scholarly journals ASSESSMENT OF THE AUTOPHAGY PROCESS IN MEN OF DIFFERENT BODY WEIGHT IN DIFFERENT AGE PERIODS

2021 ◽  
Vol 2 (68) ◽  
pp. 5-9
Author(s):  
I. Tkhakushinov
Keyword(s):  
Body Weight ◽  
Muscle Mass ◽  
Positive Relationship ◽  
Normal Weight ◽  
Beclin 1 ◽  
Study Group ◽  
Extracellular Water ◽  
Total Water ◽  
Significant Positive Relationship ◽  
Normal Body Weight

The study group consisted of 20 men of various ages (14-69 years) and weight. To assess the processes of autophagy, the activity of the protein Beclin-1 was used. In individuals with normal body weight, the presence of positive reliable correlations between the level of beclin-1 and extracellular water was revealed (r = 0.96; p <0.01). In the obese group, there was a significant positive relationship between beclin-1 and the amount of triglycerides (r = 0,57; p <0,05); muscle mass (r = 0,62; p <0,05); lean mass (r = 0,62; p <0,05); common liquid (r = 0,62; p <0,05). In old age, there was a direct correlation between the level of beclin-1 and intracellular fluid (r = 0,84; p <0,05). In men, autophagy was less dependent on age, and to a greater extent on the content of extracellular water in persons with normal weight and muscle mass and total water content in persons with obesity.

scholarly journals Comparative characteristics of bioimpedanceometry indices dynamics in young men with normal and insufficient body weight in the treatment of community-acquired pneumonia

2018 ◽  
Vol 20 (1) ◽  
pp. 24-28
Author(s):  
I N Gayvoronsky ◽  
Yu Sh Khalimov ◽  
I G Pashkova
Keyword(s):  
Body Weight ◽  
Water Content ◽  
Muscle Mass ◽  
Community Acquired Pneumonia ◽  
The Body ◽  
Total Water Content ◽  
Total Water ◽  
Normal Body ◽  
Normal Body Weight ◽  
Total Muscle

The component composition of the body of men with normal body weight and insufficient body weight in the age from 18 to 44, patients with community-acquired pneumonia of non-severe course, was studied. Its changes at various periods of treatment are revealed. These changes were expressed in the statistically significant dynamics of indicators of total water content, total muscle mass with water and total fat content in men with normal body weight, as well as significant changes in the total water content and total muscle mass with water in men with insufficient body weight. At the same time, all examinees showed slight changes in body mass, body mass index and stability of the total defat-dehydrated bone mass. At the same time, the total water content and total muscle mass with water were lower at the 3rd, 7th and 15th days of treatment compared to the day of hospitalization. The lowest values of these parameters were recorded on the 3rd day of treatment. In addition, in men with normal body weight, significant changes in the total fat content on the 3rd and 15th days of treatment were noted, compared with 1 day of treatment. It was found that the total water content of men with insufficient body weight was not normal even by the 15th day of treatment. This fact indicates the need for medical rehabilitation after completion of treatment in order to normalize the body composition and prevent recurrence of the disease.

Influence of the body weight on the onset and progression of puberty in boys

2015 ◽  
Vol 28 (7-8) ◽  
Author(s):  
Analia Tomova ◽  
Ralitsa Robeva ◽  
Philip Kumanov
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Positive Relationship ◽  
Pubertal Development ◽  
Pubic Hair ◽  
Normal Weight ◽  
The Body ◽  
Significant Positive Relationship ◽  
Penis Length ◽  
The Relationship

AbstractUnlike in girls, the data on the relationship between pubertal development and body weight in boys are controversial.We measured the height, body weight, body mass index (BMI), pubic hair stages, testicular volume, penis length and circumference of 4030 boys, aged between 7 and 19 years. According to their body weight, the investigated children and adolescents were divided in four groups at each age: underweight boys (BMI <12th percentile), boys with normal weight (12th–84.99th percentile), overweight boys (85th–94.99th percentile) and boys with obesity (BMI ≥95th percentile), and their data were compared.The onset of puberty occurred when the boys’ weight gained 40.33±9.03 kg (median 39.00) and BMI was 18.62±3.12 kg/mThe onset and progression of puberty in boys are in a significant positive relationship with weight and BMI. Moreover, in the overweight boys pubertal development begins and comes to the late stage earlier in comparison with normal weight children, whereas in those who are underweight a delay at every stage of the development is observed.

scholarly journals POS0358 EVALUATION OF THE EFFECT OF mTOR EXPRESSION ON THE CLINICAL MANIFESTATIONS OF KNEE OSTEOARTHRITIS IN OBESE AND NORMAL WEIGHT PATIENTS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 409.2-409
Author(s):  
E. Strebkova ◽  
E. Tchetina ◽  
L. Alekseeva
Keyword(s):  
Body Weight ◽  
Knee Pain ◽  
Mammalian Target Of Rapamycin ◽  
Clinical Manifestations ◽  
Normal Weight ◽  
Womac Pain ◽  
Obese Patients ◽  
Normal Body ◽  
Knee Oa ◽  
Normal Body Weight

Background:Currently, a large number of molecular biological and genetic markers are known to be involved in the development of osteoarthritis (OA). The mammalian target of rapamycin (mTOR) signaling pathway is responsible for chondrocyte proliferation, cartilage matrix production, and cell growth. OA is characterized by increased mTOR synthesis, which is accompanied by an increase in proliferative activity and destruction of chondrocytes. Obesity is an important factor in the progression of knee OA. The study of mTOR expression in patients with OA and obesity is an urgent task in the development of personalized OA therapy.Objectives:To determine the expression of mTOR in patients with knee OA in combination with obesity and normal body weight. To evaluate the effect of mTOR on the clinical manifestations of OA in patients with different body mass index (BMI).Methods:The study included 73 female patients aged 45-65 y.o. with Kellgren-Lawrence stage II-III knee OA. The patients were divided into 2 groups: group 1 (n=50) with obesity (BMI > 30 kg / cm2) and group 2 (n=23) with normal or increased body weight (BMI < 30 kg/cm2). The average age of patients with obesity is 56.5 ± 5.87 years, without obesity - 58.7 ± 5.43 years. Clinical manifestations were evaluated by a WOMAС. RNA was isolated from the patients ‘ blood samples, which was used to determine the expression of mTOR.Results:Patients with knee OA with and without obesity did not differ in age. OA develops at an earlier age in obese patients, than in non-obese patients (p < 0.001). Patients from 1 group had a high BMI > 30 kg/m2 at the onset of OA. Obese patients had more severe knee OA is significantly more often detected: Kellgren-Lawrence stage III was determined in 10% of obese patients and in 4.35% - without obesity (p < 0.001). Significantly higher values of the WOMAC index pain, stiffness, joint functional failure, and total WOMAC were observed in obese patients (p = 0.006, p = 0.039, p = 0.037, and p = 0.014, respectively). Obese patients had higher VAS pain scores (p < 0.05) compared to patients with a lower BMI. Obese patients had a higher mTOR expression (p < 0.05) of 8.02±8.62, compared to non-obese patients. High mTOR expression was associated with VAS knee pain (r=0.78; p < 0.05) and WOMAC pain (r=0.89; p<0.05) in obese patients (Table 1).Table 1.Correlation of m-TORParametersmTOR (1 group, n=50)mTOR (2 group, n=23)Body weightр > 0,05р > 0,05Pain (VAS)r=0,78; р<0,05p = 0,07; r = 0,45Pain (WOMAC)r=0,89; р<0,05р > 0,05Total WOMACр > 0,05р > 0,05Conclusion:Our study showed that patients with obesity and knee OA have higher rates of mTOR expression, compared to patients with normal body weight. High mTOR expression correlates with the severity of knee pain in obese patients. Thus, the evaluation of mTOR expression in obese patients and knee OA plays an important role in predicting the severity of clinical manifestations of OA, and may influence the choice of personalized therapy tactics for such patients.Disclosure of Interests:None declared

Whole Body Protein Turnover in Chronically Undernourished Individuals

1994 ◽  
Vol 86 (4) ◽  
pp. 441-446 ◽  
Author(s):  
M. J. Soares ◽  
L. S. Piers ◽  
P. S. Shetty ◽  
A. A. Jackson ◽  
J. C. Waterlow
Keyword(s):  
Body Weight ◽  
Protein Synthesis ◽  
Metabolic Rate ◽  
Muscle Mass ◽  
Basal Metabolic Rate ◽  
Normal Weight ◽  
Fat Free Mass ◽  
Whole Body ◽  
Body Protein ◽  
Chronic Undernutrition

1. Two groups of adult men were studied in Bangalore, India, under identical conditions: the ‘normal weight’ subjects (mean body mass index 20.8 kg/m2) were medical students of the institute with access to habitual energy and protein intakes ad libitum. The other group, designated ‘undernourished’, were labourers on daily wages (mean body mass index 16.7 kg/m2). 2. In an earlier study we obtained lower absolute values for both basal metabolic rate and protein synthesis in the undernourished subjects; however, when the data were expressed on a body weight or fat-free mass basis, a trend towards higher rates of protein synthesis, as well as higher basal metabolic rate, was evident. The suggestion was made that such results reflected the relatively higher energy intakes per kg body weight of the undernourished subjects on the day of study. The objective of the present study was therefore to control for the dietary intake during the measurement of whole body protein turnover. 3. In the present study dietary intakes were equated on a body weight basis; however, expressed per kg fat-free mass, the normal weight subjects had received marginally higher intakes of energy and protein. The results, however, were similar to those of the previous study. In absolute terms, basal metabolic rate, protein synthesis and breakdown were lower in the undernourished subjects. When expressed per kg body weight or per kg fat-free mass, the undernourished subjects had higher basal metabolic rates than the well-nourished subjects, whereas no differences were seen in the rate of protein synthesis or breakdown. 4. Estimates of muscle mass, based on creatinine excretion, indicated that the undernourished subjects had a higher proportion of non-muscle to muscle mass. Nitrogen flux (Q) was determined from 15N abundance in two end products, urea (Qu) and ammonia (Qa). The ratio Qu/Qa was increased in the undernourished subjects and was significantly correlated with the ratio of non-muscle to muscle mass (r = 0.81; P < 0.005). These results fit in with our earlier suggestion of a greater proportion of non-muscle (visceral) mass in undernourished subjects. 5. The present data suggest that there are no changes in the rate of protein synthesis or breakdown in chronic undernutrition when results are expressed, conventionally, per kg fat-free mass. It can be theoretically shown, however, that there could be a 15% reduction in the rate of turnover of the visceral tissues in chronic undernutrition. This, together with the reduced urinary nitrogen excretion, would contribute to nitrogen economy in these individuals.

scholarly journals Osteodensitometric Characteristics of Bone Tissue in Women with Normal Body Weight

2021 ◽  
Vol 10 (3) ◽  
pp. 108-111
Author(s):  
I. G. Pashkova
Keyword(s):  
Body Weight ◽  
Bone Tissue ◽  
Muscle Mass ◽  
Bone Mineralization ◽  
Lumbar Vertebrae ◽  
The Body ◽  
Mineral Density ◽  
Normal Body ◽  
Age Related ◽  
Normal Body Weight

The aim of the study was to investigate age-related changes in bone mineralization indicators in the lumbar vertebrae in women with normal body weight living in the conditions of the Northern region.Material and methods. A complex somatometric examination and quantitative assessment of the bone tissue mineral density in the lumbar vertebrae were performed according to dual-energy X-ray absorptiometry of a group of Slavic women (n=127) with a normal body weight (BMI values from 18.5 to 24.9 kg/m2) aged 20 to 87 years, permanently residing in the Republic of Karelia. Statistical processing of the material was performed using the program "STATISTICA 6.0".Results. The BMI values in women increased significantly every decade of life. Direct correlations of mineral bone density (MBD) with the body length (r=0.46, p<0.001), with the body surface area (r=0.46, p<0.001), with absolute muscle mass (MM) (r=0.39, p<0.001), and with body mass (r=0.29, p<0.001) were revealed. No significant correlation with the adipose mass was found. The incidence of low MBD of the lumbar vertebrae was 48%: osteopenia was in 29%, osteoporosis was in 19% of women. The analysis of the component composition of the body in women with different levels of bone mass showed significant differences in the absolute content of muscle mass.Conclusion. In women with a normal BMI, body weight and muscle mass play an essential role in maintaining lumbar vertebrae bone mineral density.

scholarly journals Levels of keratinocyteand fibroblast-derived chemokines in skin cells isolated from abdominoplasty surgical materials from patients with normal weight and obesity

2020 ◽  
pp. 47-53
Author(s):  
А.Е. Копасов ◽  
Е.Н. Волкова ◽  
С.Н. Блохин ◽  
С.Г. Морозов
Keyword(s):  
Flow Cytometry ◽  
Body Weight ◽  
Subcutaneous Fat ◽  
Normal Weight ◽  
Obese Patients ◽  
Becton Dickinson ◽  
Skin Cells ◽  
Inflammatory Chemokines ◽  
Normal Body Weight ◽  
Body Weight Index

Цель работы - определение уровня хемокинов, ассоциированных с фибробластами и кератиноцитами, в клетках кожи, выделеных из операционного материала при абдоминопластике у пациенток с нормальной массой тела и ожирением. Методика. Для исследования использовали фрагменты кожи пациенток с нормальной массой тела и ожирением. Степень ожирения оценивали по индексу массы тела (ИМТ) согласно международным критериям. ИМТ, принятый в исследовании за норму, составлял 19,8±1,7 кг/м2, для пациенток с ожирением - 38,3±4,1 кг/м2. Клетки выделяли путем ферментативной обработки коллагеназой II. Проводили иммунотипирование клеток моноклональными антителами меченными флуоресцентными красителями. Использовали антитела к хемокинам семейства CXCL (R&D systems) и CCL (Boeringer Ingelheim, Германия). Меченные флуоресцентными красителями иммунотипированные клетки анализировали на проточном цитометре FACSCalibur (Becton Dickinson, США) по программе SimulSet. Статистический анализ проводили по программе ANOVA. Результаты. Были проанализированы хемокины семейства CCL и CXCL, секретируемые кератиноцитами и фибробластами кожи. Показано, что в коже пациенток с ожирением повышен процент клеток, экспрссирующих рецепторы CXCR3, CXCR4, CCR3, CCR10, регулирующие секрецию хемокинов кератиноцитами и фибробластами кожи. При ожирении в клетках кожи повышен уровень хемокинов CXCL8, CXCL9, CXCL10, CXCL13, CCL24 и CCL27, имеющих отношение к развитию и поддержанию воспалительного процесса в коже, а уровень хемокинов CCL17, CCL22, CCL28 снижен, что указывает на нарушение хемокиновой и цитокиновой регуляции при ожирении и является основой для развития послеоперационных осложнений при абдоминопластике. Заключение. Полученные данные указывают на нарушение хемокиновой регуляции при ожирении, что способствует развитию послеоперационных осложнений при абдоминопластике. The aim of the study was to compare chemokine expression in skin cells obtained from patients with normal body weight and obesity after abdominoplasty. Methods. Obesity was determined by body weight index (normal, 19.8±1.7 kg/m2; obesity, 38.3±4.1 kg/m2). Only skin without subcutaneous fat was isolated from surgical material. The skin cells obtained from surgical material were stained with monoclonal antibodies to chemokines. Fluorescence of proteins and receptors was analyzed by flow cytometry. Statistical analysis was performed with ANOVA. Results. Keratinocyte- and fibroblast-derived chemokines of the CCL and CXCL families were analyzed. Percentage of cells expressing CXCR3, CXCR4, CCR3, and CCR10 receptors (regulators of chemokine secretion by keratinocytes and skin fibroblasts) was increased in the skin of obese patients. Expression of the pro-inflammatory chemokines, CXCL8, CXCL9, CXCL10, CXCL13, CCL24, and CCL27, was increased in skin cells from obese patients. Obesity was associated with reduced expression of the chemokines CCL17, CCL22, and CCL28 in skin cells. Conclusion. Chemokine regulation is disturbed in obesity, which may underlie the development of complications after abdominal surgery.

scholarly journals Factors affecting velvet antler weights in free-ranging reindeer in Alaska

Rangifer ◽  
1999 ◽  
Vol 19 (2) ◽  
pp. 71 ◽  
Author(s):  
Alexander K. Prichard ◽  
Greg L. Finstad ◽  
Drew H. Shain
Keyword(s):  
Body Weight ◽  
Positive Relationship ◽  
Factors Affecting ◽  
Significant Positive Relationship ◽  
Julian Date ◽  
Velvet Antler ◽  
Lactating Females ◽  
Males And Females ◽  
Seward Peninsula ◽  
Free Ranging

<p>Free-ranging reindeer on the Seward Peninsula in western Alaska are rounded up from late May to early July and antlers are removed. We used data collected from 1987 to 1997 to determine how velvet antler weights of males and females varied with age, year, reproductive status, Julian date, and body weight. Male antler weights increased with age up to age five years, and were lower in castrates than in bulls. There was a significant positive relationship between body weight and antler weight in both sexes. Female antler weights increased with age until at least age nine. Lactating females had lower antler weights than non-lactating females, but this effect is better explained by differences in body weight. Antler weight of individual reindeer at age two years was better predicted by their antler weights as yearlings than their body weight as yearlings.</p>

scholarly journals Cardiopulmonary Capacity in Overweight and Obese Children and Adolescents: A Cross-Sectional Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Agata Grzyb ◽  
Małgorzata Domagalska-Szopa ◽  
Andrzej Siwiec ◽  
Ilona Kwiecień-Czerwieniec ◽  
Andrzej Szopa
Keyword(s):  
Body Weight ◽  
Children And Adolescents ◽  
Cardiopulmonary Exercise Testing ◽  
High Body Mass Index ◽  
Normal Weight ◽  
Control Group ◽  
Overweight Children ◽  
Obese Children ◽  
Normal Body ◽  
Normal Body Weight

Background: One of the objective methods of assessing the level of cardiopulmonary capacity in overweight and obese children and adolescents is cardiopulmonary exercise testing (CPET).Aims: The purpose of present study is an evaluation of aerobic capacity in high body mass index (BMI) children and adolescents by comparing them with a normal weight control group by CPET.Methods and Procedures: The subjects were recruited from participants of the Program of Treatment for Overweight and Obese Children organized by a local pediatric rehabilitation center in Poland. Based on BMI for age and gender, two validation groups were selected: (1) a group of overweight children (n = 49) and (2) a group of obese children (n = 48). The study included also 53 normal weight participants as a reference group (REF). The study consisted of two parts: anthropometric measurements and CPET. The Godfrey protocol for CPET was applied.Outcomes and Results: In this study, obese children and adolescents showed similar absolute VO2peak values in liters per minute (1.64 L/min) compared to overweight children (1.48 L/min), but significantly higher than children with normal body weight (1.39 L/min). The obese children and adolescents presented lower VO2peak in relation to body weight (25.44 ml/kg/min) compared to their peers with normal body weight (36.5 ml/kg/min), and overweight children (29.18 ml/kg/min).Conclusion and Implications: The main finding of our study was recognition of significant differences between cardiopulmonary capacity parameters in obese children in comparison not only to normal weight peers, but to overweight, too.

scholarly journals Oxygen Supply System Management in an Overweight Adult after 12 Months in Antarctica—Study Case

2021 ◽  
Vol 18 (8) ◽  
pp. 4077
Author(s):  
Maria Radziejowska ◽  
Yevgen Moiseyenko ◽  
Paweł Radziejowski ◽  
Michał Zych
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Respiratory System ◽  
Normal Weight ◽  
System State ◽  
Oxygen Homeostasis ◽  
Overweight Adult ◽  
Excessive Body Weight ◽  
Normal Body Weight ◽  
First Time

The aim of the study was to try to determine the functional state of the respiratory system, i.e., selected parameters and indicators of physiological systems responsible for the supply of oxygen at all stages of its delivery in people as their body weight increases from normal weight to overweight. The studies include an analysis of test results of functional respiratory system state (FSD) indicators of a 30-year-old and 170-cm tall man. Measurements of FSD were conducted two times: the first time before an expedition to Antarctica at 70 kg (normal body weight); the next measurements were taken a year later, after coming back from the expedition, at 82 kg (overweight). When analyzing the functional respiratory system state in terms of the effect of overweight it was found that the maintenance of the oxygen homeostasis in those conditions occurred at the level of a compensated hypoxic state. That is why the decision to engage in physical activity can be made only if we are sure that significant destructive additive effects of both types of hypoxic influences (from excessive body weight and from the physical activity) are not overlapping.

scholarly journals The association of positive mental health indicators and normal body weight, Belgian HIS 2018

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
K De Ridder ◽  
S Drieskens ◽  
S Demarest
Keyword(s):  
Mental Health ◽  
Life Satisfaction ◽  
Body Weight ◽  
Psychological Distress ◽  
Health Indicators ◽  
Normal Weight ◽  
Positive Mental Health ◽  
Normal Body ◽  
Normal Body Weight ◽  
Low Educated

Abstract Background An important health promotion goal is to maintain a normal body weight. However, knowledge about positive mental health indicators that might be associated with normal weight is scarce. The aim is to study positive mental health indicators and normal weight in a cross-sectional national representative population sample. Methods Study participants included adults aged ≥ 18 year (n = 6643) of the Belgian Health Interview Survey (HIS) 2018. Mental health indicators were having no psychological distress (GHQ-12&lt;2), no self-reported anxiety or depression (EQ_5D), medium to high vitality (SF-36 vitality scale) and high to medium level of life satisfaction. BMI was calculated on self-declared height and weight. The associations were assessed through logistic regression taking into account confounding and effect modification by age, gender, educational level, health status, physical activity, daily eating of fruit and vegetables and daily consuming sugared soft drinks or sweet/salty snacks. Results 50.1% had a BMI≥25. In the crude models, all indicators were negatively associated with being obese, but there was no association between having a normal weight (versus overweight and obesity) and absence of psychological distress, absence of anxiety and depression, and medium to high vitality. Medium to high level of life satisfaction was associated with normal weight in the fully adjusted model (OR 1.3; 95%CI 1.0-1.6) but when stratified, medium to high life satisfaction was associated with normal weight only among high educated women (OR 1.8; 95%CI 1.1-2.9), but not among men and low educated women. Surprisingly, among low educated women, having no psychological distress was negatively associated with normal weight (OR 0.7; 95%CI 0.5-0.9). Conclusions These preliminary results showed a variable impact of gender and educational levels on the association between positive mental health indicators and normal weight. Trends and distribution in society should be further explored. Key messages Although unequivocal associations with obesity, positive mental health is not clearly associated with normal body weight in today’s obesogenic society. The effect of a shift towards a higher BMI in society on mental health needs to be further explored.

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