scholarly journals The Role of Long Non-Coding RNAs (lncRNAs) in Female Oriented Cancers

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6102
Author(s):  
Faiza Naz ◽  
Imran Tariq ◽  
Sajid Ali ◽  
Ahmed Somaida ◽  
Eduard Preis ◽  
...  
Keyword(s):  
Clinical Importance ◽  
Cancer Proliferation ◽  
Aberrant Expression ◽  
Diagnostic Biomarkers ◽  
The Past ◽  
Current State ◽  
Proliferation And Metastasis ◽  
Non Coding Rnas ◽  
Therapy Studies

Recent advances in molecular biology have discovered the mysterious role of long non-coding RNAs (lncRNAs) as potential biomarkers for cancer diagnosis and targets for advanced cancer therapy. Studies have shown that lncRNAs take part in the incidence and development of cancers in humans. However, previously they were considered as mere RNA noise or transcription byproducts lacking any biological function. In this article, we present a summary of the progress on ascertaining the biological functions of five lncRNAs (HOTAIR, NEAT1, H19, MALAT1, and MEG3) in female-oriented cancers, including breast and gynecological cancers, with the perspective of carcinogenesis, cancer proliferation, and metastasis. We provide the current state of knowledge from the past five years of the literature to discuss the clinical importance of such lncRNAs as therapeutic targets or early diagnostic biomarkers. We reviewed the consequences, either oncogenic or tumor-suppressing features, of their aberrant expression in female-oriented cancers. We tried to explain the established mechanism by which they regulate cancer proliferation and metastasis by competing with miRNAs and other mechanisms involved via regulating genes and signaling pathways. In addition, we revealed the association between stated lncRNAs and chemo-resistance or radio-resistance and their potential clinical applications and future perspectives.

Current state and main directions of preservation and strengthening of health of the working population of Russia

2020 ◽  
pp. 527-532 ◽  
Author(s):  
I. V. Bukhtiyarov
Keyword(s):  
Working Conditions ◽  
Russian Federation ◽  
Production Environment ◽  
Working Population ◽  
Industrial Enterprises ◽  
The Past ◽  
Production Factors ◽  
Current State ◽  
The Russian Federation

The article presents the results of the analysis of health, working conditions and prevalence of adverse production factors, the structure of the detected occupational pathology in the working population of the Russian Federation. The article presents Statistical data on the dynamics of the share of workplaces of industrial enterprises that do not meet hygienic standards, occupational morbidity in 2015-2018 for the main groups of adverse factors of the production environment and the labor process. The indicators of occupational morbidity over the past 6 years in the context of the main types of economic activity, individual subjects of the Russian Federation, classes of working conditions, levels of specialized occupational health care. The role of the research Institute of occupational pathology and occupational pathology centers in solving organizational, methodological and practical tasks for the detection, treatment, rehabilitation and prevention of occupational diseases is shown. The basic directions of activity in the field of preservation and strengthening of health of workers, and also safety at a workplace are defined.

scholarly journals Long non-coding RNAs in brain tumors

NAR Cancer ◽  
2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Keisuke Katsushima ◽  
George Jallo ◽  
Charles G Eberhart ◽  
Ranjan J Perera
Keyword(s):  
Gene Expression ◽  
Brain Tumors ◽  
Brain Cancer ◽  
Regulation Of Gene Expression ◽  
Therapeutic Targets ◽  
Diagnostic Biomarkers ◽  
Cancer Pathogenesis ◽  
Current State ◽  
Non Coding Rnas ◽  
Post Transcriptional Regulation

Abstract Long non-coding RNAs (lncRNAs) have been found to be central players in the epigenetic, transcriptional and post-transcriptional regulation of gene expression. There is an accumulation of evidence on newly discovered lncRNAs, their molecular interactions and their roles in the development and progression of human brain tumors. LncRNAs can have either tumor suppressive or oncogenic functions in different brain cancers, making them attractive therapeutic targets and biomarkers for personalized therapy and precision diagnostics. Here, we summarize the current state of knowledge of the lncRNAs that have been implicated in brain cancer pathogenesis, particularly in gliomas and medulloblastomas. We discuss their epigenetic regulation as well as the prospects of using lncRNAs as diagnostic biomarkers and therapeutic targets in patients with brain tumors.

Jerzy Topolski’s Marxist Anthropocentrism

2021 ◽  
Vol 15 (3) ◽  
pp. 361-377
Author(s):  
Ewa Domańska ◽  
Paul Vickers
Keyword(s):  
Historical Materialism ◽  
Philosophy Of History ◽  
Marxist Theory ◽  
Collective Agency ◽  
Future Developments ◽  
The Past ◽  
Current State ◽  
The World ◽  
Separate Discipline

Abstract In this article I demonstrate that the ideas outlined in Jerzy Topolski’s Methodology of History (Polish 1968, English translation 1976) could not only offer a reference point for and indeed enrich ongoing debates in the philosophy of history, but also help to set directions for future developments in the field. To support my argument, I focus on two themes addressed in Topolski’s work: 1) the understanding of the methodology of history as a separate discipline and its role both in defending the autonomy of history and in creating an integrated knowledge of the past, which I read here through the lens of the current merging of the humanities and natural sciences; and 2) the role of a Marxist anthropocentrism based on the notion of humans as the creators of history, which I consider here in the context of the ongoing critique of anthropocentrism. I point to the value of continuing to use concepts drawn from Marxist vocabulary, such as alienation, emancipation, exploitation and overdetermination, for interpreting the current state of the world and humanity. I stress that Marxist anthropocentrism, with its support for individual and collective agency, remains crucial to the creation of emancipatory theories and visions of the future, even if it has faced criticism for its Eurocentrism and might seem rather familiar and predictable when viewed in the context of the contemporary humanities. Nevertheless, new manifestations of Marxist theory, in the form of posthumanist Marxism and an interspecies historical materialism that transcends anthropocentrism, might play an important role in redefining the humanities and humanity, including its functions and tasks within human and multispecies communities.

scholarly journals Regulatory Role of N6-methyladenosine (m6A) Modification in Osteosarcoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Yujie Zhang ◽  
Yanyan Wang ◽  
Liwei Ying ◽  
Sifeng Tao ◽  
Mingmin Shi ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Research Trends ◽  
Rna Modification ◽  
Future Research ◽  
Related Factors ◽  
The Past ◽  
Pathophysiological Role ◽  
Primary Bone ◽  
Non Coding Rnas

Osteosarcoma is the most common primary bone malignancy, typically occurring in childhood or adolescence. Unfortunately, the clinical outcomes of patients with osteosarcoma are usually poor because of the aggressive nature of this disease and few treatment advances in the past four decades. N6-methyladenosine (m6A) is one of the most extensive forms of RNA modification in eukaryotes found both in coding and non-coding RNAs. Accumulating evidence suggests that m6A-related factors are dysregulated in multiple osteosarcoma processes. In this review, we highlight m6A modification implicated in osteosarcoma, describing its pathophysiological role and molecular mechanism, as well as future research trends and potential clinical application in osteosarcoma.

scholarly journals Long Non-Coding RNAs and Related Molecular Pathways in the Pathogenesis of Epilepsy

2019 ◽  
Vol 20 (19) ◽  
pp. 4898 ◽  
Author(s):  
Villa ◽  
Lavitrano ◽  
Combi
Keyword(s):  
Biological Processes ◽  
Complete Understanding ◽  
Aberrant Expression ◽  
Protein Coding ◽  
Diagnostic Biomarkers ◽  
Functional Roles ◽  
The Central Nervous System ◽  
Non Coding Rnas ◽  
Underlying Mechanisms ◽  
Coding Capacity

Epilepsy represents one of the most common neurological disorders characterized by abnormal electrical activity in the central nervous system (CNS). Recurrent seizures are the cardinal clinical manifestation. Although it has been reported that the underlying pathological processes include inflammation, changes in synaptic strength, apoptosis, and ion channels dysfunction, currently the pathogenesis of epilepsy is not yet completely understood. Long non-coding RNAs (lncRNAs), a class of long transcripts without protein-coding capacity, have emerged as regulatory molecules that are involved in a wide variety of biological processes. A growing number of studies reported that lncRNAs participate in the regulation of pathological processes of epilepsy and they are dysregulated during epileptogenesis. Moreover, an aberrant expression of lncRNAs linked to epilepsy has been observed both in patients and in animal models. In this review, we summarize latest advances concerning the mechanisms of action and the involvement of the most dysregulated lncRNAs in epilepsy. However, the functional roles of lncRNAs in the disease pathogenesis are still to be explored and we are only at the beginning. Additional studies are needed for the complete understanding of the underlying mechanisms and they would result in the use of lncRNAs as diagnostic biomarkers and novel therapeutic targets.

scholarly journals Idiopathic Pulmonary Fibrosis: Pathogenesis and the Emerging Role of Long Non-Coding RNAs

2020 ◽  
Vol 21 (2) ◽  
pp. 524 ◽  
Author(s):  
Marina R. Hadjicharalambous ◽  
Mark A. Lindsay
Keyword(s):  
Chronic Disease ◽  
Epithelial Cell ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Cell Activation ◽  
Lung Fibroblast ◽  
Biological Processes ◽  
Aberrant Expression ◽  
Non Coding Rnas

Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disease characterized by excessing scarring of the lungs leading to irreversible decline in lung function. The aetiology and pathogenesis of the disease are still unclear, although lung fibroblast and epithelial cell activation, as well as the secretion of fibrotic and inflammatory mediators, have been strongly associated with the development and progression of IPF. Significantly, long non-coding RNAs (lncRNAs) are emerging as modulators of multiple biological processes, although their function and mechanism of action in IPF is poorly understood. LncRNAs have been shown to be important regulators of several diseases and their aberrant expression has been linked to the pathophysiology of fibrosis including IPF. This review will provide an overview of this emerging role of lncRNAs in the development of IPF.

The role of non-coding RNA/microRNAs in cardiac disease

2018 ◽  
Author(s):  
Yolan J. Reckman ◽  
Yigal M. Pinto
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Hypertrophy ◽  
Cardiac Disease ◽  
Cardiac Development ◽  
Rna Transcripts ◽  
The Past ◽  
Non Coding Rna ◽  
Organ Systems ◽  
Non Coding Rnas

In the past two decades, our knowledge about non-coding DNA has increased tremendously. While non-coding DNA was initially discarded as ‘junk DNA’, we are now aware of the important and often crucial roles of RNA transcripts that do not translate into protein. Non-coding RNAs (ncRNAs) play important functions in normal cellular homeostasis and also in many diseases across all organ systems. Among the different ncRNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been studied the most. In this chapter we discuss the role of miRNAs and lncRNAs in cardiac disease. We present examples of miRNAs with fundamental roles in cardiac development (miR-1), hypertrophy (myomiRs, miR-199, miR-1/133), fibrosis (miR-29, miR-21), myocardial infarction (miR-15, miR17~92), and arrhythmias/conduction (miR-1). We provide examples of lncRNAs related to cardiac hypertrophy (MHRT, CHRF), myocardial infarction (ANRIL, MIAT), and arrhythmias (KCNQ1OT1). We also discuss miRNAs and lncRNAs as potential therapeutic targets or biomarkers in cardiac disease.

scholarly journals MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 340 ◽  
Author(s):  
Pei-Ling Hsieh ◽  
Yi-Wen Liao ◽  
Martin Pichler ◽  
Cheng-Chia Yu
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Cancer Stemness ◽  
Aberrant Expression ◽  
The Past ◽  
Key Players ◽  
Non Coding Rnas ◽  
Theranostic Applications ◽  
Significant Attention

Oral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has drawn significant attention over the past decade. Among various molecules that are associated with CSCs, non-coding RNAs (ncRNAs) have been indicated as key players in the acquisition and maintenance of cancer stemness. In addition, accumulating studies have shown that the aberrant expression of these ncRNAs may serve as surrogate diagnostic markers or even therapeutic targets for cancer treatment. The current study reviews the previous work by us and others to summarize how these ncRNAs affect oral cancer stemness and their potential theranostic applications. A better understanding of the implication of these ncRNAs in oral tumorigenesis will facilitate the translation of basic ncRNA research into clinical application in the future.

A compendium of the histone H1 family of somatic subtypes: An elusive cast of characters and their characteristics

2001 ◽  
Vol 79 (3) ◽  
pp. 289-304 ◽  
Author(s):  
Missag H Parseghian ◽  
Barbara A Hamkalo
Keyword(s):  
Historical Context ◽  
Histone H1 ◽  
General Function ◽  
Linker Histones ◽  
Chromatin Compaction ◽  
The Core ◽  
The Past ◽  
Current State ◽  
Core Histones

The last 35 years has seen a substantial amount of information collected about the somatic H1 subtypes, yet much of this work has been overshadowed by research into highly divergent isoforms of H1, such as H5. Reports from several laboratories in the past few years have begun to call into question some of the traditional views regarding the general function of linker histones and their heterogeneity. Hence, the impression in some circles is that less is known about these ubiquitous nuclear proteins as compared with the core histones. The goal of the following review is to acquaint the reader with the ubiquitous somatic H1s by categorizing them and their characteristics into several classes. The reasons for our current state of misunderstanding is put into a historical context along with recent controversies centering on the role of H1 in the nucleus. Finally, we propose a model that may explain the functional role of H1 heterogeneity in chromatin compaction.Key words: histone H1, linker histones, chromatin organization, chromatin compaction, heat shock.

The Place of Political Science in Canadian Universities

1998 ◽  
Vol 31 (4) ◽  
pp. 643-658 ◽  
Author(s):  
Tom Pocklington
Keyword(s):  
Political Science ◽  
Reflective Inquiry ◽  
Remedial Action ◽  
Canadian Universities ◽  
The Past ◽  
Proper Role ◽  
Current State

AbstractThis article addresses the proper role of political science in Canadian universities. The thesis is twofold: first, the main tasks of political scientists are first-rate teaching and reflective inquiry about citizenship: second, in the past few years we have been moving away from this understanding, and remedial action is required. Our delinquency stems mainly from our obsession with “frontier research,” the main result of which is the widespread decline of attentive teaching, which we rationalize with a number of implausible myths. We are primarily responsible for the current state of political science, and only we can remedy it.

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