Abstract 16584: Association of Lower Height and Higher LDL-c in a Statewide Schoolchild Cholesterol Screening Program

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Lee A Pyles ◽  
Christa Lilly ◽  
Eloise Elliott ◽  
William A Neal
Keyword(s):  
Short Stature ◽  
Odds Ratio ◽  
Screening Program ◽  
Nucleotide Polymorphisms ◽  
Chi Square ◽  
Primordial Prevention ◽  
Lipid Panel ◽  
Increased Risk ◽  
Lower Height ◽  
Chi Square Analysis

Introduction: The Coronary Artery Risk Detection in Appalachian Communities (CARDIAC) Project has screened West Virginia 5th graders since 1998 to facilitate primordial prevention of coronary heart disease (CHD) in WV. LDL-c levels above 175 mg/dl in children suggest Familial Hyperlipidemia (FH) in the child’s family and a level above 160 mg/dl with history of CHD in relatives can also establish a diagnosis. Hypothesis: Based on previous adult literature, the association of lower height with higher LDL level observed in adults begins in childhood and is prominent in children with LDL in FH range. Methods: Fifth graders are screened yearly in WV schools with parental consent for Body Mass Index and lipid panel. Lipids were analyzed with respect to either short stature < 2 SD for height or comparing 1st (shortest) and 4th quartiles of the population. Statistical analysis for age- and gender-adjusted height percentiles was performed in SAS. Results: 59,386 children had lipid and height data. Mean LDL-c for 1st vs. 4th quartile of height was 94.08 mg/dl (95% Confidence Interval-CI 93.66-94.51) vs. 90.03 mg/dl (CI 89.65-90.42). First quartile of height students had average 4.05 mg/dl higher LDL-c (95% CI 3.48 -4.62 mg/dl). 4398 children had an LDL level above 130 g/dl, 632 above 160 mg/dl and 247 above 175 mg/dl. The Chi square analysis of short stature (height 130 g/dl was also significant (p=0.013) with increased odds of LDL-c above 130 g/dl compared to non-short stature (OR= 1.37, CL 1.07-1.75). Table 1 shows odds ratio for varying levels of elevated LDL-c for the first (shortest) vs. 4th (tallest) quartile of students. Conclusions: Shorter stature is associated with higher LDL-c level in WV 5th graders generally and in those children with increased risk for genetic dyslipidemia. The trend to increasing odds ratio in strata of higher LDL-c supports a recent report of association of single nucleotide polymorphisms selecting for lower genetic height and higher LDL-c.

scholarly journals Metabolic and lifestyle factors in relation to senile cataract: a Mendelian randomization study

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Shuai Yuan ◽  
Alicja Wolk ◽  
Susanna C. Larsson
Keyword(s):  
Standard Deviation ◽  
Odds Ratio ◽  
Mendelian Randomization ◽  
Coffee Consumption ◽  
Smoking Initiation ◽  
Lifestyle Factors ◽  
Senile Cataract ◽  
Nucleotide Polymorphisms ◽  
Standard Deviation Increase ◽  
Increased Risk

AbstractWe conducted a Mendelian randomization study to determine the associations of body mass index (BMI), type 2 diabetes (T2D), systolic blood pressure (SBP), coffee and alcohol consumption and smoking initiation with senile cataract. Independent single nucleotide polymorphisms associated with the metabolic and lifestyle factors at the p < 5 × 10–8 were selected as instrument variables. Summary-level data for senile cataract were obtained from the FinnGen consortium (20,157 cases and 154,905 non-cases) and UK Biobank study (6332 cases and 354,862 non-cases). Higher genetically predicted BMI and SBP and genetic predisposition to T2D and smoking initiation were associated with an increased risk of senile cataract. The combined odds ratios were 1.19 (95% confidence interval (CI) 1.09–1.29; p < 0.001) per one standard deviation increase in BMI (~ 4.8 kg/m2), 1.13 (95% CI 1.04–1.23; p = 0.004) per 10 mmHg increase in SBP, 1.06 (95% CI 1.03–1.09; p < 0.001) per one unit increase in log-transformed odds ratio of T2D, and 1.19 (95% CI 1.10–1.29; p < 0.001) per one standard deviation increase in prevalence of smoking initiation. Genetically predicted coffee consumption showed a suggestive association with senile cataract (odds ratio per 50% increase, 1.18, 95% CI 1.00–1.40; p = 0.050). This study suggests causal roles of obesity, T2D, SBP and smoking in senile cataract.

scholarly journals Identifying High-Risk Children in the Emergency Department

2016 ◽  
Vol 31 (10) ◽  
pp. 660-666 ◽  
Author(s):  
Katie R. Nielsen ◽  
Russ Migita ◽  
Maneesh Batra ◽  
Jane L. Di Gennaro ◽  
Joan S. Roberts ◽  
...  
Keyword(s):  
Emergency Department ◽  
High Risk ◽  
Characteristic Curve ◽  
Pediatric Intensive Care ◽  
Receiver Operator Characteristic Curve ◽  
Clinical Deterioration ◽  
Chi Square ◽  
Inpatient Ward ◽  
Increased Risk ◽  
Chi Square Analysis

Purpose: Early warning scores (EWS) identify high-risk hospitalized patients prior to clinical deterioration; however, their ability to identify high-risk pediatric patients in the emergency department (ED) has not been adequately evaluated. We sought to determine the association between modified pediatric EWS (MPEWS) in the ED and inpatient ward-to-pediatric intensive care unit (PICU) transfer within 24 hours of admission. Methods: This is a case–control study of 597 pediatric ED patients admitted to the inpatient ward at Seattle Children’s Hospital between July 1, 2010, and December 31, 2011. Cases were children subsequently transferred to the PICU within 24 hours, whereas controls remained hospitalized on the inpatient ward. The association between MPEWS in the ED and ward-to-PICU transfer was determined by chi-square analysis. Results: Fifty children experienced ward-to-PICU transfer within 24 hours of admission. The area under the receiver–operator characteristic curve was 0.691. Children with MPEWS > 7 in the ED were more likely to experience ward-to-PICU transfer (odds ratio 8.36, 95% confidence interval 2.98-22.08); however, the sensitivity was only 18.0% with a specificity of 97.4%. Using MPEWS >7 for direct PICU admission would have led to 167 unnecessary PICU admissions and identified only 9 of 50 patients who required PICU care. Conclusions: Elevated MPEWS in the ED is associated with increased risk of ward-to-PICU transfer within 24 hours of admission; however, an MPEWS threshold of 7 is not sufficient to identify more than a small proportion of ward-admitted children with subsequent clinical deterioration.

scholarly journals Kringle IV Type 2, Not Low Lipoprotein(a), as a Cause of Diabetes: A Novel Genetic Approach Using SNPs Associated Selectively with Lipoprotein(a) Concentrations or with Kringle IV Type 2 Repeats

2017 ◽  
Vol 63 (12) ◽  
pp. 1866-1876 ◽  
Author(s):  
Andra Tolbus ◽  
Martin B Mortensen ◽  
Sune F Nielsen ◽  
Pia R Kamstrup ◽  
Stig E Bojesen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Odds Ratio ◽  
Plasma Concentrations ◽  
Nucleotide Polymorphisms ◽  
Genetic Approach ◽  
Lipoprotein A ◽  
Heart Study ◽  
Increased Risk ◽  
Per Se

Abstract BACKGROUND Low plasma lipoprotein(a) concentrations are associated with type 2 diabetes. Whether this is due to low lipoprotein(a) concentrations per se or to a large number of kringle IV type 2 (KIV-2) repeats remains unclear. We therefore aimed to identify genetic variants associated selectively with lipoprotein(a) concentrations or with the number of KIV-2 repeats, to investigate which of these traits confer risk of diabetes. METHODS We genotyped 8411 individuals from the Copenhagen City Heart Study for 778 single-nucleotide polymorphisms (SNPs) in the proximity of the LPA gene, and examined the association of these SNPs with plasma concentrations of lipoprotein(a) and with KIV-2 number of repeats. SNPs that were selectively associated with lipoprotein(a) concentrations but not with KIV-2 number of repeats, or vice versa, were included in a Mendelian randomization study. RESULTS We identified 3 SNPs (rs12209517, rs12194138, and rs641990) that were associated selectively with lipoprotein(a) concentrations and 3 SNPs (rs1084651, rs9458009, and rs9365166) that were associated selectively with KIV-2 number of repeats. For SNPs selectively associated with lipoprotein(a) concentrations, an allele score of 4–6 vs 0–2 had an odds ratio for type 2 diabetes of 1.03 (95% CI, 0.86–1.23). In contrast, for SNPs selectively associated with KIV-2 number of repeats, an allele score of 4–6 vs 0–2 had an odds ratio for type 2 diabetes of 1.42 (95% CI, 1.17–1.69). CONCLUSIONS Using a novel genetic approach, our results indicate that it is a high number of KIV-2 repeats that are associated causally with increased risk of type 2 diabetes, and not low lipoprotein(a) concentrations per se. This is a reassuring finding for lipoprotein(a)-lowering therapies that do not increase the KIV-2 number of repeats.

scholarly journals Zinc transporter-3 [SLC30A3 (rs11126936)] polymorphism is associated with major depressive disorder in Asian subjects

2019 ◽  
Vol 2 (3) ◽  
pp. 20-28 ◽  
Author(s):  
Munn Sann Lye ◽  
Aishah-Farhana Shahbudin ◽  
Yin Yee Tey ◽  
Yin Sim Tor ◽  
King Hwa Ling ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Conditional Logistic Regression ◽  
Zinc Transporter ◽  
Polymorphism Analysis ◽  
Nucleotide Polymorphisms ◽  
Major Depressive ◽  
Chi Square ◽  
Increased Risk ◽  
Chi Square Test

Major depressive disorder (MDD) compromises the individual’s capacity for self-care and productivity. Single nucleotide polymorphisms (SNP) of a number of genes have been associated with MDD. The zinc transporter-3 protein, encoded by the ZnT3 (SLC30A3) gene, maintains zinc-glutamate homeostasis at the glutamatergic synapse, a disruption of which increases risk of MDD. We hypothesise that variation in SLC30A3 (rs11126936) SNP increases risk of MDD. We recruited 300 MDD cases and 300 controls, matched in the ratio of 1:1 by age, gender and ethnicity. PCR-restriction fragment length polymorphism analysis was used in DNA genotyping, validated by sequencing 10% of samples. Deviation from the Hardy-Weinberg equilibrium was tested using the chi-square test. Conditional logistic regression was used to estimate adjusted odds ratios, controlling for age, gender, ethnicity, occupation and family monthly income. Genotypes G/G and G/T showed two times greater odds of developing MDD compared to variant genotype T/T (OR=1.983, 95% CI=1.031-3.815; p=0.040 and OR=2.232, 95% CI=1.100-4.533; p=0.026 respectively). Carriers of genotypes G/G and G/T of the SNP rs11126936 in SLC30A3 are associated with increased risk of MDD.

scholarly journals EPIDEMIOLOGY OF ZOONOTIC Cryptosporidium spp. ISOLATES IN NJORO SUB_COUNTY NAKURU COUNTY, KENYA

2021 ◽  
Vol 15 (2) ◽  
pp. 3-9
Author(s):  
Essendi Miding'a Walter ◽  
Muleke Charles ◽  
Otachi Elick ◽  
Miheso Manfred ◽  
Kyule Domitila
Keyword(s):  
Odds Ratio ◽  
The Elderly ◽  
Domestic Animals ◽  
Risk Of Infection ◽  
Multivariate Logistic Regression ◽  
Chi Square ◽  
Cryptosporidium Spp ◽  
Potential Source ◽  
Increased Risk ◽  
Adolescents And Adults

Background: There is no information on human and animal Cryptosporidium spp. in Njoro sub- county. The risk posed to humans and animals within the sub-county is therefore unknown. Materials and Methods: A total of 1476 animal and 378 human fecal samples were evaluated. Multivariate logistic regression was used to evaluate association between infection status and the predisposing factors. Results were expressed as odds ratio (OR) with a 95% confidence interval. Chi-square and Maentel–Haenszel tests were used to quantify relationships among variables. Results: Prevalence of Cryptosporidium spp. was 9.8% in humans, 10.8% in cows, 19.6% in sheep and 4.5% in goats. Prevalence in humans was significantly higher in females 12/37. Infection was highest in the elderly (27.27%), and significantly lower in adolescents and adults at 8.66% and 9.59%, respectively. Goats had lowest overall parasitization at all levels, while sheep had the highest parasitization at levels (+1 and +2). Relatively, humans had the highest parasite counts +3 cases (1.5%). Conclusion: Cryptosporidium spp. is prevalent in Njoro sub-county and domestic animals are important reservoirs and a potential source of zoonosis in humans. Children, elderly and females are at increased risk of infection, especially during rainy season. The study recommends maintenance of proper sanitation when handling domestic animals, treatment of drinking water and use of alternative safer sources of water in order to reduce infection.

scholarly journals THE ANALYSIS OF FACTORS INFLUENCING GRADUATION ACHIEVEMENT IN NURSE COMPETENCE TEST OF NURSE PROFESSION PROGRAM

2018 ◽  
Vol 37 (2) ◽  
Author(s):  
Lukmanulhakim Lukmanulhakim ◽  
Lenny Stia Pusporini
Keyword(s):  
Logistic Regression ◽  
Odds Ratio ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Factors Influencing ◽  
Nurse Competence ◽  
Competence Test ◽  
Chi Square Analysis ◽  
Simple Logistic

Abstract: Competence test is conducted to fulfil the graduates’ performance competence standards. Nurse competence is oriented to the performance quality in giving a comprehensive care. Study intends to identify factors influencing graduation achievement in UKNI of Nurse Profession Program students of STIKes Faletehan Serang. It is a quantitative study with analytical correlational design and cross sectional approach. Samples are 106 respondents who were selected by using total sampling technique. The statistical used are Chi Square and simple logistic regression prediction model. The Chi Square analysis result with α = 0.05 finds p value of the three variables are 0.804 (anxiety and family support), and 1.000 (peers support). Besides, the analysis result of other three variables obtains p value of 0.034 (GPA), p value of 0.000 (liveliness), and p value of 0.000 (try out result). The analysis result of simple logistic regression shows that Odds Ratio (OR) of liveliness variable is 156.734. The research results can be an evaluation material to increase graduation achievement in UKNI are the benchmark of improving the implementation of university quality assurance. Keywords: capaian kompetensi, kompetensi perawat, uji kompetensi Ners, progra profesi Ners ANALISIS FAKTOR YANG MEMPENGARUHI CAPAIAN KELULUSAN UJI KOMPETENSI NERS MAHASISWA PROGRAM PROFESI NERS  Abstrak: Uji kompetensi dilaksanakan untuk mencapai lulusan yang memenuhi standar kompetensi kinerja. Kompetensi perawat berorientasi terhadap kualitas kinerja dalam memberikan pelayanan keperawatan secara komprehensif.Penelitian bertujuan untuk mengetahaui faktor-faktor yang mempengaruhi capaian kelulusan UKNI mahasiswa Program Profesi Ners STIKes Faletehan Serang. Penelitian berjenis kuantitatif dengan rancangan korelasi analitik melalui pendekatan Cross Sectional.Sampel penelitian sebanyak 106 responden yang diambil dengan teknik total sampling. Data dikumpulkan lewat angket. Analisis data dilakukan dengan menggunakan Chi Square dan regresi logistik sederhana model prediksi.Hasil analisis uji Chi Square dengan α = 0.05, ketiga variabel diperoleh p value sebesar 0,804 (kecemasan dan dukungan keluarga), serta 1,00 (dukungan teman sebaya). Hasil analisis ketiga variabel lainnya diperoleh p value sebesar 0.034(IPK Akademik), 0.000 (keaktfikan), dan 0.000 (try out nasional). Hasil analisis regresi logistik, teridentifikasi Odds-Ratio (OR) dari variabel keaktifan adalah 156.734.Hasil ini dapat dijadikan evaluasi dalam peningkatan capaian kelulusan UKNI yang merupakan tolak ukur dalam penyelenggaraan penjaminan mutu perguruan tinggi. Kata kunci : capaian kompetensi, kompetensi perawat, uji kompetensi Ners, progra profesi Ners

scholarly journals The Effect of Extrinsic Motivation on Housewife Actions in IVA Test in the Working Area of Community Health Center at Bandar Kalipah

2020 ◽  
Vol 2 (1) ◽  
pp. 352-356
Author(s):  
Vani Olin Arysha ◽  
Heru Santosa ◽  
Sri Rahayu Sanusi
Keyword(s):  
Cervical Cancer ◽  
Odds Ratio ◽  
Extrinsic Motivation ◽  
Community Health Center ◽  
Case Control ◽  
Childbearing Age ◽  
Chi Square ◽  
Significance Level ◽  
Processing Data ◽  
Chi Square Analysis

Cervical cancer is a cancer that attacks many women. The high number of cervical cancer sufferers in Indonesia is caused by only 5% who screen for cervical cancer, because this disease does not cause symptoms and low awareness of women to check their health. Every woman of childbearing age should be motivated to do an IVA Test. The purpose of this study is to analyze the effect of extrinsic motivation on housewives actions in IVA Test. The design of this study is a case control with 36 samples in cases and controls. Processing data using chi square analysis with a 95% significance level by calculating the odds ratio. The results showed that there was an influence of extrinsic motivation (p = 0,000) on the housewives actions in IVA Test. The results of the analysis showed that the OR 10.969 95% CI (3.425-35.129) that did Possible IVA Test 10.9 is more effect than housewives who have extrinsic motivation.

Mortality From Burns Sustained on Home Oxygen Therapy Exceeds Predicted Mortality

2020 ◽  
Vol 41 (5) ◽  
pp. 976-980
Author(s):  
Kathleen E Singer ◽  
Jalen A Harvey ◽  
Victor Heh ◽  
Elizabeth L Dale
Keyword(s):  
Mortality Rate ◽  
Length Of Stay ◽  
Average Length ◽  
Severity Index ◽  
Burn Severity ◽  
Chi Square ◽  
Risk Of Mortality ◽  
Increased Risk ◽  
Secondary Outcomes ◽  
Chi Square Analysis

Abstract The Boston Criteria and the Abbreviated Burn Severity Index are two widely accepted models for predicting mortality in burn patients. We aimed to elucidate whether these models are able to predict the risk of mortality in patients who sustain burns while smoking on home oxygen given their clinical fragility. We conducted a retrospective chart review of 48 patients admitted to our burn center from November 2013 to September 2017 who sustained a burn while smoking on home oxygen. Yearlong mortality was the primary outcome of the investigation; secondary outcomes included discharge to facility, length of stay, and need for tracheostomy. We calculated the expected mortality rate for each patient based on Boston Criteria and Abbreviated Burn Severity Index and compared the mortality rate observed in our cohort. Patients in our cohort suffered a 54% mortality rate within a year of injury, compared to a 23.5% mortality predicted by Boston Criteria, which was found to be statistically significant by chi-square analysis (P &lt; .05). Abbreviated Burn Severity Index predicted mortality was 19.7%. While the absolute value of the difference in mortality was greater, this was not significant on chi-square analysis due to sample size. Our secondary outcomes revealed 42% discharge to facility, the average length of stay of 6.2 days, and 6.25% required tracheostomy. Patients whose burns are attributable to smoking on home oxygen may have an increased risk of mortality than prognostication models would suggest. This bears significant clinical impact, particularly regarding family and provider decision making in pursuing aggressive management.

114. HYPERTENSIVE DISORDERS OF PREGNANCY ARE ASSOCIATED WITH IMMUNOREGULATORY GENE POLYMORPHISMS

2010 ◽  
Vol 22 (9) ◽  
pp. 32
Author(s):  
A. Highet ◽  
S. Thompson ◽  
D. Furness ◽  
V. Zhang ◽  
G. Dekker ◽  
...  
Keyword(s):  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Gestational Hypertension ◽  
Nucleotide Polymorphisms ◽  
Chi Square ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
Adverse Pregnancy ◽  
Cytokine Networks ◽  
Maternal Tolerance

Pregnancy is a controlled state of inflammation. Deregulation of cytokine networks can lead to adverse pregnancy outcomes including preeclampsia (PE). We aimed to identify single nucleotide polymorphisms in immunoregulatory genes that signify an increased risk of the gestational hypertensive disorders PE and gestational hypertension (GH). 1169 nulliparous pregnant women and their partners were recruited prospectively for the Adelaide SCOPE study. PE and GH were classified using strict guidelines. Uncomplicated pregnancies served as controls. Peripheral blood from couples and cord blood from neonates were collected. DNA was extracted and genotyped for Interleukin (IL)-6 rs1800795, IL-4 rs2243250, IL-10 rs1800896 and rs1800871, mannose binding lectin (MBL) rs1800450, transforming growth factor beta 1 (TGFβ-1) rs1800469 and cyclooxygenase (COX)-2 rs20417 & rs5275 and inducible nitric oxide synthase (NOS2A) rs1137933 using the Sequenom MassARRAY system. Genotypes for Caucasian PE (n = 75) and GH (n = 102) were compared with controls (n = 422) and analysed using Chi-Square. In neonates IL-6 G allele carriage was associated with PE (P = 0.011, OR=2.0, 95% CI = 1.2–3.7) and the CC genotype associated with GH (P = 0.002). Neonatal IL-10 RS180071 AA genotype associated with PE (P = 0.041) and IL-10 RS1800896 AA associated with GH (P = 0.022). Paternal NOS2A C allele was more frequent in PE (P = 0.03, OR = 2.1, 95% CI = 1.1–4.5), and maternal NOS2A CC more frequent in GH (P = 0.018). Increased neonatal carriage of MBL rs1800450 AA+GA genotypes associated with GH (P = 0.03, OR = 2.2, 95% CI = 1.1–4.5). No associations were observed between TGFβ-1 or COX2 genotypes and PE or GH. Associations between neonatal IL-6 G, which confers high placental IL-6 expression, and PE suggest a possible mechanism by which PE is a pro-inflammatory exacerbation of placental origin. Since placental IL-10 is important for maternal tolerance of the fetus, genotypes predisposing to low IL-10 expression in the neonate which associate with both PE and GH, suggest a role for decreased placental IL-10 in these disorders.

IL1R2 Polymorphisms are Associated with Increased Risk of Esophageal Cancer

2020 ◽  
Vol 20 (5) ◽  
pp. 379-387
Author(s):  
Jianfeng Liu ◽  
Yonghui Yang ◽  
Haiyue Li ◽  
Yuanwei Liu ◽  
Yao Sun ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Odds Ratio ◽  
Chinese Population ◽  
Additive Models ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Single Nucleotide ◽  
Han Population ◽  
Increased Risk ◽  
Prevention And Treatment

Background: Esophageal cancer (EC) is the sixth leading cause of cancer death worldwide, and the overall incidence is increasing. Objective: The aim of this study was to evaluate the association between single nucleotide polymorphisms in IL1R2 and EC risk in the Chinese population. Methods: Genotyping of six SNPs of IL1R2 was performed with the Agena MassARRAY platform from 384 EC and 499 controls. The association between polymorphisms and EC risk was assessed by performing genetics models and haplotype analyses. Results: Overall analysis results showed that the allele C of rs11674595 (odds ratio [OR] = 1.42, 95% confidence interval [CI]: 1.14-1.77, p = 0.002) and allele G of rs2072472 (allele: OR = 1.35, 95% CI: 1.08-1.69, p = 0.008) were associated with an increased EC risk. The rs11674595 and rs2072472 were found to be correlated with EC risk under the codominant, dominant, and additive models. Stratification analysis found that rs11674595 and rs2072472 were associated with increased EC risk in male and in age > 55 years old subgroup. In addition, Crs11674595Grs4851527 haplotype was significantly associated with 1.44-fold increased risk of EC (95% CI: 1.12-1.84, p = 0.004). Conclusions : Our results reveal the significant association between SNPs (rs11674595 and rs2072472) in the IL1R2 and EC risk in the Chinese Han population. The findings may provide meaningful reference for the prevention and treatment of EC.

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