scholarly journals EFFECT OF STIMULIN-VET ON THE COWS PREGNANCY CONSOLIDATION AFTER INSEMINATION

2020 ◽  
Vol 11 (4) ◽  
pp. 19-24
Author(s):  
M. S. Gruntkovskyi

Improving the reproductive performance of cattle is one of the main tasks in livestock. Numerous stressors, high productivity, poor feeding, improper conditions of care and operation cause hormonal changes in the system "hypothalamus-pituitary-ovaries" of females, which negatively affects reproduction. As a result, farms do not receive a certain amount of offspring and milk, and in the future - an increase in the infertility rate of uterine cattle. In cows after calving at the initial stage of lactation, the trophic function of the pituitary gland is more aimed at ensuring the secretion of milk than at restoring the cyclic activity of the ovaries. Therefore, to correct the reproductive capacity of cows use: feed additives, hormonal drugs, trace elements, physiotherapy methods and more. There are a small number of studies on the effects of biologically active drugs with neurohumoral action on the reproductive function of cows. The aim of our research was to establish the effects of biologically active substances of the neurotropic-metabolic drug "Stimulin-Cattle" on the reproductive capacity of cows. The studies were conducted on the basis of groups of analogues. The experiment selected cows after the first insemination and females who came back to sexual hunting. Experimental animals on day 7 - 9 of the sexual cycle were injected subcutaneously in the scapular region with 20 ml of the drug "Stimulin-Vet", and control according to the same scheme saline sodium chloride solution 0.9%. Cows were inseminated once by recto-cervical method. Three months later, rectal examinations of the animals were performed to determine pregnancy. The analysis of the obtained results showed that in experimental cows the fertility exceeded the control by 15.4 %. In the experimental group, 56.4 % came to sexual hunting again, and in the control group 71.8 %. Among 22 non-pregnant experimental cows, the cause of infertility in 63.6 % of animals was the anovulatory cycle, and in 36.4 % embryonic mortality. Whereas in the control of animals with anovulatory cycle was less by 42.2 %, and with embryonic mortality by the same percentage is probably higher. This situation with infertile animals suggests that the drug stimulates the development of the corpus luteum on the ovary, which promotes the secretion of more progesterone, which causes better conditions for embryo engraftment and thus reduces embryonic mortality. It was also found that animals after the first insemination react worse to the introduction of the drug than those who were inseminated for the first time, which confirms the level of fertility of 41.7 % vs. 46.7 %, respectively.

2018 ◽  
Vol 56 ◽  
pp. 136-140
Author(s):  
G. S. Sharapa ◽  
O. V. Boyko

Scientific and production experiments were carried out on cows of Ukrainian Black-and-White diary breed (UBAWD) of SE "Seagull" (branch "Lisne") during 2016–2017. The anatomical and physiological state of genital organs of cows was determined by the method of clinical and gynecological research of animals before conducting experiments and during them every 40–50 days. In total 486 cows were kept under control, which were kept in typical rooms with running platforms, but the active motivation of animals was clearly insufficient. Feeding cows according to the recommended standards. The milk yield from the cow in 2017 was 7813 kg. The experiments studied the effect of feeding cows during the dry period, the conditions of retention and some other paratypic factors on the course of the genera and the postnatal period, the duration of the service period and the fertility of cows. In analyzing the research results, personal records and veterinary documentation were used. In conducting experiments, it was found that normal calving was in 89% of cows, and severe and pathological – in 11% of cases. The main diseases in the afterlife period were: detention of the litter – 9.5%, postpartum endometritis – 21.5%, hypofunction of the ovaries – 23.0%, persistent yellow ovarian bodies – 25.6% and others. Normal intervals between stages of excitation of the sexual cycle (18–22 days) were in 63% of cows, and violations of the rhythm of sexual cycle, associated with dysfunction of the ovaries and missed the hunt – 30% of animals. Subunvulation of the genital organs of the cows contributed to the diseases of the limbs, udder and digestive disorders. During 2016–2017, the effect of feeding cows (173 g.) in the dry period on the course of calving, post-autumn period and their fertility was studied. Under the same conditions, keeping cows in the maternity ward and feeding rough and succulent feeds concentrated feeds fed cows of the control group (98 heads) to 1–2 kg daily during the dry period, and experimental (75 heads) – for 18–20 days to calving 2–3 kg. A positive difference was found in favor of cows of the experimental group: there was a more active stage of expulsion of the fetus, less delay of the placenta (by 7%) and endometritis (by 12%), the duration of the postoperative regenerative period decreased by 8.6 days; service period – 19.0 days; fertility from two inseminans was higher by 5.7%. Study of the reproductive capacity of cows at the hotel in different seasons showed that the recovery period was shorter by 11 days in the presence of cows in 3–4 quarters, and the service period – by 23.2 days at hotel in I and IV sq. The average duration of the recovery period was 79.5 days, while the service period was 123.4 days. The longest duration of the joint ventricle was in cows at hotel during the hot summer days of the year. The average fertilization rate from the first insemination of 339 cows was 44.9% with fluctuations in individual groups of milkers from 26.8% to 55.0%. The following indicators were in the number 1 and number 3 (respectively 26.8% and 31.4%). The best fertility rates were in groups № 4, 6 and 7, where there were more cows of the second and third lactation, and the responsible attitude of the milkers to work in organizing cows walks and sexually explicit hunting. When comparing the assessment of the duration of the IP and SP in full-age cows and cows, the first-born, taking into account 225 goals. It was found that these indicators were longer in primitive cows – 20.7 days respectively and 21.9 days in relation to full-age cows. The obtained results are completely consistent with the results obtained by a number of both domestic and foreign researchers. More attention is needed to grow heifers and to prepare newborns for delivery. In 15–17% of cows at and after the hotel, gynecological diseases that occurred in the presence of gastrointestinal diseases, lameness, mastitis and others were diagnosed. This has negatively affected the overall performance of the herd. In studying the duration of HP and SP in healthy and sick cows after calving, it was found that if the SP in healthy cows lasts 73.4 days, then in patients – 116.3 days (the difference was 42.9 days), and the difference in the duration of the joint venture reached 98.7 days. On the basis of the results of the research, it can be concluded that the reproductive function of the cows is influenced by such paratypic factors as feeding animals in the dry period, the temperature factor (time of year), the human factor (the effect of milking on a group of cows), age and physiological state of cows in the hotel and in the afterlife period. When feeding 2–3 kg of bovine feed for cows, together with rough and juicy fodder for 18–20 days prior to calving, the recovery period decreased by 8.6 days and service period – by 19 days, and fertility from two inseminals increased by 5.7%, reaching 85.3%. The smallest duration of the service-period was in the presence of cows in the I and IV quarters year (107.7–117.1 days). In primary cows, the recovery period was longer than that of full-age cows by 20.7 days, and the service period was 21.9 days. In the physiologically healthy cows after calving, the recovery period lasted an average of 73.4 days and service period – 98.7 days, and in patients, after the prescribed treatment – respectively 116.3 days and 197.4 days.


Author(s):  
L. P. Yarmots ◽  
G. A. Yarmots ◽  
A. E. Belenkaya ◽  
M. O. Smyshlyaeva

Unbalanced mineral and vitamin nutrition of lactating cows can be a critical factor in the realization of their productive potential. The development and introduction into production of inexpensive, but effective feed additives is the main trend of improving the feeding of modern animal husbandry. Under the conditions of the Tyumen region such natural raw materials can be sapropels, which successfully combine a variety of biologically active substances. The purpose of the research was to study the digestibility of nutrients and energy metabolism in lactating cows when sapropel is included in the ration. Scientifi c and economic experiment in the study of the effectiveness of feeding sapropel lake Nepryak has been carried out in the training and experimental farm of the State Northern Trans-Urals Agrarian University. The animals of the control group have been fed the main diet. Cows of the 1st and 2nd experimental groups have been fed 300 and 500 g of sapropel per head/day, respectively, in addition to the main ration. It has been found as a result of research that the introduction of sapropel into the ration of cows has a positive effect on the digestibility of nutrients. The digestibility coefficients were higher in the animals of the 1st and 2nd experimental groups compared with the cows of the control group. Cows from the experimental groups digested all the organic substances of the ration better. During the experiment period cows of the 1st and 2nd experimental groups in contrast to the control group had higher milk yield by 11,31 and 10,38 %, respectively, milk protein yield by 10,56 and 5,95 %, milk fat yield by 17,18 and 12,99 %. It has been established that the introduction of sapropel into the ration of cows has the positive effect on the digestibility of nutrients, contributes to the increase of milk productivity, normalizes the metabolism in the body.


2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 294-294
Author(s):  
Kirill Plemyashov ◽  
Alexander Aristov ◽  
Sergey Semenov ◽  
Natal’ya Kudinova ◽  
Polina Anipchenko ◽  
...  

Abstract Over recent years, the range of biologically active substances aimed at the productivity increase, animals preservation, feed use efficiency, product quality improvement and product safety has been significantly expanded. In this regard, the study of the effectiveness of hepatoprotective farm-produced feed additives in the diets of broiler chickens is of particular interest to science and practice. The broiler chickens pectoral muscles of the control group contained 68–0.08% of water, 32–0.06% of dry matter, 20.45–0.08% of protein, and 1.62–0.09% fat. In a comparative analysis of the obtained data, it may be concluded that the use of the feed additive Hepatron 85% as a hepatoprotector improves the detoxification ability of the liver and promotes the regeneration of the liver cells. Betaine as a lipotropic agent contributes to the fat oxidation, enhances appetite, and adds muscle mass. When determining the chemical composition of the muscles of the leg, thigh, body, wings and neck, it was established that the broiler chickens of the experimental group contained 70–0.07% of water, 30–0.05% of dry matter, 19.7±0.08% of protein and 2.11±0.09% of fat. Using the feed with the additive Hepatron 85% causes a 0.5% increase in protein and 0.18% increase in fat compared to the meat of the broiler chickens on general feed. Thus, the inclusion of the feed additive Hepatron 85% in the ration of broiler chickens instead of 50% of methionine and choline contributes to an increase in average daily gains and meat quality improvement in a number of indicators.


2020 ◽  
Vol 50 (4) ◽  
pp. 670-680
Author(s):  
Tatyana Giro ◽  
Andrey Kulikovsky ◽  
Alexandra Knyazeva ◽  
Ivan Domnitsky ◽  
Anna Giro

Introduction. The present research featured biochemical and microstructural features of thyroid glands obtained from lambs raised on various feeds enriched with essential elements. The article focuses on iodine as the most important physiologically active microelement. Iodine participates in the synthesis of thyroid hormones, namely thyroxine and triiodothyronine, which are known to regulate metabolic processes. Iodine deficiency may impair reproductive function and cause such diseases as endemic goiter. Study objects and methods. The study involved thyroid glands from lambs of the Edilbaev breed aged seven months. The lambs were divided into four experimental groups, ten animals in each. The lambs received several feed additives. Ioddar-Zn and DAFS-25 had a balanced protein and carbohydrate content, while the mineral feed of Coretron brand contained such trace elements and minerals as iodine, selenium, and silicon. Results and discussion. The experiment made it possible to describe the microstructural profile of the thyroid glands extracted from seven-month-old lambs raised on feeds enriched with iodine and selenium. Ioddar-Zn and DAFS-25 did not harm the structure of the thyroid tissue, while causing its functional activation in some cases. The morphological parameters of the thyroid glands indicated some breed differences. The iodine concentration in the thyroid glands obtained from the experimental animals was five or six times higher than that in the control group. The content of mono- and diiodotyrosine depended on the accumulation profile of organic iodine. Conclusion. Diets enforced with DAFS-25, Ioddar-Zn, silicon, and a protein-carbohydrate complex produced no negative effect on the structure of the thyroid tissue. It fact, the diet increased the organic iodine content in the thyroid glands in the form of iodotyrosines. The gland structure revealed some cubic epithelium or follicular cells. The mass spectrometric studies confirmed the presence of covalently bound iodine in the form of mono- and diiodotyrosine. Thus, the abovementioned feed additives can be recommended for industrial use.


Author(s):  
M. I. Zhyla ◽  
G. M. Mykhalus ◽  
O. A. Maksymovych ◽  
O. V. Lapin ◽  
O. V. Mykhalyuk ◽  
...  

Poultry farming using modern technologies requires the employment of veterinary preparation for the prevention of infectious diseases and also feed additives for the improvement of metabolic functions and correction of body resistance. The article presents the results of clinical trials of feed additives in the form of an ionic solution concentrate of the biologically active nanosilicon "Arsil". The clinical study was performed on healthy ten-day-old broiler chicken, cross "Cobb-500", organized into three groups of 20 heads each: Group I received a feed additive at a dose of 0.5 ml per 1 liter of water, group II – at a dose of 1.0 ml per 1 liter of water and group III was the control group (on a regular diet, without feed additives). The use of the studied feed additive was carried out by watering with water for 30 days. Poultry of all groups were fed with identical feeds in accordance with regulatory requirements taking into account the age of the bird. The clinical condition of the bird was monitored daily, control weightings were performed once a week and blood samples were taken for laboratory tests on days 15 and 35 of the experiment. At the end of the experiment, a diagnostic slaughter of birds of all groups and a complete pathological autopsy with selection of material for histological examination were performed. Studies have shown that the use of the feed additive "Arsil" contributed to weight gain and average daily gain, improved the feed conversion and the tendency for the growth of the concentration of hemoglobin, hematocrit and erythrocytes in broiler chicken from the experimental groups compared with the control group at the end of fattening. The structure of the internal organs of birds of all studied groups is preserved, macroscopic changes in organs and tissues are not detected. An increase in the coefficients of mass of immune-competent organs in broiler chicken fed the feed additive "Arsil" compared with the control group was found.


2020 ◽  
Vol 11 (2) ◽  
pp. 65-72
Author(s):  
M. V. Seba ◽  
M. I. Yagofarov ◽  
D. K. Nosevich ◽  
V. G. Kaplunenko

The aim of the researches was to improve the reproductive capacity of cows by accelerating the uterus involution after the use of a complex substances mixture of neurotropic-metabolic action (L-arganine (C6H14N4O2), sodium succinate (Na2C4H4O4), sodium glutamate (C5H8NNaO4)) and trace elements nanocarboxylates (Fe, Ca, Mn, Cu, Zn)) in the first decade of the postpartum period. The experiment was conducted on cows of the Ukrainian black-spotted dairy breed. One control and three experimental groups were formed, 10 animals in each group. Animals of the first experimental group were injected into the caudal fold in a volume of 10 ml once a day for 6 days from the fifth day after calving, the total volume of the drug was 60 ml. Animals of the second experimental group were injected the drug in a volume of 20 ml once a day for 3 days on the fifth, seventh and ninth days after calving, the total volume of the drug was 60 ml. Animals of the third experimental group were injected the drug in a volume of 20 ml once a day for three days on the seventh, eighth and ninth days after calving, the total volume of the drug was 60 ml. Animals in the control group were not injected the drug. It was found that the use of a complex substances mixture of neurotropic-metabolic compounds with nanocarboxylates of trace elements has a positive effect on the timing of uterine involution in cows and their first arrival in sexual hunting after calving. Thus, the injection of the complex according to the scheme of the second group reduces the involution of the uterus by 2.3 days (P - 0.01) and reduces the independence period by 3.4 days (P - 0.05). Injection according to the scheme of the third experimental group accelerates the involution of the uterus by 2.1 days (P - 0.05) and reduces by 2.5 days (P - 0.05) the period from calving to the onset of the first sexual hunt. The scheme in which animals were injected within six days after calving (the first experimental group) in a volume of 10 ml from the fifth day was less effective and more time consuming.


Author(s):  
N. A. Ruban ◽  
O. S. Orishchuk ◽  
S. V. Tsap ◽  
L. M. Darmohray

One of the important conditions for the successful conduct of geese farming industry is normalized physiologically reasonable feeding birds that carried out by the use of complete feed and feed additives, including biologically active substances. Since days old, I (control) group of geese received during the research period, complete feed is made in terms of private enterprise «Orbita», II, III, IV and V (experimental) group received a complete feed with the addition of its composition of different doses of lecithin sunflower instead of a similar amount of soybean meal. At the beginning of the experiment live weight of geese had no significant differences in terms of research groups, indicating that similar selected poultry and averaged 116 – 118 grams. Since the first week of growing live weight of geese in experimental groups fed sunflower lecithin slightly increased. If, at the beginning it was not quite expressed, starting from the second week of growing this advantage becomes more significant. So, the live weight of geese at the age of two weeks in the control group was 1287 g, while the live weight of geese II, III, IV and V of experimental groups was higher by 1.4%, 4.3% (P < 0.01), 6.2% (P < 0.001) and 4.9% (P < 0.001), respectively. These differences observed between the experimental groups during the growing period. Thus, at the end of the first period of growth, namely four weeks of age, live weight of geese fourth experimental group was 3350 g, 8.0% (P < 0.001) higher relative to the control group by 5.6% compared to II experimental group, 2.8% (P < 0.01) III and 2.2% (P < 0.01) V research group. It should be noted that at the end of the second period, growing at the age of nine weeks goslings in control group matched the experimental group II on 2,3%, III – 5.1% (P <0.01), IV – 10.3% (P < 0.001) and V – 7.5% (P < 0.05), respectively. To study the anatomical and morphological structure of the experimental birds at the end of the scientific and economic experiment in the 60 days age were held control of slaughter. Our results indicate that different amounts of sunflower lecithin in diets of young geese during their growing meat differently affect their slaughter capacity. Table 3 shows that young geese feeding in the composition of animal feed sunflower lecithin has contributed to their live weight in experimental groups respectively 1.8%, 5.3%, 9.4% and 7.5% compared to the control group counterparts. For goose gut carcass weight preference geese in experimental group was respectively – 3.2%, 6.9%, 12.3% and 8.6%. The biggest muscle mass was observed in the experimental group IV geese and amounted to 1 895 g, that on 14.2% more muscle mass geese control group. The mass of muscle II, III and V of the research groups on the same indicator was higher by 3.0%, 7.7% and 9.2% in comparison with I control group. The use of sunflower lecithin in diets of young geese caused the increase in weight of internal fat. Thus this indicator preference experimental groups was – 5.7%, 15.4%, 25.1% and 18.3% according to analogue control. These changes have led to improved of meat and bone index. Thus, birds III, IV and V research groups preference for this indicator was 5.1%, 11.9% and 6.8% according to analogue controls. The indicator in poultry II experimental group was on par with the control group. Thus, putting in the diets of young geese sunflower lecithin positively affected the rate of growth of young geese slaughter their performance and made it possible to reduce the cost of feed per unit of growth. However, the best results were obtained when control weighing and slaughter, which is part of the feed was injected 0.4% sunflower lecithin.


2016 ◽  
Vol 18 (2(66)) ◽  
pp. 44-48
Author(s):  
V. Gryban ◽  
D. Mylostiva ◽  
E. Pecheniy

The article presents research data on the impact of deficient dietary microelements (cobalt and selenium) and biologically active supplement Humilid  on the indicators of the reproductive function of heifers after the first calving. We have found out that Humilid and trace elements influence on the physiological state of reproductive organs and stimulate the sexual heat of animals. Regarding the duration of the period from calving to fertilized insemination, the difference between the control and experimental groups is more visible. Thus, the service period in the experimental group I (under the influence of Humilid) was 293.2 days, which is 2.6 days less than in the control group. In the experimental group II (under the influence of cobalt and selenium), it was, respectively, by 3.9 days less than in the control one. This may indicate that the minerals and dietary supplements contribute to more rapid recovery of the ovarian cycle. Protein composition of blood serum was investigated in the study of the biochemical spectrum of blood. Balancing the nutrition of animals with deficient dietary microelements and adding Humilid increase the concentration of protein molecules, which is visible from the indicator of crude protein and its components - albumen and globulin.In comparison with animals in the control group, a total protein level of heifers in the experimental group I was higher by 8.8% (P <0.05), and in the experimental group II - by 8.6% (P <0.05). This may indicate the increased intensity of synthetic and redox processes in heifers’ bodies in preovulatory period which serve best for the insemination.The level of albumen was also higher by 8.0 and 7.3% respectively under the influence of Humilid and trace elements in relation to the control group, indicating the improvement of transport of substances, in our case estradiol.As far as globulin is concerned, the growth of this class of proteins was marked by 9.4 and 9.6%, indicating the improvement of the level of resistance of the organism. Thus, the increase in blood biochemical parameters creates certain conditions in heifers’ body to improve their insemination.


Author(s):  
Irina Bondarenko ◽  
Kristinа Velikodna

Comparative estimation of the periods sexual cycle under futile inseminations cortex and heifers sexual mature age in facilities Sumy region. The profitability of dairy farming in the farms of Sumy region will remain an unresolved issue to this day, as the indicators of reproductive capacity of breeding cows and repair heifers need analysis and correction. Inadequate feeding and inadequate care of pregnant cows and parturients are often added to this. As a consequence of the above - the reproductive capacity inherent in this species of animals is not fully realized, most cows remain infertile, and farms are short of calves and milk. The percentage of barren animals can be calculated only at the end of the calendar year, taking into account the data of statistical reporting, while infertility must be fought daily. Detection of infertile animals is effective only in the case of regular obstetric and gynecological medical examinations on the farm. It is during this time that experts find out the causes and calculate the percentage of the main components of infertility, which includes anaphrodisia. The article presents the results of the study of the main folds of anaphrodisia of cows and repair heifers of the experimental farm of Sumy region. The results of obstetric and gynecological examination, indicators of reproductive capacity of cows and heifers of mating age, reflect the basis of technology used in the economy, the intensity of use of breeding stock, as well as determine the economic feasibility of livestock in general. The main indicators of reproductive capacity of cows in the conditions of livestock farms are: indicators of inseminations, fertility, number of hotels, indicators of fruitless inseminations, and also duration of the service period The aim of the research was to study and analyze the components of anaphrodisia of cows and repair heifers of the farm during the experimental years. The results obtained will be a criterion for assessing the state of reproductive function of the uterine population of cattle. The research was conducted at Kosivshchynska Agricultural Company, Sumy District, Sumy Region, on Holstein-Friesian cows during 2019-2020. The main indicators of reproduction of uterine cattle were studied on the basis of annual reports. The obtained digital material was processed by methods of variation statistics using Student's parametric t-test. It was found that a significant percentage of culled animals occurred due to functional disorders of reproductive ability, namely due to repeated and ineffective inseminations. It was found that in 2019, 19.3% showed a sexual cycle after calving in less than 30 days, in 2020 - 18.9%, in 31-60 days in 2019 - 27%, in 2020 - 26%, in 61 -90 days in 2020 - 52.7%, in 2019 - 51.8%, for 91-120 days in 2019 - 22.1%, in 2020 - 23.5%. There is a steady growth of the service period, which worsens the performance of the experimental economy. It was found that the largest percentage of culled cows and repair heifers were animals with anaphrodisia: in 2019 33.7% of the total number of culled animals, in 2020 - 51.10%. The number of inseminations during the experimental years decreased, and the insemination index increased : in 2019 it was equal to 60, and in 2020 -80. Studies in this area highlight the problem of infertility in cattle, which encourages the study of this issue, and the search for ways to solve this problem.  


Author(s):  
М.В. ЛУКЬЯНЕНКО ◽  
Р.В. КАЗАРЯН ◽  
Т.В. ВАНИЦКАЯ ◽  
Е.В. КУЗЬМИНОВА ◽  
М.П. СЕМЕНЕНКО ◽  
...  

Для интенсификации производства животноводческой продукции и повышения ее качества необходимо обогащать рацион сельскохозяйственных животных и птицы кормовыми добавками, содержащими комплекс биологически активных веществ. Исследованы образцы комплексной кормовой добавки, содержащей масляную композицию БАВ в-каротина, витаминов Е и С, жидкого рапсового лецитина и селена, и пробиотическую добавку (ПД) Целлобактерин в соотношениях соответственно от 1 : 1 до 1 : 5. Установлено, что при соотношении масляная композиция БАВ : ПД Целлобактерин 1 : 3 количество пробиотической культуры Enterococcus faecium 1-35, содержащейся в ПД Целлобактерин, в опытном образце достигает максимального значения 6,4 Ч 105 КОЕ/г. При этом обеспечивается равномерное распределение масляной композиции БАВ на поверхности ПД. В опытах in vivo определена эффективность применения комплексной добавки с установленным соотношением компонентов для нормализации обменных процессов в организме животных. Доказано, что введение в рацион лабораторных крыс опытной группы многокомпонентной кормовой добавки в количестве 3 к основному рациону (ОР), контаминированному микотоксинами, позволяет достичь опережения прироста массы тела на 15-е и 45-е сутки эксперимента на 6,45 и 33,05 соответственно снижения содержания мочевины в сыворотке крови на 58,43 по сравнению с аналогичными показателями у животных контрольной группы, получавших только ОР. Степень снижения аланинаминотрасферазы и аспартатаминотрансферазы по отношению к аналогичным показателям контрольной группы составила 18,53 и 29,89 соответственно. Следовательно, комплексная кормовая добавка при соотношении масляная композиция БАВ : ПД Целлобактерин 1 : 3 обладает ярко выраженными гепатопротекторными и антитоксическими свойствами. Enriching the diet of farm animals and poultry by feed additives containing a complex of biologically active substances is necessary to intensify the production of livestock products and improve their quality. Samples of a complex feed additive containing an oil composition of BAS в-carotene, vitamins E and C, liquid rapeseed lecithin and selenium, and a probiotic additive (PA) Cellobacterin in ratios from 1 : 1 to 1 : 5 respectively were studied. It was found that the ratio of the oil composition of BAS : PA Cellobacterin 1 : 3 respectively the amount of probiotic culture Enterococcus faecium 1-35 contained in PA Cellobacterin in the experimental sample reaches a maximum value 6,4 Ч 105 CFU/g. In this case, the distribution of BAS oil composition on the PA surface is uniform. The effectiveness of using a complex additive with a set ratio of components to normalize metabolic processes in animals was determined in in vivo experiments. It is established that introduction in a diet of laboratory rats of the experimental group multicomponent feed additive in an amount of 3 to the basic ration (BR), contaminated with mycotoxins, can achieve compared to the same indicators in animals of the control group who received only the BR, the timing of weight gain on 15-th and 45-th day of the experiment by 6,45 and 33,05 respectively reduction of urea content in blood serum at 58,43. The degree of reduction of alanine aminotransferase and aspartate aminotransferase in relation to similar indicators of the control group was 18,53 and 29,89 respectively. Therefore, a complex feed additive with the ratio of oil composition of BAS : PA Cellobacterin 1 : 3 has pronounced hepatoprotective and antitoxic properties.


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