scholarly journals Activity-induced fluidization of arrested coalescence in fusion of cellular aggregates

2021 ◽  
Author(s):  
Steven Ongenae ◽  
Maxim Cuvelier ◽  
Jef Vangheel ◽  
Herman Ramon ◽  
Bart Smeets
Keyword(s):  
Time Scale ◽  
Relaxation Times ◽  
Fusion Process ◽  
Cortical Tension ◽  
Tissue Constructs ◽  
Liquid Theory ◽  
Long Time ◽  
The Relationship ◽  
Cellular Aggregates

At long time scales, tissue spheroids may flow or appear solid depending on their capacity to reorganize their internal structure. Understanding the relationship between intrinsic mechanical properties at the single cell level, and the tissue spheroids dynamics at the long-time scale is key for artificial tissue constructs, which are assembled from multiple tissue spheroids that over time fuse to form coherent structures. The dynamics of this fusion process are frequently analyzed in the framework of liquid theory, wherein the time scale of coalescence of two droplets is governed by its radius, viscosity and surface tension. In this work, we extend this framework to glassy or jammed cell behavior which can be observed in spheroid fusion. Using simulations of an individual-cell based model, we demonstrate how the spheroid fusion process can be steered from liquid to arrested by varying active cell motility and repulsive energy as established by cortical tension. The divergence of visco-elastic relaxation times indicates glassy relaxation near the transition towards arrested coalescence. Finally, we investigate the role of cell growth in spheroid fusion dynamics. We show that the presence of cell division introduces plasticity in the material and thereby increases coalescence during fusion.

scholarly journals Activity-Induced Fluidization and Arrested Coalescence in Fusion of Cellular Aggregates

2021 ◽  
Vol 9 ◽  
Author(s):  
Steven Ongenae ◽  
Maxim Cuvelier ◽  
Jef Vangheel ◽  
Herman Ramon ◽  
Bart Smeets
Keyword(s):  
Time Scale ◽  
Relaxation Times ◽  
Fusion Process ◽  
Cortical Tension ◽  
Tissue Constructs ◽  
Liquid Theory ◽  
Long Time ◽  
The Relationship ◽  
Cellular Aggregates

At long time scales, tissue spheroids may flow or appear solid depending on their capacity to reorganize their internal structure. Understanding the relationship between intrinsic mechanical properties at the single cell level, and the tissue spheroids dynamics at the long-time scale is key for artificial tissue constructs, which are assembled from multiple tissue spheroids that over time fuse to form coherent structures. The dynamics of this fusion process are frequently analyzed in the framework of liquid theory, wherein the time scale of coalescence of two droplets is governed by its radius, viscosity and surface tension. In this work, we extend this framework to glassy or jammed cell behavior which can be observed in spheroid fusion. Using simulations of an individual-cell based model, we demonstrate how the spheroid fusion process can be steered from liquid to arrested by varying active cell motility and repulsive energy as established by cortical tension. The divergence of visco-elastic relaxation times indicates glassy relaxation near the transition toward arrested coalescence. Finally, we investigate the role of cell growth in spheroid fusion dynamics. We show that the presence of cell division introduces plasticity in the material and thereby increases coalescence during fusion.

The Problem of Identifying and Modeling the Relationship between Monetary Factor and Inflation in the Russian Economy

2008 ◽  
pp. 61-76
Author(s):  
A. Porshakov ◽  
A. Ponomarenko
Keyword(s):  
Money Supply ◽  
Money Demand ◽  
Russian Economy ◽  
Long Run ◽  
Complex Approach ◽  
Wide Range ◽  
Long Time ◽  
The Relationship ◽  
Supply Side Factors

The role of monetary factor in generating inflationary processes in Russia has stimulated various debates in social and scientific circles for a relatively long time. The authors show that identification of the specificity of relationship between money and inflation requires a complex approach based on statistical modeling and involving a wide range of indicators relevant for the price changes in the economy. As a result a model of inflation for Russia implying the decomposition of inflation dynamics into demand-side and supply-side factors is suggested. The main conclusion drawn is that during the recent years the volume of inflationary pressures in the Russian economy has been determined by the deviation of money supply from money demand, rather than by money supply alone. At the same time, monetary factor has a long-run spread over time impact on inflation.

scholarly journals ROLE OF GUT MICROBIOTA IN LIPID METABOLISM

2018 ◽  
Vol 11 (4) ◽  
pp. 4 ◽  
Author(s):  
Khrystyna Kvit ◽  
Viacheslav Kharchenko
Keyword(s):  
Lipid Metabolism ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Blood Lipids ◽  
Published Data ◽  
Long Time ◽  
Lipid Balance ◽  
The Relationship

 Researchers have studied the connection between cholesterol and microbiota for a long time. The results of widely published data demonstrate that the relationship between the lipid balance of the blood and the composition of the intestinal microbiota is apparent. The oblective of this study was, we tried to find the path through which this connection is carried out. Furthermore, the aim was to analyze the studies, which demonstrate the decrease of blood lipids as the result of different prebiotics and probiotics prescribtion. Also, the screening of different data from previous years was done for comparing the changes in the pathogenesis.

scholarly journals The Role of Spirituality in the Medical Care of Patients Suffering from Addiction and Mental Disease

2020 ◽  
Keyword(s):  
Mental Disease ◽  
Psychiatric Patients ◽  
Religious Schools ◽  
Male Predominance ◽  
Long Time ◽  
Religious Aspects ◽  
The Impact ◽  
The Relationship ◽  
Positive Effect

For a long time, a separation has been made between medicine and spirituality, but since the 90s, there has been an advent of spirituality after several researchers in North America have found that this dimension is linked to several pathologies and could play a role in the recovery of psychiatric patients. After a brief reminder about spirituality and religion and some concepts of mental health, we present three qualitative studies. The first aims to measure the degree of religiosity of the consultants of the center of addiction of Marrakech by using A religiosity Scale created by DR Dany R.Khalaf. The result of this first study is unequivocal, the patients of the center of addictology have a middle degree of religiosity with a certain profile a clear male predominance having less than 30 years, sedentary. Half of them is unemployed and did not passed secondary school in non-religious schools. Mostly Muslim, while occasionally consuming alcohol and consuming more than 10 cigarettes a day. The second study attempts to establish a link between religiosity and the impact it may have on the abstinence of alcohol addicts. The final result of this study is that religiosity has a definite impact on alcohol dependent abstinence and is even the main reason behind the abstinence of some patients. The third study sought to demonstrate the relationship between religion and suicidality among depressed patients. The result is that religion is one of the reasons for abandoning suicidal ideation and that it brings tremendous benefit to patients, which make them quit the idea of committing suicide. During both studies, questions relating to the integration of the spiritual and religious aspects of care were asked. The majority of patients want spirituality and religiosity / religion to be taken into consideration and integrated into their care while being with their doctor. After having seen all the benefits of spirituality and the positive effect it had on patients in the various studies, we can only conclude that spirituality has a primordial and very important role in the care of patients. . Herein, everything needs to be done, a protocol of care taking should be established, including this dimension and future psychiatrists needs to be trained to do it, and it should include a panelist such as “the leaders of the cults” in the care.

scholarly journals The Role of Coloristic Decoration of the Architectural Order in Shaping the Façade Tectonics in the Baroque Period

2021 ◽  
Author(s):  
Bogna Ludwig
Keyword(s):  
Vertical Direction ◽  
Work Of Art ◽  
Original State ◽  
Color Separation ◽  
Long Time ◽  
Architectural Structures ◽  
The Relationship

The article is dedicated to the role of polychrome solutions of the architectonic order in the concept of the Baroque façade. The ancient principles of designing architectural structures, inherited from the Renaissance were subjected to reinterpretations in order to impart different expressive values. The arrangements of façades, initially balanced or even horizontal, were replaced by ambiguous bivalent compositions. Vertical layouts began to dominate in the Baroque. Appropriately selected polychrome of the elements of the order could emphasize the compositional expression. The relationship between the layout of the polychrome in a given architectural order and the expression of a work of art has been established for quite a long time. However, the generally available data on color schemes of architectural structures in baroque buildings are still not fully organized. The paper analyses examples of Baroque façades preserved in their original state and revalorized in recent years after thorough conservator’s research in the field of architecture and color. The examples are mainly designed in the so-called great order, i.e. pertaining largely to church façades. In the Baroque, the vertical direction of the composition was strongly emphasized by multiplying or applying perspective arrangements of supports, and finally by embattled entablatures. The decisive field of change became the shaping of the coloristic decoration of the entablature – decisions regarding the material and color separation of elements of the frieze above the supports. The uniform color of all vertical elements of the façade structure guaranteed an unambiguous verticality of the composition.

scholarly journals The Role of Human Capital in the Economic Development and Social Welfare In Albania

2016 ◽  
Vol 6 (1) ◽  
pp. 63 ◽  
Author(s):  
Arjola Mitaj ◽  
Klodian Muco ◽  
Jonida Avdulaj
Keyword(s):  
Human Capital ◽  
Economic Development ◽  
Empirical Studies ◽  
Theoretical Models ◽  
University Education ◽  
Long Time ◽  
Training Courses ◽  
The Relationship

Continuously, the relation between education and economic development has been the focus of development researchers’ studies that study long-term growth. While theoretical models recognize education as the key to a country's economic growth (Bassanini and Scarpetta, 2001; Fuente and Ciccone, 2003; Jones, 2005 Bassanini, 2007), the importance of education is very low in empirical models.The reason for this discrepancy is that for a long time education is measured by the years attended in school and not by the knowledge and skills gained, which according to an OSCE study, a student competences growth of 100 points (measuring unit) produces an increase of 2% of GDP per capita. Thanks to this identification, education is recognized as one of the main keys to development.Various empirical studies show that productivity can be increased through training (Barrett and O'Connell, 2001; Scrutinio et al., 2006). In sum, these studies show that pre university, university education and training courses positively affect the increase of production, which in turn can positively affect the economic development of a country.Thus, this article tends to evaluate the role of Albanian human capital in economic development of the country considering the relationship between education and productivity.

scholarly journals Motivation, Attitude, Role Of Drug Control (Pmo) With Drug Compliance In Patients Tb

2019 ◽  
Vol 3 (2) ◽  
pp. 53-62
Author(s):  
Marniati ◽  
Nurlina ◽  
Safruddin
Keyword(s):  
Data Analysis ◽  
Sampling Technique ◽  
Cluster Sampling ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Long Time ◽  
Chi Square Test ◽  
The Relationship

Pulmonary tuberculosis is a direct infectious disease caused by TB (Mycobacterium Tuberculosis) bacteria. The level of compliance with the use of pulmonary TB drugs is very important and requires a long time that is 6-8 months, because if treatment is not carried out regularly or is not compliant and does not correspond to the specified time then there will be resistance (resistance) of tuberculosis germs against drugs Widespread Anti Tuberculosis (OAT) or Multi Drugs Resistance (MDR). The purpose of this study was to determine the relationship between motivation, attitudes, the role of supervisors taking medication (PMO) in TB sufferers. The design of the study used an Analytical Observational design using the Cross-Sectional approach. The population in this study were all TB sufferers in Bulukumba District with a sampling technique using cluster sampling. The number of samples in this study were 60 respondents. Data were obtained through questionnaire sheets made by researchers to respondents. Data analysis used Fisher's alternative Chi-square Test, with significance level α = 0.05. The results of the data analysis show that the motivation variable p = 0.023, the attitude variable p = 0.012, and the role of the supervisor for taking medication (PMO) p = 0.017. So it can be concluded that there is a relationship between motivation, attitude, the role of supervisors taking medication (PMO) with adherence to taking medication in TB patients in Bulukumba Regency.

scholarly journals Riders on the storm: the role of populism in the global crisis of democracy and in the functioning of electoral autocracies

2021 ◽  
Vol 17 (2) ◽  
pp. 197-225
Author(s):  
István Benedek
Keyword(s):  
Eastern European ◽  
Global Crisis ◽  
Life And Death ◽  
The People ◽  
Core Elements ◽  
Long Time ◽  
General Elections ◽  
The Relationship ◽  
Pluralist Approach

Abstract It is my contention that populism could be an appropriate framework to describe, explain and connect the phenomena of global crisis of democracy and functioning of electoral autocracies. In order to substantiate this claim, with the method of literature review, I examine first the characteristics of these phenomena. Then I focus on the nature of the relationship between them, in particular on the complex system of new types of autocracies’ stability, in which populism could play a crucial role. Populism, understood as an autocratic (re-)interpretation of democracy and representation, could be a particularly dangerous Trojan Horse for democracy. First and foremost, because its idea of a single, homogeneous and authentic people that can be legitimately represented only by the populist leader is a moralised form of antipluralism which is contrary to the pluralist approach of democracy (i.e. polyarchy). For precisely this reason, populism could play a key role in autocracies, especial in electoral autocracies which may use its core elements. Namely, the Manichean worldview, the image of a homogeneous people, people-centrism and the autocratic notion of representation are very compatible with electoral autocracies, since these regimes hold general elections and their power is built largely upon the alleged will of the people. By using populism, it is possible for these regimes to camouflage and even legitimise their autocratic trends and exercise of power behind the formally multi-party but not fair elections and democratic façade. As a radical turn towards closed autocracies (without de facto multiparty elections) would be too expensive, electoral autocrats need manipulated multi-party elections and other plebiscite techniques that could serve as quasi-democratic legitimation. Because of this, they tend to use the political logic of populism which could transform political contestation to a life- and- death struggle and provides quasi-democratic legitimation and other important cognitive functions. Therefore, populist electoral autocracies, as a paradigmatic type of electoral autocracies, could remain with us for a long time, giving more and more tasks to researchers, especially in the Central and Eastern European region.

scholarly journals Integrated Field Surveying and Land Surface Quantitative Analysis to Assess Landslide Proneness in the Conero Promontory Rocky Coast (Italy)

2020 ◽  
Vol 10 (14) ◽  
pp. 4793
Author(s):  
Francesco Troiani ◽  
Salvatore Martino ◽  
Gian Marco Marmoni ◽  
Marco Menichetti ◽  
Davide Torre ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Time Scale ◽  
Land Surface ◽  
Slope Instability ◽  
Space And Time ◽  
Coastal Slope ◽  
Long Time ◽  
Landslide Processes ◽  
Rocky Coast

Rock slopes involved in extensive landslide processes are often characterized by complex morphodynamics acting at different scales of space and time, responsible for different evolutionary scenarios. Mass Rock Creep (MRC) is a critical process for long-term geomorphological evolution of slopes and can likewise characterize actively retreating coastal cliffs where, in addition, landslides of different typologies and size superimpose in space and time to marine processes. The rocky coast at the Conero promontory (central Adriatic Sea, Italy) offers a rare opportunity for better understanding the predisposing role of the morphostructural setting on coastal slope instability on a long-time scale. In fact, the area presents several landslides of different typologies and size and state of activity, together with a wide set of landforms and structural features effective for better comprehending the evolution mechanisms of slope instability processes. Different investigation methods were implemented; in particular, traditional geomorphological and structural field surveys were combined with land surface quantitative analysis based on a Digital Elevation Model (DEM) with ground-resolution of 2 m. The results obtained demonstrate that MRC involves the entire coastal slope, which can be zoned in two distinct sectors as a function of a different morphostructural setting responsible for highly differentiated landslide processes. Therefore, at the long-time scale, two different morphodynamic styles can be depicted along the coastal slopes that correspond to specific evolutionary scenarios. The first scenario is characterized by MRC-driven, time-dependent slope processes involving the entire slope, whereas the second one includes force-driven slope processes acting at smaller space–time scales. The Conero promontory case study highlights that the relationships between slope shape and structural setting of the deforming areas are crucial for reaching critical volumes to induce generalized slope collapse as the final stage of the MRC process. The results from this study stress the importance of understanding the role of morphostructures as predisposing conditions for generalized slope failures along rocky coasts involved in MRC. The findings discussed here suggest the importance of the assessment of the slope instability at the long time scale for a better comprehension of the present-day slope dynamics and its major implications for landslide monitoring strategies and the hazard mitigation strategies.

scholarly journals The Role Of CSR In Achieving Sustainable Development – Theoretical Approach

2016 ◽  
Vol 12 (22) ◽  
pp. 10 ◽  
Author(s):  
Karoly Behringer ◽  
Krisztina Szegedi
Keyword(s):  
Sustainable Development ◽  
Corporate Social Responsibility ◽  
Social Responsibility ◽  
Development Process ◽  
The Sustainable Development ◽  
Long Time ◽  
Corporate Social ◽  
Relationship Of ◽  
The Relationship

The study is looking for the answer to the question that how the theory of Sustainable Development and that of Corporate Social Responsibility are linked, by means of what development process the two theories came near to each other and why is it that CSR is considered to be the corporate concept of Sustainable Development. The aims of this study are: (1) to give a synthesized approach to both of Sustainable Development and Corporate Social Responsibility concepts (2) to find the relationship between Sustainable Development and Corporate Social Responsibility based on the content analysis of the main milestones of Sustainable Development process, and (3) to highlight some practical relevance of the relationship of the two concepts which can be a basis of further empirical researches. Based on the research the concept of Corporate Social Responsibility and that of Sustainable Development progressed separately for a long time. The business sphere got a larger and larger role in sustainable development and it has become clear by now that CSR contributes to the sustainable development of the business sphere and without that sustainable development cannot be attained.

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