Kaempferol ameliorates symptoms of metabolic syndrome by improving blood lipid profile and glucose tolerance

2021 ◽  
Author(s):  
Ayasa Ochiai ◽  
Mahmoud Ben Othman ◽  
Kazuichi Sakamoto
Keyword(s):  
Metabolic Syndrome ◽  
Glucose Tolerance ◽  
Molecular Mechanisms ◽  
Ldl Receptor ◽  
Blood Lipid ◽  
Apolipoprotein A1 ◽  
High Density Lipoproteins ◽  
Blood Lipid Profile ◽  
Beneficial Effects ◽  
Apoa1 Gene

Abstract Kaempferol (KPF) is a dietary polyphenol reported to have various beneficial effects on human health. However, its molecular mechanisms in regulating lipid and glucose metabolism are not fully understood. This study examined the effects of KPF on obesity, dyslipidemia, and diabetes in Tsumura, Suzuki, Obese Diabetes (TSOD) mice. The six-week administration of KPF decreased fat weight, serum total cholesterol, and low-density lipoproteins (LDLs); increased high-density lipoproteins (HDLs); and improved glucose tolerance. Additionally, KPF increased LDL receptor (LDLR) and apolipoprotein A1 (ApoA1) gene expression and decreased serum resistin levels. These findings suggest that the decrease in LDL and the increase in HDL caused by KPF may be due to increases in hepatic LDLR and ApoA1 expression, respectively. Furthermore, it is possible that the improvement in glucose tolerance by KPF may occur via resistin reduction. These mechanisms may be parts of complex mechanism by which KPF improves metabolic syndrome.

scholarly journals Greenselect Phytosome for Borderline Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Gianni Belcaro ◽  
Andrea Ledda ◽  
Shu Hu ◽  
Maria Rosa Cesarone ◽  
Beatrice Feragalli ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Blood Lipid ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Dietary Changes ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Green Tea Catechin ◽  
Disease Signature ◽  
Asymptomatic Subjects

The beneficial effects of Greenselect Phytosome, a proprietary lecithin formulation of a caffeine-free green tea catechin extract, were evaluated in a controlled registry study on 50 asymptomatic subjects borderline for metabolic syndrome factors and with increased plasma oxidative stress. After 24 weeks of intervention, improvement in weight, blood lipid profile, and blood pressure positioned 68% of subjects in the treatment arm out of the metabolic syndrome profile, while 80% of the subjects in the control group still remained in their initial borderline disease signature. Compared to the control (lifestyle and dietary changes alone), Greenselect Phytosome was especially effective for weight/waist changes. These results highlight the relevance of addressing multiple factors involved in the development of metabolic syndrome with a pleiotropic agent capable of improving the beneficial effects of lifestyle and dietary changes and foster the attainment of a globally improved health profile.

The beneficial effects of taurine in preventing metabolic syndrome

2016 ◽  
Vol 7 (4) ◽  
pp. 1849-1863 ◽  
Author(s):  
Wen Chen ◽  
Junxia Guo ◽  
Yanzhen Zhang ◽  
Jing Zhang
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Molecular Mechanisms ◽  
Human Studies ◽  
Beneficial Effects

A review of the data fromin vitro, animal and limited human studies of the beneficial effects of taurine on obesity, dyslipidaemia, diabetes mellitus and hypertension, as well as the possible metabolic and molecular mechanisms for the prevention of metabolic syndrome by taurine.

scholarly journals Fish Oil-Derived Furan Fatty Acid: A New Player in the Regulation of Metabolic Syndrome and Fatty Liver Disease

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1243-1243
Author(s):  
Pascal Rowart ◽  
Sonia Salvatore ◽  
Fei Chang ◽  
Nicholas Khoo ◽  
Francisco Schopfer
Keyword(s):  
Mass Spectrometry ◽  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Glucose Tolerance ◽  
Fatty Liver ◽  
Fish Oil ◽  
Glucose Tolerance Test ◽  
Tolerance Test ◽  
Omega 3 ◽  
Beneficial Effects

Abstract Objectives Obesity and non-alcoholic fatty liver diseases (NAFLD) are multifactorial diseases that affect more than 35% of the world's population. Fish oil (FO) is an important dietary component that provides essential omega-3 fatty acids (Ω-3) effective for hypertriglyceridemia with eicosapentaenoic acid shown to reduce cardiovascular and metabolic syndrome-related events. However, the mechanisms involved in these beneficial activities are still unclear. A metabolomic study of healthy volunteers receiving Lovaza, an omega-3-drug, showed a large increase in plasma and urinary metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF). Moreover, in the diet-induced obesity (DIO) mouse model, CMPF was protective and reversed steatosis. We identified furan fatty acids (FuFA) present both in FO and Lovaza (0.1–1%) as the sources of CMPF and hypothesised that they were responsible for these beneficial effects. Methods We synthesized one FuFA and confirmed its structure by NMR and mass spectrometry and tested whether it had protective effects in this DIO model (23 weeks, 60 kcal% fat). After 16 weeks of the diet, FuFA (25mg/kg/day) was administered by gavage for the last 7 weeks. A glucose tolerance test was performed at week 4th. Tissues and blood were collected at week 7th after 5h fasting. Mass spectrometry, ELISA, and multiplex analysis were performed on plasma. Liver staining (H&E) was also performed to quantify steatosis and ballooning. Results The glucose tolerance test showed improved glucose clearance in FuFA-treated mice compared to vehicle. The fasting level of insulin and c-peptide 2 were respectively 2.9- and 1.5-fold lower in FuFA- compared to the vehicle-treated mice. Additionally, circulating TNF-α was significantly lower (1.6-fold) in FuFA-treated mice. NAFLD activity scores - hepatocytes ballooning and steatosis - were also significantly decreased in FuFA-treated mice by 1.6- and 1.4-fold, respectively. Finally, an MS-based analysis of plasma showed a significant decrease in cholesterol (1.2-fold) and cholesterol-ester (1.4-fold) levels in FuFA-treated mice. Conclusions In conclusion, the beneficial effects observed in Ω-3 and FO treatment on DIO and NAFLD may be related to the presence of FuFA in these dietary preparations. Funding Sources NIH.

scholarly journals Potential opportunities for treatment of metabolic syndrome withalpha-lipoic acid (Berlithion®300)

2009 ◽  
Vol 6 (3) ◽  
pp. 10-14 ◽  
Author(s):  
T I Romantsova ◽  
I S Kuznetsov
Keyword(s):  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Food Intake ◽  
Lipoic Acid ◽  
Adipocyte Differentiation ◽  
Blood Lipid ◽  
Alpha Lipoic Acid ◽  
Blood Lipid Profile ◽  
Biological Targets ◽  
Brown Adipose

There are a lot of experi mental data confirmed the influence of alpha-lipoi с acid on activity of AMPK enzyme, receptors PPARα/γ and uncoupling proteins that prev ent oxidative phosphorylation (UCPl). AMPK is the enzyme responsible for food intake and energy expenditure in hypothalamus as w ell as in peripheral adipose tissue. PPARγ is the key modulator of lipid ho meostasis and adipocyte differentiation. UCPl is located in the brown adipose tissue and provides termogenesis. Via regulation of mentioned biological targets alpha-lipoic acid (Berlithion®300) lowers insulinresistance, favors weight losing process and improvement of blood lipid profile.

scholarly journals Effects of Wine and Tyrosol on the Lipid Metabolic Profile of Subjects at Risk of Cardiovascular Disease: Potential Cardioprotective Role of Ceramides

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1679
Author(s):  
Jose Rodríguez-Morató ◽  
Anna Boronat ◽  
Gabriele Serreli ◽  
Laura Enríquez ◽  
Alex Gomez-Gomez ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Function ◽  
Blood Lipid ◽  
White Wine ◽  
Cvd Risk ◽  
Blood Lipid Profile ◽  
Beneficial Effects ◽  
Before And After ◽  
Risk Biomarkers

Ceramides are a class of sphingolipids which have recently been shown to be better cardiovascular disease (CVD) risk predictors than traditional CVD risk biomarkers. Tyrosol (TYR) is a dietary phenolic compound known to possess cardioprotective effects per se or through its in vivo active metabolite hydroxytyrosol. The purpose of this study was to evaluate the effects of the co-administration of white wine (WW) and TYR on circulating levels of ceramides and other lipids in humans at high CVD risk. Volunteers underwent a randomized controlled crossover clinical trial (4-week duration per intervention) with three different interventions: control, WW, and WW enriched with a capsule of TYR (WW + TYR). Endothelial function cardiovascular biomarkers and plasma lipidomic profile were assessed before and after each intervention. It was found that the WW + TYR intervention resulted in lower levels of three ceramide ratios, associated with an improvement of endothelial function (Cer C16:0/Cer C24:0, Cer C18:0/Cer C24:0, and Cer C24:1/Cer C24:0), when compared to the control intervention. Moreover, WW + TYR was able to minimize the alterations in plasma diacylglycerols concentrations observed following WW. Overall, the results obtained show that the antioxidant TYR administered with WW exerts beneficial effects at the cardiovascular level, in part by modulating blood lipid profile.

scholarly journals Nuts, metabolic syndrome and diabetes

2010 ◽  
Vol 104 (4) ◽  
pp. 465-473 ◽  
Author(s):  
Cyril W. C. Kendall ◽  
Andrea R. Josse ◽  
Amin Esfahani ◽  
David J. A. Jenkins
Keyword(s):  
Metabolic Syndrome ◽  
Glycaemic Control ◽  
Blood Lipid ◽  
Glycaemic Index ◽  
Postprandial Blood Glucose ◽  
Blood Lipid Profile ◽  
Glucose Levels ◽  
The Metabolic Syndrome ◽  
Long Run ◽  
Control Diabetes

The ability of nuts to improve the blood lipid profile and reduce the risk of CHD is now well established. The interest that health effects of nuts have gained recently has brought the possible benefits of consuming nuts, such as improvement in the conditions of the metabolic syndrome, and their potential to prevent and control diabetes into focus. Results from cohort studies have associated nut consumption with a reduced risk of developing diabetes and CVD. However, few randomised controlled trials have assessed the effect of nuts on diabetes control, and those that have been undertaken have shown improvements in blood lipids but not in the glycaemic control. Diabetes agencies are increasingly recognising the importance of controlling postprandial glycaemia fluctuations. Acute feeding studies indicate that nuts have minimal effects on rising postprandial blood glucose levels when eaten alone, and diminish the postprandial glycaemic response when consumed with high-glycaemic index carbohydrate foods in both normoglycaemic and type 2 diabetic individuals. Nuts have a healthy nutritional profile, high in MUFA and PUFA, are a good source of vegetable protein and are rich in fibre, vitamins and minerals. Incorporation of nuts in the diet may therefore improve the overall nutritional quality of the diet. While more research is required to establish the ability of nuts to improve glycaemic control in the long run, early data indicate that the inclusion of nuts in the diets of individuals with diabetes and the metabolic syndrome is warranted, in view of their potential to reduce CHD risk.

scholarly journals Effect of Lactobacillus paracasei HII01 Supplementation on Total Cholesterol, and on the Parameters of Lipid and Carbohydrate Metabolism, Oxidative Stress, Inflammation and Digestion in Thai Hypercholesterolemic Subjects

2021 ◽  
Vol 11 (10) ◽  
pp. 4333
Author(s):  
Chaiyavat Chaiyasut ◽  
Yaowalak Tirawat ◽  
Bhagavathi Sundaram Sivamaruthi ◽  
Periyanaina Kesika ◽  
Subramanian Thangaleela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Placebo Group ◽  
Total Cholesterol ◽  
Blood Lipid ◽  
Lactobacillus Paracasei ◽  
Blood Lipid Profile ◽  
Beneficial Effects ◽  
Tnf Α ◽  
Total Antioxidant ◽  
Hypercholesterolemic Subjects

Hypercholesterolemia is one of the leading causes of cardiovascular disease. Probiotics can help to improve high blood lipid levels in hypercholesterolemia patients. Lactobacillus paracasei has been reported to have beneficial effects in several subjects; however, there is a lack of studies on Thai hypercholesterolemic subjects. Thus, this study was conducted in order to investigate the effect of L. paracasei HII01 on cholesterol, oxidative stress, and other biomarkers. Fifty-two subjects were randomized into two groups: the L. paracasei treatment group and the placebo group. The study was conducted over an intervention period of 12 weeks of supplementation. The results show that L. paracasei HII01 significantly reduced the total cholesterol (TCH), triglycerides (TGs), tumor necrosis factor (TNF)-α and lipopolysaccharide (LPS) of the patients, and increased their HDL, total antioxidant capacity (TAC) and propionic acid compared to the placebo group. Moreover, the supplementation of L. paracasei HII01 significantly increased lactic acid, IL-10 and IFN-γ, and substantially decreased malondialdehyde (MDA) at the end of the treatment. The results suggest that L. paracasei HII01 improves the blood lipid profile, reduces oxidative stress, and is beneficial for health among Thai hypercholesterolemic subjects.

scholarly journals Blood lipid profile of female and male rats in case of toxic cardiomyopathy, due to the introduction of sodium nitrite

2017 ◽  
Author(s):  
I. Ya. Krynytska ◽  
M. I. Marushchak ◽  
I. O. Stahurska ◽  
I. R. Bekus ◽  
M. V. Kyryliv ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Lipid Profile ◽  
Sodium Nitrite ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Male Rats ◽  
Cholesterol Concentration ◽  
High Density Lipoproteins ◽  
Blood Lipid Profile

The indices of the blood plasma lipid profile of female and male rats in case of toxic cardiomyopathy, due to the introduction of sodium nitrite were sudied. It was determined the increasing of cholesterol concentration in the blood plasma and its redistribution between lipoproteins due to reduction in high density lipoproteins and an increase in low-density lipoprotein, which have proatherogenic properties in animals of both sexes. In gender comparison of changes in blood lipid profile in case of sodium nitrite intoxication their significant prevalence in male rats was found. 

scholarly journals Dietary Lipids and Dyslipidemia in Chronic Kidney Disease

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3138
Author(s):  
Zdzislaw Kochan ◽  
Natalia Szupryczynska ◽  
Sylwia Malgorzewicz ◽  
Joanna Karbowska
Keyword(s):  
Chronic Kidney Disease ◽  
Lipid Metabolism ◽  
Kidney Disease ◽  
Unsaturated Fatty Acids ◽  
Blood Lipid ◽  
Dietary Lipids ◽  
High Density Lipoproteins ◽  
Dietary Recommendations ◽  
Metabolic Disturbances ◽  
Blood Lipid Profile

The progression of chronic kidney disease (CKD) leads to altered lipid metabolism. CKD patients exhibit high blood triglyceride (TG) levels, reduced concentrations and functionality of high-density lipoproteins (HDL), and elevated levels of atherogenic small, dense, low-density lipoproteins (sdLDL). Disorders of lipid metabolism and other metabolic disturbances place CKD patients at high risk for cardiovascular disease (CVD). Extensive evidence supports the cardioprotective effects of unsaturated fatty acids, including their beneficial effect on serum cholesterol and TG levels. Dietary lipids might therefore be especially important in the nutritional management of CKD. We review current dietary recommendations for fat intake by CKD patients and suggest potential nutritional interventions by emphasizing dietary lipids that might improve the blood lipid profile and reduce cardiovascular risk in CKD.

Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids

2018 ◽  
Vol 25 (3) ◽  
pp. 336-345 ◽  
Author(s):  
Paramjit S. Tappia ◽  
Adriana Adameova ◽  
Naranjan S. Dhalla
Keyword(s):  
Oxidative Stress ◽  
Amino Acids ◽  
Antioxidant Properties ◽  
Blood Lipid ◽  
Cardiovascular Complications ◽  
Blood Lipid Profile ◽  
Beneficial Effects ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Patients With Diabetes

Background: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications. Observations: It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions. Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.

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