol 11 (2) ◽  
pp. 69-73
Author(s):  
Natalya Y. Beldovskaya ◽  
Sergey A. Karpichenko ◽  
Marina A. Shavgulidze ◽  
Elmaz E. Farikova
Keyword(s):  
Nasal Cavity ◽  
Paranasal Sinuses ◽  
Control Group ◽  
Negative Results ◽  
Group I ◽  
Group 12 ◽  
Drainage Effect ◽  
Essential Problem ◽  
Positive Effect

The pathology of upper lacrimal pathways associated with cicatrical strictures and obliteration, anatomical features of this zone is an essential problem of epiphora occurrence. The diseases of nasal cavity and paranasal sinuses play a significant role in the etiopathogenesis of this kind of epiphora. The search of new methods of preventing or eliminating epiphora, also caused by rinological pathology, is reasonable. Aim: To estimate the efficacy of drainage implant HEALAFLOW (Aptissen, Switzerland) in patients with complains on epiphora and concomitant nasal cavity pathology. Material and methods. 29 patients (50 eyes) with complains on permanent (more than 6 months) epiphora were under the supervision. Ge nerally accepted ophthalmological, dacryological, rhinological examinations, including cone-ray computer tomography of the paranasal sinuses with preliminary contrast of the lacrimal pathways were carried out. Patients were divided into two groups. 15 people (28 eyes) composed the main group (I). 14 people (22 eyes) formed a control group (II). In I group the drainage implant HEALAFLOW (Aptissen, Switzerland) was inserted in 1 day after operation aimed on elimination of nasal cavity pathology. Patients of the II group instillation of Tobradex according to the scheme and moistening drops were prescribed. Results. According to dacryological examination 29 patients (50 eyes) with complains on epiphora had normal passive lacrimal pathway passablness, but delayed or negative results of probes characterizing active passablness. All 29 patients had a rhinological pathology, which was eliminated by the otorhinolaryngologist with the operation at the first stage. In I group 9 patients noticed an increased epiphora immediately after the administration of HEALAFLOW in lacrimal pathway, which lasted during the first 24 hours after the procedure. Based on the results of the follow-up examination, after 3 months, all patients showed an improvement, expressed in the absence or decrease of epiphora. It should be noted that in the I group (after the insertion of the implant) the positive effect was more expressed. In the I group 12 of 15 patients didn’t have epiphora and in 3 patients it decreased. In the II group — 7 patients didn’t have epiphora and in 6 patients it decreased. Conclusion. Insertion of drainage implant HEALAFLOW in the lacrimal pathway after elimination of rhinological pathology in patients with complains on epiphora is safe, well tolerated and produces a positive drainage effect. This allows to recommend the implant to patients with tear-off device abnormality in the complex treatment of tear outflow disorders.

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