Analytical Discovery of Water Disinfection Byproducts of Toxicological Relevance: Highlighting Halobenzoquinones

2021 ◽  
Author(s):  
Caley B Craven ◽  
Lindsay K. Jmaiff Blackstock ◽  
Jiaojiao Xie ◽  
Jinhua Li ◽  
Chun-Gang Yuan ◽  
...  
Keyword(s):  
Epidemiological Studies ◽  
Disinfection Byproducts ◽  
Water Disinfection ◽  
Water Research ◽  
The Public ◽  
Toxicological Effects ◽  
Toxicological Studies ◽  
Wide Range ◽  
Current Water ◽  
Analytical Development

Analytical advancement enables the discovery water research, while challenges in identification and determination of a wide range of trace level toxic compounds in water drives the development of new analytical platforms and tools. Identification of toxic disinfection byproducts (DBPs) in disinfected drinking water is an excellent example. Water disinfection is necessary to protect the public from waterborne disease. However, an unintentional consequence is the formation of DBPs resulting from reactions of disinfectants with natural organic matter in source water. To date, regulated DBPs do not account for the increased bladder cancer risk estimated in epidemiological studies. The majority of halogenated DBPs remain unidentified and the discovery of unknown DBPs of toxicological relevance continues to be a major focus of current water research. This review will highlight halobenzoquinones as a class of DBPs that serves as an example of analytical development and toxicological studies. We will feature recent trends and gaps in analytical technologies for identification of unknown DBPs and bioassays for evaluation of the toxicological effects of specific DBPs and their mixtures.

Epidemiology, the press and the EMF controversy

1992 ◽  
Vol 1 (4) ◽  
pp. 383-394 ◽  
Author(s):  
Daniel Wartenberg ◽  
Michael Greenberg
Keyword(s):  
Media Coverage ◽  
Critical Evaluation ◽  
Epidemiological Studies ◽  
Press Coverage ◽  
The Public ◽  
Adverse Health Effects ◽  
Expert Opinions ◽  
Wide Range ◽  
The Press ◽  
Do So

Epidemiological study of the adverse health effects from exposure to electromagnetic fields has become an issue of public concern over the past decade. The public, in general, rely on mass media coverage of epidemiological studies for information regarding the nature, extent and severity of the risks. We review the press coverage of this issue in three major, US national newspapers in terms of epidemiological goals, noting strengths and weaknesses of the reporting. Our principal goal is to determine whether epidemiologists are getting their message across, and how could they do so more effectively. We find that: (1) coverage is sparse; (2) issues are presented in a framework consistent with the primary investigator's interpretation; (3) there is little critical evaluation of the investigators' views; (4) little context is provided of the risks of exposure to EMFs as compared with other environmental hazards; and (5) few recommendations are given for avoiding or remedying exposure. The press do, however, present adequately the uncertainty in our knowledge base on this issue and do provide a wide range of `expert' opinions. We conclude with a set of recommendations to scientists and other sources for responding to press inquiries in a meaningful way.

DISINFEKSI UNTUK PROSES PENGOLAHAN AIR MINUM

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Nusa Idaman Said
Keyword(s):  
Drinking Water ◽  
Water Purification ◽  
Distribution System ◽  
Residual Effect ◽  
Drinking Water Treatment ◽  
Disinfection Byproducts ◽  
Water Disinfection ◽  
Pathogenic Microorganisms ◽  
Microbiological Contamination ◽  
Disinfection Process

Water disinfection means the removal, deactivation or killing of pathogenic microorganisms. Microorganisms are destroyed or deactivated, resulting in termination of growth and reproduction. When microorganisms are not removed from drinking water, drinking water usage will cause people to fall ill. Chemical inactivation of microbiological contamination in natural or untreated water is usually one of the final steps to reduce pathogenic microorganisms in drinking water. Combinations of water purification steps (oxidation, coagulation, settling, disinfection, and filtration) cause (drinking) water to be safe after production. As an extra measure many countries apply a second disinfection step at the end of the water purification process, in order to protect the water from microbiological contamination in the water distribution system. Usually one uses a different kind of disinfectant from the one earlier in the process, during this disinfection process. The secondary disinfection makes sure that bacteria will not multiply in the water during distribution. This paper describes several technique of disinfection process for drinking water treatment. Disinfection can be attained by means of physical or chemical disinfectants. The agents also remove organic contaminants from water, which serve as nutrients or shelters for microorganisms. Disinfectants should not only kill microorganisms. Disinfectants must also have a residual effect, which means that they remain active in the water after disinfection. For chemical disinfection of water the following disinfectants can be used such as Chlorine (Cl2),  Hypo chlorite (OCl-), Chloramines, Chlorine dioxide (ClO2), Ozone (O3), Hydrogen peroxide etch. For physical disinfection of water the following disinfectants can be used is Ultraviolet light (UV). Every technique has its specific advantages and and disadvantages its own application area sucs as environmentally friendly, disinfection byproducts, effectivity, investment, operational costs etc. Kata Kunci : Disinfeksi, bakteria, virus, air minum, khlor, hip khlorit, khloramine, khlor dioksida, ozon, UV.

Phytochemical, Analytical and Medicinal Studies of Holoptelea integrifolia Roxb. Planch - A Review

2019 ◽  
Vol 5 (4) ◽  
pp. 270-277 ◽  
Author(s):  
Vijay Kumar ◽  
Simranjeet Singh ◽  
Ragini Bhadouria ◽  
Ravindra Singh ◽  
Om Prakash
Keyword(s):  
Liquid Chromatography ◽  
Thin Layer ◽  
Thin Layer Chromatography ◽  
High Performance ◽  
Biologically Active ◽  
Toxicological Studies ◽  
Wide Range ◽  
Layer Chromatography

Holoptelea integrifolia Roxb. Planch (HI) has been used to treat various ailments including obesity, osteoarthritis, arthritis, inflammation, anemia, diabetes etc. To review the major phytochemicals and medicinal properties of HI, exhaustive bibliographic research was designed by means of various scientific search engines and databases. Only 12 phytochemicals have been reported including biologically active compounds like betulin, betulinic acid, epifriedlin, octacosanol, Friedlin, Holoptelin-A and Holoptelin-B. Analytical methods including the Thin Layer Chromatography (TLC), High-Performance Thin Layer Chromatography (HPTLC), High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography With Mass Spectral (LC-MS) analysis have been used to analyze the HI. From medicinal potency point of view, these phytochemicals have a wide range of pharmacological activities such as antioxidant, antibacterial, anti-inflammatory, and anti-tumor. In the current review, it has been noticed that the mechanism of action of HI with biomolecules has not been fully explored. Pharmacology and toxicological studies are very few. This seems a huge literature gap to be fulfilled through the detailed in-vivo and in-vitro studies.

Unified approach to spatial description of objects terrain departmental registries / cadastres as a perspective basis of the state system territory mapping

2019 ◽  
Vol 942 (12) ◽  
pp. 41-49
Author(s):  
A.M. Portnov
Keyword(s):  
Spatial Data ◽  
Spatial Description ◽  
Unified Approach ◽  
Technological Basis ◽  
The Public ◽  
Wide Range ◽  
The Russian Federation ◽  
Map Data ◽  
Consistency Verification ◽  
Thematic Data

Using unified principles of formation and maintenance of register/cadaster with information about spatial data of landscape objects as the informational and technological basis for updating the public topographic maps and modernization of state cartographic system is proposed. The problems of informational relevancy of unified electronical cartographic basis and capacity of its renovation in case of public cadaster map data. The need to modernize the system of classification and coding of cartographic information, the use of unified standards for the coordinate description of register objects for their topological consistency, verification and updating is emphasized. Implementing such solutions is determined by economical expediency as well as necessity of providing a variety of real thematic data for wide range of consumers in the field of urban planning, territories development and completing the tasks of Governmental program “Digital economy of the Russian Federation”.

scholarly journals Citizen views on genome editing: effects of species and purpose

2021 ◽  
Author(s):  
Gesa Busch ◽  
Erin Ryan ◽  
Marina A. G. von Keyserlingk ◽  
Daniel M. Weary
Keyword(s):  
Disease Resistance ◽  
Product Quality ◽  
Genome Editing ◽  
Total Sample ◽  
Moral Foundations ◽  
Perceived Risks ◽  
Public Response ◽  
The Public ◽  
Wide Range ◽  
The Us

AbstractPublic opinion can affect the adoption of genome editing technologies. In food production, genome editing can be applied to a wide range of applications, in different species and with different purposes. This study analyzed how the public responds to five different applications of genome editing, varying the species involved and the proposed purpose of the modification. Three of the applications described the introduction of disease resistance within different species (human, plant, animal), and two targeted product quality and quantity in cattle. Online surveys in Canada, the US, Austria, Germany and Italy were carried out with a total sample size of 3698 participants. Using a between-subject design, participants were confronted with one of the five applications and asked to decide whether they considered it right or wrong. Perceived risks, benefits, and the perception of the technology as tampering with nature were surveyed and were complemented with socio-demographics and a measure of the participants’ moral foundations. In all countries, participants evaluated the application of disease resistance in humans as most right to do, followed by disease resistance in plants, and then in animals, and considered changes in product quality and quantity in cattle as least right to do. However, US and Italian participants were generally more positive toward all scenarios, and German and Austrian participants more negative. Cluster analyses identified four groups of participants: ‘strong supporters’ who saw only benefits and little risks, ‘slight supporters’ who perceived risks and valued benefits, ‘neutrals’ who showed no pronounced opinion, and ‘opponents’ who perceived higher risks and lower benefits. This research contributes to understanding public response to applications of genome editing, revealing differences that can help guide decisions related to adoption of these technologies.

scholarly journals Molecular Subtyping of Blastocystis sp. Isolated from Farmed Animals in Southern Italy

2021 ◽  
Vol 9 (8) ◽  
pp. 1656
Author(s):  
Simona Gabrielli ◽  
Marialetizia Palomba ◽  
Federica Furzi ◽  
Emanuele Brianti ◽  
Gabriella Gaglio ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Pcr Amplification ◽  
Epidemiological Studies ◽  
Fallow Deer ◽  
Small Subunit ◽  
Zoonotic Transmission ◽  
Ssu Rrna ◽  
Molecular Approaches ◽  
Wide Range ◽  
Blastocystis Sp

Blastocystis is a common intestinal protist distributed worldwide, infecting humans and a wide range of domestic and wild animals. It exhibits an extensive genetic diversity and, so far, 25 distinct small subunit ribosomal RNA (SSU rRNA) lineages termed subtypes (STs)) have been characterized; among them, 12 have thus far been reported in humans. The aims of the present study were to detect and genetically characterize Blastocystis sp. in synantropic animals to improve our current knowledge on the distribution and zoonotic transmission of Blastocystis STs in Italy. Samples were collected from N = 193 farmed animals and submitted to DNA extraction and PCR amplification of the SSU rRNA. Blastocystis was detected in 60 samples (31.08%) and successfully subtyped. Phylogenetic analysis evidenced that the isolates from fallow deer, goats, and pigs (N = 9) clustered within the ST5; those from pheasants (N = 2) in the ST6; those from chickens (N = 8) in the ST7; those from sheep (N = 6) in the ST10; and those from water buffaloes (N = 9) in the ST14 clade. The comparison between the present isolates from animals and those previously detected in humans in Italy suggested the animal-to-human spillover for ST6 and ST7. The present study represents the widest Blastocystis survey performed thus far in farmed animals in Italy. Further epidemiological studies using molecular approaches are required to determine the occurrence and distribution of Blastocystis STs in other potential animal reservoirs in Italy and to define the pathways of zoonotic transmission.

scholarly journals Veterinary Education during Covid-19 and Beyond—Challenges and Mitigating Approaches

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1818
Author(s):  
Jennifer Routh ◽  
Sharmini Julita Paramasivam ◽  
Peter Cockcroft ◽  
Vishna Devi Nadarajah ◽  
Kamalan Jeevaratnam
Keyword(s):  
Interprofessional Education ◽  
Negative Impact ◽  
Group Discussion ◽  
Learning Gain ◽  
The Public ◽  
Core Competences ◽  
Wide Range ◽  
Veterinary Student ◽  
Knowledge Content ◽  
Video Group

The public health implications of the Covid-19 pandemic have caused unprecedented and unexpected challenges for veterinary schools worldwide. They are grappling with a wide range of issues to ensure that students can be trained and assessed appropriately, despite the international, national, and local restrictions placed on them. Moving the delivery of knowledge content largely online will have had a positive and/or negative impact on veterinary student learning gain which is yet to be clarified. Workplace learning is particularly problematic in the current climate, which is concerning for graduates who need to develop, and then demonstrate, practical core competences. Means to optimise the learning outcomes in a hybrid model of curriculum delivery are suggested. Specific approaches could include the use of video, group discussion, simulation and role play, peer to peer and interprofessional education.

scholarly journals Definitions and Prevalence of Multimorbidity in Large Database Studies: A Scoping Review

2021 ◽  
Vol 18 (4) ◽  
pp. 1673
Author(s):  
Ying Pin Chua ◽  
Ying Xie ◽  
Poay Sian Sabrina Lee ◽  
Eng Sing Lee
Keyword(s):  
Scoping Review ◽  
Chronic Conditions ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Cross Sectional ◽  
Coding Systems ◽  
Wide Range ◽  
Scoping Reviews ◽  
Retrospective Cohort Studies ◽  
Definition Of

Background: Multimorbidity presents a key challenge to healthcare systems globally. However, heterogeneity in the definition of multimorbidity and design of epidemiological studies results in difficulty in comparing multimorbidity studies. This scoping review aimed to describe multimorbidity prevalence in studies using large datasets and report the differences in multimorbidity definition and study design. Methods: We conducted a systematic search of MEDLINE, EMBASE, and CINAHL databases to identify large epidemiological studies on multimorbidity. We used the Preferred Reporting Items for Systematic Reviews and Meta-analysis Extension for Scoping Reviews (PRISMA-ScR) protocol for reporting the results. Results: Twenty articles were identified. We found two key definitions of multimorbidity: at least two (MM2+) or at least three (MM3+) chronic conditions. The prevalence of multimorbidity MM2+ ranged from 15.3% to 93.1%, and 11.8% to 89.7% in MM3+. The number of chronic conditions used by the articles ranged from 15 to 147, which were organized into 21 body system categories. There were seventeen cross-sectional studies and three retrospective cohort studies, and four diagnosis coding systems were used. Conclusions: We found a wide range in reported prevalence, definition, and conduct of multimorbidity studies. Obtaining consensus in these areas will facilitate better understanding of the magnitude and epidemiology of multimorbidity.

Nothing in Popular Culture Makes Sense except in the Light of Evolution

2012 ◽  
Vol 16 (2) ◽  
pp. 109-120 ◽  
Author(s):  
Gad Saad
Keyword(s):  
Popular Culture ◽  
Evolutionary Psychology ◽  
Case Analysis ◽  
Human Mind ◽  
Cultural Form ◽  
The Public ◽  
Psychology Today ◽  
Wide Range ◽  
Current Article ◽  
Song Lyrics

An evolutionary lens can inform the study of cultural forms in a myriad of ways. These can be construed as adaptations, as exaptations (evolutionary byproducts), as gene–culture interactions, as memes, or as fossils of the human mind. Products of popular culture (e.g., song lyrics, movie themes, romance novels) are to evolutionary cultural theorists what fossils and skeletal remains represent to paleontologists. Although human minds do not fossilize or skeletonize (the cranium does), the cultural products created by human minds do. By identifying universally recurring themes for a given cultural form (song lyrics and collective wisdoms in the current article), spanning a wide range of cultures and time periods, one is able to test key tenets of evolutionary psychology. In addition to using evolutionary psychology to understand the contents of popular culture, the discipline can itself be studied as a contributor to popular culture. Beginning with the sociobiology debates in the 1970s, evolutionary informed analyses of human behavior have engendered great fascination and animus among the public at large. Following a brief summary of studies that have explored the diffusion of the evolutionary behavioral sciences within specific communities (e.g., the British media), I offer a case analysis of the penetration of evolutionary psychology within the blogosphere, specifically the blog community hosted by Psychology Today.

Marketing Town Centres: Retailing and Town Centre Management

2005 ◽  
Vol 20 (2) ◽  
pp. 183-204 ◽  
Author(s):  
Gary Warnaby ◽  
David Bennison ◽  
Barry J. Davies
Keyword(s):  
Marketing Strategies ◽  
Place Marketing ◽  
Marketing Practice ◽  
Public And Private ◽  
The Public ◽  
Wide Range ◽  
Town Centre ◽  
The Uk ◽  
Consensual Approach

The role of town centre management (TCM) schemes in the UK has expanded to incorporate a more overt and explicit focus on marketing and promotion. This paper considers the marketing/promotional activities of TCM schemes in the UK. TCM schemes operate at the interface of the public and private sectors. The implications of this are discussed, including the need for a consensual approach by a wide range of urban stakeholders, and the actual activities undertaken, influenced by the funding imperative under which such schemes operate (which impacts on the feasibility of certain activities and the efforts made to evaluate them). Comparisons are drawn between specific place marketing practice by TCM schemes and wider place marketing strategies.

Sign in / Sign up

Export Citation Format

Share Document