scholarly journals Clinical Application of Silver Nanoparticles Coated by Benzalkonium Chloride

Coatings ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1382
Author(s):  
Shakeel Ahmed Ansari ◽  
Asim Muhammed Alshanberi
Keyword(s):  
Silver Nanoparticles ◽  
Surface Modification ◽  
Benzalkonium Chloride ◽  
Experimental Conditions ◽  
E Coli ◽  
Neem Leaves ◽  
Potential Applications ◽  
Research Findings ◽  
Bioactive Agents ◽  
Biomedical Fields

The present study investigates the surface modification of AgNPs (synthesized by neem leaves) by benzalkonium chloride (BAC). It was observed that 22 × 109 CFU were formed at 0.25 mM AgNPs concentration. However, it was reduced to 14 × 109 CFU for BAC-coated AgNPs at similar experimental conditions. The enzymatic activity of β-glucosidase was significantly enhanced from 0.0625 mM to 0.5 mM concentration of AgNPs, as well as BAC–AgNPs. However, there was no further change of activity beyond this concentration. ZOI of AgNPs and BAC–AgNPs was measured against E. coli, B. subtilis, P. aeruginosa, and S pneumoniae at 0.25 mM and 0.50 mM concentrations of these bioactive agents. ZOI was 3.45 cm and 3.56 cm for AgNPs and BAC–AgNPs at 0.25 mM of these bioactive agents, respectively, against E. coli. However, these values were 4.28 cm and 4.40 cm, respectively, against B. subtilis. ZOI was obtained at 3.36 cm and 3.47 cm, respectively, against P. aeruginosa under similar experimental concentrations. However, ZOI was achieved at 3.44 cm and 3.62 cm, respectively, against S. pneumonia, under similar experimental conditions. Hence, such research findings can be exploited for potential applications in numerous environmental and biomedical fields.

SYNTHESIS OF SILVER NANOPARTICLES USING AQUEOUS EXTRACT OF PERGULARIA DAEMIA AND ANALYSIS OF ANTIMICROBIAL ACTIVITY

INDIAN DRUGS ◽  
2020 ◽  
Vol 57 (08) ◽  
pp. 25-29
Author(s):  
Jambuwant A. Kadam ◽  
Mahesh A Karale ◽  
Pushpa Karale
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Aqueous Extract ◽  
Visual Observation ◽  
Leaf Extracts ◽  
Tem Analysis ◽  
E Coli ◽  
Antimicrobial Potential ◽  
Transmission Electron ◽  
Research Findings

The present work deals with the green synthesis of silver nanoparticle from aqueous extract of Pergularia daemia as reducing agent and evaluation of the antimicrobial potential of synthesized green nanoparticles (GNPs). The synthesized silver nanoparticles (SNPs) were characterized by UltravioletVisible absorption spectroscopy (UV-Vis) and high-resonance transmission electron microscopy (TEM) analysis. Visual observation showed that the color of the fresh leaf extracts of P. daemia turned into dark brown after incubation of 24 h with Ag precursors. The TEM analysis showed that nanoparticles were spherical in shape and the size was found to be in the range of 7-22 nm. The green synthesized nanoparticles showed concentration dependent (25 µg/mL, 50 µg/mL and 100 µg/mL) noteworthy antimicrobial activity against E. coli, S. aureus and B. subtilis with ciprofloxacin as a standard. Research findings conclude that GNPs possess superior antimicrobial potential and it is a new option to combat antibiotic resistance.

scholarly journals Biosynthesis of Silver Nanoparticles With Antimicrobial and Anticancer Properties Using Two Novel Yeasts

2021 ◽  
Author(s):  
Xin Liu ◽  
Jiale Chen ◽  
Wenyu Yang ◽  
Yucheng Qian ◽  
Jingyu Pan ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Antibacterial Activities ◽  
Normal Lung ◽  
Antiproliferative Effects ◽  
E Coli ◽  
Anticancer Properties ◽  
Potential Applications ◽  
Low Toxicity

Abstract AgNPs is nanomaterials with many potential biomedical applications. In this study, two novel yeast strains named as HX-YS and LPP-12Y capable of producing biological silver nanoparticles were isolated. Based on sequencing of ribosomal DNA-ITS fragments, as well as partial D1/D2 regions of 26S rDNA be similar with genus Metschnikowia. The BioAgNPs produced by HX-YS and LPP-12Y at pH of 5.0 - 6.0 and 26℃ ranged in size from 50 to 500 nm. The antibacterial activities of yeast BioAgNPs against five pathogenic bacteria were determined. The highest antibacterial effect was observed on P. aeruginosa, with additional obvious effects on E. coli ATCC8099 and S. aureus ATCC10231. Additionally, the BioAgNPs showed antiproliferative effects on lung cancer cell lines H1975 and A579, with low toxicity in Beas 2B normal lung cells. Therefore, the AgNPs biosynthesized by HX-YS and LPP-12Y may have potential applications in the treatment of bacterial infections and cancer.

scholarly journals Biosynthesis of silver nanoparticles with antimicrobial and anticancer properties using two novel yeasts

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xin Liu ◽  
Jia-Le Chen ◽  
Wen-Yu Yang ◽  
Yu-Cheng Qian ◽  
Jing-Yu Pan ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Antibacterial Activities ◽  
Normal Lung ◽  
Antiproliferative Effects ◽  
E Coli ◽  
Anticancer Properties ◽  
Potential Applications ◽  
Low Toxicity

AbstractAgNPs are nanomaterials with many potential biomedical applications. In this study, the two novel yeast strains HX-YS and LPP-12Y capable of producing biological silver nanoparticles were isolated. Sequencing of ribosomal DNA-ITS fragments, as well as partial D1/D2 regions of 26S rDNA indicated that the strains are related to species from the genus Metschnikowia. The BioAgNPs produced by HX-YS and LPP-12Y at pH 5.0–6.0 and 26 °C ranged in size from 50 to 500 nm. The antibacterial activities of yeast BioAgNPs against five pathogenic bacteria were determined. The highest antibacterial effect was observed on P. aeruginosa, with additional obvious effects on E. coli ATCC8099 and S. aureus ATCC10231. Additionally, the BioAgNPs showed antiproliferative effects on lung cancer cell lines H1975 and A579, with low toxicity in Beas 2B normal lung cells. Therefore, the AgNPs biosynthesized by HX-YS and LPP-12Y may have potential applications in the treatment of bacterial infections and cancer.

Antimicrobial Activity of Silver Nanoparticles Prepared Under an Ultrasonic Field

2011 ◽  
Vol 4 (3) ◽  
pp. 1491-1496
Author(s):  
Umadevi M ◽  
Rani T ◽  
Balakrishnan T ◽  
Ramanibai R
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Reduction Method ◽  
Therapeutic Potential ◽  
Chemical Reduction ◽  
Ultrasonic Field ◽  
Great Promise ◽  
Chemical Reduction Method ◽  
E Coli

Nanotechnology has great promise for improving the therapeutic potential of medicinal molecules and related agents. In this study, silver nanoparticles of different sizes were synthesized in an ultrasonic field using the chemical reduction method with sodium borohydride as a reducing agent. The size effect of silver nanoparticles on antimicrobial activity were tested against the microorganisms Staphylococcus aureus (MTCC No. 96), Bacillus subtilis (MTCC No. 441), Streptococcus mutans (MTCC No. 497), Escherichia coli (MTCC No. 739) and Pseudomonas aeruginosa (MTCC No. 1934). The results shows that B. subtilis, and E. coli were more sensitive to silver nanoparticles and its size, indicating the superior antimicrobial efficacy of silver nanoparticles. 

Antimicrobial Activity of Silver Nanoparticles Synthesized by Streptomyces Species JF714876

2012 ◽  
Vol 5 (1) ◽  
pp. 1638-1642 ◽  
Author(s):  
Vidyasagar G M ◽  
Shankaravva B ◽  
R Begum ◽  
Imrose ◽  
Sagar R ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Silver Ions ◽  
Human Beings ◽  
Streptomyces Species ◽  
Force Microscopy ◽  
E Coli ◽  
Extracellular Synthesis ◽  
Atomic Force ◽  
Uv Visible

Microorganisms like fungi, actinomycetes and bacteria are considered nanofactories and are helpful in the production of nanoparticles useful in the welfare of human beings. In the present study, we investigated the production of silver nanoparticles from Streptomyces species JF714876. Extracellular synthesis of silver nanoparticles by Streptomyces species was carried out using two different media. Silver nanoparticles were examined using UV-visible, IR and atomic force microscopy. The size of silver nanoparticles was in the range of 80-100 nm. Antimicrobial activity of silver nanoparticle against bacteria such as E. coli, S. aureus, and dermatophytes like T. rubrum and T. tonsurans was determined. Thus, this study suggests that the Streptomyces sp. JF741876 can produce silver ions that can be used as an antimicrobial substance.

Efficacy of Silver Nanoparticles Synthesized from Hymenocallis species (Spider Lilly) Leaf Extract as Antimicrobial Agents

2019 ◽  
Vol 12 (5) ◽  
pp. 4644-4647
Author(s):  
K.K. Gupta ◽  
Neha Kumari ◽  
Neha Sinha ◽  
Akruti Gupta
Keyword(s):  
Silver Nanoparticles ◽  
Leaf Extract ◽  
Antimicrobial Agents ◽  
Color Change ◽  
Bacterial Species ◽  
Antimicrobial Property ◽  
Biogenic Synthesis ◽  
E Coli ◽  
Light Yellow ◽  
Antibiotic Property

Biogenic synthesis of silver nanoparticles synthesized from Hymenocallis species (Spider Lilly) leaf extract was subjected for investigation of its antimicrobial property against four bacterial species (E. coli, Salmonella sp., Streptococcus sp. & Staphylococcus sp.). The results revealed that synthesized nanoparticles solution very much justify the color change property from initial light yellow to final reddish brown during the synthesis producing a characteristics absorption peak in the range of 434-466 nm. As antimicrobial agents, their efficacy was evaluated by analysis of variance in between the species and among the different concentration of AgNPs solution, which clearly showed that there was significant variation in the antibiotic property between the four different concentrations of AgNPs solution and also among four different species of bacteria taken under studies. However, silver nanoparticles solution of 1: 9 and 1:4 were proved comparatively more efficient as antimicrobial agents against four species of bacteria.

Potential Pharmaceutical and Food Applications of Postbiotics: A Review

2020 ◽  
Vol 21 (15) ◽  
pp. 1576-1587 ◽  
Author(s):  
Aziz H. Rad ◽  
Amin Abbasi ◽  
Hossein S. Kafil ◽  
Khudaverdi Ganbarov
Keyword(s):  
Functional Foods ◽  
Animal Health ◽  
Pharmaceutical Formulations ◽  
Live Cells ◽  
Beneficial Effects ◽  
Safe Product ◽  
Potential Applications ◽  
Food Applications ◽  
Potential Alternative ◽  
Bioactive Agents

In recent decades, functional foods with ingredients comprising probiotics, prebiotics and postbiotics have been gaining a lot of attention from scientists. Probiotics and postbiotics are usually applied in pharmaceutical formulations and/or commercial food-based products. These bioactive agents can be associated with host eukaryotic cells and have a key role in maintaining and restoring host health. The review describes the concept of postbiotics, their quality control and potential applications in pharmaceutical formulations and commercial food-based products for health promotion, prevention of disease and complementary treatment. Despite the effectiveness of probiotic products, researchers have introduced the concept of postbiotic to optimize their beneficial effects as well as to meet the needs of consumers to provide a safe product. The finding of recent studies suggests that postbiotics might be appropriate alternative agents for live probiotic cells and can be applied in medical, veterinary and food practice to prevent and to treat some diseases, promote animal health status and develop functional foods. Presently scientific literature confirms that postbiotics, as potential alternative agents, may have superiority in terms of safety relative to their parent live cells, and due to their unique characteristics in terms of clinical, technological and economical aspects, can be applied as promising tools in the drug and food industry for developing health benefits, and therapeutic aims.

Properties and Applications of Modified Bacterial Cellulose-Based Materials

2020 ◽  
Vol 16 ◽  
Author(s):  
Munair Badshah ◽  
Hanif Ullah ◽  
Fazli Wahid ◽  
Taous Khan
Keyword(s):  
Surface Modification ◽  
Bacterial Cellulose ◽  
Degree Of Polymerization ◽  
Biomedical Science ◽  
Hydroxyl Groups ◽  
Market Demand ◽  
Ideal Candidate ◽  
Fibrous Network ◽  
Potential Applications ◽  
Surface Modification Techniques

Background: Bacterial cellulose (BC) is purest form of cellulose as it is free from pactin, lignin, hemicellulose and other active constituents associated with cellulose derived from plant sources. High biocompatibility and easy molding into desired shape make BC an ideal candidate for applications in biomedical field such as tissue engineering, wound healing and bone regeneration. In addition to this, BC has been widely studied for applications in the delivery of proteins and drugs in various forms via different routes. However, BC lacks therapeutic properties and resistance to free movement of small molecules i.e., gases and solvents. Therefore, modification of BC is required to meet the research ad market demand. Methods: We have searched the updated data relevant to as-synthesized and modified BC, properties and applications in various fields using Web of science, Science direct, Google and PubMed. Results: As-synthesized BC possesses properties such as high crystallinity, well organized fibrous network, higher degree of polymerization, and ability of being produced in swollen form. The large surface area with abundance of free accessible hydroxyl groups makes BC an ideal candidate for carrying out surface functionalization to enhance its features. The various reported surface modification techniques including, but not limited to, are amination, methylation and acetylation. Conclusion: In this review, we have highlighted various approaches made for BC surface modification. We have also reported enhancement in the properties of modified BC and potential applications in different fields ranging from biomedical science to drug delivery and paper-making to various electronic devices.

Momordica balsamina L.: An Appraisal on Morphology, Ecological Diversity, Phytochemistry, Pharmacological and Biotechnological Applications

2020 ◽  
Vol 06 ◽  
Author(s):  
Saheed Sabiu ◽  
Christiana Eleojo Aruwa ◽  
Viresh Mohanlall ◽  
Himansu Baijnath
Keyword(s):  
Relevant Information ◽  
Perennial Herb ◽  
Biotechnological Applications ◽  
Tropical Regions ◽  
Toxicological Data ◽  
Human Disorders ◽  
Potential Applications ◽  
Baseline Information ◽  
The Caribbean ◽  
Bioactive Agents

Background: Momordica balsamina L. is a monoecious climbing vine and perennial herb native to the tropical regions of Asia, Arabia and the Caribbean, and with prominent presence in Nigeria, Botswana, Namibia, Swaziland and Southern African provinces. While evidence of its anecdotal usage as medicine exist, scientific reports complementing the claims are still emerging or at their infancy. Objective: This review appraised the morphology, therapeutic and biotechnological significance of M. balsamina. Method: Online resources such as Google Scholar, PubMed, ScienceDirect and MeSH were utilized for literature search and included relevant information from inception till May 2020 to streamline sought outcomes for in-depth discussion. Results: The data gathered and considered worthy of inclusion in this study revealed that M. balsamina is rich in phytonutrients of medicinal significance with cucurbitane-type triterpenoids, balsamin and momordins well characterized and fully elucidated. These compounds and other novel bioactive agents in M. balsamina have found remarkable pharmacological relevance and could further be harnessed for use against several debilitating human disorders. Conclusion: The potential applications of M. balsamina as nutraceutical and pharmaceutical agent should not be undermined. Also, with the inadequate toxicological data on this wild species, its consumption should be with caution and translational studies that could advance scientific knowledge and aid better understanding of both its pharmacokinetics and pharmacodynamics without sidelining its potent biotechnological applications are highly encouraged. It is hoped that this paper will provide baseline information that could serve as a guide and inspiration for further studies on the prospects of M. balsamina.

scholarly journals Graphene Integrated Hydrogels Based Biomaterials in Photothermal Biomedicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 906
Author(s):  
Le Minh Tu Phan ◽  
Thuy Anh Thu Vo ◽  
Thi Xoan Hoang ◽  
Sungbo Cho
Keyword(s):  
Photothermal Therapy ◽  
Biomedical Applications ◽  
High Light ◽  
Conversion Materials ◽  
Potential Applications ◽  
Good Biocompatibility ◽  
Biomedical Field ◽  
Hydrogel Composites ◽  
Material Fabrication ◽  
Biomedical Fields

Recently, photothermal therapy (PTT) has emerged as one of the most promising biomedical strategies for different areas in the biomedical field owing to its superior advantages, such as being noninvasive, target-specific and having fewer side effects. Graphene-based hydrogels (GGels), which have excellent mechanical and optical properties, high light-to-heat conversion efficiency and good biocompatibility, have been intensively exploited as potential photothermal conversion materials. This comprehensive review summarizes the current development of graphene-integrated hydrogel composites and their application in photothermal biomedicine. The latest advances in the synthesis strategies, unique properties and potential applications of photothermal-responsive GGel nanocomposites in biomedical fields are introduced in detail. This review aims to provide a better understanding of the current progress in GGel material fabrication, photothermal properties and potential PTT-based biomedical applications, thereby aiding in more research efforts to facilitate the further advancement of photothermal biomedicine.

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