scholarly journals PREPARATION OF CHITOSAN- SULFATHIAZOLE FILMS WITH POTENTIAL BIOMEDICAL APPLICATIONS

2018 ◽  
Vol 28 (2) ◽  
pp. 433-439
Author(s):  
Dilyana Zvezdova ◽  
Snezhina Georgieva
Keyword(s):  
Wound Healing ◽  
Water Absorption ◽  
Biomedical Applications ◽  
Transmission Rate ◽  
Composite Films ◽  
Absorption Capacity ◽  
Nanocomposite Films ◽  
Hydrophilic Nature ◽  
Folding Endurance ◽  
Positively Charged

A series of novel chitosan-zeolite-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. The physicochemical properties namely thickness, folding endurance, water absorption capacity, and water vapour transmission rate (WVTR) of the films were studied. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged zeolite and positively charged chitosan. The surface morphology of the prepared composite films was also studied by scanning electron microscopy (SEM). Due to strong hydrophilic nature of zeolite, it great lyenhances the water absorption capacities of the prepared nanocomposite films. In addition, the presence of zeolite in the said films also increases the mechanical strength. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

Application of self-healing, swellable and biodegradable polymers for wound treatment

2021 ◽  
Vol 30 (Sup9a) ◽  
pp. IVi-IVx
Author(s):  
Chukwuma O Agubata ◽  
Mary A Mbah ◽  
Paul A Akpa ◽  
Godwin Ugwu
Keyword(s):  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Biodegradable Polymers ◽  
Hydroxypropyl Methylcellulose ◽  
Composite Films ◽  
Self Healing ◽  
Moisture Uptake ◽  
Folding Endurance

Aim: Self-healing, swellable and biodegradable polymers are vital materials that may facilitate the different stages of wound healing. The aim of this research was to prepare wound healing films using self-healing polyvinyl alcohol (PVA), swellable hydroxypropyl methylcellulose (HPMC), biodegradable polyglycolic acid (PGA) sutures and ciprofloxacin antibiotic for improved treatment outcome. Methods: Films were formulated through aqueous-based mixing of varying amounts of polyvinyl alcohol (10–20% weight/weight (w/w)) and hydroxypropyl methylcellulose (0.5, 1% w/w) with fixed quantities of ciprofloxacin. PGA sutures were placed as grids within the wet mixtures of the polymers and ciprofloxacin, and thereafter products were air dried. The formulated films were evaluated for swelling ratio, breaking elongation, folding endurance, moisture uptake and loss, compatibility and in vitro antibiotic release. Furthermore, in vivo wound healing was studied using excision model and histopathological examinations. Results: Swelling ratios were above 1.0 and the films were minimally stretchable, with folding endurance greater than 500. Films were stable while moisture uptake and loss were observed to be less than 30%. Among the optimised hydrogel batches, those containing 10% w/w PVA and 1% w/w HPMC with no PGA showed the highest drug release of 73%, whereas the batches with higher PGA content showed higher percentage wound size reduction with minimal scar. The completeness of wound healing with batches containing PVA, HPMC, ciprofloxacin and PGA, along with the standard, is evident considering the massive cornification, regeneration of the epithelial front and stratum spinosum. Conclusion: The findings show that polymer-based multifunctional composite films are suitable for use as dressings for improved wound healing.

scholarly journals SUSTAINABLE CELLULOSE NANOCRYSTAL REINFORCED CHITOSAN/HPMC BIO-NANOCOMPOSITE FILMS CONTAINING MENTHOL OIL AS PACKAGING MATERIALS

2021 ◽  
Vol 55 (5-6) ◽  
pp. 649-658
Author(s):  
SALAH A. A. MOHAMED ◽  
AHMED SALAMA ◽  
MOHAMED EL-SAKHAWY ◽  
ABDELMAGEED M. OTHMAN
Keyword(s):  
Mechanical Properties ◽  
Water Absorption ◽  
Food Packaging ◽  
Hydroxypropyl Methylcellulose ◽  
Composite Films ◽  
Antibacterial Properties ◽  
Film Structure ◽  
Cellulose Nanocrystal ◽  
Nanocomposite Films ◽  
Low Oxygen

There is a growing demand to develop biodegradable composite films, with enhanced water resistance, antimicrobial activity, high mechanical properties and low oxygen permeability. In the present study, chitosan/hydroxypropyl methylcellulose (HPMC) films reinforced with cellulose nanocrystal (CNC) and containing menthol oil were prepared for food packaging applications. Menthol oil was selected due to its antibacterial properties, as well as relatively low cost and wide availability. CNC was prepared from bagasse via acid degradation. The bio-composites were prepared through a simple and versatile solution mixing and casting method. The morphology, chemical composition, water absorption, mechanical properties and antibacterial activity of the films were investigated. FTIR spectra were used to evaluate the film structure in terms of the interactions between components. Data showed that the addition of CNC improved the mechanical properties of the formed films and the menthol oil enhanced their antibacterial properties. HPMC and HPMC/CNC reduced the water absorption of the pure chitosan membrane from 70% to 22% and 9-11% by weight, respectively, which makes these constituents a good alternative for producing packaging.

Nanostructured superhydrophobic lyocell fabrics with asymmetric moisture absorbency: Moisture managing properties

2016 ◽  
Vol 87 (7) ◽  
pp. 807-815 ◽  
Author(s):  
Seong-ok Kwon ◽  
Jooyoun Kim ◽  
Myoung-Woon Moon ◽  
Chung Hee Park
Keyword(s):  
Water Absorption ◽  
Transmission Rate ◽  
Chemical Vapor ◽  
Absorption Capacity ◽  
Wound Dressings ◽  
Water Repellent ◽  
Water Contact ◽  
Moisture Management ◽  
Vertical Wicking ◽  
Opposite Face

This study investigated moisture management properties of a single-faced superhydrophobic fabric. A single-faced superhydrophobic lyocell fabric, where one face of the surface is superhydrophobic and the opposite face is hydrophilic, was produced by a two-step plasma process on one side of the fabric: (1) the addition of nano-scale roughness by 5 minutes of O2 plasma etching; (2) subsequent 30 seconds of plasma enhanced chemical vapor deposition with hexamethyldisiloxane to lower the surface energy of lyocell fibers. As a result, the superhydrophobic lyocell fabric exhibited water repellency with a static water contact angle greater than 161° on the treated surface, allowing water absorption from the untreated face. The nanometer depth of the superhydrophobic layer in the hydrophilic textile affected water absorption capacity, drying rate, vertical wicking rate, and moisture management properties. The air permeability and water vapor transmission rate of the superhydrophobic treated lyocell fabric were hardly changed. The superhydrophobic properties were maintained after a gentle wash cycle, although the level of superhydrophobicity was reduced, especially when it was washed with detergent. This superhydrophobic and moisture managing textile would be relevant for an application that requires a water repellent property on one face and water absorbing property on the opposite face, such as medical operation gowns, wound dressings, and hygienic products.

Preparation and Characterization of Cellulose Nanofiber/Zinc Oxide Composite Films

2020 ◽  
Vol 14 (2) ◽  
pp. 203-208 ◽  
Author(s):  
Xiuqiang Zhang ◽  
Suxia Ren ◽  
Xiaofeng He ◽  
Lili Dong ◽  
Wei Bai ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Biomedical Applications ◽  
Cellulose Nanofibers ◽  
Composite Films ◽  
Cellulose Nanofiber ◽  
Nanocomposite Films ◽  
Zno Films ◽  
X Ray Diffraction

Zinc oxide (ZnO)/cellulose nanofiber (CNF) nanocomposite films were prepared using cellulose nanofibers and ZnO nanoparticles. First, suspensions of CNF and ZnO mixtures were blended with different CNF/ZnO ratios; then, the mixtures were stirred, homogenized, filtered, and hot pressed to form nanofilms with various ZnO weight ratios (0–50 wt%). Rheological tests showed that the CNF shear thinning behavior was not affected by the addition of ZnO. X-ray diffraction and scanning electron microscopy studies proved the existence of ZnO nanoparticles in the nanocomposite films. Thermogravimetric results indicated that the presence of ZnO had almost no effect on the thermal properties of the composite. As the ZnO content increased, the tensile strength and strain-to-failure rate decreased. In comparison with neat CNF nanofilms, the nanocomposite films showed greater antimicrobial ability against Gram-positive Staphylococcus aureus due to the presence of ZnO nanoparticles, allowing the CNF/ZnO films to be used in some targeted biomedical applications.

scholarly journals Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials

2017 ◽  
Vol 19 (3) ◽  
pp. 255 ◽  
Author(s):  
I. Savitskaya ◽  
A. Kistaubayeva ◽  
I. Digel ◽  
D. Shokatayeva
Keyword(s):  
Bacterial Cellulose ◽  
Simple Procedure ◽  
Composite Films ◽  
Antibacterial Properties ◽  
Water Vapor Permeability ◽  
Absorption Capacity ◽  
Nanocomposite Films ◽  
Diffusion Method ◽  
Vapor Permeability ◽  
Degradation Temperature

New bacterial cellulose/chitosan (BC/Ch) nanocomposite films were obtained using a simple procedure by immersing BC synthesized by Komagataeibacter xylinus in 1% acetic acid solutions of Ch with the degree of deacetylation 75‒85% of medium molecular weight. The BC and BC/Ch composites chemical composition was examined by FTIR, the mechanical properties by a tensile tester, surface morphology by scanning electron microscopy, and antibacterial activity against S. aureus, E. coli and P. aeruginosa by diffusion and joint incubation methods. The FTIR spectra indicated the intermolecular interaction between BC and Ch. Due to addition of 0.6% (w/v) Ch, the films of BC/Ch become more homogeneous with a significantly denser fibril structure, smaller pore diameter and higher surface area in comparison to those of pure BC films. Micro- (15‒35 nm) and macrofibrils (50‒150 nm) in both BC and BC/Ch films are joined in ribbon-like fibers, providing a high degree of mechanical strength (Young’s modulus: 33‒36 MPa, tensile strength and elongation et break: 17, 22 MPa). The obtained hybrid material is transparent, flexible and displays good water absorption capacity and water vapor permeability. The films have reasonable thermal stability to be in contact with body or during steam sterilization, since maximum degradation temperature (Td) of both biocomposites is around 400‒600 °C. The disc diffusion method confirmed that the BC/Ch films have predominantly non-diffusible antibacterial properties. Antibacterial assessment by the joint incubation method proved that addition of Ch to BC films resulted in significant growth inhibition against target bacteria. The BC/Ch biocomposites’ notable properties make them suitable for wound healing applications.

APPLICATIONS OF CHITOSAN-SULFATHIAZOLE AS ANTIMICROBIAL AGENT

2018 ◽  
Vol 28 (2) ◽  
pp. 429-432
Author(s):  
Dilyana Zvezdova
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Antimicrobial Agent ◽  
Defense Mechanisms ◽  
Solvent Casting ◽  
Casting Method ◽  
Gram Negative ◽  
Positively Charged

Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

The effect of sugar beet fiber addition on the chemical properties of tortilla chips

2012 ◽  
pp. 385-388 ◽  
Author(s):  
Azadeh Saadatmandi ◽  
Mohammad Elahi ◽  
Reza Farhoosh ◽  
Mahdi Karimi
Keyword(s):  
Sugar Beet ◽  
Water Absorption ◽  
Protein Content ◽  
Chemical Properties ◽  
Absorption Capacity ◽  
Ash Content ◽  
Oil Absorption ◽  
Water Absorption Capacity ◽  
Overall Acceptability ◽  
Tortilla Chips

The incorporation of sugar beet fiber (0–5%) to tortilla chips and the effects on the chemical and sensory properties were studied. Addition of sugar beet fiber (SBF) led to an increasing of water absorption capacity, ash content and darkness while lowering the protein content and oil absorption. Sensory evaluation showed that the overall acceptability of tortilla chips reduces if adding more than 2% SBF.

Proximal and Functional Properties of Edible Ripened Split Beans of Coastal Wild Legume Canavalia maritima

2019 ◽  
Vol 15 (3) ◽  
pp. 228-233
Author(s):  
Prabhavathi Supriya ◽  
Kandikere R. Sridhar
Keyword(s):  
Water Absorption ◽  
Functional Properties ◽  
Crude Protein ◽  
Functional Foods ◽  
Protein Solubility ◽  
Calorific Value ◽  
Absorption Capacity ◽  
Total Lipids ◽  
Crude Fibre ◽  
Protein Rich

Background: Utilization of wild legumes has received prime importance in the recent past to compensate the scarcity of protein-rich foods as well as to tackle the protein energy malnutrition. Ripened split beans of Canavalia maritima devoid of seed coat and testa serve as traditional nutraceutical source for the coastal dwellers of Southwest India. Objective: The present study projects proximal and functional attributes of uncooked and cooked ripened split beans of C. maritima to be used in the preparation of functional foods. Methods: Proximal properties (moisture, crude protein, total lipids, crude fibre, carbohydrates and calorific value) and functional properties (protein solubility, gelation capacity, water-absorption, oilabsorption, emulsion qualities and foam qualities) of split beans were evaluated by standard methods. Results: Cooking did not significantly changed the crude protein, total lipids, ash, carbohydrates and calorific value, while it significantly increased the crude fibre. The protein solubility, water-absorption capacity, foam capacity and foam stability were significantly higher in uncooked than cooked beans. The cooked beans were superior to uncooked beans in least gelation concentration, low oil-absorption capacity, emulsion activity and emulsion stability. Conclusion: The functional properties of split bean flours were influenced by the proximal components like crude protein, total lipids and crude fibre. The energy-rich ripened split beans of C. maritima can serve as a new potential source for production of value added functional foods owing to their rich protein, rich carbohydrates, low-lipid and potential bioactive attributes.

scholarly journals Characteristics of Biodegradable Gelatin Methacrylate Hydrogel Designed to Improve Osteoinduction and Effect of Additional Binding of Tannic Acid on Hydrogel

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2535
Author(s):  
Ji-Bong Choi ◽  
Yu-Kyoung Kim ◽  
Seon-Mi Byeon ◽  
Jung-Eun Park ◽  
Tae-Sung Bae ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Water Absorption ◽  
Tannic Acid ◽  
Absorption Capacity ◽  
Animal Testing ◽  
High Concentration ◽  
Cell Compatibility ◽  
Property Evaluation ◽  
Bone Minerals ◽  
Cell Adhesion And Proliferation

In this study, a hydrogel using single and double crosslinking was prepared using GelMA, a natural polymer, and the effect was evaluated when the double crosslinked hydrogel and tannic acid were treated. The resulting hydrogel was subjected to physicochemical property evaluation, biocompatibility evaluation, and animal testing. The free radicals generated through APS/TEMED have a scaffold form with a porous structure in the hydrogel, and have a more stable structure through photo crosslinking. The double crosslinked hydrogel had improved mechanical strength and better results in cell compatibility tests than the single crosslinked group. Moreover, in the hydrogel transplanted into the femur of a rat, the double crosslinked group showed an osteoinductive response due to the attachment of bone minerals after 4 and 8 weeks, but the single crosslinked group did not show an osteoinductive response due to rapid degradation. Treatment with a high concentration of tannic acid showed significantly improved mechanical strength through H-bonding. However, cell adhesion and proliferation were limited compared to the untreated group due to the limitation of water absorption capacity, and no osteoinduction reaction was observed. As a result, it was confirmed that the treatment of high-concentration tannic acid significantly improved mechanical strength, but it was not a suitable method for improving bone induction due to the limitation of water absorption.

scholarly journals Effect of tungsten disulfide nanotubes on crystallization of polylactide under uniaxial deformation and annealing

2021 ◽  
Vol 2 (1) ◽  
Author(s):  
Fausta Loffredo ◽  
Loredana Tammaro ◽  
Tiziana Di Luccio ◽  
Carmela Borriello ◽  
Fulvia Villani ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Structural Evolution ◽  
Tungsten Disulfide ◽  
Fine Tuning ◽  
Nanocomposite Films ◽  
Uniaxial Deformation ◽  
Scanning Calorimetry ◽  
X Ray ◽  
X Ray Scattering

AbstractTungsten disulfide (WS2) nanotubes (NTs) are examined here as a filler for polylactide (PLA) for their ability to accelerate PLA crystallization and for their promising biocompatibility in relevant to biomedical applications of PLA-WS2 nanocomposites. In this work, we have studied the structural and thermal properties of PLA-WS2 nanocomposite films varying the concentration of WS2 NTs from 0 (neat PLA) to 0.6 wt%. The films were uniaxially drawn at 90 °C and annealed at the same temperature for 3 and 10 min. Using wide angle x-ray scattering, Raman spectroscopy and differential scanning calorimetry, we probed the effects of WS2 NT addition on the structure of the PLA films at various stages of processing (unstretched, stretching, annealing). We found that 0.6 wt% of WS2 induces the same level of crystallinity in as stretched PLA-WS2 as annealing in neat PLA for 10 min. These data provide useful insights into the role of WS2 NTs on the structural evolution of PLA-WS2 composites under uniaxial deformation, and extend their applicability to situations where fine tuning of PLA crystallinity is desirable.

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