Effectiveness of Giving Secang Wood Extract (Caesalpinia Sappan L) Against IL-6 And IL-10 Levels in Balb / C Mice With Vulvovaginalis Candidiasis

2021 ◽  
Keyword(s):  
Caesalpinia Sappan ◽  
Wood Extract

scholarly journals EFEK PENAMBAHAN EKSTRAK KAYU SECANG (Caesalpinia sappan L.) DAN MINYAK IKAN LEMURU DALAM RANSUM PAKAN TERHADAP HEN DAY PRODUCTION, KONVERSI PAKAN, DAN MORTALITAS PUYUH PETELUR

2020 ◽  
Vol 14 (2) ◽  
pp. 1-8
Author(s):  
Anang Widigdyo ◽  
Adiguna Sasama Wahyu Utama
Keyword(s):  
Fish Oil ◽  
Egg Production ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Caesalpinia Sappan ◽  
Flavonoid Compounds ◽  
Randomized Design ◽  
Low Concentrations ◽  
Wood Extract ◽  
Completely Randomized Design

The purpose of this study was to evaluate the effect of giving levels of secang wood extract and lemuru fish oil on the appearance of laying quails which included feed consumption, Hen Day Production (HDP), feed conversion of quail egg mortality. This study used Autumn strain quail with a population of 168 individuals with basal feed supplemented with several levels of secang wood extract. This research method is an experiment using a completely randomized design (CRD) factorial with 4 treatments with 6 replications with each repetition consisting of 7 quails aged 10-15 weeks. The treatment was as follows: P0 = basal feed without the addition of secang wood extract P1 = basal feed + 0.2% EKS + 4% MIL, P2 = basal feed + 0.4% EKS + 4% MIL, P3 = basal feed + 0 , 6% EX + 4% MIL. The addition of a combination of secang wood extract and fish oil was carried out according to the level of quail feeding. The variable being measured; feed consumption, Hen Day Production (HDP), Feed conversion, mortality. Addition of secang wood extract with a level of 0%; 0.2%; 0.4%; 0.6%, and 4% lemuru fish oil had no significant effect on feed consumption, hen day production, feed conversion, mortality, this was due to flavonoids, polyphenols and active compounds in oil. lemuru fish does not affect the appearance of quail egg production. Flavonoid compounds in low concentrations have no effect on chicken feed consumption, because the content of flavonoid compounds can still be tolerated by the chicken body. The use of lemuru fish oil with a concentration of up to 6% in quails does not affect the consumption of quail feed, because the addition of lemuru fish oil does not affect the palatability of quail feed. The conclusion of this study was that the addition of secang wood extract. The addition of secang wood extract and lemuru fish oil did not affect hen day production, feed conversion and mortality of laying quails

scholarly journals KANDUNGAN SENYAWA FLAVONOID DAN ANTOSIANIN EKSTRAK KAYU SECANG (Caesalpinia sappan L.) SERTA AKTIVITAS ANTIBAKTERI TERHADAP Vibrio cholerae

2019 ◽  
Vol 8 (2) ◽  
pp. 216
Author(s):  
Ni Made Gress Rakasari Nomer ◽  
Agus Selamet Duniaji ◽  
Komang Ayu Nocianitri
Keyword(s):  
Experimental Design ◽  
Vibrio Cholerae ◽  
Optimal Concentration ◽  
Strong Inhibition ◽  
Design Study ◽  
Caesalpinia Sappan ◽  
Flavonoid Compounds ◽  
Wood Extract ◽  
Inhibitory Power

The aim of this research to determine the concentration of flavonoid and anthocyanin compounds in sappan wood extract (Caesalpinia sappan L.), as well as to determine the concentration of inhibitory power against the growth of Vibrio cholerae. This experimental design study uses 5 kind of concentration, which are 20%, 40%, 60%, 80%, 100%. The analysis were repeated 3 times and resulting in 15 experimental units. The data were presented in descriptive statistic with tables, drawings and discussed. The results showed that the extract of sappan wood contained flavonoid compounds of 6,02%, anthocyanin compounds of 2,43% and was able to inhibit the growth of Vibrio cholerae with optimal concentration at a concentration of 80% with an average 20,1 mm and very strong inhibition categories.

scholarly journals UJI SIFAT SENSORIS DAN AKTIVITAS ANTIOKSIDAN KOLANG-KALING DENGAN PENAMBAHAN EKSTRAK KAYU SECANG (Caesalpinia sappan L.) SEBAGAI PEWARNA ALAMI

2019 ◽  
Vol 8 (4) ◽  
pp. 368
Author(s):  
Dhimas Ridwan Thoyibi ◽  
Agus Selamet Duniaji ◽  
I Ketut Suter
Keyword(s):  
Experimental Data ◽  
Antioxidant Activity ◽  
Sensory Evaluation ◽  
Research Design ◽  
Duncan Multiple Range Test ◽  
Palm Fruit ◽  
Caesalpinia Sappan ◽  
Wood Extract ◽  
Sensory Color ◽  
Range Test

This study purpose to determine the effect of added sappan wood extract to be sugar palm fruit natural colored toward characteristic sensory evaluation, activities of antioxidant, and to know the best concentrate of sappan wood extract with higgest characteristic sensory and antioxidant. The research design was used Completely Randomize Design with 6 treated exctract concentrating which is 0% ; 2% ;  4% ; 6% ; 8% ; 10%. The treatment was repeated three times so that have 18 unit experimental. Data were analyzed by Analysis of  Variance (ANOVA) and then continued with Duncan Multiple Range Test (DMRT). Result of this shown that the extract concentrate have very significant effect towards activities antioxidant, and anthocyanin levels. Have significant effect towards color (hedonic test). Has not significant effect towards flavour, taste, and overall acceptance (hedonic test). Concentrate 10% was the best treatment for produce sugar palm fruit with characteristic sensory color (liked), taste (rather liked), flavour (liked) and overall acceptance (rather liked), the highest value of  antioxidant activitiest (based on IC50) 169.65 mg/ml, and anthocyanin 0.40 mg/100g. Keywords : sappan wood, sugar palm fruit, extraction, natural colored, antioxidant activity.

scholarly journals FORMULASI DAN EVALUASI FISIK KRIM KOSMETIK DENGAN VARIASI EKSTRAK KAYU SECANG (Caesalpinia sappan) DAN BEESWAX SUMBAWA

2020 ◽  
Vol 4 (2) ◽  
pp. 8-15
Author(s):  
Samuyus Nealma ◽  
Nurkholis
Keyword(s):  
Caesalpinia Sappan ◽  
Power Test ◽  
Average Value ◽  
Physical Evaluation ◽  
Organoleptic Test ◽  
Cream Formulation ◽  
A Value ◽  
Wood Extract

In this research, secang wood will be used as a cream using Sumbawa beeswax base. The purpose of this study was to obtain the best cream formulation with secang wood extract and beeswax. Cream formula is based on the concentration of secang extract 0.5-2.5 grams and beeswax 0.2-4 grams in 20 grams of the preparation. Determination of physical evaluation will be carried out several tests, namely organoleptic test, pH, adhesion, dispersal power and protective power. The results showed that all three formulas, Formulation 1 (F1) and F3 were homogeneous, while F2 was not homogeneous. In pH testing, all formulations 1,2 and 3 have an average pH of 6. And in organoleptic testing, F3 shows a score of 3.9 in form and is the highest compared to the two other formulations, F1 has a score of 2.8, F2 scores 2.2. Whereas in color organoleptic, the highest score is F3 with a score of 3.8, F1 score 2.8 and F3 score 2.2. And in odorless organoleptics, F1 has the highest score of 3.6, F3 score of 3.3 and F2 score of 2.7. In the scatter power test, F1 has an average value of 11.8, F2 with a value of 53.52 and F3 with a value of 11.68. F1, F2 and F3 adhesion tests have values ??of 2.3 seconds, 2.3 and 3.67, respectively. And in KOH protection testing all formulas show changes.

scholarly journals ANTI-MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV AND IRON CHELATION ACTIVITY OF SAPPAN WOOD EXTRACT (CAESALPINIA SAPPAN L.) IN VITRO

2018 ◽  
Vol 11 (6) ◽  
pp. 444
Author(s):  
Ratu Safitri ◽  
Ida Indrawati ◽  
Mas Rizky A A Syamsunarno ◽  
Mohammad Ghozali ◽  
Basri A Gani ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Inhibitory Concentration ◽  
Minimum Bactericidal Concentration ◽  
Iron Chelation ◽  
Iron Chelate ◽  
Caesalpinia Sappan ◽  
Lowenstein Jensen ◽  
Wood Extract ◽  
Strain H37rv

Objective: The objective of this study is to determine anti-Mycobacterium tuberculosis (MTB) strain H37Rv and iron chelation activities of sappan wood extract (SWE).Methods: The evaluation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) by proportion methods. Whereas the iron chelate in Lowenstein–Jensen (LJ) medium as the indicator of Mycobacterium growth and SWE effect.Results: The SWE has bacteriocidal to MTB of 10−3 and 10−5 dilutions in of all concentrations (250, 500, 750, 1000, 2000, 4000, 8000, and 16000 part per millions [ppm]) also bacteriostatic in concentration 50 and 100 ppm.Conclusion: The SWE at 100 ppm could inhibit 87% of the MTB in 10−3 and 10−5 dilutions, respectively, also to reduce to growth the colony of MTB, and has chelating effects of iron expression of LJ medium and MTB.

scholarly journals The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

2017 ◽  
Vol 3 (6) ◽  
pp. 497
Author(s):  
Ratu Safitri ◽  
Lelani Reniarti ◽  
Madihah Madihah ◽  
Lila Delia ◽  
Mas Rizky A.A Syamsunarno ◽  
...  
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Iron Overload ◽  
Rattus Norvegicus ◽  
Liver Weight ◽  
Iron Dextran ◽  
Morphological Abnormality ◽  
Caesalpinia Sappan ◽  
Liver Structure ◽  
Wood Extract

This research was carried out to detect the effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the liver structure of iron overload rat (Rattus norvegicus).The method of experimental used Completely Random Design (CRD in triple repetition. The treatment had been carried out orally. Iron dextran with total dose of 1.5 g kg-1 of body were given to rat on the first, fourth, seventh, ten and thirteenth day. Sappan Wood Extract (Caesalpinia sappan)200 mg kg-1 bw, 400 mg kg-1 bw, Wheat grass extract 100 mg kg-1 bw and Vitamin E 60 mg kg-1 bw were given to rat everyday for 15 days. At the seventeenth, rat were killed and their liver were taken. The observed parameters are morphological abnormality including the colour, the contour, ratio between liver weight and body weight as well as histological destruction. The result showed iron dextran treatment was proved the abnormality on morphological and histological desruction. Futhermore, Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment can decrease the morphological abnormality and the liver histological destructionon of iron overload rat. Keywords: Sappan Wood Extract, Wheat grass, Vitamin E, Iron, Morphological abnormality, Histological destruction

scholarly journals Production of Compact Powder Blush on from Secang Wood (Caesalpinia sappan L.) Extract

2020 ◽  
Vol 16 (2) ◽  
pp. 125
Author(s):  
Rety Setyawaty ◽  
Mela Dwiyanti ◽  
Dewanto Dewanto
Keyword(s):  
Room Temperature ◽  
Color Stability ◽  
Natural Dye ◽  
Isopropyl Myristate ◽  
Caesalpinia Sappan ◽  
Power Test ◽  
Natural Pigments ◽  
Local Resources ◽  
Compact Powder ◽  
Wood Extract

Secang wood (Caesalpinia sappan L.) is one of the local resources that contain natural pigments, namely brazilin. Brazilin is a pigment derived from Secang wood (Caesalpinia sappan L.) that is potentially used as a natural dye. This study aims to prove that Secang Wood (Caesalpinia sappan L.) can be applied as a dye in Compact Powder Blush On.The method for obtaining Secang wood (Caesalpinia sappan L.) extract uses the maceration extraction method with a sample of Secang wood (Caesalpinia sappan L.) of 250 gram and ethanol 96% then evaporated in a water bath with a temperature below 80 0C resulting in a yield of Secang wood (Caesalpinia sappan L.) extract of 27.87%. pH during the maceration process must be kept neutral, if it is not stable then it is added citric acid or sodium bicarbonate. The components of the Compact Powder Blush On are Talcum, Kaolin, Parrafin Liquid, Okside Zinc, Isopropyl myristate, and the addition of Secang wood extract (Caesalpinia sappan L.) with a concentration of 5%, 10%, 20%. Tests on preparations made include pH test, sticky power test, topical test, and stability test.The observations show that the Compact Powder Blush On preparation at a concentration of 5%, 10%, and 20% Secang wood extract (Caesalpinia sappan L.)  is pink, easily applied, has an average adhesion of 13.83%, produces a pink color when applying, and has a pH of 7. However, using Secang wood (Caesalpinia sappan L.) as a Blush On dye does not have color stability. Based on the results of the study it can be concluded that Secang Wood (Caesalpinia sappan L.) can be used as a natural dye Compact Powder Blush On, but additional ingredients are needed so that the color remains stable during storage at room temperature.

scholarly journals A FORMULATION OF ORALLY DISINTEGRATING SECANG (CAESALPINIA SAPPAN L.) TABLETS AS AN ANTIOXIDANT WITH HYDROXYPROPYL CELLULOSE AS A MASKING AGENT

2019 ◽  
pp. 236-241
Author(s):  
Resmi Mustarichie ◽  
DRADJAD PRIAMBODO
Keyword(s):  
Pharmaceutical Preparation ◽  
Research Work ◽  
Magnesium Stearate ◽  
Disintegration Time ◽  
Caesalpinia Sappan ◽  
Orally Disintegrating Tablets ◽  
Dpph Method ◽  
Ic50 Values ◽  
Wood Extract ◽  
Tablet Preparation

Objective: The objective of this research was to formulate Orally Disintegrating Tablets (ODT) preparations for secang (Caesalpinia sappan L.) wood extract as antioxidants that met the requirements as a pharmaceutical preparation. Methods: Three ODT formulas were made using the composition of the extract of secang wood, HPC-H, kollidon® CL, Avicel® PH 101, mannitol, acesulfame, magnesium stearate, citric acid, and menthol. The bitter taste of the extract of wood secang was covered with the Hydroxy Propyl Cellulose High Substitution (HPC-H) masking agent. Variations in HPC-H concentration were 4%, 4.5%, and 5%. The evaluation of tablet print mass tested included water content, flow velocity, and resting angle, real density, incompressible density, and compressibility. Evaluation of tablets tested included weight uniformity, uniformity of size, hardness, friability, and disintegration time. The tablet antioxidant activity testing was carried out by the Diphenylpicylhydrazyl (DPPH) method. Results: The results showed that all ODT formulas of secang wood extract were fulfilling the requirements as a tablet preparation according to Indonesian Pharmacopoeia IV. IC50 values ​​obtained from antioxidant testing on the three ODT formulas for a secang wood extract for formula I was 3.614 ppm, formula II was 3.464 ppm, formula III was 3.173 ppm, and the wood extract was 3.757 ppm. Conclusion: The results obtained in this research work clearly indicated ODT formulas of secang wood extract fulfilled Indonesian Pharmacopea IV requirement and belong to the category of very strong antioxidants because they have an IC50 value of less than 50 ppm.

scholarly journals Utilization of Secang (Caesalpinia Sappan L) Wood Extract in Optimization of Liquid Soap Formulation

2018 ◽  
Vol 15 (1) ◽  
pp. 1-7
Author(s):  
Dwi Saryanti ◽  
Iwan Setiawan
Keyword(s):  
Antibacterial Activity ◽  
Foam Stability ◽  
Physical Stability ◽  
Liquid Soap ◽  
Dry Skin ◽  
Optimal Method ◽  
Caesalpinia Sappan ◽  
Wood Extract ◽  
Optimal Formula

One of the plants used in traditional medicine is secang (Caesalpinia sappan L.). Liquid soap is now widely produced because of its practical use and better appearance. The use of anionic surfactants can cause irritation and dry skin due to strong binding of skin proteins. Cocamid DEA is used as nonionic surfactant in the liquid soap formulation to reduce the irritation caused by the anionic surfactant. The determination of optimal formula of secang wood extract liquid soap used D-optimal method by using parameter of pH test, viscosity, density and antibacterial activity. The organoleptic, pH, viscosity, density, antibacterial activity, foam stability, and physical stability of optimal formula were tested by cycling test. The ratio of sodium lauryl sulfate:cocamid DEA in optimal formula of secang wood extract liquid soap was (98.95: 1.05). The optimal formula of liquid soap has pH 4.6, viscosity 51.67 dPas, density 1.06 g / mL, antibacterial activity of Staphylococcus aureus 16.2 mm and foam stability 96.67%.

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