scholarly journals Isolation and structure elucidation of anti-malarial principles from Terminalia mantaly H. Perrier stem bark

2021 ◽  
Vol 15 (1) ◽  
pp. 282-292
Author(s):  
Babatunde Samuel ◽  
Yemi Adekola Adekunle
Keyword(s):  
Statistical Significance ◽  
Solvent System ◽  
Stem Bark ◽  
P Value ◽  
Resonance Spectroscopy ◽  
Global Public Health ◽  
1H And 13C Nmr ◽  
Malaria Therapy ◽  
Student’S T

Emergence of malaria parasite resistance to drugs has raised global public health concerns for a compelling need to develop improved malaria therapy. This study is a bio-guided isolation of triterpenoid antimalarial compounds from Terminalia mantaly. Methanol extract of the plant was subjected to column chromatography, and eluted with a ternary solvent system gradient-wise. Two compounds, 1 and 2, were isolated and characterised by spectroscopic data (IR, 1H and 13C NMR, COSY, HMQC, HMBC) and by comparison with literature. Isolated compounds were investigated for antimalarial property by spectrophotometric determination of inhibition of β-Hematin formation, absorbance taken at 405 nm. Results were analysed using Graghpad Prism® (6.0) and presented as mean IC50±SEM. Statistical significance, determined using Student’s t-test and one-way ANOVA, set at p-value of 0.05. Quantitative β-Hematin formation inhibitory activities gave IC50±SEM values of (compound 1; 4.434±0.47), (compound 2; 5.140±4.2) with (chloroquine; 0.335±0.1 mg/ml). Compound 1 was identified as 2,3,19,23-tetrahydroxyolean-12-en-28-oic acid glucopyranoside (arjunglucoside I), and compound2 as its aglycone, 2,3,19,23-tetrahydroxyolean-12-en-28-oic acid (arjungenin). This study provided credence for folkloric use of Terminalia mantaly to treat malaria, and this observed activity was probably due to these isolated triterpenoids.Keywords: β-Hematin, triterpenoids, nuclear magnetic resonance spectroscopy

scholarly journals Substance Use: Prevalence, Pattern and Risk Factors among Undergraduate Students in a Tertiary Institution in Southwest Nigeria

2021 ◽  
Vol 33 (2) ◽  
pp. 83-99
Author(s):  
K.A. Durowade ◽  
O.E. Elegbede ◽  
G.B. Pius-Imue ◽  
A. Omeiza ◽  
M. Bello ◽  
...  
Keyword(s):  
Risk Factors ◽  
Substance Use ◽  
Secondary Education ◽  
Undergraduate Students ◽  
Statistical Significance ◽  
Public Health Problem ◽  
Peer Pressure ◽  
Civil Servant ◽  
P Value ◽  
Global Public Health

Background: Substance use is a global public health problem with increasing burden among university students. This study assessed the prevalence, pattern and risk factors of substance use among undergraduate students of Afe Babalola University, Ado-Ekiti, Nigeria.Methods: This was a cross-sectional study of undergraduate students of Afe Babalola University, Ado-Ekiti. A multi-stage sampling technique was used to select respondents. Data collection tool was a structured self-administered questionnaire. Data analysis was done using Statistical Package for the Social Sciences (SPSS) version 23. Statistical significance was set at p value <0.05Results: The respondents’ mean age was 19.5 ± 2.0 years and all 416 (100.0%) were aware of substance abuse. The prevalence of substance use was 299 (71.9%). Alcohol 133 (32.0%) and over-the-counter drugs (29.9%) were the two most commonly used substance. Being male (p=0.017) and in 400 level (p=0.047) were associated with substance use while curiosity 112 (37.5%), peer pressure 95 (31.8%) and school stress 85 (28.4%) were reasons given. Predictors of substance use were being a female (aOR: 2.54; 95% CI=1.89-3.66; p=0.011), civil servant mother (aOR: 5.75; 95% CI=1.90-17.4; p=0.002) and mother with secondary education (aOR: 5.27; 95% CI= 2.20- 12.65; p<0.001).Conclusion: There was high prevalence of substance use with curiosity, peer pressure and school stress being influencers of substance use among the study population. Predictors of substance use were being a female, civil servant mother and mother with secondary education. The University authority should institute measures to prevent access to alcohol and other substances by the students.

Galectin-1 and -3 contents in primary and reccurent nasal and paranasal sinus polyps

2019 ◽  
Vol 73 (6) ◽  
pp. 1-5
Author(s):  
Jarosław Markowski ◽  
Krzysztof Siemianowicz ◽  
Wirginia Likus
Keyword(s):  
Surgical Treatment ◽  
Paranasal Sinus ◽  
Statistical Significance ◽  
P Value ◽  
Cancer Tissue ◽  
Benign Lesions ◽  
Galectin 3 ◽  
Clinical Surveillance

Introduction: Nasal and paranasal sinus polyps are one of the most common laryngological problems. Often, despite surgical treatment of nasal and paranasal sinus polyps, they grow back and require surgical retreatment. It is very difficult to predict which patients are particularly exposed to it. Markers are still being sought to predict which patients are particularly exposed to regrowth of polyps and thus require increased clinical surveillance. Galectins are a group of glycoproteins that have been intensively studied recently. The sugar part of these proteins can play a role in transmitting intercellular signals. Laryngologists are especially interested in galectins-1 and-3. The determination of their increased content in cancer tissue is considered as a marker of malignancy, which worsens prognosis in patients. Recently, more and more attention has been paid to the role of galectins in benign lesions, and such are the nasal and paranasal sinus polyps. Materials and methods: In our work, the contents of galectin-1 and-3 were determined in the tissue of the surgically removed primary (n = 35) and recurrent polyps (n = 15). Results: The content of galectin-1 and-3 showed no statistically significant differences between primary and recurrent polyps. Conclusions: The content of galectin-3 was lower in recurrent polyps, however the observed difference did not reach statistical significance (p = 0.07). Since the obtained "p" value is close to the significance limit, it is advisable to broaden the submitted studies to a larger group of patients in order to be able to fully assess whether the determination of the content of galectin-3 may be helpful in assessing the risk of recurrence of nasal and paranasal sinus polyps.

Comparing Platelet Loss in 2 Common Apheresis Machines for Collecting Autologous Peripheral Blood Stem Cells (PBSC).

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5261-5261
Author(s):  
Ping Law ◽  
Fathalha Yasir ◽  
Joanna K.Y. Mah ◽  
Teck Guan Soh ◽  
Susan T.T. Lim ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Statistical Significance ◽  
Autologous Transplantation ◽  
Blood Platelet ◽  
P Value ◽  
Peripheral Blood Stem Cells ◽  
Cd34 Cells ◽  
Blood Stem Cells ◽  
Student’S T ◽  
Automated Procedures

Abstract Chemotherapy together with G-CSF is commonly used to mobilize patients prior to leukapheresis (LP) of PBSC for autologous transplantation. For many patients, peripheral blood platelet counts (PLT) were below 75,000/μl when LP was initiated. Minimizing PLT loss is an important consideration, especially for these patients. The aim of this retrospective analysis is to compare PLT loss during LP for autologous PBSC in two common apheresis machines (Baxter Amicus and Cobe Spectra). Between August 2004 and May 2005, 57 autologous PBSC products were collected from 28 adult patients (weight &gt; 40 kg) with results (mean ± SD) summarized in Table 1. LP were collected using automated procedures and 3 times blood volume was processed. Collection efficiencies (EFF) were calculated as total cells (CD34+ or PLT) in product divided by the circulating count prior to LP times processed volume. Statistical significance was determined by unpaired Student’s t-test. There were no significant differences (p &gt; 0.1) (NS) in patient age, weight, CD34+ cell count (data not shown) and PLT count prior to LP. There were also no differences in the proportion and the total CD34+ cells in the PBSC products collected by either machines. While both devices collected CD34+ cells with similar EFF (data not shown), the Amicus PBSC products have a trend (p = 0.08 and 0.07 when all LP or only those initiated with PLT count below 75,000/μl, respectively)towards a smaller volume (VOL) and contained significantly (p &lt; 0.05) fewer PLT than those collected by Spectra. The PLT EFF was also significantly lower with Amicus, indicating a smaller PLT loss. The same findings were observed whether all LP or only those LP initiated with low PLT counts (&lt; 75, 000/μl) were considered. Our results showed that lower PLT loss is achieved with Amicus during autologous PBSC collection. The machine would be more appropriate for collecting patients with low PLT counts. Table 1: PLT Loss during Autologous PBSC Collection in Amicus or Spectra N Pre LP PLT (x103/μ l) LP VOL (ml) LP Total PLT (x1010) PLT EFF (%) ALL LP Spectra 17 49.5 ± 20.2 178.0 ± 41.7 8.7 ± 3.5 17.6 ± 16.9 Amicus 40 57.0 ± 32.9 164.5 ± 16.5 6.8 ± 2.6 8.4 ± 4.1 p value NS ≤ 0.08 ≤0.05 ≤0.05 Low PLT Spectra 17 49.5 ± 20.2 178.0 ± 41.7 8.7 ± 3.5 17.6 ± 16.9 Amicus 35 46.8 ± 15.4 162.9 ± 16.8 6.5 ± 2.4 9.0 ± 3.9 p value NS 0.07 ≤ 0.05 ≤ 0.05

P6203Intramyocellular lipid saturation as a new metabolic biomarker

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
A M Mezincescu ◽  
T Ahearn ◽  
A E Rudd ◽  
L Cheyne ◽  
C Scally ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Exercise Training ◽  
Exercise Intervention ◽  
Vastus Lateralis ◽  
Statistical Significance ◽  
Degree Of Saturation ◽  
P Value ◽  
Water Suppression ◽  
Resonance Spectroscopy ◽  
1H Mrs

Abstract Background Endurance trained athletic healthy volunteers (Athl-HV) and type 2 diabetes patients (T2D) have higher levels of lipids in their skeletal myocytes compared to healthy controls. Despite apparently similar metabolic storage, they are at opposite ends of insulin sensitivity and cardio-metabolic risk. Purpose We investigated if the degree of saturation of the IntraMyoCellular Lipids (IMCL) will differentiate Athl-HV from T2D; and explored if an exercise intervention will induce changes in the IMCL saturation. Methods Male, age matched Athl-HV and T2D were enrolled (n=25/group). Athl-HV had ≥5 years endurance training, T2D were sedentary. Subjects were studied at baseline and after an exercise intervention (4 week deconditioning in Athl-HV and supervised bike training at ≥65% of peakVO2, 5 hours/week x 8 weeks in T2D). All subjects underwent cardio-pulmonary exercise testing (CPET), blood sampling for insulin sensitivity (QUICKI*) and single voxel 1H-magnetic resonance spectroscopy (1H-MRS) of the right vastus lateralis. 1H-MRS was acquired on 3T Philips Achieva with a 16-channel coil, point-resolved spectroscopy, variable pulse power and optimized relaxation delay water suppression and analysed in LCModel. We derived fractional lipid mass (fLM) and fractions of saturated (fSL) and unsaturated (fUL) lipids. Data were analysed by t tests, shown as mean±SEM, statistical significance p<0.05. Results CPET and insulin sensitivity are presented in Table 1. T2D had higher fLM in the skeletal muscle compared to Athl-HV, at baseline (p=0.003) and after the exercise intervention (p=0.009), Figure 1A. At baseline, T2D had a different phenotype with a lower fSL and higher fUL compared to Athl-HV (82±3 vs 88±1% and 18±3 vs 12±1%, p=0.02 for both). Whilst deconditioning did not attract any significant changes in either fSL or fUL in Athl-HV (88±1 to 86±1% and 12±1 to 14±1, p=0.2), in contrast, with exercise training T2D significantly increased fSL (82±3 to 88±1%) and decreased their fUL (18±3 to 12±1%) (both p=0.01). Figure 1B and 1C. CPET and insulin sensitivity results Athl-HV Baseline Athl-HV Deconditioning p value T2D Baseline T2D After Training p value VO2 peak, (mL/kg/min) 45.0±0.9† 41.7±0.9‡ <0.0001 23.6±0.6† 30.3±0.6‡ <0.0001 QUICKI* 0.346±0.002† 0.343±0.003‡ 0.2 0.308±0.004† 0.317±0.004‡ 0.02 *QUICKI: Quantitative Insulin Sensitivity Check Index; †Athl-HV vs T2D at baseline p≤0.001, ‡Athl-HV vs T2D after exercise intervention p≤0.001. Figure 1 Conclusion We demonstrate for the first time, in vivo, significant differences in the IMCL amount and saturation between Athl-HV and T2D. IMCL saturation was changed by exercise training in T2D to mirror the phenotype seen in Athl-HV uncovering a new, independent biomarker of improved cardio-metabolic health. Acknowledgement/Funding British Heart Foundation Project Grant no. PG/15/88/31780

scholarly journals APPENDECTOMY

2011 ◽  
Vol 18 (01) ◽  
pp. 97-101
Author(s):  
ZULFIQAR ALI ◽  
TANVEER AHMAD ◽  
IRSHAD AHMAD ◽  
Muhammad Suhail Amir ◽  
AG Rehan
Keyword(s):  
Acute Appendicitis ◽  
Statistical Significance ◽  
Operating Time ◽  
Laparoscopic Appendicectomy ◽  
P Value ◽  
Continuous Variables ◽  
Open Appendicectomy ◽  
Chi Square ◽  
Student’S T ◽  
Study Setting

Objective: The aim of this study was to compare the outcomes and morbidities of laparoscopic appendicectomy (LA) and open appendicectomy (OA) in patients with acute appendicitis. Design: Interventional study. Setting: The study was conducted at Madina Teaching Hospital, University Medical & Dental College, Faisalabad. Period: From June 2007 to August 2009. Materials and Methods: The study group consisted of two hundred patients suffering from acute appendicitis. One hundred patients underwent LA and one hundred patients underwent OA. Comparison was based on operating time, complications, requirements for postoperative analgesia, time until resumption to regular diet, hospital stay, and return to full activity in days. Comparisons were made between continuous variables using Student’s t test of the means and were made between proportions using Fischer’s exact or chi-square testing where appropriate. Statistical significance was taken to be a p value of .05 or less. Results: Of the hundred patients, five patients (5%) had the procedure converted to open surgery. The rate of infection was significantly lower in patients undergoing LA. The median length of stay was significantly shorter after LA (2 days after LA, 5 days after OA, P < 0.05) than after OA. The operating time was shorter {OA: 25 min (median), LA: 30 min (median), P > .05} in patients undergoing open appendicectomy compared to laparoscopic appendicectomy. Conclusion: LA is associated with increased clinical comfort in terms of fewer wound infections, faster recovery, earlier return to work and improved cosmesis.

scholarly journals Prevalence of Hypertension and Its Associated Factors among Adults in Selected Areas of Bangladesh: A Community Based Cross-sectional Study

2021 ◽  
Vol 10 (6) ◽  
pp. 56
Author(s):  
Nahian Rahman ◽  
Syeda Saima Alam ◽  
Shaidaton Nisha ◽  
Faroque Md Mohsin ◽  
Mahmudul Mannan ◽  
...  
Keyword(s):  
Associated Factors ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
P Value ◽  
Global Public Health ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Bivariate Logistic Regression ◽  
Physiological Risk

Background: Hypertension is a silent killer and an overwhelming global public health challenge. This study aimed to determine the prevalence and associated factors of hypertension among adults in Bangladesh. Methods: A community-based cross-sectional study design was conducted among 400 adults who lived in Dhaka, Mymensing, Sylhet and Khulna District. Data were collected using a structured questionnaire that is adapted from the WHO Stepwise approach. Data was analyzed by SPSS version 25. Descriptive statistics and bivariate logistic regression analysis were conducted and statistical significance was declared at a p-value &le;0.05. Results: This study identified a high prevalence of hypertension in the study area and it was 39.75%. Among the male the prevalence was 23.5% and the prevalence was 16.5% among female. In this study hypertension was significantly associated with the age group 51-65 years (OR=1.02; CI 0.557-1.862) , ever smoking (OR= 2.59; CI 1.718-3.917) consume&nbsp; less fruits (OR=3.125; CI 0.839-11.632) and vegetable (OR=2.25; CI 1.364-3.725), physically inactive (OR=1.48;CI 0.973-2.252) overweight (OR=7.98; CI 4.612-13.793) and had diabetes mellitus (0R=2.38; CI 1.213-4.659). Conclusion: The prevalence of hypertension was considerably higher in this study area. Hence, the health care system needs to establish strategies to improve the diagnostic and screening services. Community-level intervention and regular assessment, screening, and diagnosis of behavioral, socio-demographic, and physiological risk factors, screening, should be institutionalized to address the occult burden of hypertension.

scholarly journals Effect of carboplatin on malondialdehyde as a marker of lipoderoxidation in the submandibular gland of rats

2021 ◽  
Vol 31 (2) ◽  
pp. 9-13
Author(s):  
E Bachmeier ◽  
◽  
ME Migueles Goitea ◽  
JA Linares ◽  
EG Ferreyra Mariani ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Wistar Rats ◽  
Statistical Significance ◽  
Control Group ◽  
P Value ◽  
Sod Activity ◽  
Paired Samples ◽  
Randomized Design ◽  
Male Wistar Rats ◽  
Student’S T

The objective of the present work was to evaluate the effect of carboplatin (Cp) on submandibular gland homogenate of Wistar rats through the determination of malondialdehyde levels, as the main end product of lipoperoxidation, in an experimental model.Sixteen three-month-old male Wistar rats were used, housed in individual cages, with controlled temperature and lighting and free diet. A completely randomized design was used and two experimental groups were established: 1) Control (C), administering an intraperitoneal dose of saline solution for one day, n: 8, 2) Animals treated with carboplatin (Cp) applying a dose i.p. of 100 mg / Kg of body weight for one day, n: 8. The animals were fasted for 24 hours and subsequently anesthetized. Then both submandibular glands were removed. Malondialdehyde levels were analyzed in submandibular gland homogenatein both experimental groups. Variations between the groups analyzed were evaluated using the Student's t test for paired samples, setting a p-value <0.05 for statistical significance. Project approved by CICUAL. Faculty of Medical Sciences (UNC).The group of Rats Co showed a concentration of 7.32± 0.48μmol / mg of gland. The Cp group had a concentration of 12.57 ± 0.71 μmol / mg of gland, expressing a significant decrease compared to the control group p <0.0006. Cp at the dose tested would cause a decrease in lipoperoxidation in the submandibular gland of rats. Possibly the glandular antioxidant battery would neutralize the oxidative stress of acinar cells. These results suggest a future evaluation of superoxide dismutase (SOD) activity and uric acid (UA) levels

scholarly journals ISOLATION AND IDENTIFICATION OF NON-POLAR CHEMICAL ENTITY FROM LEPTADENIA RETICULATA AERIAL PARTS

2019 ◽  
pp. 226-229
Author(s):  
JAYESH DHALANI ◽  
PANKAJ NARIYA
Keyword(s):  
Biological Activities ◽  
Petroleum Ether Extract ◽  
Stem Bark ◽  
Chemical Entity ◽  
Resonance Spectroscopy ◽  
Chromatographic Technique ◽  
Isolation And Identification ◽  
Aerial Parts ◽  
Phytochemical Constituents

Objective: Leptadenia reticulata is the medicinal plant having many biological activities. It is necessary to find out which types of phytochemical constituents are present in the plant. The objective of this investigation was to isolate and identify the non-polar chemical entity of the areal parts of L. reticulata a plant used for medicinal purpose in folklore. Methods: Petroleum ether extract of the stem bark was used for this study. Non-polar solvent was used to extract non-polar chemical entity from areal parts of leptadeniareticulata. Through the saponification process, saponifiable and unsaponifiable matter was separated. Phytochemical constituents were separated using column chromatography. Separated fractions were analyzed on gas chromatography and mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR). Results: Hentriacontane compound was isolated and confirmed from GC-MS and NMR whereas phytol, Lupeol, β-amyrin, Campesterol, Stigmasterol, gamma-sitosterol identified through GC and mass spectroscopy. Conclusion: The present study showed that L. reticulata areal parts three sterols chemical entity Campesterol, Stigmasterol, gamma-sitosterol and phytol (diterpene alcohol), lupeol (triterpenoid), beta-amyrin (triterpene), and hentriacontane (alkane hydrocarbon). Core determination of the experiment was the development efficient method to isolate or identify the non-polar chemical entity through chromatographic technique.

scholarly journals 3071 Cell Survival in Corneal Endothelial Dystrophies

2019 ◽  
Vol 3 (s1) ◽  
pp. 4-4
Author(s):  
Rajalekshmy Shyam ◽  
Diego Ogando ◽  
Moonjung Choi ◽  
Joseph Bonanno
Keyword(s):  
Cell Survival ◽  
Signaling Pathways ◽  
Cell Metabolism ◽  
Statistical Significance ◽  
P Value ◽  
Autophagy Flux ◽  
Western Blots ◽  
Future Studies ◽  
Student’S T ◽  
Mitotracker Green

OBJECTIVES/SPECIFIC AIMS: Purpose - The goal of this study is to understand how loss of the membrane protein SLC4A11 alters endothelial cell metabolism thereby producing Corneal Endothelial Dystrophy. Studies from our lab indicated that glutamine-dependent mitochondrial dysfunction is one of the outcomes of SLC4a11 loss. In the current study, we ask if autophagy and mitophagy pathways and the signaling pathways that regulate these processes are altered in SLC4a11 KO cells. METHODS/STUDY POPULATION: Methods – Immortalized mouse WT and SLC4a11 KO cell lines were incubated in DMEM with and without 0.5mM glutamine for 6 hours. In order to assess mitophagy, cells were stained using Lysotracker Red and Mitotracker Green. Colocalization co-efficients of red and green channels were obtained for at least 35 cells using Zeiss-Zen Pro software. Student’s t-test was used to determine statistical significance. For Western Blots, antibodies against LC3b, AMPK, pAMPK, and b-actin were used to examine autophagy flux and potential signaling pathways that regulate autophagy. RESULTS/ANTICIPATED RESULTS: Results – In the presence of glutamine, the colocalization co-efficient of Lysotracker Red and Mitotracker Green channels was significantly increased in KO cells (0.74 ±0.18) relative to WT (0.58±0.20) with a p-value ≤0.0024. In the absence of glutamine, the colocalization co-efficient was reversed, for KO cells 0.54 ±0.14 and for WT cells 0.77±0.0.16 with a p-value ≤0.0001, suggesting increased mitophagy by glutamine in KO cells. Western Blots indicated that glutamine increased autophagy flux, as indicated by increased levels of LC3b following bafilomycin A treatment in KO cells. Concomitantly, there was an increase in pAMPK/AMPK levels suggesting a potential mechanism for increased mitophagy. DISCUSSION/SIGNIFICANCE OF IMPACT: Conclusion and Future studies –Our data indicates enhanced mitophagy as well as autophagy in SLC4a11 KO cells. Future studies will determine whether these processes regulate cell survival in mouse models of corneal endothelial dystrophies.

SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pawan Kumar Saini ◽  
Devendra Yadav ◽  
Rozy Badyal ◽  
Suresh Jain ◽  
Arti Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Prolactin Level ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
R Value ◽  
Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes.  Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant  correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

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