scholarly journals Progress on Gut Health Maintenance and Antibiotic Alternatives in Broiler Chicken Production

2021 ◽  
Vol 8 ◽  
Author(s):  
Qidong Zhu ◽  
Peng Sun ◽  
Bingkun Zhang ◽  
LingLian Kong ◽  
Chuanpi Xiao ◽  
...  
Keyword(s):  
Broiler Chicken ◽  
Animal Husbandry ◽  
Complete Removal ◽  
Livestock Production ◽  
Feed Additives ◽  
Gut Health ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Health Maintenance ◽  
Beneficial Effects

The perturbation of gut health is a common yet unresolved problem in broiler chicken production. Antibiotics used as growth promoters have remarkably improved the broiler production industry with high feed conversion efficiency and reduced intestinal problems. However, the misuse of antibiotics has also led to the increase in the development of antibiotic resistance and antibiotic residues in the meat. Many countries have enacted laws prohibiting the use of antibiotics in livestock production because of the increasing concerns from the consumers and the public. Consequently, one of the most significant discussions in the poultry industry is currently antibiotic-free livestock production. However, the biggest challenge in animal husbandry globally is the complete removal of antibiotics. The necessity to venture into antibiotic-free production has led researchers to look for alternatives to antibiotics in broiler chicken production. Many strategies can be used to replace the use of antibiotics in broiler farming. In recent years, many studies have been conducted to identify functional feed additives with similar beneficial effects as antibiotic growth promoters. Attention has been focused on prebiotics, probiotics, organic acids, emulsifiers, enzymes, essential oils, tributyrin, and medium-chain fatty acids. In this review, we focused on recent discoveries on gut health maintenance through the use of these functional feed additives as alternatives to antibiotics in the past 10 years to provide novel insights into the design of antibiotic-free feeds.

scholarly journals Effects of Xylo-Oligosaccharides on Broiler Chicken Performance and Microbiota

2015 ◽  
Vol 81 (17) ◽  
pp. 5880-5888 ◽  
Author(s):  
C. De Maesschalck ◽  
V. Eeckhaut ◽  
L. Maertens ◽  
L. De Lange ◽  
L. Marchal ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Degradation Products ◽  
Hydrolytic Degradation ◽  
Feed Additives ◽  
Gut Health ◽  
Feed Conversion ◽  
Content Type ◽  
Beneficial Effects ◽  
Coa Transferase

ABSTRACTIn broiler chickens, feed additives, including prebiotics, are widely used to improve gut health and to stimulate performance. Xylo-oligosaccharides (XOS) are hydrolytic degradation products of arabinoxylans that can be fermented by the gut microbiota. In the current study, we aimed to analyze the prebiotic properties of XOS when added to the broiler diet. Administration of XOS to chickens, in addition to a wheat-rye-based diet, significantly improved the feed conversion ratio. XOS significantly increased villus length in the ileum. It also significantly increased numbers of lactobacilli in the colon andClostridiumcluster XIVa in the ceca. Moreover, the number of gene copies encoding the key bacterial enzyme for butyrate production, butyryl-coenzyme A (butyryl-CoA):acetate CoA transferase, was significantly increased in the ceca of chickens administered XOS. In this group of chickens, at the species level,Lactobacillus crispatusandAnaerostipes butyraticuswere significantly increased in abundance in the colon and cecum, respectively.In vitrofermentation of XOS revealed cross-feeding betweenL. crispatusandA. butyraticus. Lactate, produced byL. crispatusduring XOS fermentation, was utilized by the butyrate-producingAnaerostipesspecies. These data show the beneficial effects of XOS on broiler performance when added to the feed, which potentially can be explained by stimulation of butyrate-producing bacteria through cross-feeding of lactate and subsequent effects of butyrate on gastrointestinal function.

scholarly journals Galacto-oligosaccharides modulate the juvenile gut microbiome and innate immunity to improve broiler chicken performance

2019 ◽  
Author(s):  
Philip J. Richards ◽  
Geraldine M. Flaujac Lafontaine ◽  
Phillippa L. Connerton ◽  
Lu Liang ◽  
Karishma Asiani ◽  
...  
Keyword(s):  
Growth Rate ◽  
Innate Immunity ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
Control Diet ◽  
Innate Immune ◽  
Gut Health ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Key Species

ABSTRACTImprovements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides in broiler feed enhanced the growth rate and feed conversion of chickens relative to a calorie-matched control diet. Comparison of the cecal microbiota identified key differences in abundance ofLactobacillusspp. Increased levels ofL. johnsoniiin GOS-fed juvenile birds at the expense ofL. crispatuswas linked to improved performance (growth rate and market weight). Investigation of the innate immune responses highlighted increases of ileal and cecal IL-17A gene expression counterposed to a decrease in IL-10 and IL-17F. Quantification of the autochthonousLactobacillusssp. revealed a correlation between bird performance andL. johnsoniiabundance. Shifts in the cecal populations of keyLactobacillusspp. of juvenile birds primed intestinal innate immunity without harmful pathogen challenge.IMPORTANCEImprovements in the growth rate of broiler chickens can be achieved through dietary manipulation of the naturally occurring bacterial populations whilst mitigating the withdrawal of antibiotic growth promoters. Prebiotic galacto-oligosaccharides (GOS) are manufactured as a by-product of dairy cheese production, which can be incorporated in the diets of juvenile chickens to improve their health and performance. This study investigates the key mechanisms behind this progression and pin pointsL. johnsoniias a key species that facilitates the enhancements in growth rate and gut health. It also relates the role of the innate immune system in the response to the GOS diet.

scholarly journals The Effect of α-Monolaurin and Butyrate Supplementation on Broiler Performance and Gut Health in the Absence and Presence of the Antibiotic Growth Promoter Zinc Bacitracin

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 651
Author(s):  
Bakang R. Letlole ◽  
Ellen P. C. W. Damen ◽  
Christine Jansen van Rensburg
Keyword(s):  
Bacterial Resistance ◽  
Feed Additives ◽  
Growth Promoter ◽  
Gut Health ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Broiler Performance ◽  
Positive Effects ◽  
Zinc Bacitracin ◽  
The Impact

The use of antibiotic growth promoters (AGP) is common practice to improve broiler production and performance. The use of AGP is under discussion as it can induce bacterial resistance. The purpose of this study was to determine the impact of removing AGP from broiler feed and study the effect of feed additives. For those countries where in-feed AGP are still permitted, the effect of the products in the presence of AGP was evaluated. Half the number of male broilers received a diet free of AGP, whereas the other half received a diet supplemented with zinc bacitracin at 0.5 g/kg. Both diets were either without additional additives or combined with a coated sodium butyrate, α-monolaurin or a combination of these additives. Raised under optimal conditions, the incorporation of AGP had no effect on broiler performance, but negatively affected villi height and villi height to crypt depth (VH:CD) ratio in the duodenum. In the absence of AGP, butyric acid and α-monolaurin had a positive effect on villi height. In the presence of AGP, α-monolaurin resulted in the lowest feed conversion ratio and improved VH:CD ratio in the duodenum, jejunum and ileum. Both feed additives had minimal effect on performance parameters but showed small positive effects on gut health in the absence of AGP and could play a role in the strategy to replace AGP.

scholarly journals Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance

mSystems ◽  
2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Philip J. Richards ◽  
Geraldine M. Flaujac Lafontaine ◽  
Phillippa L. Connerton ◽  
Lu Liang ◽  
Karishma Asiani ◽  
...  
Keyword(s):  
Growth Rate ◽  
Innate Immunity ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
Control Diet ◽  
Gut Health ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Content Type ◽  
Key Species

ABSTRACT Improvements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides (GOS) in broiler feed enhanced the growth rate and feed conversion of chickens relative to those obtained with a calorie-matched control diet. Comparison of the cecal microbiota identified key differences in abundances of Lactobacillus spp. Increased levels of Lactobacillus johnsonii in GOS-fed juvenile birds at the expense of Lactobacillus crispatus were linked to improved performance (growth rate and market weight). Investigation of the innate immune responses highlighted increases of ileal and cecal interleukin-17A (IL-17A) gene expression counterposed to a decrease in IL-10. Quantification of the autochthonous Lactobacillus spp. revealed a correlation between bird performance and L. johnsonii abundance. Shifts in the cecal populations of key Lactobacillus spp. of juvenile birds primed intestinal innate immunity without harmful pathogen challenge. IMPORTANCE Improvements in the growth rate of broiler chickens can be achieved through dietary manipulation of the naturally occurring bacterial populations while mitigating the withdrawal of antibiotic growth promoters. Prebiotic galacto-oligosaccharides (GOS) are manufactured as a by-product of dairy cheese production and can be incorporated into the diets of juvenile chickens to improve their health and performance. This study investigated the key mechanisms behind this progression and pinpointed L. johnsonii as a key species that facilitates the enhancements in growth rate and gut health. The study identified the relationships between the GOS diet, L. johnsonii intestinal populations, and cytokine immune effectors to improve growth.

scholarly journals Role of probiotics in nutrition and health of small ruminants

2016 ◽  
Vol 19 (4) ◽  
pp. 893-906 ◽  
Author(s):  
M.M. Abd El-Tawab ◽  
I.M.I. Youssef ◽  
H.A. Bakr ◽  
G.C. Fthenakis ◽  
N.D. Giadinis
Keyword(s):  
Volatile Fatty Acids ◽  
Animal Health ◽  
Small Ruminants ◽  
Nutrient Digestibility ◽  
Feed Additives ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Livestock Farming ◽  
Main Component ◽  
Research On Application

AbstractSmall ruminants represent an important economic source in small farm systems and agriculture. Feed is the main component of livestock farming, which has gained special attention to improve animal performance. Many studies have been done to improve feed utilisation through addition of feed additives. For a long period, antibiotics have been widely used as growth promoters in livestock diets. Due to their ban in many countries, search for alternative feed additives has been intensified. Probiotics are one of these alternatives recognised to be safe to the animals. Use of probiotics in small ruminant nutrition has been confirmed to improve animal health, productivity and immunity. Probiotics improved growth performance through enhancing of rumen microbial ecosystem, nutrient digestibility and feed conversion rate. Moreover, probiotics have been reported to stabilise rumen pH, increase volatile fatty acids production and to stimulate lactic acid utilising protozoa, resulting in a highly efficient rumen function. Furthermore, use of probiotics has been found to increase milk production and can reduce incidence of neonatal diarrhea and mortality. However, actual mechanisms through which probiotics exert these functions are not known. Since research on application of probiotics in small ruminants is scarce, the present review attempts to discuss the potential roles of this class of feed additives on productive performance and health status of these animals.

scholarly journals Perspectives for rare earth elements as feed additive in livestock — A review

2020 ◽  
Vol 33 (3) ◽  
pp. 373-381 ◽  
Author(s):  
Hujaz Tariq ◽  
Amit Sharma ◽  
Srobana Sarkar ◽  
Lamella Ojha ◽  
Ravi Prakash Pal ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Feed Additives ◽  
Egg Laying ◽  
Farm Animals ◽  
Feed Additive ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Potential Growth ◽  
Safe Alternative

There is a need for newer feed additives due to legal prohibition on inclusion of growth promoting antibiotics in livestock diets in several countries due to antimicrobial resistance. In this context, rare earth elements (REE) have gained attention among animal nutritionists as potential growth promoters. Currently, several studies have reported better weight gain, milk production, egg laying capacity and feed conversion efficiency among different breeds of farm animals following supplementation with REE, with however largely inconsistent results. Furthermore, REE supplementation has also shown to improve ruminal fibrolytic and proteolytic activities as well as flavor of meat with negligible residues in edible tissue, however the mechanism behind this action is still unclear. According to existing research, due to their poor absorption and similarity with calcium REE might exert their action locally on gut microbial populations within the gastrointestinal tract (GIT). Moreover, REE have also shown anti-inflammatory, anti-oxidative as well as immune stimulating effects. The present review aims to broaden the knowledge about use of REE as feed additives for livestock and sum up efficacy of REE supplementation on performance and health of animals by comparing the findings. Till date, researches with REE have shown properties that make them a promising, new and safe alternative feed additive but further exploration is recommended to optimize effects and clarify discrepancy of various results before practical proposals can be drafted.

scholarly journals The nutritional applications of garlic (Allium sativum) as natural feed additives in animals

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11934
Author(s):  
Jiashun Chen ◽  
Fang Wang ◽  
Yexin Yin ◽  
Xiaokang Ma
Keyword(s):  
Allium Sativum ◽  
Animal Feed ◽  
Animal Husbandry ◽  
Feed Additives ◽  
Bioactive Molecules ◽  
Herbal Remedies ◽  
Organosulfur Compounds ◽  
Beneficial Effects ◽  
Stress Markers

Garlic (Allium sativum) is an essential vegetable that has been widely utilized as seasoning, flavoring, culinary and in herbal remedies. Garlic contains several characteristic organosulfur compounds, such as diallyl sulfide, allicin (diallyl thiosulphate), γ-glutamylcysteine, and S-allyl cysteine (alliin) and ajoene, which garlic has beneficial effects on inflammation, oxidative stress markers, hypertension, hyperlipidaemia and endothelial function in vitro or in animal model. These bioactive molecules are also playing pivotal role in livestock and fisheries production apart from its application in humans. Supplementation of animal feed with garlic and its related products is consistent with the modern agricultural concept of organic animal husbandry. This review compiles the information describing the effects of feeding garlic and its extracts on selected performance parameters in animals (chicken, rabbits, ruminants, pigs and fish). This review may provide reference for scientists and entrepreneurs to investigate the applications of feeds added with garlic and allicin by-products for the improvement of animal husbandry and aquatic production.

scholarly journals Analysis of Policy Making Factors on The Prohibition of Hormones and Antibiotics Use for Feed as a Public Health Protection

2017 ◽  
Vol 2 (2) ◽  
pp. 14
Author(s):  
Zaima Amalia ◽  
Wiku Adisasmito
Keyword(s):  
Local Governments ◽  
Animal Feed ◽  
Animal Husbandry ◽  
Antibiotic Use ◽  
Feed Additives ◽  
Growth Promoters ◽  
Antibiotics Use ◽  
Emerging Issues ◽  
The Government ◽  
Public Health Protection

Food safety is one of the current international emerging issues. The danger of using antibiotics in animal husbandry is one of the contributors to human resistance. In Indonesia, antibiotics are commonly used as growth promoters in animal husbandry. Prohibition on the use of hormones and antibiotics mixed into animal feed written in Law No. 18 of 2009 on Animal Husbandry and Health which is then clarified by the Minister of Agriculture Regulation No. 14/Permentan/PK.350/5/2017 on the Classification of Animal Drugs. The purpose of this study is to determine the factors which influence the formation of policy on the prohibition of hormone and antibiotic use as feed additives, especially health, legal, political and economic factors. This research uses descriptive study by qualitative approach. Data were collected using in-depth interviews and literature studies. The result shows that legal factors have a stronger influence than health, economic and political factors. The study recommends that the government should develop monitoring programs, conduct surveillance in feed and breeder entrepreneurs, establish good coordination with local governments, conduct further residue studies on animal source food, and further review the economic impact of the policy. Breeders also need to improve the cleanliness of the cage and try natural feed. While feed entrepreneurs need to find a replacement of antibiotic/hormone mixed feed safely.

scholarly journals INFLUENCE OF ARSIL FEED ADDITIVE ON HEMATOLOGICAL INDICES, PRODUCTIVITY AND STRUCTURE OF INTERNAL ORGANS BROILER CHICKENS

2020 ◽  
Vol 21 (1) ◽  
pp. 65-72
Author(s):  
M. I. Zhyla ◽  
G. M. Mykhalus ◽  
O. A. Maksymovych ◽  
O. V. Lapin ◽  
O. V. Mykhalyuk ◽  
...  
Keyword(s):  
Broiler Chicken ◽  
Average Daily Gain ◽  
Feed Additives ◽  
Biologically Active ◽  
Feed Additive ◽  
Control Group ◽  
Feed Conversion ◽  
Internal Organs ◽  
Hematological Indices ◽  
Group I

Poultry farming using modern technologies requires the employment of veterinary preparation for the prevention of infectious diseases and also feed additives for the improvement of metabolic functions and correction of body resistance. The article presents the results of clinical trials of feed additives in the form of an ionic solution concentrate of the biologically active nanosilicon "Arsil". The clinical study was performed on healthy ten-day-old broiler chicken, cross "Cobb-500", organized into three groups of 20 heads each: Group I received a feed additive at a dose of 0.5 ml per 1 liter of water, group II – at a dose of 1.0 ml per 1 liter of water and group III was the control group (on a regular diet, without feed additives). The use of the studied feed additive was carried out by watering with water for 30 days. Poultry of all groups were fed with identical feeds in accordance with regulatory requirements taking into account the age of the bird. The clinical condition of the bird was monitored daily, control weightings were performed once a week and blood samples were taken for laboratory tests on days 15 and 35 of the experiment. At the end of the experiment, a diagnostic slaughter of birds of all groups and a complete pathological autopsy with selection of material for histological examination were performed. Studies have shown that the use of the feed additive "Arsil" contributed to weight gain and average daily gain, improved the feed conversion and the tendency for the growth of the concentration of hemoglobin, hematocrit and erythrocytes in broiler chicken from the experimental groups compared with the control group at the end of fattening. The structure of the internal organs of birds of all studied groups is preserved, macroscopic changes in organs and tissues are not detected. An increase in the coefficients of mass of immune-competent organs in broiler chicken fed the feed additive "Arsil" compared with the control group was found.

scholarly journals Antibacterial activity of Bacillus species-derived surfactin on Brachyspira hyodysenteriae and Clostridium perfringens

AMB Express ◽  
2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yi-Bing Horng ◽  
Yu-Hsiang Yu ◽  
Andrzej Dybus ◽  
Felix Shih-Hsiang Hsiao ◽  
Yeong-Hsiang Cheng
Keyword(s):  
Antibacterial Activity ◽  
Clostridium Perfringens ◽  
Animal Husbandry ◽  
Feed Additives ◽  
Bacillus Species ◽  
Necrotic Enteritis ◽  
Growth Promoters ◽  
Bacterial Killing ◽  
Brachyspira Hyodysenteriae ◽  
Potential Alternative

AbstractSwine dysentery and necrotic enteritis are a bane to animal husbandry worldwide. Some countries have already banned the use of antibiotics as growth promoters in animal production. Surfactin is a potential alternative to antibiotics and antibacterial agents. However, the antibacterial activity of Bacillus species-derived surfactin on Brachyspira hyodysenteriae and Clostridium perfringens are still poorly understood. In the current study, the antibacterial effects of surfactin produced from Bacillus subtilis and Bacillus licheniformis on B. hyodysenteriae and C. perfringens were evaluated. Results showed that multiple surfactin isoforms were detected in B. subtilis, while only one surfactin isoform was detected in B. licheniformis fermented products. The surfactin produced from B. subtilis exhibited significant antibacterial activity against B. hyodysenteriae compared with surfactin produced from B. licheniformis. B. subtilis-derived surfactin could inhibit bacterial growth and disrupt the morphology of B. hyodysenteriae. Furthermore, the surfactin produced from B. subtilis have the highest activity against C. perfringens growth. In contrast, B. licheniformis fermented product-derived surfactin had a strong bacterial killing activity against C. perfringens compared with surfactin produced from B. subtilis. These results together suggest that Bacillus species-derived surfactin have potential for development as feed additives and use as a possible substitute for antibiotics to prevent B. hyodysenteriae and C. perfringens-associated disease in the animal industry.

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