The quality of life of the people is a broad spectrum area of scientific research. It is measured through 9 indicators, which include an indicator of physical and economic security, which includes a negative phenomenon - criminality. The aim of the paper is spatial analysis of criminality as one of the elements of quality of life in the Bratislava self-governing region (BSR) in four areas (violent, moral, property and economic), as well as a comparison of the crimes of the capital cities Bratislava and Prague. The basic tool of data processing is comparative analysis and techniques in GIS and Excel programs. Most criminal acts in Slovakia are committed in BSR and in Bratislava. The highest number is recorded in property crime, especially car robbery committed and car theft. 18.6% of all criminal offences in Slovakia were committed in BSR (69,635 in 2016). 56.7% were cleared up and only 43% in BSR. Although the Czech capital, Prague, has a population three times bigger than Bratislava, it has only two times larger amount of crimes per 1,000 inhabitants. In recount of 1,000 inhabitants Bratislava exceeds Prague in violent crime, which we consider to be a serious socio-pathological phenomenon of society which reflects in the quality of life of its inhabitants.