Effect of Sesame Oil on Lipid Profile and Liver Enzymes in Male Albino Rats Treated With Carbone Tetrachloride (CCl4)

2018 ◽  
pp. 41
Author(s):  
Rashaa Faiq Abdul-Lattif
Keyword(s):  
Lipid Profile ◽  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Liver Enzymes ◽  
Density Lipoprotein ◽  
Sesame Oil ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Fourth Group

      This study was designed to investigate the effect of sesame oil on lipid profile and liver enzyme in male albino rats treated with Carbone tetrachloride (CCl4).     Forty adult male rats were divided into four equal groups, first group was daily administrated with tap water, the second group was injected with CCl4 (80mg/kg.BW/day), the third group was administrated with sesame oil (150mg/kg.BW/day) and the fourth group was injected with CCl4 (80mg/kg.BW/day) and was administrated with sesame oil (150 mg /kg.BW /day) for 30 days. The statistical  results of the present study showed a significant  (p<0.05) increase in the level of cholesterol , triglycerides and Low density lipoprotein (LDL) in the group treated with CCl4 compared with control group, also a significant  (p<0.05) increase in the level of liver enzymes Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) , no difference on High density lipoprotein (HDL) level .The fourth group that was administrated with sesame oil and injected with  CCl4 showed a significant (p<0.05) decrease  in the level of cholesterol, triglyceride , LDL and also  a significant (p<0.05) decrease in liver enzymes Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) compared with the group that injected with Carbone tetrachloride CCl4. It is concluded that sesame oil has a protective effect against the toxicity of Carbone tetrachloride on the liver.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

scholarly journals Comparison between the Antioxidant and Antidiabetic Activity of Fenugreek and Buckthorn in Streptozotocin-Induced Diabetic Male Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Mohammed A. Alsieni ◽  
Haddad A. El Rabey ◽  
Abdulbasit I. Al-Sieni ◽  
Madeha N. Al-Seeni
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Negative Control ◽  
Seed Extract ◽  
Male Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Leaf Aqueous Extract

This study is aimed at comparing the antidiabetic and antioxidant potential of fenugreek and buckthorn which are commonly used in modulating diabetes in the Middle East. In this study, the antioxidant and antidiabetic activity of the aqueous extracts of the leaf and seed of fenugreek and buckthorn was tested in streptozotocin-induced diabetic male rats fed with a fat-rich diet for 8 weeks. Thirty-six male albino rats were divided into 6 groups ( n = 6 ); the 1st group was the negative control. Diabetes was induced in the other 30 rats using streptozotocin, which were then divided into 5 groups; the 2nd was the untreated positive diabetic group, the 3rd was treated with fenugreek leaf aqueous extract, the 4th was treated with the fenugreek seed aqueous extract, the 5th was treated with buckthorn leaf aqueous extract, and the 6th was treated with buckthorn seed aqueous extract. The positive control group showed an increase in blood sugar, glycated hemoglobin, liver function enzymes, lactate dehydrogenase, kidney indices, total cholesterol, triglycerides, low- and very-low-density lipoprotein, immunoglobulins, and lipid peroxidation and a decrease in high-density lipoprotein, albumin, and antioxidant activity. The histology of the liver and testes showed severe histopathological alterations. Rats of groups 4-6 that were treated with the aqueous extract of the leaf and seed extract of fenugreek and buckthorn showed improvement of all biochemical and histopathological parameters. The seed extract of fenugreek and buckthorn showed more antioxidant activity than their leaves.

scholarly journals Effect of Ashwagandharishta on the lipid profile of male and female rats

2021 ◽  
Vol 9 (1-2) ◽  
pp. 59-68
Author(s):  
Tasmina Rahman ◽  
Mohammad Salahuddin Bhuiya ◽  
Rakib Hasan ◽  
MSK Choudhuri
Keyword(s):  
Lipid Profile ◽  
Serum Cholesterol ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Female Rats ◽  
Male Rats ◽  
Albino Rats ◽  
High Dose ◽  
Male And Female ◽  
Male And Female Rats

The effect of Ashwagandharishta on the lipid profile and chronic toxicity of both male and female Albino rats were observed for 51 days. Our results demonstrate that the treatment of the plant extract failed to exhibit any statistically significant change (increase/ decrease) in the serum cholesterol (Total), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride of the male rats. But the female rats showed highly (p<0.01) and very highly (p<0.001) significant decrease in the serum cholesterol (Total) levels of the medium and high dose treated groups respectively. Regarding HDL, ASG showed statistically significant decrease at low (p <0.05), medium (p<0.01) and high (p<0.001) dose treated female rats. The LDL level of the medium dose treated female rats were statistically significant (p <0.05). The serum Triglyceride decreased significantly at low (p<0.01) and high (p <0.05) dose treated female rats. Jahangirnagar University J. Biol. Sci. 9(1 & 2): 59-68, 2020 (June & December)

scholarly journals Comparison between the Hypolipidemic Activity of Parsley and Carob in Hypercholesterolemic Male Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Haddad A. El Rabey ◽  
Madeha N. Al-Seeni ◽  
Habibah B. Al-Ghamdi
Keyword(s):  
Methanol Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
High Density Lipoproteins ◽  
Control Group ◽  
Albino Rats ◽  
Low Density ◽  
Creatine Kinase Mb ◽  
Liver Tissues

Hypercholesterolemia is commonly associated with obesity that leads to heart diseases and diabetes. The hepatocardioprotective activity of parsley and carob methanol extract was tested in hypercholesterolemic male rats. Twenty-four male albino rats were divided into four groups (n=6). Group 1 was the negative control group fed with fat rich diet, group 2 (G2) was hypercholesterolemic rats fed with fat rich diet with 2% cholesterol, and group 3 and group 4 (G3 and G4) were hypercholesterolemic rats supplemented with 2% cholesterol and cotreated with 20% w/w parsley seed methanol extract and 20% w/w carob legume methanol extract, respectively. The experiment was conducted for eight weeks. The positive hypercholesterolemic rats showed significant increase in serum levels of total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), lactate dehydrogenase (LDH), creatine kinase-mb, liver function enzymes, and decrease in the high density lipoproteins (HDL). Moreover, heart and liver tissues were ameliorated and nearly restored their normal appearance. It could be concluded that both parsley and carob extracts supplementations have a protective effect against hyperlipidemia and improved the histological alteration in heart and liver tissues. The methanol extract of parsley appeared to be more efficient than that of carob in lowering hypercholesterolemia.

scholarly journals Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity in albino male rats

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Haddad A. El Rabey ◽  
Samar M. Rezk ◽  
Mohamed I. Sakran ◽  
Ghena M. Mohammed ◽  
Omar Bahattab ◽  
...  
Keyword(s):  
Olive Oil ◽  
Liver Toxicity ◽  
Methanolic Extract ◽  
Density Lipoprotein ◽  
Positive Control ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Green Coffee ◽  
Sprague Dawley

Abstract Background During the last few decades, patients worldwide have been interested in using alternative medicine in treating diseases to avoid the increased side effects of chemical medications. Green coffee is unroasted coffee seeds that have higher amounts of chlorogenic acid compared to roasted coffee. Green coffee was successfully used to protect against obesity, Alzheimer disease, high blood pressure and bacterial infection. Methods This study aimed to investigate the probable protective activity of the green coffee methanolic extract, silymarin and their combination on CCl4-induced liver toxicity in male rats. Thirty Sprague – Dawley male albino rats were divided into 5 groups; control negative (G1) just got the vehicle (olive oil) and the other four groups received CCl4 dissolved in olive oil through an intraperitoneal injection and were divided into untreated control positive group (G2), the third group (G3) was treated with green coffee methanolic extract, the fourth group (G4) was treated with silymarin, and the fifth group (G5) was treated with a combination of green coffee methanolic extract and silymarin. Results In the positive control group treated with CCl4 (G2), the CCl4-induced toxicity increased lipid peroxidation, IL-6, kidney function parameters, liver function enzymes, total cholesterol, triglycerides and low-density lipoproteins, and decreased irisin, antioxidants, CYP450 and high-density lipoprotein levels. Hepatic tissues were also injured. However, treating the injured rats in G3, G4 and G5 significantly improved the altered parameters and hepatic tissues. Conclusions Green coffee methanolic extract, silymarin, and their combination succeeded in protecting the male rats against CCl4 hepatotoxicity due to their antioxidant activity. Effect of green coffee methanolic extract mixed with silymarin in G5 was more efficient than that of green coffee methanolic extract in G3 or silymarin in G4.

scholarly journals Hematological Parameters and Lipid Profile Changes in Albino Rats due to Administration of Ethanol Extract of Ipomea batatas Leaves

2021 ◽  
pp. 1-12
Author(s):  
M. O. Enemali ◽  
J. Akolo ◽  
G. S. Haruna ◽  
J. E. Bulus ◽  
P. J. Kassah ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Leaf Extract ◽  
Hematological Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Ethanol Extract ◽  
Control Group ◽  
Albino Rats ◽  
Ipomea Batatas ◽  
Group 2

Leaves of I. batatas have been implicated in both the hematopoietic process and in the management of hyperlipidemia in man. The current study evaluated the hematopoietic potentials and the lipid profile stabilizing potential of ethanol leaf extract of I. batatas in albino rats. The study was carried out at the Department of Biochemistry and Molecular Biology of the Nasarawa State University, Keffi, between March 2019 and October 2019. The determination of the phytochemical composition of the leaves was carried out. Sixteen albino rats weighing between 100-150g were randomly distributed into 4 groups of 4 rats each. Animals in group 1 served as the control while animals in groups 2, 3, and 4 served as the test groups and were administered 200, 300 and 400g/kg body weight respectively of ethanol leaf extract of I batata for fourteen days following standard procedures. The extract contained terpenoids in high amount, flavonoids and alkaloids in moderate amounts, while glycosides, phenolic, and steroids were present in low amounts. WBC counts increased significantly across the test groups compared to the control. PLT decreased significantly (P = 0.05) in all the test groups when compared to the control group. MCV increased significantly (P = 0.05) in all the test groups when compared to the control group. MCH increased significantly (P = 0.05) in group 2 but decreased significantly in groups 3 and 4 when compared to the control group. The lipid profile parameters; triglycerides (TAG), total cholesterol (TC), low density lipoprotein (LDL-C) showed no significant changes but HDL-C decreased significantly in group 4 compared to the control. The outcome of this study revealed that the ethanol leaves extract of I. batatas may possess a hematopoietic effect but may not be effective in the management of hyperlipidemia.

scholarly journals Effects of ethanolic extracts of Datura metel on blood lipid profile of male albino rats

2016 ◽  
Vol 2 (10) ◽  
pp. 248 ◽  
Author(s):  
Kayode A. Arowora ◽  
Chinedu Imo ◽  
Chukwuma S. Ezeonu ◽  
Zuhairah I. Muhammad
Keyword(s):  
Lipid Profile ◽  
Normal Control ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Normal Control Group ◽  
Control Group ◽  
Albino Rats ◽  
Blood Lipid Profile ◽  
Datura Metel ◽  
Ethanolic Extracts

<p class="abstract"><strong>Background:</strong> This study was carried out to investigate the effects of <em>Datura metel (</em>leaf, seed and fruit<em>)</em> on blood lipid profile of male albino rats.</p><p class="abstract"><strong>Methods:</strong> Thirty-five albino rats (8 weeks old) weighing between 66g and 84g were purchased and randomly allotted into 7 groups. The normal control (group 1) received normal saline, while groups 2 to 7 received extracts of <em>Datura metel</em> at low (300 mg/kg body weight) and high doses (600 mg/kg body weight). The extracts were administered orally for seven consecutive days, while the animals were sacrificed on the 8th day; blood samples were collected, allowed to stand for fifteen minutes and then centrifuged.  </p><p class="abstract"><strong>Results:</strong> There was a general decreasing trend in the mean values of low density lipoprotein levels across  the groups, however, group 7 (with lowest value) was found to be significantly lower (p &lt;0.05) than other groups when compared with the normal control. Also, there was a general decreasing trend in the values of high density lipoprotein compared with normal control group, however lowest value was recorded to be 1.35±0.06 mmol/l for group 5. There were no significant differences (p &gt;0.05) in triglyceride levels across the groups, while total cholesterol in groups 5 and 6 had significant differences with values of 2.05±0.06 mmol/l and 2.13±0.10 mmol/l respectively when compared with the normal control.</p><p><strong>Conclusions:</strong> This study suggests that ethanolic extracts of<em> Datura metel </em>have active ingredients that are capable of improving blood lipid profile and this might be useful in the management of cardiovascular diseases. </p>

scholarly journals Garlic Alleviates the Injurious Impact of Cyclosporine-A in Male Rats through Modulation of Fibrogenic and Steroidogenic Genes

Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 64
Author(s):  
Mustafa Shukry ◽  
Saqer S. Alotaibi ◽  
Sarah M. Albogami ◽  
Nora Fathallah ◽  
Foad Farrag ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cyclosporine A ◽  
Transforming Growth Factor ◽  
Substantial Reduction ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Albino Rats ◽  
Cell Degeneration

This work aimed to study the hepato-testicular protective effect of garlic in rats treated with cyclosporine A (CsA). Forty male Westar albino rats were randomly distributed in five groups (8 rats each): control, olive oil, garlic, CsA, and CsA co-treated with garlic. CsA induced an upsurge in the alanine transaminase, aspartate transaminase, and alkaline phosphatase levels and decreased albumin and total protein levels, expression of superoxide dismutase (SOD) gene, serum testosterone, triiodothyronine, and thyroxine levels compared to the control group. Additionally, there was an increase in the cholesterol, triglyceride, and low-density lipoprotein levels and a substantial reduction in the high-density lipoprotein levels compared to the control groups. Histopathological investigation of the liver showed abnormalities like hepatic cell degeneration, congestion of blood vessels, and highly active Kupffer cells in the CsA group. Histopathological examination of testes showed damaged seminiferous tubules, stoppage of the maturation of spermatogonia, and the presence of cells with irregular dense nuclei in the lumina of some tubules. For the groups treated with garlic, mitigation of the damage caused by CsA in the liver and testes, liver function tests, lipid profiles, and hormones was seen along with improved gene expression of SOD and steroidogenesis genes, and decreased gene expression of collagen I-α1 and transforming growth factor-1β. Conclusively, garlic had a positive impact on CsA-induced hepatic and sperm toxicity. It is recommended that garlic should be supplemented in transplant treatments using CsA to alleviate the cyclosporin-induced oxidative injuries and other harmful effects.

scholarly journals The Efficiency of Barley (Hordeum vulgare) Bran in Ameliorating Blood and Treating Fatty Heart and Liver of Male Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Khalid O. Abulnaja ◽  
Haddad A. El Rabey
Keyword(s):  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Liver Enzymes ◽  
Negative Control ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Creatine Kinase Mb ◽  
Liver And Kidney ◽  
Barley Bran

The current study focused on testing the hypolipidemic activity of two doses of barley bran on hypercholesterolemic male rats. Twenty-four male albino rats weighing 180–200 gm were divided into four groups. The first group (G1) was the negative control, the second group (G2) was the positive control group fed 2% cholesterol in the diet, and rats of the third and the fourth groups were fed 2% cholesterol and were cosupplemented with 5% and 10% barley bran, respectively, for 8 weeks. The hypercholesterolemic rats of (G2) showed an increase in lipid profile, liver enzymes, lactate dehydrogenase, creatine kinase-MB, and lipid peroxide and a decrease in antioxidant enzymes, whereas kidney function, fasting blood sugar, glycated hemoglobin total protein, and total bilirubin were not significantly affected compared with the negative control group in G1. Moreover, histology of heart, liver, and kidney of G2 rats showed histopathological changes compared with the negative control. Administration of the two doses of barley bran in G3 and G4 to the hypercholesterolemic rats ameliorated the level of lipids, liver enzymes, lactate dehydrogenase, and creatine kinase-MB. In addition, the histology of heart, liver, and kidney tissues nearly restored the normal state as in G1.

scholarly journals Study on Effects of Medroxyprogesterone Acetate on Serological Parameters, Ultrasonographic and Histopathological Profile of Uterine Endometrial Morphology in Female Rabbits

2022 ◽  
Author(s):  
H.A. Tahir ◽  
U.F. Durrani ◽  
A.K. Mahmood ◽  
K. Matloob ◽  
M. Imran ◽  
...  
Keyword(s):  
Single Dose ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Medroxyprogesterone Acetate ◽  
Reproductive Tract ◽  
Liver Enzymes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Group B

Background: Rabbits are small mammals from the family Leporidae. Rapid multiplication profile of the rabbits often necessitates contraceptive controls in which ovario-hysterectomy is the only recommended method worldwide but still rabbit owners avoid surgical manipulation and opt for the contraceptive injections but contraceptive injections are also known to cause undesired effects in different animal species. The present study was conducted to evaluate effects of Medroxyprogesterone acetate on liver enzymes, lipid profile, blood glucose and uterine endometrial morphology. Methods: The study was conducted on 20 breeding female rabbits at Pet Centre, University of Veterinary and Animal Sciences, Lahore, Pakistan. The study animals were divided into two groups, A and B having 10 rabbits each. Group A was treated with single dose of Medroxyprogesterone acetate (10 mg/kg IM). While group B was kept as control and was given a single dose of 0.9% normal saline placebo injection. Pre and post treatment serum sampling was performed on days 0, 7, 14, 21, 28, 35, 42 and histopathological evaluation of reproductive tract (mainly uterus) was conducted at the end of study. Result: Serological parameters i.e. liver profile, lipid profile and blood glucose level (random) were significantly increased after treatment along with congestion, engorgement of blood vessels, degeneration, hyperplasia of uterine epithelium and uterine glands in Treatment group in contrast to control group. On the basis of this study it was concluded that Medroxyprogesterone acetate poses undesirable effect on the uterine endometrium and different serological parameters of body like liver enzymes (total bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase), blood glucose, lipid profile (cholesterol, high density lipoprotein, low density lipoprotein, triglyceride).

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