scholarly journals Structures and Bioactive Properties of Myrtucommulones and Related Acylphloroglucinols from Myrtaceae

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3370 ◽  
Author(s):  
Rosario Nicoletti ◽  
Maria Salvatore ◽  
Pasquale Ferranti ◽  
Anna Andolfi
Keyword(s):  
Drug Development ◽  
Biological Properties ◽  
Myrtus Communis ◽  
Bioactive Components ◽  
Research Activity ◽  
Bioactive Properties ◽  
Therapeutic Properties ◽  
Fruitful Research

Myrtaceae are a group of plants that include a number of renowned species used in ethnomedicine in many areas worldwide. Their valuable therapeutic properties have stimulated a fruitful research activity addressed to the identification of the bioactive components of their extracts yielding a great diversity of terpenes; polyphenols; and other exclusive products. Among the latter, starting with the discovery of myrtucommulone A from myrtle (Myrtus communis), a series of structurally-related acylphloroglucinol compounds have been characterized from several species that represent the basic active principles to be considered in view of possible drug development. Aspects concerning chemical and biological properties of these products are reviewed in the present paper.

Diosgenin: Therapeutic Action, Pharmacology and Applications

2017 ◽  
Vol 5 (1) ◽  
pp. 7-15
Author(s):  
Sanasam Sanjeev ◽  
◽  
Maibam Sunita Devi ◽  
Khushboo Maurya ◽  
Vikas Kumar Roy ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Drug Development ◽  
Liver Diseases ◽  
Potential Role ◽  
Wide Spectrum ◽  
Herbal Product ◽  
Biological Properties ◽  
Therapeutic Action ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Beneficial Effects

Diosgenin [25R-spriost-5-en-3þ-ol], is an important steroidal metabolite found in various plant species. The discovery of diosgenin has made it one of the most researched and studied herbal product. Moreover, there is excellent opportunity to address whether diosgenin plays a role in chemoprevention versus therapy, or both. However, rigorous experimental based evidence in support of ethnomedicine-derived notions would lead to the development of products relevant to drug development. The health beneficial effects of diosgenin are further extended to its potential role to treat other ailments such as HIV and hepatitis-C infections as well as liver diseases. There is little information regarding the bioavailability, pharmacokinetics and pharmacodynamics of diosgenin in relation to its health beneficial effects. It has been reported to have wide spectrum of biological properties that contributes to several diseases in its role as a health beneficial phytochemical by citing new studies.

scholarly journals Rose Flowers—A Delicate Perfume or a Natural Healer?

Biomolecules ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 127
Author(s):  
Milka Mileva ◽  
Yana Ilieva ◽  
Gabriele Jovtchev ◽  
Svetla Gateva ◽  
Maya Margaritova Zaharieva ◽  
...  
Keyword(s):  
Essential Oils ◽  
Food Industry ◽  
Raw Materials ◽  
Biological Activities ◽  
Biological Properties ◽  
Rosa Damascena ◽  
Oil Sand ◽  
Rosa Gallica ◽  
Therapeutic Properties ◽  
Phytochemical Profile

Plants from the Rosacea family are rich in natural molecules with beneficial biological properties, and they are widely appreciated and used in the food industry, perfumery, and cosmetics. In this review, we are considering Rosa damascena Mill., Rosa alba L., Rosa centifolia L., and Rosa gallica L. as raw materials important for producing commercial products, analyzing and comparing the main biological activities of their essential oils, hydrolates, and extracts. A literature search was performed to find materials describing (i) botanical characteristics; (ii) the phytochemical profile; and (iii) biological properties of the essential oil sand extracts of these so called “old roses” that are cultivated in Bulgaria, Turkey, India, and the Middle East. The information used is from databases PubMed, Science Direct, and Google Scholar. Roses have beneficial healing properties due to their richness of beneficial components, the secondary metabolites as flavonoids (e.g., flavones, flavonols, anthocyanins), fragrant components (essential oils, e.g., monoterpenes, sesquiterpenes), and hydrolysable and condensed tannins. Rose essential oils and extracts with their therapeutic properties—as respiratory antiseptics, anti-inflammatories, mucolytics, expectorants, decongestants, and antioxidants—are able to act as symptomatic prophylactics and drugs, and in this way alleviate dramatic sufferings during severe diseases.

scholarly journals Boolean Implication Analysis Unveils Candidate Universal Relationships in Microbiome Data

2020 ◽  
Author(s):  
Daniella Vo ◽  
Shayal Charisma Singh ◽  
Sara Safa ◽  
Debashis Sahoo
Keyword(s):  
Disease Diagnosis ◽  
Biological Properties ◽  
Weak Correlation ◽  
Human Environment ◽  
Asymmetric Data ◽  
Therapeutic Properties ◽  
Almost All ◽  
Microbiome Data ◽  
The Relationship ◽  
Boolean Implication

Abstract Background: Microbiomes consist of bacteria, viruses, and other microorganisms, and are responsible for many different functions in both organisms and the environment. Some previous analyses of microbiomes focus on the relationships between specific microbiomes and a particular disease. These typically use correlation which is fundamentally symmetric with respect to pairs of microbes. Correlation focuses on the symmetry of the data distribution, and asymmetric data is often discarded as having a weak correlation. With all the data available on the microbiome, there is a need for a method that comprehensively studies microbiomes and how they are related to each other.Results: We collect publicly available datasets from human, environment, and animal samples to determine both symmetric and asymmetric Boolean relationships between a pair of microbes. We then find relationships that are potentially invariants, meaning they will hold in any microbe community. In other words, if we determine there is a relationship between two microbes, we expect the relationship to hold in almost all context. We discovered that certain pairs of microbes always exhibit the same relationship in almost all the datasets we studied, thus making them good candidates for universal relationships. Our results confirm known biological properties and seem promising in terms of disease diagnosis.Conclusions: Since the relationships are likely universal, we expect that they will hold in a clinical setting as well as in the general population. Strong universal relationships may provide insight on prognostic, predictive, or therapeutic properties of a clinically relevant disease. These new analyses may improve disease diagnosis and drug development in terms of accuracy and efficiency.

scholarly journals Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 654 ◽  
Author(s):  
Ana Isabel Barbosa ◽  
Ana Joyce Coutinho ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Final Section ◽  
Biological Properties ◽  
Production Methods ◽  
Bioactive Properties ◽  
Wide Range ◽  
Per Se

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

Bioassay-guided separation and identification of anticancer compounds in Tagetes erecta L. flowers

2016 ◽  
Vol 8 (15) ◽  
pp. 3255-3262 ◽  
Author(s):  
Hong Lu ◽  
Shanshan Yang ◽  
Hong Ma ◽  
Zhao Han ◽  
Yaozhou Zhang
Keyword(s):  
Drug Development ◽  
Tagetes Erecta ◽  
Bioactive Components ◽  
Anticancer Compounds ◽  
Tagetes Erecta L

Investigating bioactive components in marigold (Tagetes erecta L.) can provide worthy information for drug development.

scholarly journals Vesicle properties and health benefits of milk phospholipids: a review

2019 ◽  
Vol 5 ◽  
Author(s):  
Zhiguang Huang ◽  
Hui Zhao ◽  
Wenqiang Guan ◽  
Jianfu Liu ◽  
Charles Brennan ◽  
...  
Keyword(s):  
Large Scale ◽  
Antioxidant Properties ◽  
Biological Properties ◽  
Industrial Processes ◽  
Scale Production ◽  
Bioactive Components ◽  
Large Scale Production ◽  
Total Milk ◽  
Milk Lipids ◽  
New Applications

Phospholipids are important ingredients in milk. They serve as bioactive components with processing functionalities, despite representing only a small proportion of total milk lipids. There has been increasing interest in vesicle properties and health effects of milk phospholipids. However, there are limited reports on industry-scale manufacturing of related commercial products. This contribution aims to elucidate the industrial processes of manufacturing milk phospholipid products including phospholipid extraction and fraction as well as summarizing determination assays of milk phospholipids. In addition to industrial production, this review elaborates on application aspects, such as the biological properties of milk phospholipids and their technical importance as delivery vesicles of liposomes and phytosomes. In addition, new insights on large-scale production of milk phospholipids and new applications such as phytosomes and antioxidant properties are discussed.

scholarly journals ECLIPTA ALBA (BHRINGRAJ): A PROMISING HEPATOPROTECTIVE AND HAIR GROWTH STIMULATING HERB.

2021 ◽  
pp. 16-23
Author(s):  
ISHA KUMARI ◽  
HEMLATA KAURAV ◽  
GITIKA CHAUDHARY
Keyword(s):  
Medicinal Plant ◽  
Folk Medicine ◽  
Primary Source ◽  
Biological Properties ◽  
Vital Role ◽  
Eclipta Alba ◽  
Cosmetic Industry ◽  
Ancient Times ◽  
Therapeutic Properties ◽  
Phytochemical Constituents

Plants are the primary source of food, shelter, and various remedial approaches. They are being in use for treating various kinds of human ailments across the world since the ancient times. One of such important plants is Eclipta alba hassk (Asteraceae) which is commonly known as Bhringraj and false daisy. This plant is known for its extra-ordinary therapeutic properties. It is one of most widely used plant in traditional systems of medicines such as Ayurvedic, Unani, Sidha, homeopathy, Chinese, and folk. Each part of this medicinal plant contains many important phytochemical constituents such as coumestans, triterpenes, flavonoids, steroids, polypeptides, and saponins. It is majorly used for enhancing the growth, strength, and blackening of hair. It is used as the main ingredient in many hair oils. It significantly treats problems related to hair such as hair fall, dandruff, premature greying, and baldness. E. alba exhibits many other important biological properties such as anticancer, anti-bacterial, anti-viral, anti-stress, and immunomodulatory. Thus, this medicinal plant is playing a vital role in the medical field and cosmetic industry. The present review is a summary of phytomedicinal importance of E. alba in Ayurveda as well as folk medicine system.

scholarly journals Calorimetric Evaluation of Glycyrrhetic Acid (GA)- and Stearyl Glycyrrhetinate (SG)-Loaded Solid Lipid Nanoparticle Interactions with a Model Biomembrane

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4903
Author(s):  
Debora Santonocito ◽  
Carmelo Puglia ◽  
Cristina Torrisi ◽  
Alessandro Giuffrida ◽  
Valentina Greco ◽  
...  
Keyword(s):  
Cellular Membrane ◽  
Biological Properties ◽  
Glycyrrhetic Acid ◽  
Technological Parameters ◽  
Solid Lipid ◽  
Ability To Act ◽  
Nanoparticle Interactions ◽  
Therapeutic Properties ◽  
Carrier Systems ◽  
Potential Use

Glycyrrhetic acid (GA) and stearyl glycyrrhetinate (SG) are two interesting compounds from Glycyrrhiza glabra, showing numerous biological properties widely applied in the pharmaceutical and cosmetic fields. Despite these appreciable benefits, their potential therapeutic properties are strongly compromised due to unfavourable physical-chemical features. The strategy exploited in the present work was to develop solid lipid nanoparticles (SLNs) as carrier systems for GA and SG delivery. Both formulations loaded with GA and SG (GA-SLNs and SG-SLNs, respectively) were prepared by the high shear homogenization coupled to ultrasound (HSH-US) method, and we obtained good technological parameters. DSC was used to evaluate their thermotropic behaviour and ability to act as carriers for GA and SG. The study was conducted by means of a biomembrane model (multilamellar vesicles; MLVs) that simulated the interaction of the carriers with the cellular membrane. Unloaded and loaded SLNs were incubated with the biomembranes, and their interactions were evaluated over time through variations in their calorimetric curves. The results of these studies indicated that GA and SG interact differently with MLVs and SLNs; the interactions of SG-SLNs and GA-SLNs with the biomembrane model showed different variations of the MLVs calorimetric curve and suggest the potential use of SLNs as delivery systems for GA.

scholarly journals Bioactive properties and phytochemical assessment of Bacupari-anão (Garcinia brasiliensis Mart.) leaves native to Rondônia, Brazil

2018 ◽  
Vol 9 (11) ◽  
pp. 5621-5628 ◽  
Author(s):  
Renato André Zan ◽  
Ângela Fernandes ◽  
Stephanie Jedoz ◽  
Taofiq Oludemi ◽  
Ricardo C. Calhelha ◽  
...  
Keyword(s):  
Biological Properties ◽  
Bioactive Properties ◽  
Health Promoting

Extracts of Garcinia brasiliensis Mart. revealed health promoting biological properties.

scholarly journals Amino Acid and Vitamin Content of Propolis Collected by Native Caucasican Honeybees

2016 ◽  
Vol 60 (2) ◽  
pp. 101-110 ◽  
Author(s):  
Nazife Eroglu ◽  
Senem Akkus ◽  
Mustafa Yaman ◽  
Baris Asci ◽  
Sibel Silici
Keyword(s):  
Liquid Chromatography ◽  
Amino Acid ◽  
Acid Content ◽  
High Performance ◽  
Amino Acid Content ◽  
Biological Properties ◽  
Chemical Components ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Therapeutic Properties

Abstract The polyphenol content of propolis has received a lot of attention due to the benign biological properties noted in the chemical composition studies. However, there are very limited studies about other chemical components found in trace amounts in nature which contribute to the therapeutic properties of propolis. The present study, therefore, investigated the amino acid and vitamin composition of propolis. Propolis harvested by 60 colonies of Apis mellifera caucasica belonged to local non-migratory beekeepers. The A. m. caucasica is known for its distinctive propolis collecting capability which native to the secluded Ardahan Province of Turkey. Vitamin (Thiamine, Riboflavin) combinations of propolis were determined using the HPLC (High-Performance Liquid Chromatography) fluorescent detector. An amino acid analysis was also performed with the UFLC (Ultra-Fast Liquid Chromatography) system consisting of binary pump and UV/VIS. Our findings record that the vitamin and amino acid content of propolis samples collected from three areas of different altitudes in the same region differed from each other. Vitamin B1 content and Vitamin B2 content ranged between 0.025-0.16 mg/100g, and 0.304-0.777mg/100g, respectively. A maximum amount of amino acid was reported as leucine, while a minimum amount of amino acid was seen as tryptophan in Ardahan propolis. Consequently, the vitamin and amino acid content of propolis, which derived from secondary plant metabolites of resin, varied depending on their geographical altitudes. Those vitamin and amino acids found in the propolis composition are believed to have beneficial therapeutic properties.

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