scholarly journals Characteristic Features of Biochemical Indicators of Mixed Saliva in Patients with Chronic Recurrent Aphthous Stomatitis

2019 ◽  
pp. 1-7
Author(s):  
Nazira N. Khabibova
Keyword(s):  
Suppressor Cells ◽  
Recurrent Aphthous Stomatitis ◽  
The Body ◽  
Aphthous Stomatitis ◽  
Medical Institute ◽  
Control Group ◽  
Leading Role ◽  
Characteristic Features ◽  
Severity Of The Disease ◽  
Mixed Saliva

Chronic recurrent aphthous stomatitis (CRAC) is a chronic disease of the oral mucosa, characterized by periodic remissions and exacerbations with the eruption of aft. According to WHO, it affects up to 20% of the population. Currently, most scientists are inclined to the leading role of the immune system in the pathogenesis of the disease. It has been established that with increasing severity of the disease T-suppression of immunity increases, which is characterized by a decrease in the number of T-lymphocytes and their functional activity. The increase in the number of T-suppressor cells accompanied by a decrease in the number of T-helper cells. The severity and duration of the disease correspond to the severity of the sensitization of the body with these antigens. The work was carried out based on scientific-educational practical dental center at the Bukhara State Medical Institute of Therapeutic Dentistry. A clinical examination of 67 patients aged 25–35 years with chronic recurrent aphthous stomatitis was conducted, 14 healthy individuals were included in the control group.

scholarly journals Assessment of Serum Enzymatic Antioxidant Levels in Patients with Recurrent Aphthous Stomatitis: A Case Control Study

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Ishita Gupta ◽  
Arvind Shetti ◽  
Vaishali Keluskar ◽  
Anjana Bagewadi
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Serum Levels ◽  
Recurrent Aphthous Stomatitis ◽  
The Body ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Study Group ◽  
Enzymatic Antioxidant ◽  
Exact Etiology

Background and Aim. Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder characterized by recurrent, painful oral aphthae. Despite extensive research, the exact etiology of RAS remains elusive. Recently oxidant-antioxidant imbalance of the body has been implicated in the pathogenesis of recurrent aphthous stomatitis. Thus, the aim of the study was to evaluate the enzymatic antioxidant levels in patients with recurrent aphthous stomatitis. Materials and Methods. The serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured in 30 patients with recurrent aphthous stomatitis and compared to the control group, which included 30 healthy subjects. Student’s t-test was performed for statistical evaluation. Results. The mean levels of superoxide dismutase (130.2 ± 15.94 U/mL) and glutathione peroxidase (3527.93 ± 488.32 U/L) were found to be significantly lower in study group as compared to control group (211.9 ± 20.93 U/mL, 8860.93 ± 1105.31 U/L, resp.) (P=0.000) while level of catalase in study group was significantly higher when compared to control group (10981.00 ± 1018.07 U/mL versus 9764.00 ± 1621.19 U/mL) (P=0.000). Conclusion. Enzymatic antioxidant system is impaired in recurrent aphthous stomatitis patients and seems to play a crucial role in its pathogenesis.

scholarly journals Mannose-binding lectin serum levels and (Gly54asp) gene polymorphism in recurrent aphthous stomatitis: A case-control study

2021 ◽  
Vol 35 ◽  
pp. 205873842110644
Author(s):  
Shereen A Baioumy ◽  
Shaimaa H Fouad ◽  
Shaimaa A Abdalgeleel ◽  
Ahmed A Baiomy ◽  
Dina E Sallam ◽  
...  
Keyword(s):  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Recurrent Aphthous Stomatitis ◽  
Mannose Binding Lectin ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Control Study

Objectives: Dysregulation of the immune response appears to play a significant role in recurrent aphthous stomatitis (RAS) development. The main objective of this case–control study is to investigate the blood levels of mannose-binding lectin (MBL) and the frequency of the MBL2 gene (gly54asp) polymorphism in RAS patients, including 40 RAS patients and 40 healthy controls. Methods: Serum MBL levels were determined by ELISA, while the PCR-restriction fragment length polymorphism was used in MBL2 genotyping. Results: The median serum MBL level was significantly lower in the RAS group than in the control group (975 ng/mL (545–1320) vs. 1760 ng/mL (1254–2134); p≤ 0.001). The MBL levels were significantly lower in the BB genotype, whereas they were significantly higher in the wild type AA with a median of 525 and 1340 ng/mL, respectively ( p =0.005). The B allele was expressed in significantly higher percentages of RAS patients than in controls. There was no significant association between MBL serum levels ( p=0.685) or MBL2 codon 54 genotypes ( p=0.382) with the type of ulcers. Conclusion: There was an association between low MBL serum levels and the variant allele B of the MBL2 (gly54asp) gene, and the susceptibility to RAS. As a result, potential novel therapeutic options for RAS patients with MBL deficiency should be investigated.

scholarly journals Evaluation of Salivary Interferon-Gamma Level in Patients with Recurrent Aphthous Stomatitis

2020 ◽  
Author(s):  
Marieh Honarmand ◽  
Ramin Saravani ◽  
Hossein Ansari ◽  
Iman Teimoori
Keyword(s):  
Interferon Gamma ◽  
Systemic Disease ◽  
Recovery Period ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Healthy Individuals ◽  
Salivary Level ◽  
The Mean ◽  
Control Study

Introduction: Recurrent aphthous stomatitis (RAS) is defined by recurring ulcers restricted to oral mucosa in the patients with no other signs of systemic disease. The purpose of this study was to evaluate the salivary level of interferon gamma in patients with RAS. Methods: In this case-control study, 30 patients with RAS (in Recurrence and recovery period) in the experimental and 25 healthy people as the control group were compared. Salivary interferon gamma level was evaluated by the use of ELISA method. Data were analyzed via SPSS version 16 software with Mann-U-Whitney test and Wilcoxon. P <0.05 was considered significant. Results: The mean salivary interferon gamma levels were 45.01±31.02 pg/ml and 32.04±19.02 pg/ml in the patients with RAS and healthy individuals, respectively. (P>0.001). In addition, interferon gamma level was 45.01± 31.02 pg/ml and 58.03± 52.04 pg/ml in the recurrence and recovery periods, respectively. (P=0.67). Conclusion: Salivary interferon gamma levels were higher in the patients with RAS than healthy individuals.

scholarly journals Clinical Evaluation of 660 nm Diode Laser Therapy on the Pain, Size and Functional Disorders of Recurrent Aphthous Stomatitis

2019 ◽  
Vol 7 (9) ◽  
pp. 1516-1522 ◽  
Author(s):  
Hisham Abdelmonem Soliman ◽  
Diana Mostafa
Keyword(s):  
Laser Therapy ◽  
Diode Laser ◽  
Pathological Condition ◽  
Ventral Surface ◽  
Healing Time ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Functional Disorders ◽  
Significant Difference

BACKGROUND: Minor recurrent aphthous stomatitis (MiRAS) is one of the most common, recurrent, and painful mucosal pathological condition. It is characterised by round or shallow oval ulcers, less than 10 mm in diameter, surrounded by a thin erythematous halo. It involves non-keratinized mucosa such as the labial and buccal mucosa, the ventral surface or borders of the tongue and the floor of the mouth, but it is uncommon to occur on the keratinised mucosa. It heals spontaneously within 10-14 days without scarring. There is no curative remedy to prevent its recurrence; also, available modalities only reduce the symptoms and severity of the lesion. AIM: Since these lesions may be extremely painful, we decided to estimate the pain-relieving and healing properties of low energy level laser therapy using diode laser 660 nm on MiRAS. MATERIAL AND METHODS: Twenty healthy patients suffering from minor aphthous ulcers were randomly selected from the Out-Patient Clinic of Oral Medicine Department, Faculty of Dentistry, Alexandria University. They were equally divided into two groups, study group who received 660 nm diode laser irradiation while the control group received placebo (sodium bicarbonate rinse). The visual analogue scale, size reduction, effectiveness indices and functional disorders were compared between the groups. RESULTS: Both groups presented a statistically significant difference from baseline to follow up periods. But, diode laser 660 nm treatment showed more remarkable improvements in reduction of healing time, pain and lesion size. CONCLUSION: We concluded that diode laser 660 nm should be further considered as an effective alternative therapeutic regimen to patients who suffer from recurrent aphthous stomatitis.

scholarly journals Interleukin-2, Interferon-gamma Gene Polymorphisms in Recurrent Aphthous Stomatitis

2017 ◽  
Vol 118 (2-3) ◽  
pp. 81-86 ◽  
Author(s):  
Shamsolmoulouk Najafi ◽  
Hila Yousefi ◽  
Mahsa Mohammadzadeh ◽  
Alireza Zare Bidoki ◽  
Elham Farhadi ◽  
...  
Keyword(s):  
Cytokine Production ◽  
Interleukin 2 ◽  
Recurrent Aphthous Stomatitis ◽  
Allele Frequencies ◽  
Aphthous Stomatitis ◽  
Unknown Etiology ◽  
Control Group ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Ifn Γ

Recurrent aphthous stomatitis (RAS) is the most common oral ulcerative inflammatory disease with unknown etiology. IL-2 and IFN-γ are secreted by Th1 cells and the elevated levels of them have been reported in RAS. Single nucleotide polymorphisms (SNPs) of IL-2 and IFN-γ genes could alter the cytokine production. The aim of this study was to investigate frequencies of IL-2 and IFN-γ alleles and genotypes in a group of patients with minor-RAS (MiRAS). PCR-SSP method used to type genomic DNA of 64 Iranian patients with MiRAS for IL-2 gene (G –330 T) and (G +166 T) and IFN-γ gene at position UTR5644 (A/T). Frequency of each allele and genotype was compared with control group. IL-2 +166 G allele was significantly lower among patients which was reflected in significantly decreased of GG genotype at this position, while IL-2 +166 T allele was significantly higher among patients, IL-2 GT genotype was also significantly higher in RAS patients. No significant differences were found regarding IL-2 –330 G/T allele frequencies, while IL-2 GT genotype at this position was significantly higher among patients and IL-2 –330 TT genotype was significantly lower among RAS patients. Although no significant differences were found in IFN-γ allele frequencies at UTR5644 (A/T), AT genotype at this position was significantly overrepresented among patients compared with controls. Results of this study suggest that certain SNPs of IL-2 and IFN-γ genes have association with predisposition of individuals to RAS. More studies in different ethnic groups are needed to confirm results of this study.

scholarly journals Detection of HSV1 and HSV2 viruses among Iraqi patients with recurrent Stomatitis Aphthous

2018 ◽  
Vol 40 (1) ◽  
pp. 19-24
Author(s):  
Eman A Al-Hasnawi
Keyword(s):  
Family History ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Study Group ◽  
Elisa Method ◽  
Healthy Control ◽  
Simplex Virus ◽  
Positive Results ◽  
Hsv 1

Background: Recurrent aphthous stomatitis (RAS) is a global oral case that stay incompletely understood yet. It was classified into three main types of minor, major or herpetiform, based on clinical features, but the exact causative agent is unknown, therefore treatments are primarily should be experimental and aimed at decrease symptoms rather than remedy or prevention. The aim of study is to detection of Herpes simplex virus-1 and Herpes simplex virus-2 in saliva of patients with recurrent aphthous stomatitis (RAS) as a causative agents of the disease by the enzyme-linked immunosorbent assay (ELISA) assay, and correlation between positive results and finding of age, gender, and family history. Materials and Methods: Study group of (40) saliva samples were taken from 40 patients with RAS lesions included 15 male and 25 female, with mean age at (34) years, at range about (18-55) years , and healthy control group were (20) healthy volunteers were suffered from oral traumatic ulcers, consist women (13), men (7), mean age (33) years in range (18-55). for detection of HSV viruses types that may causes this disease, and healthy control group were (20) healthy volunteers were suffered from oral traumatic ulcers, ELISA method used for diagnosis HSV-1 and HSV-2, from saliva samples of the patients with (RAS) with correlation between positive results and finding of age, gender, and family history. Results: Diagnostic specimens were consisted of two groups, study group of (40) saliva samples taken from 40 patients with RAS lesions. The results of ELISA to detect HSV had high significant (17): 42.5% from (40) patients with (RAS), HSV-1: (13)32.5%, and HSV-2: (4)10%. Conclusion: This high number of RAS cases by HSV, and presence of HSV-2 in patients saliva in this study acted important cause of prevalence of this disease in Iraq, were in age group (18-25) mostly in female especially in those with family history of infection. Keywords: Recurrent Aphthous Stomatitis (RAS), Aphthous ulcer, HSV-1&2 viruses, ELISA method

scholarly journals Features of dental diseases in children with albinism

2018 ◽  
Vol 99 (3) ◽  
pp. 357-362
Author(s):  
R A Saleev ◽  
A B Abdrashitova ◽  
A I Makhmutova ◽  
N N Mayanskaya
Keyword(s):  
Immune Complexes ◽  
Oral Fluid ◽  
Primary Diagnosis ◽  
Recurrent Aphthous Stomatitis ◽  
The State ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Local Immunity ◽  
Before And After ◽  
Group 1

Aim. To comparatively characterize the state of local and general immunity in patients with the primary diagnosis of albinism and oral mucosal diseases. Methods. In the dental clinic of FSBEI HE «Kazan SMU MOH Russia» 4 patients aged 16 to 17 years are observed with the primary diagnosis of albinism and comorbid oral mucosal diseases. On initial examination 2 patients from group 1 were diagnosed with chronic recurrent aphthous stomatitis, Sutton’s disease. K12.1. The control group (group 2) included 5 children aged 12 to 15 years diagnosed with chronic recurrent aphthous stomatitis. The state of local immunity was assessed by the level of lysozyme of the oral fluid before and after the treatment. Lysozyme activity in the oral fluid was evaluated and calculated by our newly developed method. The state of local immunity was assessed by immunograms. Patients’ microbiologic status was evaluated by microscopic and bacteriological methods. Results. Among the patients from group 1 with the diagnosis of chronic recurrent aphthous stomatitis, Sutton’s disease, the analysis of immunograms prior to the study revealed severe neutropenia (5.4±0.4×109/l), lymphocytosis (Т-lymphocytes 85±3.5%), leukopenia (2.2±0.1×109/l), increased level of immunoglobulin A (2.69±0.1 g/l), decreased number of phagocytes (2.6) and circulating immune complexes (22±1.48). In patients from the control group leukopenia (2.89±0.23×109/l), lymphocytosis (Т-lymphocytes 74.3±1.32%), insignificant increase of immunoglobulin G level (14.5±0.59 g/l), decreased number of phagocytes (4.5±0.5) and circulating immune complexes (38.67±1.23), and neutropenia (25.5±0.1×109/l) were revealed. Conclusion. Cellular component of the general immunity in albinos insignificantly differs from the patients of the control group but no restoration of the cellular immunity occurs even in long-term remission; to choose the method of treatment for patients diagnosed with chronic recurrent aphthous stomatitis it is necessary to determine the etiology of the disease, particularly, immunologic status of patients before and after the treatment.

scholarly journals Effect of two percent turmeric extract gel on minor recurrent aphthous stomatitis

2016 ◽  
Vol 28 (1) ◽  
Author(s):  
Nurdiana N. ◽  
Shamini Krishnasamy
Keyword(s):  
Pain Intensity ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
P Value ◽  
Hospital Data ◽  
Initial Examination ◽  
Control Group Design ◽  
Ulcer Size ◽  
Turmeric Extract

Minor recurrent aphthous stomatitis (RAS) is recurrent oral ulcer with clinical features of shallow ulcer, round or oval shape, measuring less than 10 mm, covered with yellowish white pseudomembrane and surrounded by erythematous halo. Inflammation and pain that accompany the RAS make individual seek treatment to relieve these symptoms. Turmeric extract gel is a traditional medicine that can be used to cure RAS because it has anti-inflammatory, antibacterial, covering agents and antioxidants effect. The aim of this study was to explore the effect of 2% turmeric extract gel on minor RAS in reduction of erythematous halo, ulcer size, and pain intensity. This study was an experimental study using a pre test – post test control group design. The study involved 16 patients with minor RAS at University of Sumatera Utara Dental Hospital. Data collected by initial examination of RAS which included erythematous halo, ulcer size and pain intensity then controlled every day for the next three days. Analysis of the data in this study was used Friedman Test and Wilcoxon Signed Ranks Test to determine the difference between observations before and after RAS treatment. This study showed statistically significant results in reduction of erythematous halo at day of examination to first control with P value of 0.03 and first control to second control with P value of 0.025. Reduction of ulcer size showed statistically significant result at day of examination, first, second and third control with P value of 0.001 (P < 0.05). This study also showed statistically significant reduction in pain intensity with P value of 0.001 (P < 0.05) for day of examination to first control and first control to second control, as well as 0.014 (P < 0.05) for second control to third control. The results of this study showed a significant reduction in erythematous halo, ulcer size, and pain intensity.

scholarly journals Comparison of the Sex Hormones’ Serum Level in Women With Recurrent Aphthous Stomatitis and Healthy Population: A Cross-Sectional Study

2021 ◽  
Author(s):  
Fatemeh Lavaee ◽  
Zahra Ranjbar ◽  
Mina Jalalian ◽  
Mohammad Amin Amiri
Keyword(s):  
Serum Level ◽  
Sex Hormones ◽  
Cross Sectional Study ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Mean

Abstract Background:In this study, we aimed to evaluate the sex hormonal serum level in patients with recurrent aphthous stomatitis and compare them with healthy participants.Methods:This cross-sectional study was done on patients with recurrent aphthous stomatitis who had referred to Shiraz Dental Faculty, Oral and Maxillofacial Medicine Department during 2018-2019. The non -menopause women with recurrence of at least 3 lesions per year were enrolled in this study.The mean serum level of FSH, LH, PRL (prolactin), testosterone, DHT (Dihydrotestosterone), DHEA-S (Dehydroepiandrosterone sulfate), estradiol and progesterone of 30 participants in each group of case and control were measured and compared. The data were analyzed by SPSS version 18 and independent T-test, Mann-Whitney U test, Spearman’s correlation coefficient test, Chi-square test and Fisher’s test.Results: The mean serum level of DHEA-S in patients with recurrent aphthous stomatitis (RAS) was significantly lower than the control group (p value=0.002). In addition to DHEA-S, the mean serum level of testosterone was lower in the evaluation group although this difference was not significant (p value=0.057).Considering the effect of age on the mean serum level of sex hormones, our results revealed that only DHEA-S mean serum level was decreased by increasing the age of participants in patients with RAS (p value=0.018).The number of participants with abnormal range of testosterone (p value<0.0001) and progesterone (p value=0.037) serum level was significantly more in patients with RAS. The frequency of RAS in a year did not show a significant relationship with the serum level of the evaluated hormones.Conclusion: The patients with RAS had a lower serum level of DHEA-S. The mean serum level of testosterone and progesterone was significantly abnormal in RAS patients.

scholarly journals Expression of Inflammatory Factors in Critically Ill Patients with Urosepticemia and the Imaging Analysis of the Severity of the Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xia Huang ◽  
Zongjun Hu ◽  
Xi Yue ◽  
Yong Cui ◽  
Jiwen Cui
Keyword(s):  
Signaling Molecules ◽  
The Body ◽  
University Hospital ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Imaging Analysis ◽  
Hmgb1 Protein ◽  
High Fatality Rate ◽  
Severity Of The Disease

Urine sepsis is a complex inflammatory response of the body to infection with a high fatality rate. It is one of the main causes of death in noncardiovascular intensive care units. Nevertheless, in daily clinical practice, early sepsis is often not detected. In this paper, discharged cases of urinary sepsis from the Department of Urology and Critical Care Medicine of a university hospital were collected as the observation group, and common urinary tract infection cases were selected as the control group. We sorted and summarized the discharged case information of the observation group and the control group. The results of the study showed that, after renal pelvis perfusion, the expression of HMGB1 protein and mRNA increased, and the expression of TLR4 increased; inhibiting HMGB1 can reduce the expression of inflammatory factors caused by perfusion and reduce the infiltration of neutrophils and macrophages caused by perfusion. In addition, r HMGB1 treatment can promote the expression of inflammatory factors caused by perfusion and aggravate the infiltration of neutrophils and macrophages caused by perfusion. We found that inhibition of HMGB1 can inhibit the expression of TLR4/My D88 signaling molecules and r HMGB1 treatment can enhance the expression of TLR4/My D88 signaling molecules.

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