scholarly journals An association between dimensions and bridging of the sella turcica and dental anomalies

2021 ◽  
Vol 8 (1) ◽  
pp. 26-32
Author(s):  
Seden Akan ◽  
◽  
Nevin Kaptan Akar ◽  
Keyword(s):  
Sella Turcica ◽  
Control Group ◽  
Dental Anomalies ◽  
Supernumerary Teeth ◽  
Significant Relationships ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Chi Squared ◽  
Post Hoc ◽  
One Way Anova

Introduction The aim of this study was to determine the incidence of bridging of the sella turcica and the dimensions of the Sella in subjects with dental anomalies (transpositions, hypodontia, and supernumerary teeth) and to compare them to controls. Methodology Lateral cephalograms from 25 patients with dental transposition, 88 with hypodontia, and 26 with supernumerary teeth were evaluated. The shape, length, depth, diameter, and bridging of the Sella turcica were determined from radiographs and compared to those of control group (n=52). For statistical analysis, one-way ANOVA, Tukey post-hoc test, chi-squared test and T-test (to evaluate the influence of craniofacial growth) were used. Results The frequency of complete calcification of the Sella was greater in the group with supernumerary teeth (23%) and in the group with hypodontia (14.7%), while partial calcification of the Sella was more frequent in the control group (77%) and in the group with supernumerary teeth (73%)(p<0.05). The depth of the Sella was greater in the group with dental transposition. Oval and round Sella shapes were more frequent in all groups, and a flat Sella was rarely seen. In terms of the influence of growth on the dimensions of the Sella, there was no statistically significant difference between pre- and post-treatment radiographs. Conclusion Significant relationships were found between dental anomalies and bridging and shape of the Sella. The Sella was also significantly deeper in patients with dental transposition. The bridging and shape of the Sella may be useful in the diagnosis of dental anomalies in early childhood.

scholarly journals ANTIBACTERIAL EFFECTIVITY OF KASTURI LEAF EXTRACT (Mangifera casturi) AGAINST THE GROWTH OF Streptococcus sanguinis BACTERIA

2020 ◽  
Vol 5 (1) ◽  
pp. 33
Author(s):  
Dita Puspita Sari ◽  
Didit Aspriyanto ◽  
Irham Taufiqurrahman
Keyword(s):  
Leaf Extract ◽  
Periodontal Diseases ◽  
Tooth Surface ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Streptococcus Sanguinis ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Background: Caries is a disease that occurs because of the fermentation carbohydrates process by microorganisms in the oral cavity. One of the bacteria that causes caries is Streptococcus sanguinis. These bacteria will colonize on the tooth surface, then form dental plaques and contribute to the causes of caries and other periodontal diseases. Kasturi leaf extract (Mangifera casturi) has various compounds such as tannins, terpenoids, alkaloids, and flavonoids that have antimicrobial substances. Purpose: The aim of this study was to determine antibacterial effectivity of kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis bacteria. Method: This research was an experimental method laboratory (true experimental), with a randomized pre test and post test with control group design using 5 treatments: kasturi leaf extract (concentration: 20 mg/ml, 25 mg/ml, and 30 mg/ml); and two groups of control: positive control and negative control. Each treatment was repeated 5 times. Antibacterial activity testing used a liquid dilution method. Measurement of minimum inhibitory concentration (MIC) used a Uv-Vis Spectrophotometer and measurement of the minimum bactericidal concentration (MBC) used a colony counter. The MIC data were analyzed using One Way Anova and continued with the Dunnet Post Hoc test. MBC data were analyzed using the Kruskal-Wallis test and continued with the Mann-Whitney Post Hoc test. Result: One-Way Anova test showed that MIC had a significant difference, and the Kruskal-Wallis test showed that MBC also had significant differences. MIC was obtained at the concentration of 20 mg/ml and MBC was obtained at the concentration of 30 mg / ml. Conclusion: There is antibacterial effectiveness in kasturi leaf extract (Mangifera casturi) against the growth of Streptococcus sanguinis.

scholarly journals Cephalometric Changes Following Maxillary Expansion with Ni-Ti Leaf Springs Palatal Expander and Rapid Maxillary Expander: A Retrospective Study

2021 ◽  
Vol 11 (12) ◽  
pp. 5748
Author(s):  
Valentina Lanteri ◽  
Andrea Abate ◽  
Davide Cavagnetto ◽  
Alessandro Ugolini ◽  
Francesca Gaffuri ◽  
...  
Keyword(s):  
Los Angeles ◽  
Leaf Spring ◽  
Control Group ◽  
Maxillary Expansion ◽  
Average Decrease ◽  
Lateral Cephalograms ◽  
Significant Difference ◽  
Before And After ◽  
The Difference ◽  
One Way Anova

Background: The aim of this study is to evaluate and compare, through bidimensional cephalometry, skeletal and dental changes obtained from a rapid maxillary expander (RME) and a Ni-Ti leaf spring expander (Leaf) and compare them with an untreated control group. Methods: Records consisted of lateral cephalograms obtained before and after maxillary expansion of patients that underwent orthodontic treatment at the Department of Biomedical, Surgical and Dental Sciences. The Leaf expander group consisted of 9 males (mean age = 7.5 ± 0.9 years old) and 11 females (mean age = 8.2 ± 0.6 years old). The RME group of the present study was composed of 11 males (mean age = 7.8 ± 0.6 years old) and 12 females (mean age = 8.1 ± 0.5 years old). Digital cephalograms were traced using Dolphin Imaging software v.11.1 (Dolphin Imaging and Management Solutions; Los Angeles, CA, USA), which calculated all reported measurements. Each subject was assigned a random identification number, and the examiner was blinded to the subject when measuring. The difference between the two experimental times in all groups was evaluated using the Student’s t-test for dependent variables. The difference between the two evaluation times in each group for all the variables was used to perform a one-way ANOVA test between the three groups. Results: No statistically significant difference was noted, apart from the angle between the upper incisor and the SN and PP planes, which showed an average decrease of 3.25 and 2.55, respectively, and the angle between the lower incisors and the mandibular plane, which showed an average increase of 2.85 degrees. The one-way ANOVA showed no statistically significant difference between the three groups. Conclusions: It appears that the leaf expander and the RME present similar effects such as dental and skeletal changes.

scholarly journals The effect of combination probiotic lactobacillus brevis and leuconostoc mesenteroides on tgf-β and il-12 expression in ileum

2022 ◽  
Vol 21 (1) ◽  
pp. 175-183
Author(s):  
- Pujiati ◽  
Dono Indarto ◽  
- Susilorini ◽  
Diani Retno Widyatuti ◽  
Haneda Ilzafira Damayanti ◽  
...  
Keyword(s):  
Leuconostoc Mesenteroides ◽  
Lactobacillus Brevis ◽  
Combination Group ◽  
Control Group ◽  
P Value ◽  
Anova Test ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova ◽  
Asthma Group

Background: Asthma is a disease of the respiratory tract in the form of chronic inflammation. Chronic inflammation is one of them characterized by the remodeling of the airways mediated by the anti-inflammatory cytokine TGF-β. In addition there are also several immune cells that play a role such as macrophages, dendritic, neutrophils as producers of IL-12. The presence of the gut-lung axis allows the spread of inflammatory cytokines from the lungs to the intestines and vice versa. Lactobacillus brevis and Leuconostoc mesenteroides have the potential to modulate the immune system through its colonization of the gut. The study aimed to look at the effect of probiotics combined Lactobacillus brevis and Leuconostoc mesenteroides on the expression of TGF-β and IL-12 in the asthma model mouse ileum. Method: This experimental post-test only control group design study used 18 Sprague-Dawley mice. The mice were divided into 3 groups at random: control group (KI), asthma treatment (KII), asthma treatment with a combination of Lactobacillus brevis and Leuconostoc mesenteroides (KIII). Sensitization of asthma with OVA through intraperitoneal injection on days 0 and 14 and through inhalation on days 21 -63. Administration of combination probiotics per oral per day on days 21-63 after inhalation of OVA. The ileum network was taken on the 64th day and measured the expression of TGF-βand IL-12 with immunohistochemical methods and analyzed the percentage proportion of TGF-βand IL-12. Data analysis were conducted by One way ANOVA test and continued post hoc tests. Results: The percentage calculation of the proportion of TGF-βin thecontrol group (KI), asthma group (KII), and the combination group of L.brevis and L.mesenteroides (KIII) is 22.4 ± 15.27; 1.6 ± 2.12; 19.4 ± 6.65. While the percentage calculation of il-12 proportion in each group consecutively were 24.3 ± 19.67; 64.63 ± 9.90; 51 ± 16.62. One way ANOVA Test results on the percentage proportion of TGF-βhave a p value of 0.013 (p<0.05) which means there is a significant difference in the entire group. Furthermore, the Post Hoc Games-Howell test was conducted and obtained a p value of 0.003 (p<0.05) between the asthma group (KII) and the combination group of L.brevis and L.mesenteroides (KIII) which means there are significant differences between the two groups. One way ANOVA Test results on the percentage proportion of IL-12 have a p value of 0.011 (p<0.05) which means there is a significant difference in the entire group. Furthermore, the Post Hoc LSD test was conducted and obtained a p value of 0.001 (p<0.05) between the control group Post Hoc analyses was conducted and obtained a p value of 0.002 (p<0.05) with number of errors was 11.353 between the control group (KI) and asthma group (KII) which means there are significant differences between the two groups. Conclusion: The probiotic administration of lactobacillus brevis and Leuconostoc mesenteroides had no effect on the expression of TGF-β and had no effect on il-12 expression in the asthma model mouse ileum. It is necessary to do research on mice with asthma using combinations with other bacteria in order to get maximum effect. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 175-183

scholarly journals Pengaruh Perendaman Kopi Robusta dan Arabika terhadap Kekerasan Resin Komposit Nanofiller

e-GIGI ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Fransiska M. Pardosi ◽  
Darmawati A. Indraswari ◽  
Lusiana Batubara ◽  
Nadia Hardini
Keyword(s):  
Composite Resin ◽  
Artificial Saliva ◽  
Control Group ◽  
Arabica Coffee ◽  
Treatment Groups ◽  
Hardness Tester ◽  
Robusta Coffee ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Abstract: Nanofiller composite resin has small filler size which enhances its properties. However, these properties could decrease due to several factors. Acidic liquid such as coffee could reduce the hardness of composite resin. This study was aimed to analyze the effect of robusta and arabica coffee immersion on the hardness of nanofiller composite resin. A total of 27 composite resin samples were used and then were polished by using a soflex disc for 30 seconds on each roughness level. Samples were then divided into three groups, as follows: the control group with artificial saliva and the treatment groups with robusta coffee and arabica coffee. The composite resin molds were immersed in the three groups for 5 days. After five days of immersion, the hardness of the sample was tested by using a Vickers hardness tester. Artificial saliva as the control group had the highest mean hardness value of 112.98±8.67 VHN, followed by robusta coffee, and then by arabica coffee. The One Way Anova and post hoc LSD test showed that there were significant differences in all groups (p<0.05) except for the two treatment groups, namely robusta and arabica coffee groups which did not show any significant difference in the resin hardness (p>0.05). In conclusion, robusta and arabica coffee affect the hardness of the nanofiller composite resin, but there is no significant difference in the hardness between the robusta and arabica coffee groups.Keywords: composite resin hardness, nanofiller, robusta coffee, arabica coffee Abstrak: Resin komposit nanofiller memiliki ukuran filler kecil yang dapat meningkatkan fungsinya namun fungsi tersebut dapat menurun oleh beberapa hal. Cairan asam yang dikonsumsi seperti kopi dapat menurunkan kekerasan resin komposit. Penelitian ini bertujuan untuk mengetahui pengaruh perendaman kopi robusta dan arabika terhadap kekerasan resin komposit nanofiller. Sampel resin komposit yang digunakan sebanyak 27 buah dan dilanjutkan dengan pemolesan menggunakan soflex disc selama 30 detik setiap tingkat kekasarannya. Sampel kemudian dibagi dalam tiga kelompok, yaitu kelompok kontrol dengan saliva buatan dan dua kelompok perlakuan dengan kopi robusta dan arabika. Sebanyak 27 buah resin komposit direndam ke dalam tiga kelompok tersebut selama lima hari kemudian diuji kekerasannya dengan vickers hardness tester. Saliva buatan sebagai kelompok kontrol memiliki nilai rerata kekerasan tertinggi sebesar 112,98±8,67 VHN, diikuti kopi robusta, dan nilai terendah yaitu kopi arabika. Hasil uji One Way Anova dan post hoc LSD menunjukkan terdapat perbedaan bermakna pada semua kelompok (p<0,05) kecuali pada kedua kelompok perlakuan yaitu antara kopi robusta dan arabika tidak menunjukkan adanya perbedaan kekerasan yang bermakna (p>0,05). Simpulan penelitian ini ialah kopi robusta dan arabika memengaruhi kekerasan resin komposit nanofiller namun tidak terdapat perbedaan kekerasan antara keduanya.Kata kunci: kekerasan resin komposit, nanofiller, kopi robusta, kopi arabika

scholarly journals The In Vitro Anti-Diabetic Activity of Lime Peels (Citrus amblycarpa (Hassk.) Ochse)

2020 ◽  
Vol 13 (01) ◽  
pp. 26-33
Author(s):  
Gempita Cahya aulia tambunan ◽  
Aparna Dutt ◽  
Sayra Nadhifa ◽  
Firdha Amelia ◽  
Ermi Girsang
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Phytochemical Content ◽  
Ic50 Value ◽  
Significant Difference ◽  
Post Test ◽  
Lime Peel ◽  
Post Hoc ◽  
One Way Anova

There are various potential natural anti-diabetic drugs; one of them is lime peel or Citrus amblycarpa. This study was aimed to explore the anti-diabetic activity and phytochemical content of lime peels. This study was an experimental study that used the post-test only control group design. The lime peels that were collected from the Berastagi fruit market in Medan, North Sumatera were extracted using 70% ethanol by maceration methods. The phytochemical screening identified the presence of phenolic, steroid/triterpenoid, terpenoid, saponin, flavonoid, tannin, and alkaloid. Meanwhile, the anti-diabetic activity of lime peels was evaluate using the α-glucosidase enzyme that was gotten from Saccharomyces cerevisiae by α-glucosidase enzyme inhibition methods. Percent of inhibition was express as Mean ± SD and analyzed by One Way ANOVA, Tukey HSD Post Hoc Test, and followed by linear regression. The result of this study showed that there is a significant difference in percentage inhibition α-glucosidase enzyme in each concentration, and it had an IC50 Value amount of 125.93 ± 9.14 µg/mL. The phytochemical content of the lime peels was flavonoid, phenol, steroid/triterpenoid, and alkaloid. Hence, the lime peel has anti-diabetic activity by inhibition of the α-glucosidase enzyme.

scholarly journals PENGARUH KURMA (PHOENIX DACTYLIFERA L.) TERHADAP BERAT BADAN TIKUS PUTIH JANTAN (RATTUS NOVERGICUS)

2018 ◽  
pp. 181-188
Author(s):  
F Fadila ◽  
Brian Wasita ◽  
Paramasari Dirgahayu
Keyword(s):  
Positive Control ◽  
Negative Control ◽  
T Test ◽  
Test Weight ◽  
Control Group ◽  
Significant Difference ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova ◽  
Paired T Test

ABSTRAK Kurma merupakan salah satu buah dengan kandungan gizi terlengkap. Selain tinggi energi terutama karbohidrat (glukosa, fruktosa), kurma juga mengandung mineral besi yang berperan dalam metabolisme energi. Tujuan penelitian ini untuk mengetahui pengaruh kurma terhadap berat badan tikus (Rattus novergicus). Jenis penelitian eksperimental laboratorik dengan pre-post test with control grup. Sampel adalah 24 ekor tikus putih jantan (Rattus novergicus) strain Wistar, dibagi menjadi 4 kelompok, yaitu kelompok K1 (kontrol negatif), dan K2 (kontrol positif (diberikan suplemen FeSO )), P1 (perlakuan ekstrak air kurma mentah), dan P2 (perlakuan sari kurma). Analisis data dengan uji paired t-test untuk mengetahui perbedaan berat badan pre-post test, ANOVA untuk mengetahui perbedaan berat badan post test antar kelompok, yang dilanjutkan dengan post hoc test LSD, dengan α=0,01. Hasil penelitian menunjukan terjadi peningkatan berat badan pada semua kelompok sampel (K1, K2, P1, dan P2). Peningkatan berat badan tertinggi pada kelompok kontrol positif (K1) 11,12%, diikuti oleh kelompok perlakuan SK (P2) 11,00%, dan perlakuan EAKM (P1) 10,90%, sedangkan yang terendah pada kelompok kontrol negatif (K1) hanya 5,32%. Hasil analisis paired t-Test pada kelompok kontrol positif (K2), perlakuan EAKM (P1) dan SK (P2) menunjukan terdapat perbedaan berat badan pre- post test yang signifikan (p<0,01). Hasil analisis One Way Anova, diperoleh nilai p=0,000 (p<0,01) yang menandakan terdapat perbedaan berat badan post test yang signifikan antar 4 kelompok, di mana post hoc test LSD menunjukan perbedaan terletak antara kontrol negatif (K1) dengan kelompok yang diberikan perlakuan (K2, P1, dan P2), sedangkan diantara kelompok K2, P1, dan P2 tidak ada perbedaan yang signifikan. Kesimpulan: Kurma dapat meningkatkan berat badan tikus yang mengalami anemia defisiensi besi. Pengaruh kurma terhadap berat badan tikus sama dengan pengaruh dari pemberian suplemen FeSO4. Peningkatan berat badan tikus tanpa perlakuan sangat rendah jika dibandingkan dengan peningkatan berat badan tikus yang diberikan kurma dan suplemen FeSO .Kata Kunci: kurma (Pheonix dactylifera L.); ekstrak air kurma mentah (EAKM), sari kurma (SK), suplemen FeSO4, berat badan tikus. ABSTRACT Dates are one of the most nutritious fruits. In addition to high energy, especially carbohydrates, dates also contain iron minerals that play a role in energy metabolism. The purpose of this study was to determine the effect of dates on rat body weight (Rattus novergicus). Types of laboratory experimental studies with pre-post test with control group. The sample was 24 male white rats (Rattus novergicus) Wistar strain, divided into 4 groups, ie group K1 (negative control), and K2 (positive control (given FeSO4 supplement)), P1 (crude dates juice treatment), and P2 (dates juice treatment). Analysis of data with paired t-test to determine the difference of pre-post test weight, One Way Anova to know difference of post test between group weight, followed by post hoc test of LSD, with α = 0,01. The results showed that there was an increase in weight across all sample groups (K1, K2, P1, and P2). The highest weight gain in the positive control group (K1) was 11.12%, followed by the group of dates juice treatment (P2) 11.00%, and crude dates juice treatment (P1) 10.90%, while the lowest in the negative control group (K1) only 5 , 32%. The result of paired t-test analysis in positive control group (K2), crude dates juice treatment (P1) and dates juice treatment (P2) showed significant difference of pre-post test weight (p <0,01). The results of One Way Anova analysis showed that p = 0,000 (p <0,01) indicated that there was significant difference of post test weight between 4 groups, where post hoc test of LSD showed the difference between negative control (K1) and group that given treatment (K2, P1, and P2), whereas between groups K2, P1, and P2 there was no significant difference. Conclusion: Dates can increase the weight of rats with iron deficiency anemia. The effect of dates on body weight of rats is similar to that of FeSO4 supplementation. Increased rats weight without treatment is very low when compared with the increased weight of rats given dates and supplements of FeSO4.   Keywords: dates (Pheonix dactylifera L.); raw dates crude extract, dates juice, FeSO4 supplement, weight of rats.

scholarly journals the influence of giving katu’s leaf extract fraction toward prolactin level of breastfeeding mice and neuralgia cells of young mice

2015 ◽  
Vol 5 (2) ◽  
Author(s):  
Nurul Kamariyah
Keyword(s):  
Treatment Group ◽  
Breast Milk ◽  
Breast Feeding ◽  
Prolactin Level ◽  
Leaf Extract ◽  
Control Group ◽  
Significant Difference ◽  
Extract Fraction ◽  
Post Hoc ◽  
One Way Anova

People knew that Sauropus androgynus (L) Merr (katu’s leaf) have good nutrient and can enhance breast milk production. Study about influence of giving katu’s leaf extract fraction toward prolactin level and neuralgia cells in mice is not available recently. The purpose of this study is to find out the influence of giving katu’s leaf extract fraction toward prolactin level and neuralgia cells at mice, and influence prolactin level in breast feeding mouse towards amount of neuralgia cells in mice. Method of this study is laboratories experiment ”the post test-only control group” type experimental animals is mouse (Rattus norvegicus). The samples are 24 breast feeding mice with body weight 150-200 gram and divided into 4 groups, that are control group and treatment group which is given katu’s leaf extract fraction. Treatment group 1 with the dosage 24 mg, treatment group 2 with the dosage 48 mg and treatment group 3 with the dosage 72 mg. Treatment begun at the 3rd day post delivery until the 11th day. The 12th day the mouse is killed, blood from pericardium taken for prolactin test, while the mice is killed and it’s brain made as substance for testing of amount of neuralgia cells. Study result of prolactin with One Way Anova got significant difference (ρ=0,000). Continued with Post Hoc test got significant difference at C–T2, C–T3, T1–T2, T1–T3, and T2–T3. Result of neuralgia cells test at One Way Anova got significant difference (p=0,000).  Continued with Post Hoc test got significant difference at C–T2, C–T3, T1–T2, T1–T3, and T2–T3. Result of linier regression test got ρ (0.940) > α (0,05), means there is no influence prolactin level in breast feeding mouse towards amount of neuralgia cells in mice. The conclusion of the study was prolactin level in breast feeding mouse and amount of neuralgia cells in mice after giving katu’s leaf extract fraction have prolactin level higher and amount of neuralgia cells increase at the dosage 48 and 72 mg. If this study will be applied to human, should be done laboratorial test. More study about containing of breast milk after giving katu’s leaf extract fraction need to be continued.

scholarly journals Pengaruh lama aplikasi bahan remineralisasi casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACPF) terhadap kekerasan email

2016 ◽  
Vol 2 (3) ◽  
pp. 141 ◽  
Author(s):  
Miftah Wiryani ◽  
Billy Sujatmiko ◽  
Rini Bikarindrasari
Keyword(s):  
Vickers Hardness ◽  
Artificial Saliva ◽  
T Test ◽  
Control Group ◽  
Application Time ◽  
Hardness Tester ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova ◽  
Paired T Test

The effect of application time of CPP-ACPF on enamel hardness. Remineralization process can increase the hardness of enamel due to demineralization process. CPP-ACPF is a material used for enhancing remineralization. However, the application time of CPP-ACPF remain controversial among previous studies. This study was aimed to investigate the effect of various application times of CPP-ACPF on enamel hardness. Thirty premolar teeth were mounted on self cure acrylic resin, and were divided into 5 groups. Demineralization process was performed, and enamel hardness (pre-est) was measured by Vickers Hardness Tester. Remineralization was performed using CPP-ACPF in various application times: 3, 15, 30, 60 minutes, and the control group was only immersed in artificial saliva for 60 minutes, then enamel hardness was measured (posttest). Data were analyzed using paired t-test, one-way ANOVA, and post-hoc Bonferroni. The result of paired t-test showed that all the groups, except the control group, have an increasing enamel hardness that was statistically significant. One-way ANOVA results showed no statistically significant difference among the groups at pretest, but one-way ANOVA results showed statistically significant difference at posttest. Post hoc Bonferroni showed that the significantly difference at posttest occurred between all the treatment groups against the control group, but there were no significant differences between the 3 minutes group to 15 minutes group, between 15 minutes group to 30 minutes group, and between 30 minutes group to 60 minutes group. It was concluded that various application times of CPP-ACPF had an effect on increasing enamel hardness. ABSTRAKProses remineralisasi dapat meningkatkan kekerasan email yang menurun akibat demineralisasi. Bahan remineralisasi yang ideal adalah CPP-ACPF. Terdapat perbedaan lama aplikasi CPP-ACPF dalam berbagai penelitian, selain itu total lama aplikasi yang dibutuhkan CPP-ACPF dalam mekanisme remineralisasi belum diketahui. Penelitian ini dilakukan untuk mengetahui pengaruh lama aplikasi CPP-ACPF terhadap kekerasan email. Tiga puluh mahkota gigi premolar yang ditanam dalam resin akrilik self cure dibagi menjadi lima kelompok, kemudian dilakukan proses demineralisasi. Kekerasan email kemudian diukur menggunakan alat Vickers Hardness Tester. Proses remineralisasi menggunakan CPP-ACPF dilakukan pada masing-masing kelompok dalam berbagai lama aplikasi yaitu 3 menit, 15 menit, 30 menit, 60 menit, serta perendaman dalam saliva buatan selama 60 menit (kontrol). Kekerasan email kemudian diukur kembali (posttest). Data diuji secara statistik menggunakan t-test berpasangan, one-way ANOVA dan post hoc Bonferroni. Hasil paired t-test menunjukkan bahwa seluruh kelompok, kecuali kelompok kontrol, mengalami peningkatan rata-rata kekerasan email secara signifikan. Hasil uji one-way ANOVA pada pretest menunjukkan tidak ada perbedaan kekerasan email yang signifikan. Hasil uji one-way ANOVA pada posttest menunjukkan terdapat perbedaan kekerasan email yang signifikan. Hasil uji post Hoc Bonferroni menunjukkan bahwa terdapat perbedaan kekerasan email yang signifikan pada seluruh kelompok perlakuan terhadap kelompok kontrol, tetapi perbedaan kekerasan email antara kelompok lama aplikasi 3 menit dengan 15 menit, antara lama aplikasi 15 menit dengan 30 menit, serta antara lama aplikasi 30 menit dengan 60 menit tidak menunjukkan perbedaan kekerasan email yang signikan. Kesimpulan penelitian ini adalah berbagai lama aplikasi CPP-ACPF berpengaruh terhadap peningkatan kekerasan email.

scholarly journals Efektifitas Debridemen Mekanik Pada Luka Bakar Derajat III Terhadap Kecepatan Penyembuhan Luka

JKEP ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 93-103
Author(s):  
Nurma Afiani ◽  
Sanarto Santoso ◽  
Tina Handayani N ◽  
M. Fendi Nur Yahya
Keyword(s):  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Degree Burn ◽  
Significant Difference ◽  
Post Test ◽  
Long Time ◽  
The One ◽  
Post Hoc ◽  
One Way Anova

Third degree burn is a special wound cause consist of eschar for a long time. Kept eschar in third degree burn will delay healing procces. That is why eschar should be disapper by debridement process. Mechanical debridement used in this research. The aim of this research is to know the differences between mechanical debridement 24 hour and 48 hour in healing acceleration. This research is a true experimental by using  post test only control group design. The samples was selected by simple random sampling and was divided into three groups, each group consist of six rats, they are 24 hour group, 48 hour group and control group. The data was analyzed by one-way ANOVA then followed by Post Hoc LSD. The one way ANOVA result  p = 0,018 (p < 0,05) so there was a significant difference between control group and experimental groups. But the Post Hoc LSD results p = 0,123 ( p > 0,05)  so there was no significant difference between 24 hour group and 48 hour group in healing acceleration. For further researchers, it is suggested to use microscopic technique to know the effect of mechanical debridement in healing acceleration.

Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study

2020 ◽  
Vol 21 (2) ◽  
pp. 126-131
Author(s):  
Bhuvanachandra Pasupuleti ◽  
Vamshikrishna Gone ◽  
Ravali Baddam ◽  
Raj Kumar Venisetty ◽  
Om Prakash Prasad
Keyword(s):  
Plasma Concentration ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Plasma Concentrations ◽  
Control Group ◽  
Drug Concentrations ◽  
Significant Difference ◽  
Post Hoc ◽  
Hydrolysis Of ◽  
Cytochrome P 450

Background: Clobazam (CLBZ) metabolized primarily by Cytochrome P-450 isoenzyme CYP3A4 than with CYP2C19, Whereas Levetiracetam (LEV) is metabolized by hydrolysis of the acetamide group. Few CYP enzymes are inhibited by Proton Pump Inhibitors (PPIs) Pantoprazole, Esomeprazole, and Rabeprazole in different extents that could affect drug concentrations in blood. The aim of the present study was to evaluate the effect of these PPIs on the plasma concentrations of LEV and CLBZ. Methods: Blood samples from 542 patients were included out of which 343 were male and 199 were female patients and were categorized as control and test. Plasma samples analyzed using an HPLC-UV method. Plasma concentrations were measured and compared to those treated and those not treated with PPIs. One way ANOVA and games Howell post hoc test used by SPSS 20 software. Results: CLBZ concentrations were significantly 10 folds higher in patients treated with Pantoprazole (P=0.000) and 07 folds higher in patients treated with Esmoprazole and Rabeprazole (P=0.00). Whereas plasma concentration of LEV control group has no statistical and significant difference when compared to pantoprazole (P=0.546) and with rabeprazole and esomeprazole was P=0.999. Conclusion: The effect of comedication with PPIs on the plasma concentration of clobazam is more pronounced for pantoprazole to a greater extent when compared to esomeprazole and rabeprazole. When pantoprazole is used in combination with clobazam, dose reduction of clobazam should be considered, or significance of PPIs is seen to avoid adverse effects.

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