scholarly journals Foods, the Best Way to Take Antioxidant Natural Products

Foods ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 19
Author(s):  
Maria Eduarda Machado Araújo ◽  
Alice Martins
Keyword(s):  
Natural Products ◽  
The Body ◽  
Radical Species

Antioxidants are powerful compounds that help the body to destroy the excess of endogenous radical species responsible for many severe conditions like neurodegenerative, inflammatory, and cardiovascular impairments, and even some forms of cancer [...]

scholarly journals What Did We Accomplish in Fighting Radical Species in Human Health?

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 466
Author(s):  
Rachid Skouta
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
The Body ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Radical Species ◽  
Physiological Level

Maintaining the physiological level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body is highly important in the fight against radical species in the context of human health [...]

scholarly journals Redox Modulations, Antioxidants, and Neuropsychiatric Disorders

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Erik A. Fraunberger ◽  
Gustavo Scola ◽  
Victoria L. M. Laliberté ◽  
Angela Duong ◽  
Ana C. Andreazza
Keyword(s):  
Natural Products ◽  
Current Literature ◽  
Biological Significance ◽  
Neuropsychiatric Disorders ◽  
Redox Status ◽  
Primary Objective ◽  
The Body ◽  
Brain Health ◽  
Current Role ◽  
The Impact

Although antioxidants, redox modulations, and neuropsychiatric disorders have been widely studied for many years, the field would benefit from an integrative and corroborative review. Our primary objective is to delineate the biological significance of compounds that modulate our redox status (i.e., reactive species and antioxidants) as well as outline their current role in brain health and the impact of redox modulations on the severity of illnesses. Therefore, this review will not enter into the debate regarding the perceived medical legitimacy of antioxidants but rather seek to clarify their abilities and limitations. With this in mind, antioxidants may be interpreted as natural products with significant pharmacological actions in the body. A renewed understanding of these often overlooked compounds will allow us to critically appraise the current literature and provide an informed, novel perspective on an important healthcare issue. In this review, we will introduce the complex topics of redox modulations and their role in the development of select neuropsychiatric disorders.

scholarly journals Flavonoids on diabetic nephropathy: advances and therapeutic opportunities

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Qichao Hu ◽  
Caiyan Qu ◽  
Xiaolin Xiao ◽  
Wenwen Zhang ◽  
Yinxiao Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Natural Products ◽  
Diabetic Nephropathy ◽  
Metabolic Diseases ◽  
Inflammatory Responses ◽  
The Body ◽  
Diabetic Patients ◽  
Public Attention ◽  
Wide Range ◽  
Tgf Β1

AbstractWith the advances in biomedical technologies, natural products have attracted substantial public attention in the area of drug discovery. Flavonoids are a class of active natural products with a wide range of pharmacological effects that are used for the treatment of several diseases, in particular chronic metabolic diseases. Diabetic nephropathy is a complication of diabetes with a particularly complicated pathological mechanism that affects at least 30% of diabetic patients and represents a great burden on public health. A large number of studies have shown that flavonoids can alleviate diabetic nephropathy. This review systematically summarizes the use of common flavonoids for the treatment of diabetic nephropathy. We found that flavonoids play a therapeutic role in diabetic nephropathy mainly by regulating oxidative stress and inflammation. Nrf-2/GSH, ROS production, HO-1, TGF-β1 and AGEs/RAGE are involved in the process of oxidative stress regulation. Quercetin, apigenin, baicalin, luteolin, hesperidin, genistein, proanthocyanidin and eriodictyol were found to be capable of alleviating oxidative stress related to the aforementioned factors. Regarding inflammatory responses, IL-1, IL-6β, TNF-α, SIRT1, NF-κB, and TGF-β1/smad are thought to be essential. Quercetin, kaempferol, myricetin, rutin, genistein, proanthocyanidin and eriodictyol were confirmed to influence the above targets. As a result, flavonoids promote podocyte autophagy and inhibit the overactivity of RAAS by suppressing the upstream oxidative stress and inflammatory pathways, ultimately alleviating DN. The above results indicate that flavonoids are promising drugs for the treatment of diabetic nephropathy. However, due to deficiencies in the effect of flavonoids on metabolic processes and their lack of structural stability in the body, further research is required to address these issues.

scholarly journals Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6843
Author(s):  
Xiang-Kui He ◽  
Juan Lu ◽  
Hai-Bing Ye ◽  
Lei Li ◽  
Jun Xuan
Keyword(s):  
Natural Products ◽  
Radical Cyclization ◽  
Acyl Radical ◽  
Radical Species ◽  
Complex Molecules ◽  
Radical Generation

An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules.

scholarly journals Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3714
Author(s):  
G. Lavender Hackman ◽  
Meghan Collins ◽  
Xiyuan Lu ◽  
Alessia Lodi ◽  
John DiGiovanni ◽  
...  
Keyword(s):  
Natural Products ◽  
High Throughput ◽  
High Throughput Screening ◽  
Cancer Therapeutics ◽  
Chemotherapeutic Agents ◽  
The Body ◽  
Cancer Drug ◽  
Therapeutic Effects ◽  
Cancer Drugs ◽  
Antagonistic Effects

Natural products have been used for centuries to treat various human ailments. In recent decades, multi-drug combinations that utilize natural products to synergistically enhance the therapeutic effects of cancer drugs have been identified and have shown success in improving treatment outcomes. While drug synergy research is a burgeoning field, there are disagreements on the definitions and mathematical parameters that prevent the standardization and proper usage of the terms synergy, antagonism, and additivity. This contributes to the relatively small amount of data on the antagonistic effects of natural products on cancer drugs that can diminish their therapeutic efficacy and prevent cancer regression. The ability of natural products to potentially degrade or reverse the molecular activity of cancer therapeutics represents an important but highly under-emphasized area of research that is often overlooked in both pre-clinical and clinical studies. This review aims to evaluate the body of work surrounding the antagonistic interactions between natural products and cancer therapeutics and highlight applications for high-throughput screening (HTS) and deep learning techniques for the identification of natural products that antagonize cancer drug efficacy.

Nutraceutical and Functional Foods in Cancer Management and Therapy

2022 ◽  
pp. 1144-1182
Author(s):  
Sakshi Bajaj ◽  
Satish Manchanda
Keyword(s):  
Natural Products ◽  
Cancer Cells ◽  
Functional Foods ◽  
The Body ◽  
Food Industries ◽  
Cancer Management ◽  
Consumer Demands

Cancer is an insidious disease affecting mankind in every country. The progression of cancer cells from one part of the body to another (metastasis) is one of the biggest problems in curing cancer. The present study brings new hope of future therapies to fight cancer. Designing an appropriate food to maintain proper health has become a necessity worldwide. Due to this, the food industries in many countries are modifying their products as a response to consumer demands. In recent years, many of the natural products are gaining popularity as nutraceuticals.

Review on Obesity treatment in Ayurvedic, Homeopathic, Allopathic, and home remedies.

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Richa Tibrewal ◽  
Preeti Singh
Keyword(s):  
Natural Products ◽  
Genetic Factors ◽  
Weight Loss Surgery ◽  
Synergistic Effects ◽  
Obesity Treatment ◽  
Lifestyle Changes ◽  
The Body ◽  
Active Components ◽  
Herbal Products ◽  
Extreme Measure

Obesity, a complex interplay between environmental and genetic factors and is associated with significant morbidity and mortality. Usage of herbs for the management of obesity in the recent times is attracting attention. A web and man-ual based literature survey was conducted to assess the amount of information available on the herbal products for weight management. Traditional literature, PubMed, Scopus, Google scholar databases were screened up to February 2012. The search words were “obesity”, “herbal medicine/products/extracts”, “medicinal plants”, “traditional medicine”, Obesity in adults is characterized when the Body Mass Index (BMI) is greater than or equal to 30. It is estimated that 1.7 billion people in the world are overweight or obese, and more than one third of U.S. adults (35.7%) are obese. There are a variety of factors that play a role in obesity, such as behavior, environment, and genetic factors. Usual countermeasures include adequate physical activity, avoidance of calorie-dense foods, and use of certain drugs for promoting weight loss. Surgery is an extreme measure and anyone considering it must have failed consistently in losing weight through lifestyle changes and less invasive methods. The main drugs currently employed in obesity treatment present dangerous side effects, namely: elevation of blood pressure, insomnia, constipation, headaches, among others. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. Considering that natural anti-obesity products have different mechanisms, the recommended approach to research a more effective obesity treatment, reaching the associated synergistic effects, must involve the combination of natural products and/or products with multiple activities. This chapter describes several natural products with anti-obesity activity, and active components and mechanisms of action to combat obesity. Keywords: anti-obesity activity, metabolic syndrome, natural products, obesity

A systematic review of mechanisms by which natural products of plant origin evoke vasodilatation

2006 ◽  
Vol 84 (8-9) ◽  
pp. 803-821 ◽  
Author(s):  
J. Robert McNeill ◽  
Tannis M. Jurgens
Keyword(s):  
Nitric Oxide ◽  
Natural Products ◽  
Potassium Channel ◽  
Mechanisms Of Action ◽  
Oxide System ◽  
The Body ◽  
Plant Origin ◽  
Nitric Oxide Synthase Inhibitor ◽  
Channel Function

This article reviews the body of work aimed at elucidating the mechanisms of action by which natural products of plant origin exert a vasodilatory effect at the level of the vasculature. The search was restricted to 4 mechanisms: the nitric oxide system and (or) reactive oxygen species, the eicosanoid system, potassium channel function, and calcium channel function. The National Library of Medicine database was searched using “PubMed” without restriction to language. The search generated 266 references on 15 November 2005. Most studies were in vitro in nature and of these, most involved studies in the rat aorta. Many of the natural products evoked vasodilatation through an endothelium-dependent mechanism. The vasodilatation was attenuated or abolished by a nitric oxide synthase inhibitor and, in some of these studies, by an inhibitor of guanylate cyclase. A few studies reported a cyclooxygenase component, but most found no effect of the cyclooxygenase inhibitor, indomethacin. The vasorelaxation evoked by several natural products was attenuated by various potassium channel blocking agents, suggesting that some natural products exerted their effect either directly or indirectly through activation of potassium channels. Finally, a significant number of natural products evoked vasodilatation either through blockade of calcium channels or by inhibiting the release of calcium from intracellular stores. Many natural products evoked vasodilatation through multiple mechanisms. The information in this review on mechanisms of action should facilitate good clinical practice by increasing the predictive capabilities of the practitioner, notably the ability to predict adverse effects and interactions among medications. The knowledge should also help to provide leads to the ultimate goal of developing new therapeutic medications.

scholarly journals Evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus type 2

2020 ◽  
Vol 8 (16) ◽  
pp. 56-64
Author(s):  
Karla Guadalupe Perez-Avila ◽  
Cruz Vargas-De-León ◽  
José Antonio Morales-González ◽  
Eduardo Madrigal-Santillán
Keyword(s):  
Diabetes Mellitus ◽  
Natural Products ◽  
Alternative Treatment ◽  
The Body ◽  
In Vitro Assays ◽  
Glucose Levels ◽  
Natural Treatment ◽  
Treatment Of Diabetes

Diabetes mellitus is a disease that is characterized by the chronic presence of blood glucose levels caused by a defect in the secretion of insulin or in the action of this hormone in the body which must be treated integrally with a multidisciplinary approach. The natural treatment of this disease is a common practice around the world, especially in Latin America, there are several clinical studies, in vivo or in vitro assays that focus on assessing the hypoglycemic capacity of various natural products used empirically by the population for years for the phytotherapeutic treatment of the disease as well as the chemicals related to the mechanism of action that produces the hypoglycaemic effect. In the present article, a brief review of the evidence of the hypoglycemic capacity of some natural products for the alternative treatment of diabetes mellitus 2

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