Growth and Development

Mind Shift ◽  
2021 ◽  
pp. 92-106
Author(s):  
John Parrington
Keyword(s):  
Growth And Development ◽  
Structural Changes ◽  
Human Life ◽  
Cell Types ◽  
Cell Number ◽  
The Body ◽  
Rapid Rate ◽  
Brain Growth ◽  
Cellular Changes ◽  
Fertilized Egg

This chapter assesses the linked processes of brain growth and development. Each human life begins with the union of a sperm and an egg. Embryogenesis is the process by which the fertilized egg divides repeatedly to produce the 37 trillion cells that make up a person. But embryo development is about far more than just this dramatic increase in cell number. It also involves the formation of all the specialised cell types of the body, and their organization into tissues and organs. Initially, the embryo is just a ball of cells called a blastocyst. But then a dramatic transformation takes place called gastrulation, which is a key event in the formation of a human being. While these are the gross structural changes underlying brain development, equally important are the cellular changes. The development of the human brain occurs at such a rapid rate that a newborn baby’s brain has almost the same number of neurons as that of an adult. However, brain growth continues after birth due to the creation of new glial cells and connections between neurons.

scholarly journals Polyploidy in Cardiomyocytes

2020 ◽  
Vol 126 (4) ◽  
pp. 552-565 ◽  
Author(s):  
Wouter Derks ◽  
Olaf Bergmann
Keyword(s):  
Cardiac Injury ◽  
Physiological Role ◽  
Cell Types ◽  
Cell Number ◽  
The Body ◽  
Cardiomyocyte Hypertrophy ◽  
Heart Regeneration ◽  
Cardiomyocyte Proliferation ◽  
Hypertrophic Growth

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to regenerate upon injury. In the adult heart, however, the actual rate of cardiomyocyte renewal is too low to efficiently counteract substantial cell loss caused by cardiac injury. In mammals, cardiac growth by cell number expansion changes to growth by cardiomyocyte enlargement soon after birth, coinciding with a period in which most cardiomyocytes increase their DNA content by multinucleation and nuclear polyploidization. Although cardiomyocyte hypertrophy is often associated with these processes, whether polyploidy is a prerequisite or a consequence of hypertrophic growth is unclear. Both the benefits of cardiomyocyte enlargement over proliferative growth of the heart and the physiological role of polyploidy in cardiomyocytes are enigmatic. Interestingly, hearts in animal species with substantial cardiac regenerative capacity dominantly comprise diploid cardiomyocytes, raising the hypothesis that cardiomyocyte polyploidy poses a barrier for cardiomyocyte proliferation and subsequent heart regeneration. On the contrary, there is also evidence for self-duplication of multinucleated myocytes, suggesting a more complex picture of polyploidy in heart regeneration. Polyploidy is not restricted to the heart but also occurs in other cell types in the body. In this review, we explore the biological relevance of polyploidy in different species and tissues to acquire insight into its specific role in cardiomyocytes. Furthermore, we speculate about the physiological role of polyploidy in cardiomyocytes and how this might relate to renewal and regeneration.

scholarly journals The Process of Bali Hindu Human Life (Theoretical Study of the Process and Meaning of the Manusa Yadya Ceremony for the Balinese Hindu Community)

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
I Nengah Suastika
Keyword(s):  
Life Cycle ◽  
Growth And Development ◽  
Spiritual Growth ◽  
Theoretical Study ◽  
Human Life ◽  
The Body ◽  
Balanced Growth ◽  
Spiritual Self ◽  
Hindu Community ◽  
Large Adult

The Balinese Hindu community interpret life as a process of transformation that must always be interpreted and treated. According to the beliefs of the Balinese Hindu community, the process of the life cycle to achieve the perfection of life must go through various stages of the procession of the ceremony (the ceremony of manusa yadnya). Life cycle ceremony processions carried out since the fetus is still in the womb, born, large, adult, old, even to death. It is believed that it is not only the body that needs nutritionally complete and balanced food in its growth and development. Spiritual must also be given spiritual food to build spiritual growth itself toward a healthy, strong and steady spirit. The life cycle ceremony process is a process of spiritual self cleansing to lead to physical and spiritual purity. In the Book of Manawa Dharmasastra the life cycle ceremony process is stated as samskara sarira. Sarira samkara means a ceremony to increase the sanctity of one's body through the process of yadnya (holy sacrifice) ceremony. To achieve this increase should be balanced growth between the body (sarira) physical and spiritual. Corresponding to that, then studying the ceremonial procession and the meaning of the ceremony procession of the Hindu Balinese human life cycle is something very urgent.

scholarly journals Stem Cell – A Miraculous Cell Creating a Ray of Future Hope

1970 ◽  
Vol 9 (1) ◽  
pp. 1-4
Author(s):  
Sanjoy Kumar Chakraborty ◽  
Laila Anjuman Banu
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Human Body ◽  
Cell Types ◽  
Early Embryo ◽  
The Body ◽  
Different Types ◽  
Fertilized Egg

Ultimately, every cell in the human body can be traced back to a fertilized egg that came into existence from the union of ovum and sperm. But the body is made up of over 200 different types of cells, not just one. All of these cell types come from a pool of cells in the early embryo, called stem cells. DOI: http://dx.doi.org/10.3329/bja.v9i1.8138 Bangladesh Journal of Anatomy January 2011, Vol. 9 No. 1 pp 1-4

scholarly journals Small adipose stores in cystic fibrosis mice are characterized by reduced cell volume, not cell number

2018 ◽  
Vol 315 (6) ◽  
pp. G943-G953 ◽  
Author(s):  
Ilya Bederman ◽  
Alex DiScenna ◽  
Leigh Henderson ◽  
Aura Perez ◽  
Jeannie Klavanian ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Adipose Tissue ◽  
Body Mass ◽  
Genetic Disorder ◽  
Clinical Care ◽  
Cell Types ◽  
Cell Number ◽  
The Body ◽  
Clear Understanding ◽  
Organ Systems

Cystic fibrosis (CF) is a lethal genetic disorder that affects many organ systems of the body, including various endocrine and exocrine tissues. Health and survival positively associate with body mass, and as a consequence, CF clinical care includes high-fat, high-calorie diets to maintain and increase adipose tissue stores. Such strategies have been implemented without a clear understanding of the cause and effect relationship between body mass and patients’ health. Here, we used CF mouse models, which display small adipose stores, to begin examining body fat as a prelude into mechanistic studies of low body growth in CF, so that optimal therapeutic strategies could be developed. We reasoned that low adiposity must result from reduced number and/or volume of adipocytes. To determine relative contribution of either mechanism, we quantified volume of intraperitoneal and subcutaneous adipocytes. We found smaller, but not fewer, adipocytes in CF compared with wild-type (WT) animals. Specifically, intraperitoneal CF adipocytes were one-half the volume of WT cells, whereas subcutaneous cells were less affected by the Cftr genotype. No differences were found in cell types between CF and WT adipose tissues. Adipose tissue CFTR mRNA was detected, and we found greater CFTR expression in intraperitoneal depots as compared with subcutaneous samples. RNA sequencing revealed that CF adipose tissue exhibited lower expression of several key genes of adipocyte function ( Lep, Pck1, Fas, Jun), consistent with low triglyceride storage. The data indicate that CF adipocytes contain fewer triglycerides than WT cells, and a role for CFTR in these cells is proposed. NEW & NOTEWORTHY Adipocytes in cystic fibrosis mice exhibit smaller size due to low triglyceride storage. Adipocyte cell number per fat pad is similar, implying triglyceride storage problem. The absence of CFTR function in adipose tissue has been proposed as a direct link to low triglyceride storage in cystic fibrosis.

scholarly journals REVIEW ON PRINCIPLES OF FOOD INTAKE IN INDIAN SYSTEM OF MEDICINE

2020 ◽  
Vol 8 (10) ◽  
pp. 4783-4787
Author(s):  
Neetu 1 ◽  
Ashutosh 2 ◽  
Vyas P.P. ◽  
Harish Kumar Singhal
Keyword(s):  
Food Intake ◽  
Growth And Development ◽  
Human Life ◽  
Nutritional Supplements ◽  
The Body ◽  
Food Preparation ◽  
Nutritional Properties ◽  
Nutritional Values ◽  
Nutritional Elements ◽  
Other Substances

Under the term Nutrition, we think of nutrients and other substances of food that are responsible for main-taining the health, growth, and development of the body. So, it can be said that nutrition is the base of the body as well as life. The existence of human life depends upon nutritional food but the merely intake of nutritional food is not sufficient for proper growth and development. It is equally necessary to know that the nutritional elements required for the body are properly absorbed or not. In the present era, everyone wants to know only about nutritional supplements, but people are not much aware of the rules of food preparation, rules of proper intake, etc. Rules of proper food intake ensure the optimum benefits of the nutritional values of the food. Certain factors which influence the nutritional properties of food are de-scribed in Ayurvedic classical texts. This paper deals with the rules of proper food intake mentioned in Kashyap Samhita, Khilasthana, 5th chapter Bhojyopakramaniyadhyay i.e. Atisheeta, Atyushna, Atisnigdha, Ruksha, Atishushka food may cause diseases although these foods may be full of the nutritional substanc-es.

HISTOLOGICAL CHANGES IN THE INTESTINES OF POULTRY DURING FODDER INTOXICATION

2020 ◽  
Author(s):  
E.P. Dolgov ◽  
◽  
A.A. Abramov ◽  
E.V. Kuzminova ◽  
E.V. Rogaleva ◽  
...  
Keyword(s):  
Body Weight ◽  
Histological Examination ◽  
Aflatoxin B1 ◽  
Structural Changes ◽  
Clinical Manifestations ◽  
Feed Additives ◽  
The Body ◽  
Histological Changes ◽  
Beet Pulp

The article presents the data on the study of the influence of mycotoxins combination (T-2 toxin at the concentration of 0.095 mg/kg and aflatoxin B1 in the concentration of 0.019 mg/kg) on the body of quails and the results of pharmacocorrection of toxicosis with a complex consisting of beet pulp and lecithin. Structural changes in the intestines of quais at fodder mycotoxicosis are described. The use of antitoxic feed additives in poultry led to a weakening of the action of xenobiotics, which was confirmed by an increase in the safety of poultry and increase in body weight of quails, a decrease in the clinical manifestations of intoxication, as well as in positive changes in the structure of the intestine of the poultry during histological examination.

Chronic Hypoxia as a Potential Factor in Human Life-threatening Diseases

2017 ◽  
Vol 10 (4) ◽  
pp. 3759-3762
Author(s):  
Sandhya MNVS ◽  
Vanitha K ◽  
Ramesh A
Keyword(s):  
Chronic Hypoxia ◽  
Atmospheric Oxygen ◽  
Human Life ◽  
The Body ◽  
Cellular Damage ◽  
Otto Warburg ◽  
Regular Treatment ◽  
Breathing Exercises ◽  
Hypoxic Conditions ◽  
Cancerous Cell

The review article focuses on the importance of adequate oxygen levels in the body as cure and therapy for many ailments. It is known that hypoxia is the cause for cellular damage and if it can be applied to major patho-physiology’s, it can be observed that slow and chronic hypoxic conditions are the cause for most of the diseases. On the contrary, providing each cell of the body with proper oxygen may be helpful in maintaining the immunity of the body and therefore treating many disease conditions. This theory, if tested may show positive results in heart related diseases, neuronal disorders, stresses, digestive disorders and the unresolved cancer too. Slow decrease in the levels of atmospheric oxygen could be a reason to induce chronic hypoxia. According to Dr. Otto Warburg, a Noble laurate, a normal cell when deprived of oxygen, may get converted to a cancerous cell, whereas a cancerous cell cannot survive in aerobic conditions. If this part of his research be concentrated on, there could be fruitful results in the treatment of cancer. To maintain adequate levels of oxygen in the body, simple yogic breathing practices are helpful. And to maintain the adequate atmospheric oxygen, trees and plants which cleanse the atmospheric air are useful. Clinical surveys on volunteers who have been practicing regular breathing exercises can prove the fact that proper and concentrated respiration could prevent many diseases. Thus, supplementing breathing exercises along with the regular treatment for cancer patients could be helpful in alleviating cancer and other diseases.

Influence of Ascorbic Acid on the Structure and Function of Alpha-2- macroglobulin: Investigations using Spectroscopic and Thermodynamic Techniques

2020 ◽  
Vol 27 (3) ◽  
pp. 201-209
Author(s):  
Syed Saqib Ali ◽  
Mohammad Khalid Zia ◽  
Tooba Siddiqui ◽  
Haseeb Ahsan ◽  
Fahim Halim Khan
Keyword(s):  
Ascorbic Acid ◽  
Conformational Changes ◽  
Structural Changes ◽  
The Body ◽  
Titration Calorimetry ◽  
Spectroscopic Techniques ◽  
Human Beings ◽  
Plasma Ascorbic Acid ◽  
Dietary Antioxidant ◽  
And Function

Background: Ascorbic acid is a classic dietary antioxidant which plays an important role in the body of human beings. It is commonly found in various foods as well as taken as dietary supplement. Objective: The plasma ascorbic acid concentration may range from low, as in chronic or acute oxidative stress to high if delivered intravenously during cancer treatment. Sheep alpha-2- macroglobulin (α2M), a human α2M homologue is a large tetrameric glycoprotein of 630 kDa with antiproteinase activity, found in sheep’s blood. Methods: In the present study, the interaction of ascorbic acid with alpha-2-macroglobulin was explored in the presence of visible light by utilizing various spectroscopic techniques and isothermal titration calorimetry (ITC). Results: UV-vis and fluorescence spectroscopy suggests the formation of a complex between ascorbic acid and α2M apparent by increased absorbance and decreased fluorescence. Secondary structural changes in the α2M were investigated by CD and FT-IR spectroscopy. Our findings suggest the induction of subtle conformational changes in α2M induced by ascorbic acid. Thermodynamics signatures of ascorbic acid and α2M interaction indicate that the binding is an enthalpy-driven process. Conclusion: It is possible that ascorbic acid binds and compromises antiproteinase activity of α2M by inducing changes in the secondary structure of the protein.

Melatonin Modulates Lactation by Regulating Prolactin Secretion Via Tuberoinfundibular Dopaminergic Neurons in the Hypothalamus- Pituitary System

2020 ◽  
Vol 21 (8) ◽  
pp. 744-750 ◽  
Author(s):  
Hongyang Li ◽  
JingyaWei ◽  
Fengtao Ma ◽  
Qiang Shan ◽  
Duo Gao ◽  
...  
Keyword(s):  
Pineal Gland ◽  
Pituitary Gland ◽  
Antioxidant Capacity ◽  
Dopaminergic Neurons ◽  
Growth And Development ◽  
Endocrine System ◽  
Mammary Glands ◽  
Prolactin Secretion ◽  
The Body ◽  
Stimulation Of

In-depth studies have identified many hormones important for controlling mammary growth and maintaining lactation. One of these is melatonin, which is synthesized and secreted by the pineal gland to regulate circadian rhythms, improve antioxidant capacity, and enhance immunity. Prolactin is secreted by the pituitary gland and is associated with the growth and development of mammary glands as well as initiation and maintenance of lactation. The hypothalamus-pituitary system, the most important endocrine system in the body, regulates prolactin secretion mainly through dopamine released from tuberoinfundibular dopaminergic neurons. This review provides a reference for further study and describes the regulation of lactation and prolactin secretion by melatonin, primarily via the protection and stimulation of tuberoinfundibular dopaminergic neurons.

Review of Curd, Paneer and Cheese as Nitya Asevaniya Ahara Dravya w.s.r. to Dadhi, Kilat and Kurchika

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Saylee Deshmukh ◽  
Vyas M. K.
Keyword(s):  
Vitamin A ◽  
Growth And Development ◽  
Milk Protein ◽  
The Body ◽  
Rich Source ◽  
Food Items ◽  
Common Food ◽  
Daily Diet ◽  
Healthy Growth

Curd, Paneer and Cheese are rich source of milk protein, calcium, Vitamin A, Phosphorous, vitamins, minerals and protein which are required by the body in high proportions for healthy growth and development. It is common food in India. Cheese is also a rich source of fat. Curd, Paneer and Cheese can be correlated with Dadhi, Paneer and Cheese in Ayurveda classics which are listed in Nitya Asevaniya Ahara Dravya (food items not to be taken in daily diet). Present study aims to explain rationale behind description of these food items as Nitya Asevaniya Ahara Dravya.

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