scholarly journals Radon Over Kimberlite Pipes: Estimation of the Emanation Properties of Rocks (Lomonosov Diamond Deposit, NW Russia)

2021 ◽  
Vol 11 (13) ◽  
pp. 6065
Author(s):  
Evgeny Yakovlev ◽  
Andrey Puchkov
Keyword(s):  
Experimental Studies ◽  
State Level ◽  
The Body ◽  
Free State ◽  
Physical Factors ◽  
Diamond Deposit ◽  
Factors Affecting ◽  
Emanation Coefficient ◽  
Host Rocks ◽  
The Impact

In this paper, using the example of the Lomonosov diamond deposit, experimental studies of rocks were carried out to assess the main radiation and physical factors affecting the formation of the radon field over the kimberlite pipes of the Arkhangelsk diamondiferous province. For various types of rocks, represented by vent kimberlites, tuffaceous-sedimentary rocks of the crater and enclosing and overlying sediments, the following were studied: porosity, density, activity of radium-226, activity of radon in a free state, level of radon production, and emanation coefficient. The research results showed that the greatest amount of radon in a free state is produced by rocks of the near-pipe space, represented by the enclosing Vendian V2 deposits and characterized by high values of the emanation coefficient, radium activity, radon production level and porosity. This fact is associated with the structural and geological features of the near-pipe space, which was exposed to the impact of kimberlite magma on the host rocks. The lowest values of these parameters are characteristic of the kimberlites of the vent facies, which limits the formation of free radon in the body of the pipe. The results of the experimental studies create prospects for the development of emanation methods for searching for kimberlite pipes in the conditions of the Arkhangelsk diamondiferous province.

scholarly journals Aphid–Plant–Phytovirus Pathosystems: Influencing Factors from Vector Behaviour to Virus Spread

Agriculture ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 502
Author(s):  
Junior Corneille Fingu-Mabola ◽  
Frédéric Francis
Keyword(s):  
Influencing Factors ◽  
Virus Transmission ◽  
Physical Factors ◽  
Factors Affecting ◽  
Vector Borne Diseases ◽  
Vector Behaviour ◽  
Crop Fields ◽  
Host Seeking ◽  
The Impact ◽  
Vector Efficiency

Aphids are responsible for the spread of more than half of the known phytovirus species. Virus transmission within the plant–aphid–phytovirus pathosystem depends on vector mobility which allows the aphid to reach its host plant and on vector efficiency in terms of ability to transmit phytoviruses. However, several other factors can influence the phytoviruses transmission process and have significant epidemiological consequences. In this review, we aimed to analyse the aphid behaviours and influencing factors affecting phytovirus spread. We discussed the impact of vector host-seeking and dispersal behaviours mostly involved in aphid-born phytovirus spread but also the effect of feeding behaviours and life history traits involved in plant–aphid–phytovirus relationships on vector performances. We also noted that these behaviours are influenced by factors inherent to the interactions between pathosystem components (mode of transmission of phytoviruses, vector efficiency, plant resistance, …) and several biological, biochemical, chemical or physical factors related to the environment of these pathosystem components, most of them being manipulated as means to control vector-borne diseases in the crop fields.

scholarly journals Selecting informative biomarkers for early diagnosis of occupational neurological diseases

2021 ◽  
Vol 100 (9) ◽  
pp. 953-958
Author(s):  
Inna V. Lapko
Keyword(s):  
Insulin Resistance ◽  
Carbohydrate Metabolism ◽  
The Body ◽  
Working Environment ◽  
Total Testosterone ◽  
Physical Factors ◽  
Lumbosacral Radiculopathy ◽  
Vibration Disease ◽  
Neurohumoral Regulation ◽  
The Impact

Introduction. At present, the patterns of changes in the levels of biomarkers and the relationship of changes in their values with the pathogenesis of diseases caused by the impact of adverse factors of labour activity are not sufficiently studied. The most unresolved issues are the choice of informative laboratory indicators and diagnostic test systems in investigating the impact of physical factors on the working environment (vibration and physical overload) neurohumoral regulation: pituitary-adrenal pituitary-thyroid, pituitary-gonadal system and hormonal indicators of carbohydrate metabolism. The aim of the study was to determine diagnostic hormonal markers and integral indices to identify early changes in the neurohumoral status in the body of workers under the influence of working environment factors. Materials and methods. 330 workers of mining and machine-building enterprises were examined. Of these, 128 people with vibration disease, 45 people - with lumbosacral radiculopathy, combined pathology (vibration disease and lumbosacral radiculopathy) was detected in 60 persons. The preclinical stage (initial signs of diseases) was noted in 97 workers. Laboratory studies included hormones and integral indices of the pituitary-adrenal, pituitary-thyroid, pituitary-gonadal system, carbohydrate metabolism. To select the diagnostic significance of laboratory biomarkers, diagnostic sensitivity, prenosological value, pathognomonicity, direction, severity, and selectivity of changes in biomarker levels were evaluated. Results. The combined effect of vibration and physical overload on the body of workers was found to have a unidirectional and systemic impact on the levels of hormones of the pituitary-adrenal, pituitary-thyroid and pituitary-gonadal systems, increases insulin resistance. The severity of changes in neurohumoral regulation indicators depends on the nature and severity of the occupational neurological disease. The highest diagnostic sensitivity (Df = 72-74%) in vibration disease and its combination with lumbosacral radiculopathy was obtained for pituitary-gonadal hormones and indicators of insulin resistance. The lowest values of Dh are typical for the hormones of the pituitary-thyroid system (no more than 14%). To identify early changes in neurohumoral regulation in the body under the influence of vibration and physical exertion, it is most informative to determine the concentration of total testosterone, luteinizing hormone and insulin, as well as the integral pituitary-adrenal index, insulin resistance indices. To identify hidden disorders of the pituitary-thyroid system, the definition of the essential thyroid index can be used. Discussion. The results obtained allowed us to assess the nature of changes in the levels of hormones of the pituitary-adrenal, pituitary-thyroid and pituitary-gonadal systems and carbohydrate metabolism and to propose informative laboratory biomarkers reflecting early changes in neurohumoral regulation under the influence of physical factors of the working environment. Conclusions. To identify early changes in neurohumoral regulation in the body of workers under the influence of vibration and physical exertion, the most informative is the determination of the concentration of total testosterone, luteinizing hormone and insulin, the integral pituitary-adrenal index, and insulin resistance indices. To identify hidden disorders of the pituitary-thyroid system, the definition of the integral thyroid index can be used.

scholarly journals Environmental Factors Causing the Development of Microorganisms on the Surfaces of National Cultural Monuments Made of Mineral Building Materials—Review

Coatings ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1203
Author(s):  
Elżbieta Stanaszek-Tomal
Keyword(s):  
Environmental Factors ◽  
Building Materials ◽  
Ion Concentration ◽  
Physical Factors ◽  
Comprehensive Overview ◽  
Hydrogen Ion Concentration ◽  
Factors Affecting ◽  
Stone Concrete ◽  
The Impact ◽  
Cultural Monuments

The ability of microorganisms to degrade building materials depends on several factors. Biological corrosion occurs in close dependence with chemical and physical factors affecting microorganisms. The growth and development of microorganisms is stimulated by external stimuli, i.e., environmental factors. Microorganisms have a relatively large tolerance range for changes in environmental conditions. Under the right conditions, microorganisms thrive very well. The adverse effects may cause the inhibition of cell growth, damage, or lead to the death of the microorganism. Considering the impact of environmental factors on microorganisms, it is not possible to identify the most important of them. The result effect of overlapping factors determines the possibility of the growth of certain microorganisms. The main factors affecting the growth are temperature, humidity, hydrogen ion concentration in the environment, oxidoreductive potential, water activity in the environment, and hydrostatic pressure. This article provides a comprehensive overview of the factors causing biodeterioration. The influence of external/internal environment on the surface of cultural monuments made of mineral building materials, i.e., stone, concrete, mortar, etc., is presented.

scholarly journals The Impact of Time of Day on Energy Expenditure: Implications for Long-Term Energy Balance

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2383 ◽  
Author(s):  
Shaw ◽  
Leung ◽  
Jong ◽  
Coates ◽  
Davis ◽  
...  
Keyword(s):  
Energy Balance ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Experimental Studies ◽  
Time Of Day ◽  
Circadian System ◽  
The Body ◽  
Energy Regulation ◽  
Meal Timing ◽  
The Impact

There is evidence to indicate that the central biological clock (i.e., our endogenous circadian system) plays a role in physiological processes in the body that impact energy regulation and metabolism. Cross-sectional data suggest that energy consumption later in the day and during the night is associated with weight gain. These findings have led to speculation that when, as well as what, we eat may be important for maintaining energy balance. Emerging literature suggests that prioritising energy intake to earlier during the day may help with body weight maintenance. Evidence from tightly controlled acute experimental studies indicates a disparity in the body’s ability to utilise (expend) energy equally across the day and night. Energy expenditure both at rest (resting metabolic rate) and after eating (thermic effect of food) is typically more efficient earlier during the day. In this review, we discuss the key evidence for a circadian pattern in energy utilisation and balance, which depends on meal timing. Whilst there is limited evidence that simply prioritising energy intake to earlier in the day is an effective strategy for weight loss, we highlight the potential benefits of considering the role of meal timing for improving metabolic health and energy balance. This review demonstrates that to advance our understanding of the contribution of the endogenous circadian system toward energy balance, targeted studies that utilise appropriate methodologies are required that focus on meal timing and frequency.

scholarly journals An empirical assessment of factors affecting the brand-building effectiveness of sponsorship

2014 ◽  
Vol 4 (1) ◽  
pp. 6-25 ◽  
Author(s):  
Leah Donlan
Keyword(s):  
Brand Equity ◽  
Survey Methodology ◽  
Contextual Factors ◽  
Experimental Studies ◽  
Measurement Tool ◽  
Sporting Events ◽  
Content Type ◽  
Factors Affecting ◽  
Brand Building ◽  
The Impact

Purpose – The purpose of this study is to assess, in two different live sponsorship environments, the contribution of sponsorship to consumer-based brand equity. Design/methodology/approach – The study adopts a quantitative survey methodology, employing self-administered questionnaires at two UK sporting events (athletics and cricket). To isolate the impact of sponsorship, questionnaires were also distributed to comparison sample groups not exposed to the sponsorship activities. The elements of consumer-based brand equity are operationalized in line with Aaker's (1996) brand equity measurement tool. Findings – Sponsorship can be an appropriate vehicle through which to build consumer-based brand equity; however brand-building success is not guaranteed and is subject to a range of factors impacting upon particular sponsorships, including strength of the sponsor-event link, leverage activities and clutter. The most successful sponsorship displayed marked contributions to building brand associations, perceived quality and brand loyalty. However, the presence of sponsorship clutter in particular was found to impact negatively upon the perception of quality transferred to a brand through sponsorship. Research limitations/implications – The use of live event settings limits the ability to tightly control all variables; therefore replication of this study using experimental methodologies is recommended. Nonetheless, findings indicate managers should consider the above mentioned contextual factors when selecting sponsorships in order to maximize sponsorship success. Originality/value – This study explores the contribution of sports sponsorship to consumer-based brand equity in live sponsorship settings, addressing concerns over the generalizability of previous experimental studies. Equally, this study compares the brand equity-building effectiveness of sponsorship for two sponsors, which differ on a range of contextual factors that impact upon sponsorship success.

scholarly journals Integrated Bioinformatics Data Analysis and Experimental Studies Reveals Prognostic Significance of ALDH Family in Endometria Cancer

2021 ◽  
Author(s):  
Zhou-Tong Dai ◽  
Yuan Xiang ◽  
Xing-Hua Liao
Keyword(s):  
Cell Lines ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Experimental Studies ◽  
Female Reproductive Tract ◽  
The Body ◽  
Mouse Tumor ◽  
The Impact

Abstract Background Uterine Corpus Endometrial Cancer (UCEC) is one of the three common malignant tumors of the female reproductive tract. According to reports, the cure rate of early UCEC can reach 95%. Therefore, the development of prognostic markers will help UCEC patients to find the disease earlier and develop treatment earlier. The ALDH family was first discovered to be the essential gene of the ethanol metabolism pathway in the body. Recent studies have shown that ALDH can participate in the regulation of cancer. Methods We used the gene profile data of 33 cancers in the TCGA database to analyze the expression and survival of the ALDH family. GO, KEGG, PPI multiple functional analysis was used to predict the regulatory role of ALDH family in cancer. In addition, using CCK-8, colony formation, nude mouse tumor formation and other methods, the in vitro function of UCEC cancer cell lines was tested to further confirm the key role of ALDH2 expression in the proliferation of UCEC cell lines. Finally, Lasso and Cox regression methods were used to establish an overall survival prognosis model based on ALDH2 expression. Result In our research, we explored the expression of ALDH family in 33 cancers. It was found that ALDH2 was abnormally expressed in UCEC. Besides, in vivo and in vitro experiments were conducted to explore the effect of ALDH2 expression on the proliferation of UCEC cell lines. Meanwhile, the change of its expression is not due to gene mutations, but is regulated by miR-135-3p. At the same time, the impact of ALDH2 changes on the survival of UCEC patients is deeply discussed. Finally, a nomogram for predicting survival was constructed, with a C-index of 0.798 and AUC of 0.764. Conclusion This study suggests that ALDH2 may play a crucial role in UCEC progression and has the potential as a prognostic biomarker of UCEC.

scholarly journals A Comprehensive Insight on Pharmacokinetics

2016 ◽  
Vol I (I) ◽  
pp. 27-37
Author(s):  
Urooj Naseem ◽  
Fatima Iqbal ◽  
Gul Shahnaz
Keyword(s):  
Drug Distribution ◽  
The Body ◽  
Acid Dissociation ◽  
Physical Factors ◽  
Acid Dissociation Constant ◽  
Factors Affecting ◽  
Physicochemical Factors ◽  
Basic Parameters ◽  
Insight Into ◽  
Phase I And Ii

Pharmacokinetics can be defined as what the body does to a drug. The basic parameters of pharmacokinetics are discussed here including absorption, distribution, metabolism, and excretion. Characteristics and pathways taken by these drugs are determined by these parameters. The mechanism followed by these parameters are also discussed. Furthermore, the factors affecting these parameters including physicochemical factors, physical factors and pharmaceutical factors are also explored. Different routes of drug absorption and main barriers to drug distribution are also explained. The pharmacokinetic values namely acid dissociation constant, bioavailability and solubility are briefly explained. There is a detailed insight into the pathways of metabolism (Phase I and II reactions) and excretion.

scholarly journals Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

2020 ◽  
Vol 2020 ◽  
pp. 1-22 ◽  
Author(s):  
Andy W. C. Man ◽  
Huige Li ◽  
Ning Xia
Keyword(s):  
Oxidative Stress ◽  
Metabolic Diseases ◽  
Healthy Lifestyle ◽  
Current Knowledge ◽  
Vascular Dysfunction ◽  
The Body ◽  
Physical Factors ◽  
Normal Functions ◽  
The Impact ◽  
And Oxidative Stress

Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, and cardiovascular diseases. Oxidative stress and the imbalance between prooxidants and antioxidants are linked to cardiovascular and metabolic diseases. Changes in antioxidant capacity of the body may lead to oxidative stress and vascular dysfunction. Diet is an important source of antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that diet and physical factors are correlated to oxidative stress. Diet and physical factors have debatable roles in modulating oxidative stress and effects on the endothelium. Since endothelium and oxidative stress play critical roles in cardiovascular and metabolic diseases, dietary and physical factors could have significant implications on prevention of the diseases. This review is aimed at summarizing the current knowledge on the impact of diet manipulation and physical factors on endothelium and oxidative stress, focusing on cardiovascular and metabolic diseases. We discuss the friend-and-foe role of dietary modification (including different diet styles, calorie restriction, and nutrient supplementation) on endothelium and oxidative stress, as well as the potential benefits and concerns of physical activity and exercise on endothelium and oxidative stress. A fine balance between oxidative stress and antioxidants is important for normal functions in the cells and interfering with this balance may lead to unfavorable effects. Further studies are needed to identify the best diet composition and exercise intensity.

scholarly journals The Body Mass Index (BMI) of Human Age and Gender Structure as the Main Cause of Cardiovascular and Nephrotic Diseases

2013 ◽  
Vol 12 (3) ◽  
pp. 256-262
Author(s):  
Sheqibe Beadini ◽  
Nexhbedin Beadini ◽  
Besa Dalipi ◽  
Gazmend Iseni ◽  
Hesat Aliu ◽  
...  
Keyword(s):  
Genetic Factors ◽  
Eating Habits ◽  
Medical Science ◽  
The Body ◽  
Physical Growth ◽  
Age And Gender ◽  
Factors Affecting ◽  
Potential Risk Factors ◽  
And Gender ◽  
The Impact

Background: Factors affecting the growth of the organism may be either endogenous, such as genetic factors like genetic heritage, or exogenous such as food, social and health status, physical activity, etc. A factor of great importance for human physical growth is BMI, a parameter defined as the ratio of human body weight and height. Aims:The purpose of this article is to determine the BMI in Macedonia’s population by analyzing age and gender, and finding the correlation of endogeneous and exogeneous factors and the BMI factor. All measurements were performed at the health facility. Surveys were also conducted for gathering information about gender, age, weight, height, eating habits, socioeconomic status, and education. Results: This clinical research studied 257 patients, 143 males and 114 females. Among other factors involved in this research are blood glucose, fat parameters and potential risk factors for cardiovascular and nephrotic diseases. Conclusions: After the discovery and identification of renal disease, the impact of BMI can be distinguished from pathological processes, such as irregular eating, various inflammations, and changes in the metabolism of vitamin D, etc. Bangladesh Journal of Medical Science Vol. 12 No. 03 July ’13 Page 256-262DOI: http://dx.doi.org/10.3329/bjms.v12i3.12618 

scholarly journals Impact of Dietary, Socioeconomic, and Physical Factors on Obese and Overweight Schoolchildren Living in Sidi-Bel-Abbes (West of Algeria) and Ain Defla (Centre)

2018 ◽  
Vol 25 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Hayat Didaoui ◽  
Méghit Boumediene Khaled
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Environmental Factors ◽  
Body Mass ◽  
School Children ◽  
Task Force ◽  
The Body ◽  
Physical Factors ◽  
Obesity And Overweight ◽  
The Impact

Abstract Background and aims: The aim of the current study was to assess the impact of environmental factors; food, socio-economic, and physical activity, on a group of obese children living in Ain-Defla (Center Algeria) and Sidi-Bel-Abbes (West Algeria). Material and methods: The protocol was carried out on a cohort of 125 school children aged of 5 to 11 years, including 64 boys and 61 girls, and 139 school children, including 93 boys and 46 girls in Ain Defla and Sidi-Bel-Abbes respectively. Concerning the classification of obesity and overweight, we referred to the International Obesity Task Force and the French References' curves. Results: Regarding dietary intake our results showed that 34% of students from both regions took their breakfast, compared to 66% who did not take. Furthermore, 73% of students skipped at least one meal, however 23% respected meals frequency i.e. 4 meals a day. Regarding socio-economic factors and physical activity, our findings showed that obesity rates were high (36%) among children whose fathers are workers. However, for mothers who are housewives, obesity increases among their children (88%). The relationship was reversed between the parents' education level and the Body Mass Index. We found an opposite relationship between Body Mass Index and physical activity, and investigated children use screen devices for long time periods. Conclusions: Our study showed a positive relationship between obesity and overweight and environmental factors.

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