scholarly journals A Novel Performance Adaptation and Diagnostic Method for Aero-Engines Based on the Aerothermodynamic Inverse Model

Aerospace ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
Sangwei Lu ◽  
Wenxiang Zhou ◽  
Jinquan Huang ◽  
Feng Lu ◽  
Zhongguang Chen
Keyword(s):  
Diagnostic Method ◽  
Time Estimation ◽  
Response Speed ◽  
Diagnostic Techniques ◽  
Inverse Model ◽  
Diagnostic Methods ◽  
Convergence Time ◽  
Unbiased Estimation ◽  
Strong Nonlinearity ◽  
Aero Engines

Aero-engines are faced with severe challenges of availability and reliability in the increasing operation, and traditional gas path filtering diagnostic methods have limitations restricted by various factors such as strong nonlinearity of the system and lack of critical sensor information. A method based on the aerothermodynamic inverse model (AIM) is proposed to improve the adaptation accuracy and fault diagnostic dynamic estimation response speed in this paper. Thermodynamic mechanisms are utilized to develop AIM, and scaling factors are designed to be calculated iteratively in the presence of measurement correction. In addition, the proposed method is implemented in combination with compensation of the nonlinear filter for real-time estimation of health parameters under the hypothesis of estimated dimensionality reduction. Simulations involved experimental datasets revealed that the maximum average simulated error decreased from 13.73% to 0.46% through adaptation. It was also shown that the dynamic estimated convergence time of the improved diagnostic method reached 2.183 s decrease averagely without divergence compared to the traditional diagnostic method. This paper demonstrates the proposed method has the capacity to generalize aero-engine adaptation approaches and to achieve unbiased estimation with fast convergence in performance diagnostic techniques.

scholarly journals Coccidiosis Disease in Cattle in Indonesia and Development of Diagnostic Techniques

2019 ◽  
Vol 29 (3) ◽  
pp. 133
Author(s):  
Fitrine Ekawasti ◽  
April H Wardhana
Keyword(s):  
Diagnostic Method ◽  
Clinical Symptoms ◽  
Eimeria Species ◽  
Morphological Characteristics ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Economic Losses ◽  
Eimeria Spp ◽  
The Government ◽  
Cattle Farms

Coccidiosis is a parasitic disease caused by the protozoan of the order Coccidia, the family Eimeriidae of the genus Eimeria which breeds rapidly in the digestive tract and is the most difficult disease to be controlled on cattle farms. Eimeria spp. in cattle can cause high economic losses and increase susceptibility against infectious diseases. Therefore, coccidiosis in cattle needs attention from the government. This paper reviews a number of diagnostic methods that can be used in the detection of Eimeria spp. in cattle based on the goals and objectives of the examination. The coccidiosis cases often do not show any clinical symptoms but can cause sudden death in livestock. The diagnostic method that still used at present is based on its morphology that should not be used in identifying Eimeria species because the morphological characteristics Eimeria spp. have similar shape and size structures between species (resembling morphology). An appropriate diagnostic method for Eimeria is needed in the context of controlling coccidiosis strategically.

Forensic research of staff fraud

2020 ◽  
Vol 23 (5) ◽  
pp. 585-600
Author(s):  
V.A. Timchenko
Keyword(s):  
Effective Means ◽  
Criminal Activity ◽  
Diagnostic Techniques ◽  
Scientific Basis ◽  
Diagnostic Methods ◽  
Structural Units ◽  
Forensic Research ◽  
Economic Information ◽  
Commercial Organizations ◽  
Original Approach

Subject. This article deals with the issues of forensic diagnostics, which is an effective means of detecting, preventing and suppressing staff fraud. Objectives. The article aims to present an original approach to the development of methods of forensic diagnosis of staff fraud based on the modeling method. It is also intended to identify a structure of staff fraud patterns and justify the need to classify the staff fraud methods. Methods. For the study, I used the methods of comparative analysis, systematization, induction, and deduction. Results. The article defines approaches to the formation of diagnostic methods of staff fraud and presents typical inconsistencies that arise in economic information under the influence of fraudulent actions of staff. It describes some diagnostic techniques that can detect staff fraud elements that occur in certain ways of criminal activity. Conclusions and Relevance. The proposed original approach helps develop standard and specific methods for diagnosing staff fraud on a scientific basis. The provisions outlined in the article can serve as a basis for scholarly discussion, contribute to the effectiveness of research on counter-fraud in the field of personnel fraud, and can be applied to the practical activities of structural units and individuals whose task is to combat staff fraud in commercial organizations.

scholarly journals Tick-borne zoonoses and commonly used diagnostic methods in human and veterinary medicine

2021 ◽  
Author(s):  
Andrea Springer ◽  
Antje Glass ◽  
Julia Probst ◽  
Christina Strube
Keyword(s):  
Veterinary Medicine ◽  
Diagnostic Tests ◽  
One Health ◽  
Animal Health ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Diagnostic Tools ◽  
Zoonotic Pathogens ◽  
Health Concept ◽  
The One

AbstractAround the world, human health and animal health are closely linked in terms of the One Health concept by ticks acting as vectors for zoonotic pathogens. Animals do not only maintain tick cycles but can either be clinically affected by the same tick-borne pathogens as humans and/or play a role as reservoirs or sentinel pathogen hosts. However, the relevance of different tick-borne diseases (TBDs) may vary in human vs. veterinary medicine, which is consequently reflected by the availability of human vs. veterinary diagnostic tests. Yet, as TBDs gain importance in both fields and rare zoonotic pathogens, such as Babesia spp., are increasingly identified as causes of human disease, a One Health approach regarding development of new diagnostic tools may lead to synergistic benefits. This review gives an overview on zoonotic protozoan, bacterial and viral tick-borne pathogens worldwide, discusses commonly used diagnostic techniques for TBDs, and compares commercial availability of diagnostic tests for humans vs. domestic animals, using Germany as an example, with the aim of highlighting existing gaps and opportunities for collaboration in a One Health framework.

Characteristics of examination algorithm of patients with chronic trauma of the oral mucosa using tissue autofluorescence spectroscopy

2021 ◽  
Vol 26 (2) ◽  
pp. 163-169
Author(s):  
V. A. Gordeeva ◽  
I. V. Kulik ◽  
E. A. Khromova ◽  
A. L. Rubezhov ◽  
M. V. Gordeeva
Keyword(s):  
Oral Mucosa ◽  
Clinical Manifestations ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Control Group ◽  
Chronic Trauma ◽  
Autofluorescence Spectroscopy ◽  
Risk Zones ◽  
Cancerous Lesions ◽  
Group 5

Relevance. The paper demonstrates the need to implement modern diagnostic techniques for diagnosis of precancerous and cancerous lesions at early or preclinical stages. Additional diagnostic methods are necessary, e.g. tissue autofluorescence, which allows revealing insidious pathological risk zones, particularly precancerous and cancerous lesions, to evaluate the condition of the oral tissues in patients with chronic oral mucosa disorders, especially caused by trauma. Purpose – to assess trauma-specific effectiveness of autofluorescence spectroscopy (AFS) in risk group patients with chronic trauma of the oral mucosa to reveal early malignization signs.Materials and methods. 25 subjects were selected for the study and divided into 2 groups: main group – 20 patients with different manifestations of chronic oral mucosa trauma; control group – 5 subjects without visible clinical manifestations and without oral trauma factors. Autofluorescence spectroscopy was performed in both groups using AFS-400 stomatoscope.Results. The received data demonstrated that the change in autofluorescence doesn’t allow drawing final conclusions on the presence or absence of chronic oral trauma malignization signs.Conclusion. AFS-400 stomatoscope may be effective in differentiating between healthy and damaged tissues, but there is no solid evidence that the change in fluorescence shade can help differentiate between various types of damaged tissues. Autofluorescence spectroscopy should be considered as an additional method for examination of patients with chronic oral mucosa trauma to reveal early malignization signs.

scholarly journals Application of electrochemical aptasensors in detection of cancer biomarkers

2019 ◽  
Vol 6 (7) ◽  
pp. 3315-3324 ◽  
Author(s):  
Masoud Negahdary ◽  
Ali Moradi ◽  
Hossein Heli
Keyword(s):  
Cancer Therapy ◽  
Cost Saving ◽  
High Selectivity ◽  
Cancer Biomarkers ◽  
Diagnostic Techniques ◽  
Late Diagnosis ◽  
Diagnostic Methods ◽  
Related Factors ◽  
Cancer Markers

Today, the late diagnosis of cancers is a big challenge, and using novel diagnostic techniques will provide essential, faster and more accurate treatments. Unfortunately, existing common and traditional diagnostic methods have not been helpful completely and most cancers are diagnosed too late. Recently, researchers have found new diagnostic methods against cancers by aptasensors; these sensory systems can detect involved biomarkers in various cancers so that the research in this field is continued strictly. Aptasensors can detect cancer markers in small quantities and high selectivity; moreover, other advantages of cancer aptasensors such as optimized time and cost saving can be considered. In addition, the aptasensors have been used in the diagnosis of the effective and related factors in cancer therapy follow-up. Here, the most researches about cancer aptasensors and other involved markers were collected, reviewed and described.  

scholarly journals Detection of “Candidatus Helicobacter suis” in Gastric Samples of Pigs by PCR: Comparison with Other Invasive Diagnostic Techniques

2000 ◽  
Vol 38 (3) ◽  
pp. 1131-1135 ◽  
Author(s):  
D. De Groote ◽  
R. Ducatelle ◽  
L. J. van Doorn ◽  
K. Tilmant ◽  
A. Verschuuren ◽  
...  
Keyword(s):  
Southern Blot ◽  
Blot Hybridization ◽  
Southern Blot Hybridization ◽  
Epidemiological Studies ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Giemsa Staining ◽  
Rapid Urease Test ◽  
Pcr Assay ◽  
Urease Test

Recently, a new 16S ribosomal DNA-based PCR assay was developed for the specific detection of “Candidatus Helicobacter suis” (former “Gastrospirillum suis”) in porcine gastric samples. In the present study, this PCR assay was compared to three other invasive diagnostic methods (rapid urease test, immunohistochemistry, histologic analysis by Giemsa staining). Antral stomach samples from 200 slaughterhouse pigs from Belgium and The Netherlands were examined. Bacterial presence was determined in 77% (154 of 200) of the samples by PCR in combination with Southern blot hybridization, 56% (111 of 200) of the samples by immunohistochemistry, 61% (122 of 200) of the samples by urease testing (20 h postinoculation [p.i.]), 36% (71 of 200) of the samples by urease testing (3 h p.i.), and 33% (65 of 200) of the samples by Giemsa staining. The intrinsic specificity of the PCR assay was assessed by Southern blot analysis with an “Candidatus H. suis”-specific probe and sequencing of PCR products. Interassay sensitivity and specificity values were assessed for each test by pairwise comparisons between tests. Agreement between tests was evaluated by calculating Cohen's kappa coefficient. From that analysis, the PCR assay was considered the most reliable benchmark. Microscopic detection of immunohistochemically labeled or Giemsa-stained “Candidatus H. suis” cells in stomach sections proved to be highly specific (100%) but relatively insensitive (72 and 42%, respectively) compared to the PCR assay. A longer incubation time of the urease test improved its sensitivity considerably (74 versus 55%) but was accompanied by a loss of specificity (72 versus 93%). In conclusion, we found the “Candidatus H. suis”-specific PCR assay to be a sensitive and reliable diagnostic method for the detection of “Candidatus H. suis” in the stomachs of pigs and could prove to be a valuable tool for further epidemiological studies both for “Candidatus H. suis”- and for “Helicobacter heilmannii” type 1-related research.

scholarly journals Identification of Multiple Outliers in a Generalized Linear Model with Continuous Variables

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Loo Yee Peng ◽  
Habshah Midi ◽  
Sohel Rana ◽  
Anwar Fitrianto
Keyword(s):  
Generalized Linear Model ◽  
Diagnostic Method ◽  
Asymptotic Properties ◽  
Diagnostic Methods ◽  
Detection Methods ◽  
Diagnostic Tools ◽  
Continuous Variables ◽  
Numerical Examples ◽  
Multiple Outliers ◽  
Contamination Levels

In the statistical analysis of data, a model might be awfully fitted with the presence of outliers. Besides, it has been well established to use residuals for identification of outliers. The asymptotic properties of residuals can be utilized to contribute diagnostic tools. However, it is now evident that most of the existing diagnostic methods have failed in identifying multiple outliers. Therefore, this paper proposed a diagnostic method for the identification of multiple outliers in GLM, where traditionally used outlier detection methods are effortless as they undergo masking or swamping dilemma. Hence, an investigation was carried out to determine the capability of the proposed GSCPR method. The findings obtained from the numerical examples indicated that the performance of the proposed method was satisfactory for the identification of multiple outliers. Meanwhile, in the simulation study, two scenarios were considered to assess the validity of the proposed method. The proposed method consistently displayed higher percentage of correct detection, as well as lower rates of swamping and masking, regardless of the sample size and the contamination levels.

scholarly journals Expression Levels of Candidate Circulating microRNAs in Early-Onset Neonatal Sepsis Compared With Healthy Newborns

2018 ◽  
Vol 11 ◽  
pp. 117863101879707 ◽  
Author(s):  
Benet B Dhas ◽  
Vijaya R Dirisala ◽  
B Vishnu Bhat
Keyword(s):  
Neonatal Sepsis ◽  
Inflammatory Responses ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Large Sample Size ◽  
Case Control Studies ◽  
Circulating Micrornas ◽  
Expression Levels ◽  
Sepsis Diagnosis ◽  
Low Sensitivity

The high mortality rate of neonatal sepsis is directly connected with time-consuming diagnostic methods that have low sensitivity and specificity. The need of the hour is to develop novel diagnostic techniques that are rapid and more specific. In this study, we estimated the expression levels of circulating microRNAs (miRNAs) that are involved in regulating immune response genes and underlying inflammatory responses, which may be used for sepsis diagnosis. The total circulating miRNA was isolated and the candidate miRNAs (miR-132, miR-146a, miR-155, and miR-223) were quantified by real-time polymerase chain reaction technique. Statistical analysis revealed that miR-132 ( P < .01) and miR-223 ( P < .05) were downregulated in septic newborns compared with healthy babies. The decrease in expression of miR-132 and miR-223 may be associated with increased expression of immune-related genes involved in TLR (Toll-like receptor) signaling pathway. Further case-control studies with large sample size are required to identify the potential of miRNAs in neonatal sepsis diagnosis.

scholarly journals DUX Hunting—Clinical Features and Diagnostic Challenges Associated with DUX4-Rearranged Leukaemia

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2815
Author(s):  
Jacqueline A. Rehn ◽  
Matthew J. O'Connor ◽  
Deborah L. White ◽  
David T. Yeung
Keyword(s):  
Next Generation Sequencing ◽  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Clinical Features ◽  
Lymphoblastic Leukaemia ◽  
Diagnostic Techniques ◽  
Diagnostic Methods ◽  
Intensive Chemotherapy ◽  
Chromosome 4 ◽  
Generation Sequencing

DUX4-rearrangement (DUX4r) is a recently discovered recurrent genomic lesion reported in 4–7% of childhood B cell acute lymphoblastic leukaemia (B-ALL) cases. This subtype has favourable outcomes, especially in children and adolescents treated with intensive chemotherapy. The fusion most commonly links the hypervariable IGH gene to DUX4 a gene located within the D4Z4 macrosatellite repeat on chromosome 4, with a homologous polymorphic repeat on chromosome 10. DUX4r is cryptic to most standard diagnostic techniques, and difficult to identify even with next generation sequencing assays. This review summarises the clinical features and molecular genetics of DUX4r B-ALL and proposes prospective new diagnostic methods.

scholarly journals Several Cases of Ocular Dirofilariasis in Bulgaria

2020 ◽  
Vol 29 (6) ◽  
pp. 588-590
Author(s):  
Valeri Velev
Keyword(s):  
Morphological Analysis ◽  
Diagnostic Method ◽  
Dirofilaria Repens ◽  
Diagnostic Methods ◽  
Upper Eyelid ◽  
Subcutaneous Nodules

<b><i>Objectives:</i></b> In this study, we describe ocular dirofilariasis in Bulgaria. <b><i>Materials and Methods:</i></b> We studied 7 patients with a subconjunctival or periorbital form of <i>Dirofilaria repens</i> infection during 2010–2019. Morphological, serological, and paraclinical diagnostic methods were used. <b><i>Results:</i></b> The patients (6 females, 1 male) were aged between 23 and 72 years. In 3 patients, subcutaneous nodules were detected in the area of the upper eyelid, in 1 patient the location was suborbital. In 3 other patients, a subconjunctival location was found. All patients were cured definitively by removal of the larva, without etiologic treatment. <b><i>Conclusion:</i></b> The most reliable and easily accessible diagnostic method is morphological analysis by microscopy of histological preparations of the parasite. In dirofilariasis, ocular location is the most common in humans, and it deserves special attention of clinicians.

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