scholarly journals Chemo-Preventive Action of Resveratrol: Suppression of p53—A Molecular Targeting Approach

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5325
Author(s):  
Rokeya Akter ◽  
Md. Habibur Rahman ◽  
Deepak Kaushik ◽  
Vineet Mittal ◽  
Diana Uivarosan ◽  
...  
Keyword(s):  
Natural Product ◽  
P53 Protein ◽  
Molecular Targeting ◽  
Therapeutic Activity ◽  
Preventive Action ◽  
Epidemiological Evidence ◽  
Natural Origin ◽  
Different Types ◽  
Molecular Signals ◽  
Active Substances

Extensive experimental, clinical, and epidemiological evidence has explained and proven that products of natural origin are significantly important in preventing and/or ameliorating various disorders, including different types of cancer that researchers are extremely focused on. Among these studies on natural active substances, one can distinguish the emphasis on resveratrol and its properties, especially the potential anticancer role. Resveratrol is a natural product proven for its therapeutic activity, with remarkable anti-inflammatory properties. Various other benefits/actions have also been reported, such as cardioprotective, anti-ageing, antioxidant, etc. and its rapid digestion/absorption as well. This review aims to collect and present the latest published studies on resveratrol and its impact on cancer prevention, molecular signals (especially p53 protein participation), and its therapeutic prospects. The most recent information regarding the healing action of resveratrol is presented and concentrated to create an updated database focused on this topic presented above.

The Molecular Docking of Flavonoids Isolated from Daucus carota as a Dual Inhibitor of MDM2 and MDMX

2020 ◽  
Vol 15 (2) ◽  
pp. 154-164 ◽  
Author(s):  
Ijaz Muhammad ◽  
Noor Rahman ◽  
Gul E. Nayab ◽  
Sadaf Niaz ◽  
Mohibullah Shah ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Cancer Therapy ◽  
Natural Product ◽  
Signaling Pathway ◽  
In Silico ◽  
P53 Protein ◽  
Dual Inhibitor ◽  
P53 Signaling ◽  
In Silico Studies ◽  
P53 Signaling Pathway

Background: Cancer is characterized by overexpression of p53 associated proteins, which down-regulate P53 signaling pathway. In cancer therapy, p53 activity can be restored by inhibiting the interaction of MDMX (2N0W) and MDM2 (4JGR) proteins with P53 protein. Objective: In the current, study in silico approaches were adapted to use a natural product as a source of cancer therapy. Methods: In the current study in silico approaches were adapted to use a natural product as a source of cancer therapy. For in silico studies, Chemdraw and Molecular Operating Environment were used for structure drawing and molecular docking, respectively. Flavonoids isolated from D. carota were docked with cancerous proteins. Result: Based on the docking score analysis, we found that compound 7 was the potent inhibitor of both cancerous proteins and can be used as a potent molecule for inhibition of 2N0W and 4JGR interaction with p53. Conclusion: Thus the compound 7 can be used for the revival of p53 signaling pathway function however, intensive in vitro and in vivo experiments are required to prove the in silico analysis.

scholarly journals Evaluation of Four DNA Typing Techniques in Epidemiological Investigations of Bovine Tuberculosis

1998 ◽  
Vol 36 (1) ◽  
pp. 168-178 ◽  
Author(s):  
Debby Cousins ◽  
Suzette Williams ◽  
Ernesto Liébana ◽  
Alicia Aranaz ◽  
Annelies Bunschoten ◽  
...  
Keyword(s):  
Restriction Fragment ◽  
Dna Typing ◽  
Rflp Analysis ◽  
Direct Repeat ◽  
Single Copy ◽  
Epidemiological Evidence ◽  
Different Types ◽  
The Republic ◽  
Different Strains ◽  
Typing Technique

DNA fingerprinting techniques were used to type 273 isolates ofMycobacterium bovis from Australia, Canada, the Republic of Ireland, and Iran. The results of restriction fragment length polymorphism (RFLP) analysis with DNA probes from IS6110, the direct repeat (DR), and the polymorphic GC-rich sequence (PGRS) were compared with those of a new PCR-based method called spacer oligonucleotide typing (spoligotyping) developed for the rapid typing of Mycobacterium tuberculosis (J. Kamerbeek et al., J. Clin. Microbiol. 35:907–914, 1997). Eighty-five percent of the isolates harbored a single copy of IS6110, and 81.5% of these carried IS6110 on the characteristic 1.9-kb restriction fragment. RFLP analysis with IS6110 identified 23 different types, RFLP analysis with the DR probe identified 35 types, RFLP analysis with the PGRS probe identified 77 types, and the spoligotyping method identified 35 types. By combining all results, 99 different strains could be identified. Isolate clusters were frequently associated within herds or were found between herds when epidemiological evidence confirmed animal movements. RFLP analysis with IS6110 was sufficiently sensitive for the typing of isolates with more than three copies of IS6110, but RFLP analysis with the PGRS probe was the most sensitive typing technique for strains with only a single copy of IS6110. Spoligotyping may have advantages for the rapid typing of M. bovis, but it needs to be made more sensitive.

scholarly journals The Regenerative Potential of Substance P

2022 ◽  
Vol 23 (2) ◽  
pp. 750
Author(s):  
Patrycja Redkiewicz
Keyword(s):  
Wound Healing ◽  
Substance P ◽  
Autoimmune Diseases ◽  
Chronic Wounds ◽  
Different Types ◽  
Healing Wounds ◽  
Active Substances

Wound healing is a highly coordinated process which leads to the repair and regeneration of damaged tissue. Still, numerous diseases such as diabetes, venous insufficiencies or autoimmune diseases could disturb proper wound healing and lead to chronic and non-healing wounds, which are still a great challenge for medicine. For many years, research has been carried out on finding new therapeutics which improve the healing of chronic wounds. One of the most extensively studied active substances that has been widely tested in the treatment of different types of wounds was Substance P (SP). SP is one of the main neuropeptides released by nervous fibers in responses to injury. This review provides a thorough overview of the application of SP in different types of wound models and assesses its efficacy in wound healing.

scholarly journals Cocaine- and Amphetamine-Regulated Transcript (CART ) Peptide in Mammals Gastrointestinal System – A Review

2017 ◽  
Vol 17 (1) ◽  
pp. 3-21 ◽  
Author(s):  
Krystyna Makowska ◽  
Sławomir Gonkowski
Keyword(s):  
Nervous System ◽  
Digestive System ◽  
Gastrointestinal System ◽  
Stress Reactions ◽  
System A ◽  
Cart Peptide ◽  
Different Types ◽  
The Central Nervous System ◽  
The Subject ◽  
Active Substances

Abstract Since its first description over 30 years ago, cocaine- and amphetamine-regulated transcript (CART) peptide has been the subject of many studies. Most of these investigations pertain to occurrence and functions of CART within the central nervous system, where this peptide first of all takes part in regulation of feeding, stress reactions, as well as neuroprotective and neuroregenerative processes. However, in recent years more and more studies concern the presence of CART in the gastrointestinal system. This peptide has been described both in stomach and intestine, as well as in other digestive organs such as pancreas or gallbladder. Particularly much information relates to distribution of CART in the enteric nervous system, which is located within the wall of digestive tract. Other studies have described this peptide in intestinal endocrinal cells. Moreover, it is known that CART can be present in various types of neuronal cells and may co-localize with different types of other neuronal active substances, which play roles of neuromediators and/or neuromodulators. On the other hand precise functions of CART in the gastrointestinal system still remain unknown. It is assumed that this peptide is involved in the regulation of gastrointestinal motility, intestinal blood flow, secretion of intestinal juice, somatostatin and/or insulin, as well as takes part in pathological processes within the gastrointestinal tract. The large number of recent studies concerning the above mentioned problems makes that knowledge about occurrence and functions of CART in the digestive system rather piecemeal and requires clarifying, which is the aim of the present article.

scholarly journals Discovery of anticancer agents of diverse natural origin

2009 ◽  
Vol 81 (6) ◽  
pp. 1051-1063 ◽  
Author(s):  
A. Douglas Kinghorn ◽  
Esperanza J. Carcache de Blanco ◽  
Hee-Byung Chai ◽  
Jimmy Orjala ◽  
Norman R. Farnsworth ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Anticancer Agents ◽  
Diverse Group ◽  
Multidisciplinary Research ◽  
Tropical Plants ◽  
Natural Origin ◽  
Bioactive Secondary Metabolites ◽  
Drug Leads ◽  
Made In

A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.

Meditation and psychosis

2011 ◽  
Vol 26 (S2) ◽  
pp. 1200-1200 ◽  
Author(s):  
S. Gonzalez Vives ◽  
J. Garcia-Albea Martin ◽  
H. Trebbau ◽  
J.J. López-Ibor Aliño
Keyword(s):  
Risk Factors ◽  
Affective Disorders ◽  
Tai Chi ◽  
Traumatic Experiences ◽  
Psychotic Symptoms ◽  
Epidemiological Evidence ◽  
Buddhist Meditation ◽  
Different Types ◽  
The Central Nervous System ◽  
San Carlos

IntroductionFor the last years, there has been a wordlwide increase in the interest of oriental culture, specifically in the practice of meditation. This technic is known to produce cognitive and sensorial perception alterations, with changes in the hormonal and autonomic system. This practice has been associated with different mental disorders such as neurotic manifestations, dissociative and regressive, and even psychotic symptoms.ObjectivesTo analyze the influence of an intensive practice of different styles of meditation in the psychopathology found in our patients (Hospital Clínico San Carlos, Madrid). To study the changes produced in the Central Nervous System measured by Electroencephalogram, PET, and functional MRI.AimsTo define the clinical characteristics, prognois, risk factors and biological changes of an “atypical” psycopathologic case which seems to be more frequent everyday.MethodsExtensive bibliographic review focused in psychopathology related to different types of meditation, either auto or hetero-induced (exorcism). We analyzed the patients attended in our hospital with psychotic semiology after having practiced intensive types of meditacion (transcendental meditation, buddhist meditation, tai-chi, qi-gong, tiao-shen, etc).ResultsWe found serious psychotic and affective symptomatology produced after using these technics. It is important to point out the risk factors and traumatic experiences characteristic of these processes.ConclusionsThere is clinical and epidemiological evidence that a group of psychosis, with different symptomatology and prognosis than schizophrenia and affective disorders, exists. We describe a syndrome of sudden manifestation, with flourished symptoms and serious behavior alterations, etc.

ECDYSTEROIDS IN NATURE AND THEIR PROPERTIES

2019 ◽  
Vol 5 (3) ◽  
pp. 26-28
Author(s):  
Э. Наумова ◽  
E. Naumova ◽  
Б. Валентинов ◽  
B. Valentinov
Keyword(s):  
Raw Materials ◽  
Folk Medicine ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Natural Sources ◽  
Natural Origin ◽  
Adaptogenic Activity ◽  
Active Substances

Ecdysteroids are biologically active substances of natural origin. Their adaptogenic activity, hormone-like and bioregulatory effects used in traditional and folk medicine are known. Sources of raw materials are diverse. Applications depend on the methods of obtaining ecdysteroids and their natural sources.

scholarly journals Cheminformatics Analysis of Natural Product Scaffolds: Comparison of Scaffolds Produced by Animals, Plants, Fungi and Bacteria

2020 ◽  
Author(s):  
Peter Ertl ◽  
Tim Schuhmann
Keyword(s):  
Natural Products ◽  
Natural Selection ◽  
Natural Product ◽  
Selection Process ◽  
Structural Features ◽  
New Drugs ◽  
Large Database ◽  
Biologically Relevant ◽  
Different Types ◽  
Selection Of

AbstractNatural products (NPs) have evolved over a very long natural selection process to form optimal interactions with biologically relevant macromolecules. NPs are therefore an extremely useful source of inspiration for the design of new drugs. In the present study we report the results of a cheminformatics analysis of a large database of NP structures focusing on their scaffolds. First, general differences between NP scaffolds and scaffolds from synthetic molecules are discussed, followed by a comparison of the properties of scaffolds produced by different types of organisms. Scaffolds produced by plants are the most complex and those produced by bacteria differ in many structural features from scaffolds produced by other organisms. The results presented here may be used as a guidance in selection of scaffolds for the design of novel NP-like bioactive structures or NP-inspired libraries.

scholarly journals ANTIBACTERIAL ACTIVITY AND THIN LAYER CHROMATOGRAPHY PROFILE Muntingia Calabura LEAF EXTRACT AS A MATERIAL CANDIDATE HAND SANITIZER

2018 ◽  
Vol 11 (1) ◽  
pp. 43
Author(s):  
Santy Pristianingrum ◽  
Baiq Lely Zainiati ◽  
Iwan Doddy Dharmawibawa
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Preventive Action ◽  
Hand Sanitizer ◽  
Layer Chromatography ◽  
Active Substances ◽  
Muntingia Calabura

Abstract : the utilization of antibacterial active substances from several plants is increasingly not only as the ingredients of medicine, but its utilization is also utilized for an antibacterial ingredient for preventive action, one of them is hand sanitizer material. This research focused to find the antibacterial active substances alternative from Muntingia calabura leaves extract. The data were analyzed descriptively including the inhibitory of ethanol absolute extract and ethanol 95% of M. Calabura against isolate clinical bacteria by Kirby Bauer method and the type of coumpund that contains in M.calabura leaf by thin layer chromatography utilizingeluen n-hexan- Methanol. Etanol absolute extract M.calabura leaf showing the average inhibition zone against Pseudomonas aeruginosa 15.67 mm, Staphylococcus aureus 19.33 mm and Escherichia coli 13 mm. While, The etanol extract 95% showing higher inhibition Pseudomonas aeruginosa 19.67 mm, Staphylococcus aureus 19.33 mm and Escherichia coli 16.67 mm. This inhibitory zone was slightly lower than chlorhexidine gluconate with an average of 20-24 mm against the three bacteria that utilized in the test but belongs to the strongly sensitive category for natural materials according to Mukherjee (1988). From thin layer chromatography profile with eluen n-hexan: methanol found three compounds that were in the range of Rf value 0.4; 0.5 and 0.7. The Conclusion for this study is the bioactive material from etanol 95% extract M.calabura leaf can be optimized to the hand sanitizer active compound candidate.

scholarly journals HS-SPME Combined with GC-MS/O to Analyze the Flavor of Strong Aroma Baijiu Daqu

Foods ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 116
Author(s):  
Zhe Wang ◽  
Song Wang ◽  
Pengfei Liao ◽  
Lu Chen ◽  
Jinyuan Sun ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Aromatic Compounds ◽  
Aroma Compounds ◽  
Aroma Profile ◽  
Maturity Stages ◽  
Flavor Components ◽  
Volatile Flavor ◽  
Different Types ◽  
Active Substances

Daqu has gained wide attention because it is an essential source of microorganisms and flavor in baijiu production. In this study, HS-SPME combined with GC-MS/O was used to analyze the volatile flavor components of Strong aroma baijiu Daqu. DI-GC-O was used to choose the best extraction fiber to extract the representative overall aroma profile of Daqu. A total of 139 compounds were identified in the six different maturity stages of Daqu, and these compounds are of different types and concentrations. HS-SPME combined with GC-MS/O was used to analyze the aroma active substances in the finished Daqu, and a total of 43 aroma compounds were identified. The OAVs of 21 aromatic compounds were calculated based on the quantitative analysis results of MHS-SPME. Eighteen compounds with OAVs ≥ 1 made significant contributions to the overall aroma of Daqu, including guaiacol, 4-ethyl-2-methoxy phenol, 2-ethyl-3,5-dimethylpyrazine, etc.

Sign in / Sign up

Export Citation Format

Share Document