scholarly journals Safety of Yamamoto New Scalp Acupuncture in Healthy Subjects and the Relationship Between Shoulder Stiffness, Diagnosis Points, and Stimulation Points

2021 ◽  
Vol 46 (2) ◽  
pp. 111-122
Author(s):  
Tetsuharu Kamiya ◽  
Takuya Suematsu ◽  
Fumiya Omata ◽  
Sachie Kasukabe ◽  
Manami Suzuki ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Subjective Evaluation ◽  
Pressure Pain Threshold ◽  
Objective Evaluation ◽  
Scalp Acupuncture ◽  
Shoulder Stiffness ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Post Hoc ◽  
The Relationship

Yamamoto New Scalp Acupuncture (YNSA) has been used in clinical practice for pain symptoms worldwide. However, the safety of YNSA and the role of the diagnosis and stimulation points have never been investigated. This study aimed to investigate the safety of YNSA and the relationship between the diagnosis points, the stimulation points, and changes in shoulder stiffness. YNSA was performed at the shoulder point A, acupuncture at the non-shoulder point D, and no intervention as a control in 15 healthy participants three times with a washout period of 1 week. Adverse reactions (changes in blood pressure, changes in heart rate, or bleeding), objective evaluation of the pressure pain threshold (PPT) and muscle hardness (MH) scores at the shoulder, and subjective evaluation of shoulder stiffness with a visual analog scale (VAS) were recorded before, during, and 20 min after stimulation. In the safety evaluation, no adverse reactions such as hypotension, bradycardia, or bleeding/hematoma were observed. PPT and MH revealed no significant difference between the conditions. There was a significant difference in the VAS between all three conditions (p = 0.039). Post-hoc analysis showed a significant difference between controls and D-point stimulation (p = 0.034), but no significant difference between A- and D-point stimulation. VAS subanalysis and post-hoc analysis in right-LI4-positive subjects (n = 4) showed a significant difference in VAS between A-point stimulation and controls (p = 0.01, 0.015, respectively). Our pilot investigation exhibited the safety of YNSA. Diagnosis and stimulation points may relate to changes in shoulder stiffness; however, further comparative studies with YNSA are required.

Validation of Several Methods of Estimating Maximal Oxygen Uptake in Young Men

1998 ◽  
Vol 87 (2) ◽  
pp. 575-584 ◽  
Author(s):  
Lars McNaughton ◽  
Phil Hall ◽  
Dean Cooley
Keyword(s):  
Young Men ◽  
Gas Analysis ◽  
Accurate Predictor ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Run Test ◽  
Post Hoc ◽  
The Relationship ◽  
Treadmill Protocol ◽  
Shuttle Run

The purpose of this study was to identify the most accurate predictor of VO2max from a variety of running tests. 32 young adult male undergraduates of (mean ± SE) age 20.14 ± 0.34 yr., height 179.4 ± 1.8 cm, weight 73.7±2.8 kg, and VO2max 57.89 ± 1.1 ml · kg−1 · min.−1 were randomly tested on four different predictive VO2max running tests to assess their actual VO2max, based on a continuous, progressive treadmill protocol and obtained via gas analysis. The four tests consisted of a treadmill jogging test, 1.5 mile run, Cooper's 12-min. run, and the 20-m progressive shuttle-run test. An analysis of variance applied to means indicated significance. Post hoc analysis between the means with correction by Scheffé showed significant difference between the predictive submaximal treadmill jogging test and the 12-min. run but no other difieren .es. The strength of the relationship between predictive tests and VO2max varied, wit1 the 12-min run having the highest correlation of .87, followed by the 1.5 mile rur .87, 20-m progressive shuttle run .82, and the treadmill jogging test .50. The 12-min. run had the highest correlation of all tests with VO2max in young men, with active to trained levels of fitness. The 1.5 mile and 20-m shuttle run also provided accurate predictions of VO2max and so should be used for an accurate prediction of young men's VO2max.

scholarly journals Using Wearable Cameras to Assess Foods and Beverages Omitted in 24 Hour Dietary Recalls and a Text Entry Food Record App

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1806
Author(s):  
Virginia Chan ◽  
Alyse Davies ◽  
Lyndal Wellard-Cole ◽  
Silvia Lu ◽  
Hoi Ng ◽  
...  
Keyword(s):  
Dietary Assessment ◽  
Fats And Oils ◽  
Point Of View ◽  
Self Report ◽  
Smartphone App ◽  
Food Record ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Post Hoc ◽  
Paired T Test

Technology-enhanced methods of dietary assessment may still face common limitations of self-report. This study aimed to assess foods and beverages omitted when both a 24 h recall and a smartphone app were used to assess dietary intake compared with camera images. For three consecutive days, young adults (18–30 years) wore an Autographer camera that took point-of-view images every 30 seconds. Over the same period, participants reported their diet in the app and completed daily 24 h recalls. Camera images were reviewed for food and beverages, then matched to the items reported in the 24 h recall and app. ANOVA (with post hoc analysis using Tukey Honest Significant Difference) and paired t-test were conducted. Discretionary snacks were frequently omitted by both methods (p < 0.001). Water was omitted more frequently in the app than in the camera images (p < 0.001) and 24 h recall (p < 0.001). Dairy and alternatives (p = 0.001), sugar-based products (p = 0.007), savoury sauces and condiments (p < 0.001), fats and oils (p < 0.001) and alcohol (p = 0.002) were more frequently omitted in the app than in the 24 h recall. The use of traditional self-report methods of assessing diet remains problematic even with the addition of technology and finding new objective methods that are not intrusive and are of low burden to participants remains a challenge.

scholarly journals The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Suvanjaa Sivalingam ◽  
Emil List Larsen ◽  
Daniel H. van Raalte ◽  
Marcel H. A. Muskiet ◽  
Mark M. Smits ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Nucleic Acid ◽  
Urinary Excretion ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Post Hoc

AbstractGlucagon-like peptide 1 receptor agonists have shown cardioprotective effects which have been suggested to be mediated through inhibition of oxidative stress. We investigated the effect of treatment with a glucagon-like peptide 1 receptor agonist (liraglutide) on oxidative stress measured as urinary nucleic acid oxidation in persons with type 2 diabetes. Post-hoc analysis of two independent, randomised, placebo-controlled and double-blinded clinical trials. In a cross-over study where persons with type 2 diabetes and microalbuminuria (LIRALBU, n = 32) received liraglutide (1.8 mg/day) or placebo for 12 weeks in random order, separated by 4 weeks of wash-out. In a parallel-grouped study where obese persons with type 2 diabetes (SAFEGUARD, n = 56) received liraglutide (1.8 mg/day), sitagliptin (100 mg/day) or placebo for 12 weeks. Endpoints were changes in the urinary markers of DNA oxidation (8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG)) and RNA oxidation [8-oxo-7,8-dihydroguanosine (8-oxoGuo)]. In LIRALBU, we observed no significant differences between treatment periods in urinary excretion of 8-oxodG [0.028 (standard error (SE): 0.17] nmol/mmol creatinine, p = 0.87) or of 8-oxoGuo [0.12 (0.12) nmol/mmol creatinine, p = 0.31]. In SAFEGUARD, excretion of 8-oxodG was not changed in the liraglutide group [2.8 (− 8.51; 15.49) %, p = 0.62] but a significant decline was demonstrated in the placebo group [12.6 (− 21.3; 3.1) %, p = 0.02], resulting in a relative increase in the liraglutide group compared to placebo (0.16 nmol/mmol creatinine, SE 0.07, p = 0.02). Treatment with sitagliptin compared to placebo demonstrated no significant difference (0.07 (0.07) nmol/mmol creatinine, p = 0.34). Nor were any significant differences for urinary excretion of 8-oxoGuo liraglutide vs placebo [0.09 (SE: 0.07) nmol/mmol creatinine, p = 0.19] or sitagliptin vs placebo [0.07 (SE: 0.07) nmol/mmol creatinine, p = 0.35] observed. This post-hoc analysis could not demonstrate a beneficial effect of 12 weeks of treatment with liraglutide or sitagliptin on oxidatively generated modifications of nucleic acid in persons with type 2 diabetes.

Could Be % MMEF and sGaw Determinant Diagnostic Parameters Between Partial Reversibility and Reversibility in Evaluating Short-Acting Bronchodilator Response?

2021 ◽  
Author(s):  
Gökhan Erdoğan ◽  
Elif Altuğ ◽  
Sacide Rana Işık ◽  
Levent Tabak
Keyword(s):  
Independent Predictor ◽  
Binary Logistic Regression ◽  
Threshold Value ◽  
Test Results ◽  
Binary Logistic Regression Model ◽  
Bronchodilator Response ◽  
Significant Difference ◽  
Post Hoc ◽  
The Relationship ◽  
Airway Conductance

INTRODUCTION: By examining the relationship between changes in maximum mild-expiratory flow( MMEF) and specific airway conductance(sGaw), parameters with the change in FEV1 when evaluating the spirometer test and the bronchodilator response, we investigated their diagnostic contribution to the bronchodilator response in those with partial responses to FEV1. METHODS: The retrospective study sample consists of data from 112 patients between Jun 1, 2019, and Feb 1, 2020 who applied to the pulmonary function laboratory with a pre-diagnosis of bronchial hyperreactivity as well as body plethysmography test performed together with the reversibility test. RESULTS: MMEF% and ▲sGaw were linearly correlated with ▲FEV1 (respectively r = 0.752; p <0.001, r = 0.611; p <0.001). While there was a significant difference between ▲MMEF% and ▲sGaw between reversible, partially reversible, and irreversible groups (P <0.001), there was no significant difference in ▲sGaw between partial reversible and reversible groups in post-hoc comparisons (P> 0.05). In the binary logistic regression model created between the partially reversible and reversible groups, demographic characteristics, MMEF% and ▲sGaw variables, ▲MMEF was an independent predictor [OR: 1.132; 95% CI (1.036-1.238), p = 0.006]. The 24% threshold for absolute reversibility or partial reversibility calculated with MMEF% was significant, indicating significance at 86.2% sensitivity and 80.8% specificity (AUC: 0.811, 95% CI: 0.686-0.936; p <0.001). This value we found defined 81% of the partially reversible group as reversible. DISCUSSION AND CONCLUSION: We observed that ▲sGaw alone didn' have a determinant contribution for determining reversibility in bronchodilator response, which showed partial reversibility with respect to FEV1 change. We believe that ▲MMEF% can be an independent predictor between these two groups and the calculated threshold value of 24% can be used as a criterion for determining the reversibility in cases where FEV1 is not determinant.

scholarly journals Diastolic function in patients with preeclampsia during pre- and post-partum period using tissue doppler imaging

2016 ◽  
Vol 25 (2) ◽  
pp. 93-7 ◽  
Author(s):  
I B Rangga Wibhuti ◽  
Amiliana M. Soesanto ◽  
Fahmi Shahab
Keyword(s):  
Diastolic Function ◽  
Tissue Doppler Imaging ◽  
Pregnancy Termination ◽  
Post Partum ◽  
Tissue Doppler ◽  
Doppler Imaging ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Post Partum Period ◽  
Post Hoc

Background: Prior studies have compared the E/e’ elevation in preeclampsia patients to normal patients, however there are no data whether this elevation persists after birth. The aim of this study is to analyze diastolic function in preeclampsia patients during pre- and post-partum period using E/e’ parameter measurement.Methods: This is a prospective cohort study of pregnant women with preeclampsia who were hospitalized and planned for pregnancy termination. Basic clinical characteristics were obtained from all samples. Echocardiography was done prepartum, 48-72 hours after termination, and 40-60 days postpartum. Post hoc analysis using least significant difference method was used to compare the results between measurements.Results: 30 subjects were enrolled in the study. Analysis on E/e’ characteristics showed statistical difference between prepartum E/e’ and 40 days postpartum E/e’ (11.87±3.184 vs 9.43±2.529, p=0.001, CI=1.123-3.751), as well as between 48 hours post-partum and 40 days post-partum period (12.12±2.754 vs 9.43±2.529, p<0.001, CI=1.615-3.771). There were no statistical differences between pre-partum E/e’ and 48 hours post-partum E/e’ (11.87±3.184 vs 12.12±2.754, p=0.633, CI=-1.345-0.832).Conclusion: This study showed diastolic dysfunction in preeclampsia patients persists up until a few days after birth, but resolves in time (40 days after birth) as measured by tissue doppler imaging.

scholarly journals The relationship between the expression of PLIN3 and PLIN5 protein flowing endurance training in streptozotocin rats

2019 ◽  
Vol 21 (4) ◽  
pp. 194-199
Author(s):  
Mahdi Ghafari ◽  
Ebrahim Banitalebi ◽  
Mohamad Faramarzi
Keyword(s):  
Insulin Resistance ◽  
Endurance Training ◽  
High Intensity ◽  
Training Group ◽  
Control Group ◽  
High Intensity Training ◽  
Significant Difference ◽  
Post Hoc ◽  
The Relationship ◽  
Intensity Training

Background and aims: Intermuscular lipolysis disorder plays an important role in insulin resistance and diabetes mellitus and perilipin PLIN5 and PLIN3 are the key proteins in regulating muscle cellular lipolysis. Therefore, the purpose of this study was to examine the relationship between the expression of PLIN3 and PLIN5 protein following endurance training in streptozotocin (STZ) rats. Methods: A number of 24 male Wistar rats were randomly divided into low endurance training group (n = 8), high-intensity training group (n = 8), and control group (n = 8). Diabetes was induced in every rat by STZ injection. Three days after injection, the blood samples were taken from the cut tip of the tails of the mice and animals with blood glucose greater than 300 mg/dL were considered diabetic. The training program included eight weeks of aerobic training at different intensities. Training in high- and low-intensity groups included 22-25 and 5-8 m/min of training. Finally, one-way analysis of variance (ANOVA) and correlation was used to determine the significance of the differences between variables, followed by utilizing Tukey’s post-hoc test for significance. Results: The comparison between the groups by ANOVA showed significant differences in PLIN3 (P=0.0006) and PLIN5 (P=0.012). The results of Tukey post hoc test also demonstrated a statistical difference between the mean values of diabetic control group and high-intensity endurance group regarding PLIN3 (P=0.01) and PLIN5 (P=0.009), but no significant increase was observed in the lowintensity exercise group as compared to the control group (PLIN3, P=0.067 & PLIN5, P=0.44). As regards insulin resistance, there was a significant difference among the three groups (P=0.0001). Eventually, the result of the correlation between PLIN3 and PLIN5 showed similar enhancement by increasing the intensity (P=0.0026). Conclusion: According to research results, high-intensity endurance training increased the expression of PLIN3 and PLIN5 in diabetic specimens and PLIN3 and PLIN5 followed a similar increase pattern in high-intensity training

Function and Knee Range of Motion Plateau Six Months following Lateral Tibial Plateau Fractures

2019 ◽  
Vol 33 (05) ◽  
pp. 481-485 ◽  
Author(s):  
Anthony V. Christiano ◽  
Christian A. Pean ◽  
David N. Kugelman ◽  
Sanjit R. Konda ◽  
Kenneth A. Egol
Keyword(s):  
Range Of Motion ◽  
Tibial Plateau ◽  
Tibial Plateau Fractures ◽  
Lateral Tibial Plateau ◽  
Post Hoc Analysis ◽  
Time Points ◽  
Significant Difference ◽  
Friedman's Test ◽  
Post Hoc ◽  
Bicondylar Tibial Plateau

AbstractThe purpose of this study is to determine when functional outcome no longer improves following tibial plateau fracture. A patient series of operatively treated tibial plateau fractures was reviewed. Patients were evaluated using the short musculoskeletal function assessment (SMFA), range of motion (ROM) assessment, and pain levels at visual analog scale (VAS) at 3, 6, and 12 months postoperatively. Fractures were classified by the Schatzker's classification using preoperative imaging. The case series was divided into two groups based on fracture patterns. Friedman's tests were conducted to determine if there were differences in SMFA, ROM, or VAS throughout the postoperative course. A total of 117 patients with tibial plateau fractures treated operatively, with complete follow-up and without complication, were identified. Seventy-seven patients (65.8%) sustained lateral tibial plateau fractures (Schatzker's I–III). Friedman's test demonstrated significant differences in SMFA (p < 0.0005) and ROM (p < 0.0005) at the three time points. Post hoc analysis demonstrated a significant difference in SMFA (p < 0.0005) and ROM (p = 0.003) between 3 and 6 months postoperatively but no significant difference in either metric between 6 and 12 months postoperatively. Friedman's test demonstrated no significant difference in VAS postoperatively (p = 0.210). Forty patients (34.2%) sustained medial or bicondylar tibial plateau fractures (Schatzker's IV–VI). Friedman's test demonstrated significant differences in SMFA (p < 0.0005) and ROM (p < 0.0005) at the three time points. Post hoc analysis demonstrated a strong trend toward significance in SMFA between 3 and 6 months postoperatively (p = 0.088), and demonstrated a significant difference between 6 and 12 months postoperatively (p = 0.013). ROM was found to be significantly different between 3 and 6 months postoperatively (p = 0.010), but no difference was found between 6 and 12 months postoperatively (p = 0.929). Friedman's test demonstrated no significant difference in VAS postoperatively (p = 0.941). In this cohort, no significant difference in function, ROM, or pain level exists between 6 and 12 months after treatment of lateral tibial plateau fractures. However, there are significant improvements in function for at least 1 year following medial or bicondylar tibial plateau fractures.

scholarly journals Contamination and washing of cloth masks and risk of infection among hospital health workers in Vietnam: a post hoc analysis of a randomised controlled trial

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e042045
Author(s):  
Chandini Raina MacIntyre ◽  
Tham Chi Dung ◽  
Abrar Ahmad Chughtai ◽  
Holly Seale ◽  
Bayzidur Rahman
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Poor Performance ◽  
Full Time ◽  
Risk Of Infection ◽  
Viral Contamination ◽  
Post Hoc Analysis ◽  
Significant Difference ◽  
Randomised Controlled ◽  
Post Hoc

BackgroundIn a previous randomised controlled trial (RCT) in hospital healthcare workers (HCWs), cloth masks resulted in a higher risk of respiratory infections compared with medical masks. This was the only published RCT of cloth masks at the time of the COVID-19 pandemic.ObjectiveTo do a post hoc analysis of unpublished data on mask washing and mask contamination from the original RCT to further understand poor performance of the two-layered cotton cloth mask used by HCWs in that RCT.Setting14 secondary-level/tertiary-level hospitals in Hanoi, Vietnam.ParticipantsA subgroup of 607 HCWs aged ≥18 years working full time in selected high-risk wards, who used a two-layered cloth mask and were part of a randomised controlled clinical trial comparing medical masks and cloth masks.InterventionWashing method for cloth masks (self-washing or hospital laundry). A substudy of contamination of a sample of 15 cloth and medical masks was also conducted.Outcome measureInfection rate over 4 weeks of follow up and viral contamination of masks tested by multiplex PCR.ResultsViral contamination with rhinovirus was identified on both used medical and cloth masks. Most HCW (77% of daily washing) self-washed their masks by hand. The risk of infection was more than double among HCW self-washing their masks compared with the hospital laundry (HR 2.04 (95% CI 1.03 to 4.00); p=0.04). There was no significant difference in infection between HCW who wore cloth masks washed in the hospital laundry compared with medical masks (p=0.5).ConclusionsUsing self-reported method of washing, we showed double the risk of infection with seasonal respiratory viruses if masks were self-washed by hand by HCWs. The majority of HCWs in the study reported hand-washing their mask themselves. This could explain the poor performance of two layered cloth masks, if the self-washing was inadequate. Cloth masks washed in the hospital laundry were as protective as medical masks. Both cloth and medical masks were contaminated, but only cloth masks were reused in the study, reiterating the importance of daily washing of reusable cloth masks using proper method. A well-washed cloth mask can be as protective as a medical mask.Trial resgistration numberACTRN12610000887077.

Vibration Transmissibility on Foot during Controlling and Operating Car Accelerator Pedal

2013 ◽  
Vol 471 ◽  
pp. 151-155
Author(s):  
A.R. Yusoff ◽  
Baba M. Deros ◽  
D.D.I Daruis
Keyword(s):  
Lower Extremity ◽  
Medium Size ◽  
Accelerator Pedal ◽  
Vehicle Engine ◽  
Large Size ◽  
Honestly Significant Difference ◽  
Significant Difference ◽  
Vibration Transmissibility ◽  
Post Hoc ◽  
The Relationship

The purpose of this paper is to discuss the vibration transmissibility from a cars body to pedal-pad, and the lower extremity, especially on the foot. The vibration transmissibility will occur when the foot interacts with the pedal-pad once the vehicle engine is turned on. The vibrations transmissibility will cause drivers discomfort, especially on the lower extremity due to fatigue and tiredness of the foot. The relationship between vibration transmissibility with the different sizes pedal-pad to the foot, and whether it can contribute to the foot discomfort during handling and controlling pedal-pad while driving is investigated. The variables are the different sizes of pedal-pad. Data was recorded from foot on three different sizes of pedal-pads. The data was measured in root mean square (r.m.s) unit, of the frequency weighted acceleration (m/s2) for every minute. The result for the foot-transmitted-vibration shows the ratio value of medium sized pedal-pad is greater than 1; compared to small sized and large sized pedal-pads which is less than 1. Analysis of One-way Anova shows that the mean of different sizes of pedal-pad is significant. Tukeyspost-hocwith HSD (Honestly Significant Difference) test on the foot transmitted-vibration proves that the means for medium size pedal-pad is the highest compared with the small and large size pedal-pads.

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