scholarly journals P0130THE MORPHOMETRIC ANALYSIS OF GLOMERULI IN OBESE AND NON-OBESE PATIENTS WITH GLOMERULAR DISEASES

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Elena Jordanova ◽  
Radmila Jankovic ◽  
Radomir Naumovic ◽  
Dejan Celic ◽  
Bojana Ljubicic ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Significant Positive Correlation ◽  
Kidney Biopsy ◽  
Membranous Glomerulonephritis ◽  
Positive Association ◽  
Significant Negative Correlation ◽  
Obese Patients ◽  
Significant Positive Association ◽  
Glomerular Diseases ◽  
Positive Correlation

Abstract Background and Aims The aim of the study was to evaluate glomerular morphometry in obese and non-obese patients with glomerular diseases: FSGS, IgA nephropathy, membranous glomerulonephritis (MGN) and membranoproliferative glomerulonephritis (MPGN). Method The study included 125 patients with glomerular diseases (77 males, mean age 46± 15.2 years): obese (BMI> 27kg/m2- 63 patients) and non-obese (BMI< 27kg/m2-62 patients). The serum concentration of creatinine, proteins, albumin, cholesterol, trygliceride, daily proteinuria were measured at the time of kidney biopsy. Formula Cockcroft-Gault#(Cockcroft-Gault: non-obese) and Cockcroft-GaultLBW: obese) was calculated. Glomerular radius (GR), glomerular volume (GV) and glomerular density (GD) were compared morphometrically between two groups. Results At the time of kidney biopsy the obese had significantly lower eGFR, significantly higher creatinine, trygliceride, daily proteinuria compared to non-obese. Obese FSGS patients had significantly higher GR (109.44±6.03 μm vs 98.53±14.38 μm) and GV (3.13±0.49 x106 μm?vs 2.26±0.83 x106 μm?, only midly lower GD (1.91±0.39/mm2 vs 1.95±0.61/mm2) compared to non-obese. Obese IgA nephropathy patients had higher GR (110.69± 15.24 μm vs 107.77±14.53 μm), significantly higher GV(3.34±1.78 x106 μm?vs 2.31± 1.51 x106 μm? and significantly lower GD (1.21±0.29/mm2 vs 2.14±0.54/mm2) in comparation with non-obese. Significant positive association between GV and BMI (r=0.439; p<0.01) in FSGS patients was found. Significant positive correlation between GV and BMI (r=0.683; p< 0.01), but significant negative correlation between GD and BMI (r=-0.710; p< 0.01) in IgA nephropathy patients were found. Obese MGN patients had lower GR (112.82± 13.65 μm vs 118.39± 14.52 μm), GV (3.57± 1.19 x106 μm?vs 4.07± 1.28 x106 μm? and GD (1.89± 0.17/ mm2 vs 1.91± 0.92/mm2) but without significance compared to non-obese. Obese MPGN patients had higher GR(105.89± 12.24 μm vs 92.73± 30.01 μm), GV (2.94± 0.91 x106 μm?vs 2.31± 1.27 x106 μm? and GD (2.32± 0.63/ mm2 vs 2.03± 0.73/ mm2) but without significance in comparation with non-obese. Significant negative association between GD and daily proteinuria (r=-0.417; p<0.01) in MGN patients was found. Conclusion Obese FSGS patients had significantly higher GV, lower GD compared to non-obese. Obese IgA nephropathy patients had significantly higher GV and significantly lower GD. Obese MGN patients had lower and obese MPGN patients had higher morphometric parameters of glomeruli compared to non-obese. Significant positive correlation between GV and BMI in FSGS and IgA nephropathy patients were found.

scholarly journals Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 1061
Author(s):  
Wajdy J. Al-Awaida ◽  
Baker Jawabrah Al Hourani ◽  
Samer Swedan ◽  
Refat Nimer ◽  
Foad Alzoughool ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Vaccine Development ◽  
Case Fatality ◽  
Significant Negative Correlation ◽  
Reference Sequence ◽  
Genome Sequences ◽  
Positive Correlation ◽  
Case Fatality Ratio ◽  
Epidemiological Surveys

The outbreak of coronavirus disease 2019 (COVID-19), by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly developed into a worldwide pandemic. Mutations in the SARS-CoV-2 genome may affect various aspects of the disease including fatality ratio. In this study, 553,518 SARS-CoV-2 genome sequences isolated from patients from continents for the period 1 December 2020 to 15 March 2021 were comprehensively analyzed and a total of 82 mutations were identified concerning the reference sequence. In addition, associations between the mutations and the case fatality ratio (CFR), cases per million and deaths per million, were examined. The mutations having the highest frequencies among different continents were Spike_D614G and NSP12_P323L. Among the identified mutations, NSP2_T153M, NSP14_I42V and Spike_L18F mutations showed a positive correlation to CFR. While the NSP13_Y541C, NSP3_T73I and NSP3_Q180H mutations demonstrated a negative correlation to CFR. The Spike_D614G and NSP12_P323L mutations showed a positive correlation to deaths per million. The NSP3_T1198K, NS8_L84S and NSP12_A97V mutations showed a significant negative correlation to deaths per million. The NSP12_P323L and Spike_D614G mutations showed a positive correlation to the number of cases per million. In contrast, NS8_L84S and NSP12_A97V mutations showed a negative correlation to the number of cases per million. In addition, among the identified clades, none showed a significant correlation to CFR. The G, GR, GV, S clades showed a significant positive correlation to deaths per million. The GR and S clades showed a positive correlation to number of cases per million. The clades having the highest frequencies among continents were G, followed by GH and GR. These findings should be taken into consideration during epidemiological surveys of the virus and vaccine development.

scholarly journals Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

2021 ◽  
pp. 1-8
Author(s):  
Foad Alzoughool ◽  
Huda Al Hourani ◽  
Manar Atoum ◽  
Sajedah Bateineh ◽  
Hanan Alsheikh ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Biochemical Parameters ◽  
Significant Positive Correlation ◽  
Glycosylated Hemoglobin ◽  
Significant Negative Correlation ◽  
Diabetic Patients ◽  
Positive Correlation ◽  
Obesity Indices ◽  
Group Serum

BACKGROUND/AIM: The newly described proteins adropin and irisin are a highly conserved polypeptide that plays essential roles in metabolic and energy homeostasis, insulin resistance, and fat browning. The aim of this study is to evaluate the circulating levels of serum adropin and irisin in type 2 diabetes mellitus (T2DM) patients and also to elucidate possible relationships between serum adropin and irisin levels with anthropometric obesity indices and biochemical parameters. SUBJECTS AND METHODS: Single-center prospective observational study included 90 T2DM patients referred to the diabetes outpatient clinic. Height, weight, and waist circumference (WC) were measured. Body mass index (BMI) and waist to height ratio (WHtR) were calculated. Fasting blood glucose, glycosylated hemoglobin, serum lipids, creatinine, urea, and blood urea nitrogen were evaluated. Estimated glomerular filtration rate (GFR) was calculated, serum adropin and irisin were evaluated. RESULTS: The results showed a significant positive correlation between adropin and irisin in females but not in males (r = 0.311; P = 0.042). In males’ group, serum adropin levels showed significant negative correlation with serum glucose (–0.423, P = <  0.05), HbA1C (–0.364, P = <  0.05), and GFR (–0.355, P = <  0.05). In contrast, creatinine was showed a significant positive correlation with adropin in males (0.381, P = <  0.05). In females’ group, adropin showed a significant negative correlation with weight (–0.371, P = <  0.05), BMI (–0.349, P = <  0.05), WC (–0.402, P = <  0.01), and WHtR (–0.398, P = <  0.01). Contrary, in males’ group, serum irisin levels showed significant positive correlation with weight (0.338, P = <  0.05), BMI (0.332, P = <  0.05), WC (0.409, P = <  0.01), and WHtR (0.432, P = <  0.01). CONCLUSION: This study demonstrated that, in T2DM patients, circulating serum adrpoin correlated negatively with anthropometric obesity indices of obesity in females, while serum irisin was positively correlated with anthropometric obesity indices of obesity in males.

scholarly journals European survey shows poor association between soil organic matter and crop yields

2020 ◽  
Vol 118 (3) ◽  
pp. 325-334
Author(s):  
Wytse J. Vonk ◽  
Martin K. van Ittersum ◽  
Pytrik Reidsma ◽  
Laura Zavattaro ◽  
Luca Bechini ◽  
...  
Keyword(s):  
Organic Matter ◽  
Soil Organic Matter ◽  
Sugar Beet ◽  
Significant Positive Correlation ◽  
Agricultural Land ◽  
Crop Yields ◽  
Carbon Sink ◽  
Significant Negative Correlation ◽  
Positive Correlation ◽  
Farm Survey

AbstractA number of policies proposed to increase soil organic matter (SOM) content in agricultural land as a carbon sink and to enhance soil fertility. Relations between SOM content and crop yields however remain uncertain. In a recent farm survey across six European countries, farmers reported both their crop yields and their SOM content. For four widely grown crops (wheat, grain maize, sugar beet and potato), correlations were explored between reported crop yields and SOM content (N = 1264). To explain observed variability, climate, soil texture, slope, tillage intensity, fertilisation and irrigation were added as co-variables in a linear regression model. No consistent correlations were observed for any of the crop types. For wheat, a significant positive correlation (p < 0.05) was observed between SOM and crop yields in the Continental climate, with yields being on average 263 ± 4 (95% CI) kg ha−1 higher on soils with one percentage point more SOM. In the Atlantic climate, a significant negative correlation was observed for wheat, with yields being on average 75 ± 2 (95%CI) kg ha−1 lower on soils with one percentage point more SOM (p < 0.05). For sugar beet, a significant positive correlation (p < 0.05) between SOM and crop yields was suggested for all climate zones, but this depended on a number of relatively low yield observations. For potatoes and maize, no significant correlations were observed between SOM content and crop yields. These findings indicate the need for a diversified strategy across soil types, crops and climates when seeking farmers’ support to increase SOM.

Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome

1996 ◽  
Vol 26 (4) ◽  
pp. 857-862 ◽  
Author(s):  
H. Rickards ◽  
S. M. Dursun ◽  
G. Farrar ◽  
T. Betts ◽  
J. A. Corbett ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Negative Correlation ◽  
Plasma Levels ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Healthy Controls ◽  
Positive Correlation ◽  
Control Value ◽  
Cellular Immune ◽  
Patient Value

SynopsisFasting plasma levels of tryptophan, kynurenine and the pteridines, neopterin and tetrahydrobiopterin were measured in seven patients with Gilles de la Tourette syndrome (GTS) and 10 healthy controls. Plasma kynurenine was significantly elevated in the GTS patients. The lowest patient value was higher than the highest control value. Values for tryptophan, neopterin and tetrahydrobiopterin were similar in TS patients and controls. However, in TS patients only, there was a significant negative correlation between tryptophan and neopterin and a significant positive correlation between kynurenine and neopterin when controlling for tryptophan. This finding indicates that activation of cellular immune processes is a possible explanation for the rise in plasma kynurenine.

scholarly journals Effect of Fermented Feed on the Microbial Population of the Gastrointestinal Tracts of Pigs

2001 ◽  
Vol 67 (7) ◽  
pp. 3071-3076 ◽  
Author(s):  
Ren� L. van Winsen ◽  
Bert A. P. Urlings ◽  
Len J. A. Lipman ◽  
Jos M. A. Snijders ◽  
David Keuzenkamp ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Significant Positive Correlation ◽  
Stomach Contents ◽  
Significant Negative Correlation ◽  
Inhibitory Effect ◽  
Positive Correlation ◽  
Fermented Feed ◽  
The Family ◽  
Colon And Rectum

ABSTRACT An in vivo experiment was performed with pigs to study the inhibitory effect of fermented feed on the bacterial population of the gastrointestinal tract. Results demonstrated a significant positive correlation between pH and lactobacilli in the stomach contents of pigs in dry feed as well as in the stomach contents of pigs fed fermented feed. Furthermore, a significant positive correlation between the pH and the numbers of bacteria in the familyEnterobacteriaceae in the contents of the stomach of pigs fed dry feed was found. In the stomach contents of pigs fed fermented feed, a significant negative correlation was found between the concentration of the undissociated form of lactic acid and the numbers of Enterobacteriaceae. The numbers ofEnterobacteriaceae in the contents of the stomach, ileum, cecum, colon, and rectum of pigs fed fermented feed were significantly lower compared with the contents of the stomach, ileum, caecum, colon, and rectum of pigs fed dry feed. The numbers of total lactobacilli were significantly higher in the stomach contents of pigs fed fermented feed and in the ileum contents of one pig group fed fermented feed compared with the contents of pigs fed dry feed. However, the influence of lactobacilli on numbers of Enterobacteriaceae could not be demonstrated. It was concluded that fermented feed influences the bacterial ecology of the gastrointestinal tract and reduces the levels of Enterobacteriaceae in the different parts of the gastrointestinal tract.

Morpho-Biochemical Characteristics of Brinjal Germplasms Affect the Abundance And Infestation of Jassid

2021 ◽  
Vol 19 (1) ◽  
pp. 81-91
Author(s):  
F Yasmin ◽  
MR Amin ◽  
M Afroz ◽  
MAH Swapon ◽  
MM Hossain
Keyword(s):  
Protein Content ◽  
Chlorophyll Content ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Reducing Sugar ◽  
Total Sugar ◽  
The Other ◽  
Biochemical Characteristics ◽  
Positive Correlation

The tropical vegetable, brinjal is cultivated throughout the year in Bangladesh but the crop is infested by a number of insects including jassid. This study investigated the effects of different biophysical and biochemical characteristics of twelve brinjal germplasms on the abundance and infestation of jassid. The experiment was conducted during September 2018 to March 2019 in Gazipur, Bangladesh with twelve brinjal germplasms namely BD-7320, BD-7328, BD-9952, BD-10154, BD-10158, BARI Begun-1, BARI Begun-4, BARI Begun-5, BARI Begun- 6, BARI Begun-7, BARI Begun-8 and BARI Begun-9. The incidence of jassid was recorded from 3rd December to 26th March, and the lowest population was found on BARI Begun- 6. Among the biophysical traits, plant height, number of branch and leaf per plant, and leaf area exerted significant positive correlation; whereas trichome on lower and upper surfaces of leaf, spine per stem and leaf showed significant negative correlation with the abundance of jassid. On the other hand, moisture, reducing sugar, total sugar and protein content of the leaves and fruits, chlorophyll content of the leaves exerts significant positive correlation but ash and pH contents of the leaves and fruits were negatively correlated with the abundance of jassid. Jassids showed the lowest level of leaf infestation on BARI Begun-6, which could be for further analysis to develop jassid resistant brinjal. SAARC J. Agric., 19(1): 81-91 (2021)

scholarly journals Estimation of mean performance and genetic association of yield and yield components traits under rainfed condition in sunflower (Helianthus annuus L.)

2020 ◽  
Vol 5 (02) ◽  
pp. 203-207
Author(s):  
Mohan Vamsi D. ◽  
Sandhyasree G. ◽  
Meena H. P. ◽  
Payasi S. K.
Keyword(s):  
Seed Yield ◽  
Positive Association ◽  
Significant Negative Correlation ◽  
Plant Oil ◽  
Significant Positive Association ◽  
Rainfed Condition ◽  
Head Diameter ◽  
Research Fields ◽  
Volume Weight ◽  
Almost All

The present investigation was carried out at the Research Fields, ICAR-Indian Institute of Oilseeds Research, Rajendranagar, Hyderabad, Telangana, India. The material for present study consisted of twenty newly developed mono and multi headed restorer lines including CMS lines. The data for agronomic and yield traits i.e. days to 50% flowering, days to physiological maturity, plant height, head diameter, volume weight, 100 seed weight, seed yield per plant oil content and oil yield was recorded. The analysis of variance revealed significant differences among the genotypes for almost all characters which favour the selection. Associations among characters especially indicated that among the seven traits studied, seed yield per plant had a highly significant positive association with head diameter and significant negative correlation with days to 50% flowering and days to maturity. The genotypes, COSF-6B, COSF-7B, RGP-11-P1-S2, RGP-58-P4-S1-1 and RGP-46-P3 were identified as the most important genotypes for different traits and should be utilized in heterosis breeding programme to realize high heterosis for yield and yield contributing traits.

scholarly journals Correlation of spirometry and six minute walk test in patients with chronic obstructive pulmonary disease from Sundargarh, Odisha, India

2019 ◽  
Vol 8 (1) ◽  
pp. 205
Author(s):  
Yara Dinakar ◽  
Pradeep Panchadi Kiran ◽  
Akshaya K. Mohanty ◽  
Praveen Kishore Sahu ◽  
Anita Mohanty
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Chronic Obstructive ◽  
Walk Test ◽  
Obstructive Pulmonary Disease ◽  
Positive Correlation ◽  
Six Minute Walk Test ◽  
Copd Patients ◽  
Minute Walk

Background: Six‑Minute Walk Test (6MWT) is a simple, objective, reproducible test which correlated well with different spirometric indices, and thus able to predict severity of Chronic Obstructive Pulmonary Disease (COPD) and can replace spirometry in resource poor set‑up. Here, author evaluated the correlation of 6 minute walk distance (6MWD) with spirometric indices in COPD patients and the potential of 6MWT as an alternative to the assessment of severity of COPD.Methods: This cross-sectional observational study included a total of 80 COPD patients, diagnosed by GOLD criteria (Post bronchodilator FEV1/ FVC ratio <0.7). Modified Medical Research Council (mMRC) grading was used (age, weight, height, body mass index- BMI and breathlessness) and all the patients underwent spirometric measurement of FEV1, FVC and FEV1/ FVC ratio and tests were repeated after bronchodilation using 200-400 μg of salbutamol. 6MWT was performed following American Thoracic Society (ATS) protocol of 6MWT and distance was measured in meters.Results: Author found significant negative correlation of 6MWT with age (r=-0.384, p=0.00) and mMRC grading of dyspnea (r=-0.559, p=0.00) and significant positive correlation with height (r=0.267, p=0.019) and weight (r=0.293, p=0.008). Significant positive correlation of 6MWD was noted with post bronchodilator FEV1(r=0.608, p=0.00), FEV1% (r=0.429, p=0.00), FVC (r=0.514 p=0.00), FVC% (r=0.313 p=0.005), FEV1/FVC % (r=0.336, p=0.001). Positive correlation was also observed between 6MWT and BMI but statistically insignificant (r=0.177, p=0.116). There was significant negative correlation between 6MWT and GOLD staging (r=-0.536, p=0.00).Conclusions: This finding concludes that 6MWT can be used for the assessment of severity of disease in COPD patients in places where spirometry is not available.

scholarly journals THE CORRELATION OF MOBILITY TREND AND SITUATION OF COVID-19 BY COUNTRY, TERRITORY, AND AREA

2021 ◽  
Vol 8 (3) ◽  
pp. 153-164
Author(s):  
Adrina Esther Liaw ◽  
Jihan Natra Shafira ◽  
Muhammad Aziz ◽  
Iche Andriyani Liberty
Keyword(s):  
Negative Correlation ◽  
Government Policy ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Research Paper ◽  
Analytic Study ◽  
Cross Sectional ◽  
Positive Correlation ◽  
The World ◽  
The Government

Each country around the world has taken several approaches in order to stop the spreading of the virus. This study was conducted to correlate the mobility trend and the situation of COVID-19 by country, territory, and area. This research paper adopts an observational analytic study with a cross-sectional approach for 115 countries from February 17th to August 27th, 2020. Tajikistan (r=0,956) and Italy (r=0,931) has the highest positive correlation for retail and recreations. For grocery,the highest degree of positive correlation is Mongolia (r=0,945) and Tajikistan (r=0,933). Bostwana and Italy showed highest significant positive correlation among countries (r=0,985 and r=0,902, respectively) for transit stations and residential  (r=0,994 and r=0,984). Bostwana also has the highest significant positive correlation for the park (r=0.980). Meanwhile, for the workplace, Mauritius (r=0,863) and Dominica (r=0,785) are countries with the highest degree of positive correlation with a cumulative case of COVID-19. Society's behavior plays an important role by following the government policy in order to slow down the spread of the virus. Retail and recreations, groceries and pharmacy stores, transit stations, parks, and workplaces found to have a significant positive correlation while residential have a significant negative correlation with cumulative cases of COVID-19 in most countries.  

scholarly journals Analysis of the Correlation between Commodity Grade and Quality ofAngelica sinensisby Determination of Active Compounds Using Ultraperformance Liquid Chromatography Coupled with Chemometrics

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Zenghui Wang ◽  
Dongmei Wang ◽  
Linfang Huang
Keyword(s):  
Ferulic Acid ◽  
Bioactive Compounds ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Principal Component ◽  
Significant Negative Correlation ◽  
Average Weight ◽  
Positive Correlation ◽  
Grade Classification ◽  
The Difference

The contents of ferulic acid, senkyunolide A, butylidenephthalide, ligustilide, and n-butylphthalide were determined by UPLC analytical method; the correlation among the grade, average weight, and content was explored by correlation analysis and analysis of variance (ANOVA); the different commercial grades with average weight and content were revealed by principal component analysis (PCA) and then rationality analysis grade classification ofA. sinensis. The results showed that various commercial grades can be distinguished by PCA analysis. And there was significant negative correlation between the commodity grades and average weight, commodity, and the content of bioactive compounds, while the content of senkyunolide A had significant negative correlation with commodity grades (P<0.01). Average weight had no correlation with chemicals compounds. Additionally, there was significant positive correlation among the bioactive compounds (content of ferulic acid and phthalides) of different grades ofA. sinensis. The content of senkyunolide A, butylidenephthalide, and ligustilide had significant positive correlation with the content of ferulic acid. The content of ligustilide and butylidenephthalide had significant positive correlation with the content of senkyunolide A. The content of ligustilide had significant positive correlation with the content of butylidenephthalide. The basis of grades classification is related with the difference levels of the bioactive compounds.

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