scholarly journals Role of Chitosan Nanoparticles in Improving Hepatic and Renal Toxicity Induced by Silver Nanoparticles Coated by Fe3O4 in Rats

2021 ◽  
pp. 1-8
Author(s):  
Hadeer ElBadry ◽  
Afaf El-Atrash ◽  
Somaya Abdelhalim ◽  
Ehab Tousson
Keyword(s):  
Silver Nanoparticles ◽  
Chronic Toxicity ◽  
Renal Damage ◽  
Chitosan Nanoparticles ◽  
Chloride Ions ◽  
Control Group ◽  
Therapeutic Effects ◽  
Ag Nps ◽  
Wide Range ◽  
Liver And Kidney

Aims: Silver nanoparticles (Ag NPs) are an important class of nanomaterials used as antimicrobial agents for a wide range of medical and industrial applications.Current study was performed to study the therapeutic effects of chitosan nanoparticles extract towards the treatments with Ag NPs in rat induced kidney and liver damage. Study Design: A total of 60 male adult albino rats were equally divided into six groups (G1, Control group; G2, chitosan group; G3, Ag NPs group as acute toxicity; G4, acute Ag NPs+Chitosan group; G5, Ag NPs group as chronic toxicity; G6, chronic Ag NPs+Chitosan). Results: Current results revealed that; a significant increase in the levels of serum ALT, AST, ALP, urea, creatinine, sodium, potassium, chloride ions and MDA in liver and kidney tissues after treatments with Ag NPs (in case of acute and chronic toxicity) as compared to control group. In contrast; a significant decrease in serum albumin, total proteins, calcium ions, SOD, catalase and GSH in liver and kidney tissues after treatments with Ag NPs as compared to control groups. Treatment of Ag NPs with Chitosan nanoparticles (Ch NPs) improved this change in liver and kidney functions as compared to Ag NPs. Conclusion: These findings suggested that the misuse of silver nanoparticles may contribute to continuous hepatic and renal damage. This shows that the desired dose of Ag NPs can safely be used with Chitosan in improving hepatic and renal damage in toxic group in young rats.

scholarly journals Role of Oats in Ameliorating Hepatic and Renal Toxicity Induced by Acute Lead Nanoparticles in Male Rats

2020 ◽  
pp. 38-45
Author(s):  
Sarah Alashmouni ◽  
Afaf El- Atrash ◽  
Manar Kandeel ◽  
Ehab Tousson
Keyword(s):  
Renal Damage ◽  
Chloride Ions ◽  
The Body ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Sufficient Information ◽  
Therapeutic Effects ◽  
Male Adult ◽  
Organ Systems

Aims: Lead is well known environmental pollutant, which can cause toxic effects in multiple organ systems. Lead originates from various industrial and/or household sources, and enters the body through food and fluid intakes, as well as by inhalation. No sufficient information present about the toxic effect of acute lead nanoparticles on kidney and liver. Accordingly, current study was performed to study the therapeutic effects of Oats extract towards the injection of lead nanoparticles (Pb NPs) in rat induced kidney and liver damage by increasing kidney and liver functions, and electrolytes. Study Design:  A total of 40 male adult albino rats were equally divided into four groups (Control group, Oats group, Pb NPs group as acute toxicity and last group is Pb NPs +Oats). Results: Current results revealed that; a significant increase in the levels of serum aspartate transaminase (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP), urea, creatinine, potassium and chloride ions after injection with Pb NPs as compared to control group. In contrast; a significant decrease in serum albumin, total proteins, and sodium ions in Pb NPs as compared to control groups. Treatment of Pb NPs with Oats improved this change in liver and kidney functions as compared to Pb NPs group. Conclusion: These findings suggested that; lead nanoparticles injection induced hepatic and renal damage. This shows that the desired dose of Pb NPs can safely be used with Oats in improving hepatic and renal damage in toxic group in young rats.

scholarly journals Neurological Alterations and Testicular Damages in Aging Induced by D-Galactose and Neuro and Testicular Protective Effects of Combinations of Chitosan Nanoparticles, Resveratrol and Quercetin in Male Mice

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 435
Author(s):  
Reham Z. Hamza ◽  
Mohammad S. Al-Harbi ◽  
Munirah A. Al-Hazaa
Keyword(s):  
Oxidative Stress ◽  
Chitosan Nanoparticles ◽  
Oxidative Stress Marker ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Enzymatic Antioxidants ◽  
Protective Effects ◽  
Biochemical Alterations ◽  
Wide Range ◽  
Neurological Alterations

Aging is a neurological disease that is afforded by incidence of oxidative stress. Chitosan has received global interests due to its wide medical uses. Quercetin (Q) is a bioflavonoid and widely distributed in vegetables and fruits. Resveratrol is considered as a potent antioxidant and is a component of a wide range of foods. The using of either chitosan nanopartciles (CH-NPs), querectin (Q), and resveratrol (RV) to reduce the oxidative stress and biochemical alterations on brain and testicular tissues induced by D-galactose (DG) (100 mg/Kg) were the aim of the present study. This study investigated the probable protective effects of CH-NPs in two doses (140,280 mg/Kg), Q (20 mg/Kg) and RV (20 mg/Kg), against DG induced aging and neurological alterations. Brain antioxidant capacity as malonaldehyde (MDA), catalase (CAT), and glutathione reductase (GRx), as well as histopathological damages of the brain and testicular tissues were measured. The DG treated group had significantly elevated the oxidative stress markers by 96% and 91.4% in brain and testicular tissues respectively and lower significantly the antioxidant enzyme activities of both brain and testicular tissues than those of the control group by 86.95%, 69.27%, 83.07%, and 69.43%. Groups of DG that treated with a combination of CH-NPs in two doses, Q and RV, the levels of oxidative stress marker declined significantly by 68.70%, 76.64% in brain tissues and by 74.07% and 76.61% in testicular tissues, and the enzymatic antioxidants increased significantly by 75.55%, 79.24%, 62.32%, and 61.97% as compared to the DG group. The present results indicate that CH-NPs, Q, and RV have protective effects against DG-induced brain and testis tissue damage at the biochemical and histopathological levels. Mechanisms of this protective effect of used compounds against neurological and testicular toxicity may be due to the enhanced brain and testis antioxidant capacities.

scholarly journals Reactivity and Chemical Sintering of Carey Lea Silver Nanoparticles

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1525
Author(s):  
Sergey Vorobyev ◽  
Elena Vishnyakova ◽  
Maxim Likhatski ◽  
Alexander Romanchenko ◽  
Ivan Nemtsev ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Silver Nanoparticles ◽  
Flexible Electronics ◽  
Photoelectron Spectroscopy ◽  
Colloidal Solutions ◽  
Ag Nps ◽  
Wide Range ◽  
Carboxylic Groups ◽  
The Media ◽  
Sulfide Ions

Carey Lea silver hydrosol is a rare example of very concentrated colloidal solutions produced with citrate as only protective ligands, and prospective for a wide range of applications, whose properties have been insufficiently studied up to now. Herein, the reactivity of the immobilized silver nanoparticles toward oxidation, sulfidation, and sintering upon their interaction with hydrogen peroxide, sulfide ions, and chlorocomplexes of Au(III), Pd(II), and Pt(IV) was investigated using SEM and X-ray photoelectron spectroscopy (XPS). The reactions decreased the number of carboxylic groups of the citrate-derived capping and promoted coalescence of 7 nm Ag NPs into about 40 nm ones, excluding the interaction with hydrogen peroxide. The increased nanoparticles form loose submicrometer aggregates in the case of sulfide treatment, raspberry-like micrometer porous particles in the media containing Pd(II) chloride, and densely sintered particles in the reaction with inert H2PtCl6 complexes, probably via the formation of surface Ag-Pt alloys. The exposure of Ag NPs to HAuCl4 solution produced compact Ag films along with nanocrystals of Au metal and minor Ag and AgCl. The results are promising for chemical ambient temperature sintering and rendering silver-based nanomaterials, for example, for flexible electronics, catalysis, and other applications.

scholarly journals Preparation of Silver Nanoparticles and Their Industrial and Biomedical Applications: A Comprehensive Review

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Adnan Haider ◽  
Inn-Kyu Kang
Keyword(s):  
Silver Nanoparticles ◽  
Biomedical Applications ◽  
Consumer Products ◽  
Ag Nps ◽  
New Techniques ◽  
Governing Factor ◽  
Wide Range ◽  
Microbial Proliferation ◽  
Synthetic Routes ◽  
Biomedical Fields

Silver nanoparticles (Ag-NPs) have diverted the attention of the scientific community and industrialist itself due to their wide range of applications in industry for the preparation of consumer products and highly accepted application in biomedical fields (especially their efficacy against microbes, anti-inflammatory effects, and wound healing ability). The governing factor for their potent efficacy against microbes is considered to be the various mechanisms enabling it to prevent microbial proliferation and their infections. Furthermore a number of new techniques have been developed to synthesize Ag-NPs with controlled size and geometry. In this review, various synthetic routes adapted for the preparation of the Ag-NPs, the mechanisms involved in its antimicrobial activity, its importance/application in commercial as well as biomedical fields, and possible application in future have been discussed in detail.

scholarly journals The effect of different doses levels of silver nanoparticles (AgNPs) on the kidney and liver in Albino male Rat. Histopathological study

2014 ◽  
Vol 11 (4) ◽  
pp. 1503-1509
Author(s):  
Baghdad Science Journal
Keyword(s):  
Silver Nanoparticles ◽  
Body Weight ◽  
Male Rat ◽  
Central Vein ◽  
Average Particle ◽  
Ag Nps ◽  
Hepatic Cells ◽  
Liver And Kidney ◽  
Collecting Tubules ◽  
Convoluted Tubules

Objective: In this study ,the effects of silver nanoparticles (Ag NPs)were investigated on the liver and kidney tissues. Methodology: The produced nanoparticles have an average particle size of about 30 nm. Eighteen male albino rats were used by dividing them into three groups, each group comprise 6 rats. First group(control group) given food and water like other groups by liberty. Second group was tail injected by (AgNPs) at dose of (0.4 mg/kg. body weight/day). Third group was injected by (AgNPs) at dose of (0.6 mg/kg. body weight/day) for 15 days. All animals were sacrified at the end of experiment. The liver and kidney tissues specimens were fixed in 10% formalin and histological preparations were carried out then stained with H&E. Pathological changes in liver and kidney tissues were showed. Results: Histopathological studies revealed the harmful effect of the silver nanoparticles uses on the liver and kidney rats, second group that treated with Ag NPs (0.4 mg/kg.body.weight/day), kidney sections showed enlargement of collecting tubules, increase in interstitial tissue medulla, necrosis and enlargement in proximal and distal convoluted tubules. Liver showed enlargement of the central vein and degeneration of hepatic cells. Third group that treated with Ag NPs (0.6 mg/kg. body weight/day); kidney sections showed hyperplasia of the interstitial connective tissue of renal medulla with hemorrhages, renal cortex showed, degenerative changes and necrosis of proximal and distal convoluted tubules. Liver section showed congestion and necrosis of hepatic cells. Conclusion: Silver nanoparticles cause damage in liver and kidney tissues. Recommendation: Further study is needed for the effect of Ag NPs on the other tissues.

scholarly journals Clinical Study of Acupotomy Trinity Lysis on Cervical Spondylotic Myelopathy with Liver and Kidney Deficiency Syndrome

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Jianyong Gao ◽  
Yi Zhao ◽  
Tinglan Sun ◽  
Weike Liu ◽  
Zhenguo Wang
Keyword(s):  
Treatment Group ◽  
Cervical Spondylotic Myelopathy ◽  
Deficiency Syndrome ◽  
Control Group ◽  
Therapeutic Effects ◽  
Kidney Deficiency ◽  
Significant Difference ◽  
Before And After ◽  
Liver And Kidney ◽  
Experimental Group

Objective: To compare the therapeutic effects of acupotomy trinity lysis and traditional acupotomy on cervical spondylotic myelopathy. Methods: A total of 205 patients with cervical spondylotic myelopathy of liver and kidney deficiency syndrome were randomly divided into the experimental group (105 cases) and the control group (100 cases). The experimental group was relaxed with acupotomy in three positions: Heaven (tian), Human (ren) and Earth (di). Traditional acupotomy was used to relax Ashi acupoints of the affected vertebra in the control group. One treatment was conducted in one week, and the duration of one course of treatment was three weeks. The VAS, JOA score and NDI index were observed after treatment.  Results: Before and after treatment, the total treatment efficiency of the treatment group was 95.23%, and that of the control group was 80.00%, there was significant difference between the two groups, P<0.05; Before operation, there was no significant difference in JOA score, NDI index score, and VAS score between the treatment group and the control group (P>0.05); there was no significant difference after 1 week (P>0.05), but there were significant differences between the two groups 2 weeks and 3 weeks after operation (P<0.05). Conclusion: Acupotomy trinity lysis is a safe, effective and economical treatment for cervical spondylotic myelopathy.

scholarly journals Biochemical and Molecular Studies on the Role of Rosemary (Rosmarinus officinalis) Extract in Reducing Liver and Kidney Toxicity Due to Etoposide in Male Rats

2019 ◽  
pp. 1-11
Author(s):  
Majd Almakhatreh ◽  
Ezar Hafez ◽  
Ehab Tousson ◽  
Ahmed Masoud
Keyword(s):  
Dna Damage ◽  
Calcium Ions ◽  
Chloride Ions ◽  
Male Rats ◽  
Control Group ◽  
Potassium Ions ◽  
Sodium Ions ◽  
Total Proteins ◽  
Kidney Toxicity ◽  
Liver And Kidney

Aims: Etoposide (Vepesid) is chemotherapeutic drugs that inhibit topoisomerase II activity and long been used for treatment of human malignancies, where it is a semi-synthetic compound derived from the plant Podophyllum peltatum. The current study was designed to investigate the possible protective effect of rosemary extract against Etoposide -induced changes in liver and kidney functions, and DNA damage in rats. Materials and Methods: A total of 50 male Wistar albino rats were divided randomly into four groups (1st group was control; 2nd group was treated with rosemary, 3rd group was received etoposide, and 4th & 5th groups was co- and post treated groups respectively). Results: The administration of Etoposide revealed a significant increase in serum ALT, AST, ALP, creatinine, urea, potassium ions, chloride ions, and DNA damage. In contrast; a significant decrease in albumen, total proteins, sodium ions, and calcium ions were when compared with control group. This increased in ALT, AST, ALP, creatinine, urea, potassium ions, chloride ions, and DNA damage was reduced after administration of rosemary when co-treated with etoposide (G4), or post-treated after etoposide  (G5) for four weeks with lowest damage in G4. Also, this decreased in albumen, total proteins, sodium ions, and calcium ions was increased after administration of rosemary when co-treated with etoposide (G4), or post-treated after etoposide (G5) for four weeks with lowest damage in G4. Conclusion: It could be concluded that rosemary has a promising role and it worth to be considered as a natural substance for protective the liver and kidney toxicity induced by etoposide (Vepesid) chemotherapy.

scholarly journals SUB-ACUTE TOXICITY OF A STEROIDAL GLYCOSIDE FROM THE FLOWERS OF ALANGIUM SALVIIFOLIUM WANG

2021 ◽  
Vol 12 (6) ◽  
pp. 35-39
Author(s):  
Adeeba Anjum ◽  
Ashik Mosaddik ◽  
Mir Imam Ibne Wahed ◽  
Md. Ekramul Haque
Keyword(s):  
Clinical Trials ◽  
Acute Toxicity ◽  
Biochemical Parameters ◽  
Chronic Toxicity ◽  
Preliminary Investigation ◽  
Control Group ◽  
Blood Samples ◽  
Steroidal Glycoside ◽  
Liver And Kidney ◽  
Hematological And Biochemical Parameters

The current study was carried out to investigate the sub-acute toxicity of 3-O--D-glucopyranosyl-(24)-ethylcholesta-5,22,25-triene, a steroidal glycoside isolated from the flowers of Alangium salviifolium Wang on Long Evan’s rat. After intra-peritoneal administration of the compound at a dose of 300 μg/rat/day for 14 consecutive days, no mortality or significant changes in body weight or behavior were observed. The blood samples of the rats were examined for hematological and biochemical parameters which were statistically insignificant when compared to that of the control group. All the vital organs showed normal histopathological architecture (heart, lungs, liver and kidney) in comparison to the control group. This preliminary investigation demonstrate that the compound is safe at dose of 300 μg/rat/day for 14 consecutive days. But acute, sub-chronic and chronic toxicity evaluations as well as clinical trials need to be done.

scholarly journals Alginate-Mediated Synthesis of Hetero-Shaped Silver Nanoparticles and Their Hydrogen Peroxide Sensing Ability

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 435 ◽  
Author(s):  
Sneha Bhagyaraj ◽  
Igor Krupa
Keyword(s):  
Hydrogen Peroxide ◽  
Particle Size ◽  
Silver Nanoparticles ◽  
Linear Response ◽  
X Ray Diffraction ◽  
Ag Nps ◽  
X Ray ◽  
Transmission Electron ◽  
Wide Range ◽  
Pollution Detection

A new method for the simple synthesis of stable heterostructured biopolymer (sodium alginate)-capped silver nanoparticles (Ag-NPs) based on green chemistry is reported. The as-prepared nanoparticles were characterized using the ultraviolet-visible (UV-Vis) absorption spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS) techniques. The results showed that the as-prepared Ag-NPs have a heterostructured morphology with particle size in the range 30 ± 18–60 ± 25 nm, showing a zeta potential of −62 mV. The silver nanoparticle formation was confirmed from UV-Vis spectra showing 424 nm as maximum absorption. The particle size and crystallinity of the as-synthesized nanoparticles were analyzed using TEM and XRD measurements, respectively. FTIR spectra confirmed the presence of alginate as capping agent to stabilize the nanoparticles. The Ag-NPs also showed excellent sensing capability, with a linear response to hydrogen peroxide spanning a wide range of concentrations from 10−1 to 10−7 M, which indicates their high potential for water treatment applications, such as pollution detection and nanofiltration composites.

scholarly journals ANÁLISE ANTIMICROBIANA DO USO DA NANOPARTÍCULA DE PRATA COM HIDRÓXIDO DE CÁLCIO COMO MEDICAÇÃO INTRACANAL

2021 ◽  
Vol 4 (7) ◽  
pp. 1-9
Author(s):  
Julia de Oliveira NEVES ◽  
Franciele de Oliveira DIAS ◽  
Laís Stabile PRONI ◽  
Maria Letícia Oliveira e FREITAS ◽  
Carolina Simonetti LODI ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Calcium Hydroxide ◽  
Culture Medium ◽  
Negative Control ◽  
Bacterial Biofilm ◽  
Control Group ◽  
Ag Nps ◽  
Heating Chamber ◽  
Colony Forming Units

O objetivo desse trabalho foi avaliar a atividade antimicrobiana do hidróxido de cálcio (HC) associada a nanopartículas de prata (Ag-NPs) sobre biofilme de Enterococus faecalis. 144 espécimes de dentina foram inoculadas em placas contendo meio de cultura com E. faecalis (ATCC 29212) para a formação de biofilme.  As medicações foram preparadas na proporção de 1:1 de HC e soro estéril e, em seguida, pesada e adicionada às concentrações de Ag-NPs 2,5%, 5% e 10%. Decorridos 14 dias, os espécimes foram lavados, transferidos para uma nova placa onde as medicações foram colocadas sobre o biofilme e deixados em estufa a 37°C por 2, 7 e 14 dias. Espécimes sem tratamento foram usados como controle negativo. Após cada tempo experimental, os espécimes foram lavados, agitados, diluídos e plaqueados em triplicata em M-Enterococcus. As unidades formadoras de colônia foram contadas e analisadas estatisticamente (p<0,05). Os resultados mostraram que não houve diferença estatística entre a medicação de HC e o grupo controle nos períodos de 2 e 7 dias, mesmo quando associados às diferentes concentrações da Ag-NPs. Após 14 dias de contato direto com a medicação, houve uma redução do biofilme bacteriano nos grupos de HC sozinho e associado à prata, quando comparado com o grupo controle, mas nenhuma diferença foi observada entre os grupos de HC. Diante dos resultados, podemos concluir que a associação da Ag-NPs não contribuiu para a atividade antimicrobiana do HC.   ANTIMICROBIAL ANALYSIS OF THE USE OF SILVER NANOPARTICLES WITH CALCIUM HYDROXIDE AS INTRACANAL MEDICATION   ABSTRACT This paper aims at evaluating the antimicrobial activity of calcium hydroxide (CH) in association with silver nanoparticles (AgNPs) over the Enterococus faecalis biofilm.144 dentine specimens were inoculated in plates containing culture medium with E. faecalis (ATCC 29212) to biofilm formation. Medication was prepared in proportion 1:1 of CH and sterile serum, then weighted and added to 2,5%, 5%, and 10% AgNPs concentrations. No earlier than 14 days, the specimens were washed, transferred to a new plate where medication was applied over the biofilm and rested in heating chamber at 37 ºC during 2, 7, and 14 days. Specimens with no treatment were used as a negative control. After each trial time, the specimens were washed, mixed, diluted, and plated in triplicate at M-Enterococcus. The colony-forming units were counted and statistically analyzed (p<0,05). The results showed that there was no statistical difference between CH medication and the group of control during the period of 2 and 7 days, even when they were associated with different concentrations of AgNPs. After 14 days of direct contact with the medication, there was a reduction of the bacterial biofilm in the groups of CH itself and associated with silver, when compared to the control group, but no difference was observed in the group of CH. In view of the results, we can conclude that the association of AgNPs does not contribute to the antimicrobial activity of the CH.   Keywords: Antibacterial.  Silver. Endodontics.  Enterococcus faecalis.

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