scholarly journals Pyroptosis-Mediated Cell Death as an Approach for Novel Cancer Treatment

2021 ◽  
Author(s):  
Megan Lloren ◽  
Edward Thomas
Keyword(s):  
Cell Death ◽  
Cancer Treatment ◽  
Cause Of Death ◽  
Effective Alternative ◽  
The World ◽  
New Treatments ◽  
Cancerous Cells

Cancer is the leading cause of death in the world, which makes understanding its biology and creating new treatments to save lives vitally important. To understand the pathways through which cancer evades apoptosis and how death can be induced upon cancerous cells, apoptosis has been extensively researched, but we propose the benefits of investigating another form of mediated cell death--pyroptosis--to understand alternative ways that cancer can be treated and how utilizing pyroptosis may be a more effective alternative than apoptosis. We also review one of the most controversial usages of bacteria-mediated treatment for cancer, as well as advise future researchers hoping to implement pyroptosis-based treatment to investigate the necessity of the situation before resorting to bacteria-mediated onco-treatments.

scholarly journals Environmental Causes of Cancer

2019 ◽  
Vol 1 (1) ◽  
pp. 27-34
Author(s):  
Aliakbar Muhamdi Ameri
Keyword(s):  
Cancer Screening ◽  
Cancer Treatment ◽  
Cause Of Death ◽  
Survival Rates ◽  
Environmental Radiation ◽  
The World ◽  
Environmental Causes ◽  
In Cells

This  work   explained   most  causes  of  tumor   , cancer  in  cells  (  environmental , radiation , chem-radiation , other  like  food  ,  pollution  in air ,   water    and  food ) .Cancer is the second-leading cause of death in the world. But survival rates are improving for many types of cancer, thanks to improvements in cancer screening and cancer treatment.

FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN PNEUMONIA PADA BALITA DI WILAYAH KERJA PUSKESMAS WONOREJO SAMARINDA TAHUN 2017

2018 ◽  
Vol 3 (2) ◽  
pp. 76
Author(s):  
Novi Anggun Pusvitasary
Keyword(s):  
Environmental Factors ◽  
Family Member ◽  
Cause Of Death ◽  
Family Members ◽  
Smoking Behavior ◽  
Smoking Habits ◽  
P Value ◽  
Behavioral Factors ◽  
The World ◽  
Health Standards

Pneumonia disease is the leading cause of death of babies in the world. The prevalence of pneumonia in infants is 18.5 / mil. Data from Samarinda City Health Office during the last 1 year there are 91 cases of pneumonia in Karang Anyar Village and 63 cases in Teluk Lerong Ulu Village. Factors causing pneumonia are toddler factors, behavioral factors, and environmental factors. The results show there is a relationship between house humidity (p value = 0,013; OR = 0,192), house dwelling density (p value = 0,024; OR = 0,214), and family member smoking behavior (p value = 0,006; OR = 10,450) with incidence of pneumonia in toddlers in the Working Area of Puskesmas Wonorejo Samarinda. There was no correlation between house temperature (p value = 0,214; OR = 0,337), house lighting (p value = 0,095; OR = 3,188) and family disease history (p value = 0,707; OR = 0,753) with Pneumonia occurrence in infant in region Work Puskesmas Wonorejo Samarinda. It was concluded that there was a relationship between house humidity, home dwelling density, and smoking behavior of family members with the incidence of pneumonia in infants. It is recommended to be able to apply housing health requirements that meet health standards to reduce the incidence of pneumonia in infants and change smoking habits.

Anticancer Activity of Diosgenin and its Semi-synthetic Derivatives: Role in Autophagy Mediated Cell Death and Induction of Apoptosis

2021 ◽  
Vol 21 ◽  
Author(s):  
Nivedita Bhardwaj ◽  
Nancy Tripathi ◽  
Bharat Goel ◽  
Shreyans K. Jain
Keyword(s):  
Cell Death ◽  
Cancer Treatment ◽  
Anticancer Activity ◽  
Tumor Cells ◽  
Cancer Progression ◽  
Rational Approach ◽  
Potential Candidate ◽  
Potential Implication ◽  
Apoptosis Protein ◽  
Synthetic Derivatives

: During cancer progression, the unrestricted proliferation of cells is supported by the impaired cell death response provoked by certain oncogenes. Both autophagy and apoptosis are the signaling pathways of cell death, which are targeted for cancer treatment. Defects in apoptosis result in reduced cell death and ultimately tumor progression. The tumor cells lacking apoptosis phenomena are killed by ROS- mediated autophagy. The autophagic programmed cell death requires apoptosis protein for inhibiting tumor growth; thus, the interconnection between these two pathways determines the fate of a cell. The cross-regulation of autophagy and apoptosis is an important aspect to modulate autophagy, apoptosis and to sensibilise apoptosis-resistant tumor cells under metabolic stress and might be a rational approach for drug designing strategy for the treatment of cancer. Numerous proteins involved in autophagy have been investigated as the druggable target for anticancer therapy. Several compounds of natural origin have been reported, to control autophagy activity through the PI3K/Akt/mTOR key pathway. Diosgenin, a steroidal sapogenin has emerged as a potential candidate for cancer treatment. It induces ROS-mediated autophagy, inhibits PI3K/Akt/mTOR pathway, and produces cytotoxicity selectively in cancer cells. This review aims to focus on optimal strategies using diosgenin to induce apoptosis by modulating the pathways involved in autophagy regulation and its potential implication in the treatment of various cancer. The discussion has been extended to the medicinal chemistry of semi-synthetic derivatives of diosgenin exhibiting anticancer activity.

Innovatory role of nanomaterials as bio-tools for treatment of cancer

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Khuram Shahzad Ahmad ◽  
Muntaha Talat ◽  
Shaan Bibi Jaffri ◽  
Neelofer Shaheen
Keyword(s):  
Cancer Treatment ◽  
Cancer Therapeutics ◽  
Physicochemical Characteristics ◽  
Global Scale ◽  
Current Review ◽  
Anti Cancer ◽  
Different Types ◽  
Cancerous Cells

AbstractConventional treatment modes like chemotherapy, thermal and radiations aimed at cancerous cells eradication are marked by destruction pointing the employment of nanomaterials as sustainable and auspicious materials for saving human lives. Cancer has been deemed as the second leading cause of death on a global scale. Nanomaterials employment in cancer treatment is based on the utilization of their inherent physicochemical characteristics in addition to their modification for using as nano-carriers and nano-vehicles eluted with anti-cancer drugs. Current work has reviewed the significant role of different types of nanomaterials in cancer therapeutics and diagnostics in a systematic way. Compilation of review has been done by analyzing voluminous investigations employing ERIC, MEDLINE, NHS Evidence and Web of Science databases. Search engines used were Google scholar, Jstore and PubMed. Current review is suggestive of the remarkable performance of nanomaterials making them candidates for cancer treatment for substitution of destructive treatment modes through investigation of their physicochemical characteristics, utilization outputs and long term impacts in patients.

Recent Progress in Mitochondria-Targeting-Based Nanotechnology for Cancer Treatment

Nanoscale ◽  
2021 ◽  
Author(s):  
Jingbo Qin ◽  
Ningqiang Gong ◽  
Zhihuan Liao ◽  
Shouwen Zhang ◽  
Peter S. Timashev ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Targeted Delivery ◽  
Recent Progress ◽  
Proliferation And Apoptosis ◽  
Cancerous Cells ◽  
Mitochondria Targeting

Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer treatment have attracted increasing attention...

Road Safety at Ghats using IoT

2021 ◽  
Vol 9 (VII) ◽  
pp. 132-136
Author(s):  
Alaparthi Maneesha
Keyword(s):  
Developing Countries ◽  
Cause Of Death ◽  
Road Safety ◽  
Led Light ◽  
The Road ◽  
The World

This paper describes how to overcome accidents at Ghat roads. In the developing countries accident is the major cause of death. If we look at the top 10 dangerous roads in the world we can see that all of them are mountain roads and curve roads. In the mountain roads there will be tight curves and the roads will be narrow. In these kinds of situations the driver of a vehicle cannot see vehicles coming from opposite side. Thousands of people lose their lives each year because of this problem. The solution to this problem is developing the Aurdino based project to provide safe and secure journey while travelling to the Ghat roads, Hill Stations, etc. It is provided by alerting the driver about the vehicle coming from opposite side. This is done by keeping a sensor in one side of the road before the curve and keeping a LED light after the curve, so that if vehicle comes from one end of the curve sensor senses and LED light glows at the opposite side. By looking at the LED light on/off criteria driver can become alert and can slow down the speed of the vehicle.

Subclinical Hypothyroidism as a Risk Factor for Cardiovascular Disease

2021 ◽  
Vol 15 (9) ◽  
pp. 2748-2752
Author(s):  
Roman Evgenyevich Tokmachev ◽  
Andrey Valerievich Budnevsky ◽  
Andrey Yakovlevich Kravchenko ◽  
Tatiana Alexandrovna Chernik ◽  
Sudakov Oleg Valerievich ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Cause Of Death ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Epidemiological Studies ◽  
Cardiovascular Disorders ◽  
The World

Nowadays, more than 485 million people in the world suffer from cardiovascular diseases (CVD). According to large epidemiological studies, the group of CVD is the leading cause of death in the world. One of the neurohumoral mechanisms that appears to be a risk factor for CVD is thyroid dysfunction. In this regard, in recent years, more and more attention is paid to the study the influence of subclinical hypothyroidism on the occurrence and development of cardiovascular disorders. MeSH words: cardiovascular diseases, subclinical hypothyroidism

Simulation of cancer treatment using the MATLAB SimBiology application

2021 ◽  
Vol 14 (3) ◽  
pp. 90-96
Author(s):  
Anastasia Goncharova ◽  
Maria Vil'
Keyword(s):  
Mathematical Model ◽  
Cancer Treatment ◽  
Interference Competition ◽  
The Body ◽  
Continuous Treatment ◽  
Constant Concentration ◽  
Application Package ◽  
The Mathematical Model ◽  
Cancerous Cells

The paper presents the implementation of the mathematical model of cancer taking into account interference competition and the model of continuous treatment with a constant concentration of the drug in the patient's blood. The implementation was carried out using the MATLAB SimBiology application package. The principle of implementation of different stages of the course of the disease within the framework of one model is described. On the basis of the constructed models and SimBiology tools, a modification was carried out that implements the discrete administration of doses of the drug in courses and takes into account its dynamics in the body, taking into account the assumption that the drug is consumed only to suppress cancerous cells.

scholarly journals Ten Famous Composers of the Romantic Era and their Cause of Death

2021 ◽  
Author(s):  
Ernest K.J. Pauwels
Keyword(s):  
Medical Research ◽  
Cause Of Death ◽  
21St Century ◽  
Causes Of Death ◽  
Human Life ◽  
Modern Medicine ◽  
Expression Of Emotion ◽  
The World ◽  
Romantic Era ◽  
Clinically Significant

The musical composers in the Romantic Era (1800-1910) strived for compositions that expressed human life, including happiness, harmony and despair. They lived in a period in which freedom of thinking, expression of emotion and inspiration by nature predominate. During this period, intensive trading with other parts of the world brought new microorganisms along, which made infections and epidemics very common. This article serves to address the cause of death and relevant biographic data of a number of well- known Romantic composers. Primarily, this review refers to clinically significant findings using reports that were retrieved from Pubmed, Embase and Google over the 19th, 20th and 21st century till 14th June 2021. Here, this text dwells on diseases and the cause of death of ten composers, namely Mozart, Beethoven, Chopin, Schubert, Schumann, Mendelssohn, Brahms, Liszt, Mahler and Bruckner. It is evident that, in the sight of modern medicine, symptoms and forensic facts are not complete, but witnesses' reports and recent medical research have provided passable and plausible clarity. Although many questions will remain unanswered, it appears that the diseases of these composers and their causes of death have their origins in alcohol abuses, age, epidemics (like tuberculosis) and syphilis.

scholarly journals The “ARTS” of Cell Death in Service of Life: How Do We Force Cancer Cells to Commit Suicide?

2021 ◽  
Vol 9 ◽  
Author(s):  
Sarit Larisch
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Novel Therapy ◽  
The Arts ◽  
Wide Range ◽  
Cell Death Program ◽  
Cancerous Cells ◽  
Critical Process ◽  
Cells Death ◽  
Commit Suicide

Every cell in our body contains a “self-destruction” program. This cell death is a critical process allowing replacement of damaged cells with healthy ones to prevent wide range of diseases. When the cell’s death mechanism gets “stuck” and is not activated, cancer can result. In healthy cells there is a balanced system of proteins, some of which activate the normal death mechanism, and some of which inhibit this process. This is like the system of gas and brakes in a car. Researchers have found that cancer cells lack a protein, called ARTS, which is crucial for activating the cells’ death mechanism. The lack of ARTS causes cancer cells to escape death and become “immortal.” Small ARTS-like molecules have been discovered that can penetrate cancerous cells and reactivate the cell death program, effectively making the cancer cells “commit suicide.” We envision that these ARTS-like molecules will provide novel therapy for cancer.

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