scholarly journals E2, an Aquatic Hazard Worldwide

2016 ◽  
Vol 8 (10) ◽  
pp. 147
Author(s):  
Nagwa Elnwishy ◽  
Nada Sedky
Keyword(s):  
Biological Significance ◽  
Endocrine System ◽  
Pharmaceutical Products ◽  
Domestic Sewage ◽  
Aquatic Life ◽  
Men And Women ◽  
Adverse Health Effects ◽  
Surrounding Environment ◽  
Intact Organism ◽  
Exogenous Agents

<p>Endocrine disruptors are defined as exogenous agents that alter the function of endocrine system, which in turn, causes adverse health effects in an intact organism or its progeny. Of these compounds, 17Beta-estradiol is of primary importance, since it is physiologically present in both men and women, as well as, being produced synthetically as a component in some pharmaceutical products. Once it reaches the aquatic environment through domestic sewage, ground water and streams, it makes a serious threat to the aquatic life. The review tackles the biological significance of these compounds as well as the danger that they present to the surrounding environment, areas at which these compounds have been detected worldwide, the methods used in detection and fundamentally significant solutions to get rid of this hazard using different methods such as; the bioremediation process.</p>

scholarly journals Sexual unfaithfulness can be judged with some accuracy from men's but not women's faces

2019 ◽  
Vol 6 (4) ◽  
pp. 181552 ◽  
Author(s):  
Yong Zhi Foo ◽  
Antonina Loncarevic ◽  
Leigh W. Simmons ◽  
Clare A. M. Sutherland ◽  
Gillian Rhodes
Keyword(s):  
Biological Significance ◽  
Mate Guarding ◽  
Mating Strategies ◽  
Reproductive Costs ◽  
Same Sex ◽  
Short Term ◽  
Men And Women ◽  
Facial Masculinity ◽  
Opposite Sex

We routinely make judgements of trustworthiness from the faces of others. However, the accuracy of such judgements remains contentious. An important context for trustworthiness judgements is sexual unfaithfulness. Accuracy in sexual unfaithfulness judgements may be adaptive for avoiding reproductive costs associated with having an unfaithful partner. Indeed, emerging studies suggest that women, and to a lesser degree, men, show above-chance accuracy in judging sexual unfaithfulness from opposite-sex faces. In the context of mate guarding, it is important not only to assess the likelihood of a partner defecting, but also to detect same-sex poachers. Therefore, here, we examine whether individuals can also judge sexual unfaithfulness (self-reported cheating and poaching behaviour) from same-sex faces. We found above-chance accuracy in judgements of unfaithfulness from same-sex faces in men but not women. Conversely, we found above-chance accuracy for opposite-sex faces in women but not men. Therefore, both men and women showed above-chance accuracy, but only for men's, and not women's, faces. Raters were making accurate (above-chance) judgements of unfaithfulness from men's faces using facial masculinity, a well-established signal of propensity to adopt short-term mating strategies. In summary, we found above-chance accuracy in impressions of unfaithfulness from men's faces. Although very modest, the level of accuracy could nevertheless have biological significance as an evolved adaptation for identifying potential cheaters/poachers.

Age analysis of the population mortality from diabetes mellitus in the Tula region

10.12737/5613 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Макишева ◽  
R. Makisheva ◽  
Хромушин ◽  
Viktor Khromushin ◽  
Хадарцев ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Adult Population ◽  
Age Groups ◽  
Endocrine System ◽  
Initial Increase ◽  
Male Population ◽  
Female Population ◽  
Men And Women ◽  
Age Cohorts ◽  
Age Cohort

The article analyzes 182897 deaths of the adult population of the Tula region from the mortality register from 2007 to 2013 by age cohorts 15-19; 20-24; 25-34; 35-44; 45-54; 55-64; 65-74; &#62;=75, of which 4882 case of death from diabetes. The increasing incidence of diseases of the endocrine system, disorders of nutrition and metabolism is identified and is accordingly 63,7; 66,5; 68,4; 68,3; 69,4; 71,0 per 1000 population. The mortality rate in the Tula region in 2012 from diabetes was 59,86 per 100000 population. The analysis of mortality shows that the ratio of women to men for the period from 2007 to 2013 increases with increasing age in a power-law dependence from 0,6 to 4,49. In the age cohort 45-54 men and women, there is a decrease in the number of cases. The initial increase and the subsequent significant decline in the number of cases have a place for men in this cohort. For women, the mortality rate decreases with larger slope than for men. The dynamics of the mortality of men and women in the cohort 55-64 is characterized by an increase in the number of cases in 2007-2010 and the decrease in 2011-2013. In this cohort, the mortality rate among men increased (except 2013), and the mortality rate of the female population varies only slightly. Mortality of women, men, and for men and women in the cohort 65-74 years decreases, and in the cohort of 75 and over increased. Positive aspects of age analysis is the transfer of deaths from age groups 45-54, 55-64, 65-74 in a cohort of older ages 75 years or more. Negative aspects of age analysis is the increased mortality of the male population in the cohort 55-64 in 2007- 2012, men and women of this cohort in 2007 - 2010 years, as well as the high mortality of the female population from diabetes, compared with the male population of the Tula region.

scholarly journals Emerging Contaminants in Streams of Doce River Watershed, Minas Gerais, Brazil

2022 ◽  
Vol 9 ◽  
Author(s):  
Marcelo Pedrosa Gomes ◽  
Júlio César Moreira Brito ◽  
Fabio Vieira ◽  
Rafael Shinji Akiyama Kitamura ◽  
Philippe Juneau
Keyword(s):  
Emerging Contaminants ◽  
Local Population ◽  
Pharmaceutical Products ◽  
Aquatic Life ◽  
River Watershed ◽  
Resistance Selection ◽  
Aminomethylphosphonic Acid ◽  
Induce Resistance ◽  
The Individual ◽  
Doce River

This study investigated the occurrence and risk assessment of ten pharmaceutical products and two herbicides in the water of rivers from the Doce river watershed (Brazil). Of the 12 chemicals studied, ten (acyclovir, amoxicillin, azithromycin, ciprofloxacin, enrofloxacin, fluoxetine, erythromycin, sulfadiazine, sulfamethoxazole, glyphosate and aminomethylphosphonic acid) had a 100% detection rate. In general, total concentrations of all target drugs ranged from 4.6 to 14.5 μg L−1, with fluoroquinolones and sulfonamides being the most representative classes of pharmaceutical products. Herbicides were found at concentrations at least ten times higher than those of the individual pharmaceutical products and represented the major class of contaminants in the samples. Most of the contaminants studied were above concentrations that pose an ecotoxicological risk to aquatic biota. Urban wastewater must be the main source of contaminants in waterbodies. Our results show that, in addition to the study of metal in water (currently being conducted after the Fundão dam breach), there is an urgent need to monitor emerging contaminant in waters from Doce river watershed rivers, as some chemicals pose environmental risks to aquatic life and humans due to the use of surface water for drinking and domestic purposes by the local population. Special attention should be given to glyphosate, aminomethylphosaphonic acid, and to ciprofloxacin and enrofloxacin (whose concentrations are above predicted levels that induce resistance selection).

AFFECTING MECHANISMS AND EFFECTS OF ENDOCRINE DISRUPTOR PESTICIDES

2012 ◽  
pp. 66-74
Author(s):  
Ba Tiep Nguyen ◽  
Ngan Tam Bui
Keyword(s):  
Public Health ◽  
Endocrine Disruptors ◽  
Endocrine Disruption ◽  
Hormone Receptors ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Hormone Synthesis ◽  
Adverse Health Effects ◽  
Sustainable Agricultural Systems ◽  
Public Health Protection

Endocrine disrupting chemicals are compounds that alter the functioning of endocrine system and subsequently affect on different growth and development stages of human and animals. Endocrine disruptors including pesticides have gained a global attention in various fields like environment toxicology, reproduction, food safety and cancer. This article reviews affecting mechanisms of endocrine disruptors including (1) Interfering steroid hormone synthesis, release, transport and metabolism (2) Effecting via hormone receptors, (3) Effecting the action of thyroid hormones, and (4) affecting on central nervous system. Adverse health effects of pesticides via endocrine disruption pathways and recent discoveries in endocrine disruption mechanisms of common pesticides are also be discussed. The information is necessary for the development of safe and sustainable agricultural systems and public health protection in Vietnam. Key words: endocrine disruptors, affecting mechanisms, pesticides, public health

A Review of the Occurrence of Pharmaceutical Compounds as Emerging Contaminants in Treated Wastewater and Aquatic Environments

2021 ◽  
Vol 18 ◽  
Author(s):  
Rahul Silori ◽  
Syed Mohammad Tauseef
Keyword(s):  
Wastewater Treatment ◽  
Emerging Contaminants ◽  
Wastewater Treatment Plants ◽  
Pharmaceutical Compounds ◽  
Treated Wastewater ◽  
Aquatic Environments ◽  
Aquatic Life ◽  
Adverse Health Effects ◽  
Treatment Processes ◽  
Comprehensive Information

: In recent years, pharmaceutical compounds have emerged as potential contaminants in the aquatic matrices of the environment. High production, consumption, and limited removal through conventional treatment processes/wastewater treatment plants (WWTPs) are the major causes for the occurrence of pharmaceutical compounds in wastewater and aquatic environments worldwide. A number of studies report adverse health effects and risks to aquatic life and the ecosystem because of the presence of pharmaceutical compounds in the aquatic environment. This paper provides a state-of-the-art review of the occurrence of pharmaceutical compounds in treated wastewater from various WWTPs, surface water and groundwater bodies. Additionally, this review provides comprehensive information and pointers for research in wastewater treatment and waterbodies management.

scholarly journals Tartrazine induces structural and functional aberrations and genotoxic effectsin vivo

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e3041 ◽  
Author(s):  
Latifa Khayyat ◽  
Amina Essawy ◽  
Jehan Sorour ◽  
Ahmed Soffar
Keyword(s):  
Comet Assay ◽  
Blood Cells ◽  
White Blood Cells ◽  
Pharmaceutical Products ◽  
Food Additive ◽  
Control Group ◽  
Adverse Health Effects ◽  
Male Wistar Rats ◽  
Liver And Kidney ◽  
Experimental Group

Tartrazine is a synthetic organic azo dye widely used in food and pharmaceutical products. The current study aimed to evaluate the possible adverse effect of this coloring food additive on renal and hepatic structures and functions. Also, the genotoxic potential of tartrazine on white blood cells was investigated using comet assay. Twenty adult male Wistar rats were grouped into two groups of 10 each, control- and tartrazine-treated groups. The control group was administered orally with water alone. The experimental group was administered orally with tartrazine (7.5 mg/kg, b.wt.). Our results showed a marked increase in the levels of ALT, AST, ALP, urea, uric acid, creatinine, MDA and NO, and a decreased level of total antioxidants in the serum of rats dosed with tartrazine compared to controls. On the other hand, administration of tartrazine was associated with severe histopathological and cellular alterations of rat liver and kidney tissues and induced DNA damage in leucocytes as detected by comet assay. Taken together, the results showed that tartrazine intake may lead to adverse health effects.

scholarly journals Endocrine-Disrupting Chemicals and Infectious Diseases: from Endocrine Disruption to Immunosuppression

2021 ◽  
Vol 22 (8) ◽  
pp. 3939
Author(s):  
Elikanah Olusayo Adegoke ◽  
Md Saidur Rahman ◽  
Yoo-Jin Park ◽  
Young Ju Kim ◽  
Myung-Geol Pang
Keyword(s):  
Immune System ◽  
Influenza A ◽  
Scientific Evidence ◽  
Severe Disease ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Consumer Products ◽  
Adverse Health Effects ◽  
Endocrine Disrupting

Endocrine-disrupting chemicals (EDCs) are hormonally active compounds in the environment that interfere with the body’s endocrine system and consequently produce adverse health effects. Despite persistent public health concerns, EDCs remain important components of common consumer products, thus representing ubiquitous contaminants to humans. While scientific evidence confirmed their contribution to the severity of Influenza A virus (H1N1) in the animal model, their roles in susceptibility and clinical outcome of the coronavirus disease (COVID-19) cannot be underestimated. Since its emergence in late 2019, clinical reports on COVID-19 have confirmed that severe disease and death occur in persons aged ≥65 years and those with underlying comorbidities. Major comorbidities of COVID-19 include diabetes, obesity, cardiovascular disease, hypertension, cancer, and kidney and liver diseases. Meanwhile, long-term exposure to EDCs contributes significantly to the onset and progression of these comorbid diseases. Besides, EDCs play vital roles in the disruption of the body’s immune system. Here, we review the recent literature on the roles of EDCs in comorbidities contributing to COVID-19 mortality, impacts of EDCs on the immune system, and recent articles linking EDCs to COVID-19 risks. We also recommend methodologies that could be adopted to comprehensively study the role of EDCs in COVID-19 risk.

scholarly journals Marginal selenium status in northern Tasmania

2011 ◽  
Vol 106 (5) ◽  
pp. 718-724 ◽  
Author(s):  
Jeffrey M. Beckett ◽  
Madeleine J. Ball
Keyword(s):  
Economic Status ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Men And Women ◽  
Adverse Health Effects ◽  
Increased Risk ◽  
Gpx Activity ◽  
Se Status

Se plays many important roles in humans. Marginal Se status has been associated with adverse health effects including an increased risk of chronic disease such as cancer. There are few Australian data, but the population of Tasmania, Australia, is potentially at risk of marginal Se status. A cross-sectional study of 498 men and women aged 25–84 years was undertaken to assess the Se status of the northern Tasmanian population. Se status was assessed using dietary estimates and measures of serum Se and glutathione peroxidase (GPx). Mean Se intakes were 77·4 (sd31·3) and 65·1 (sd23·7) μg/d for men and women, respectively; 27 % of the subjects consumed less than the Australian/New Zealand estimated average requirement. Mean serum Se concentration was 89·1 (sd15·1) μg/l; 83 % of the study subjects had serum Se concentrations below 100 μg/l and 60 % had serum Se concentration below 90 μg/l, suggesting that Se status in many subjects was inadequate for maximal GPx activity. This was supported by the positive association between serum Se and serum GPx (P < 0·001), indicating that enzyme activity was limited by Se concentrations. The lowest mean serum Se concentrations were observed in the oldest age ranges; however, the prevalence of marginal Se status was similar across age ranges and did not appear to be influenced by sex or socio-economic status. The prevalence of marginal Se status was high in all sex and age subgroups, suggesting that the northern Tasmanian population could benefit from increasing Se intakes.

scholarly journals Dried blood spot microbiological assay indicates high prevalence of folate deficiency in rural adult men and women in the Haitian Central Plateau

2019 ◽  
Vol 11 (6) ◽  
pp. 487-495 ◽  
Author(s):  
Constance Harrell Shreckengost ◽  
Andrew W Kim ◽  
Sarah H Whitaker ◽  
Lei Weng ◽  
Bradley D Pearce ◽  
...  
Keyword(s):  
Folate Deficiency ◽  
Dried Blood Spots ◽  
Microbiological Assay ◽  
Reproductive Age ◽  
Lauryl Sulfate ◽  
Central Plateau ◽  
Men And Women ◽  
Adverse Health Effects ◽  
Adult Men ◽  
High Prevalence

Abstract Background Although folate deficiency is linked to adverse health effects, limited data exist characterizing the problem in rural settings. This study determined the prevalence of folate deficiency and anemia in rural adults in the Haitian Central Plateau using combined laboratory methods. Methods Dried blood spots (DBSs) and hemoglobin measurements were collected from adult men and women selected by cluster random sampling in Haiti’s Central Plateau. DBSs were analyzed for folate using a microbiological assay. Hemoglobin levels were determined using both a HemoCue photometer and the sodium lauryl sulfate microplate method. Red cell folate (RCF) levels were determined by normalizing DBS folate to hemoglobin. Results Of the 197 subjects assessed for hemoglobin, 11.4% of males and 21.0% of females were anemic (male: hemoglobin<12 g/dL; female: hemoglobin<11 g/dL). Of the 173 subjects assessed for RCF, 27.9% of men and 14.9% of women were folate deficient (RCF<340 nmol/L). Among reproductive-age women, 83.6% had RCF levels associated with a risk of neural tube defects of >14 per 10 000 live births (RCF≤699 nmol/L). Conclusions Adults in the Haitian Central Plateau suffer from high rates of anemia and folate deficiency, putting the population at elevated risk for disease. DBSs and microbiological assay make folate evaluation feasible, even in low-resource regions.

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