Abstract 13123: Early Mobilization of Older Adults in the Cardiac Intensive Care Unit

Background: Early mobilization (EM) is beneficial in general critical care units and in older hospitalized patients, but little is known about EM in older adults with acute cardiovascular disease. Methods: Consecutive admissions of adults ≥ 80 years old to a cardiac ICU at an academic tertiary care centre before (January to December 2017) and after (February 2018 to June 2019) implementation of a structured nurse-driven EM program. Mobility was measured using the validated Level of Function (LOF) Mobility Scale, which ranges from 0 (bed immobile) to 5 (able to walk > 50 feet). The primary outcome was discharge home. Results: There were 412 patients included (N=234, intervention; N=178, preintervention). There was no difference in mean age between groups (overall mean age 86.3±4.8 years old) or sex (overall female N=215, 52.2%). In the intervention group, functional impairment was present in 89 patients (38.0%) prior to hospitalization and in 209 patients (89.3%) on admission. Nearly half of patients undergoing EM (N=107; 45.7%) improved their LOF by ≥1 during cardiac ICU stay. Mobilization occurred during nearly all opportunities (838/850; 98.6%) and most mobility activities were completed (2,207/2,553; 86.4%). Adverse events were rare (5/2,207 activities [0.2%]) and transient (N=5). There were no falls, line dislodgements, or healthcare team injuries). Patients in the intervention group were more likely than patients in the preintervention group to be discharged home (74.4% vs. 65.7%, P=0.047, respectively) and had a lower rate of in-hospital death (6.4% vs. 14.6%, P=0.006, respectively). There was no difference in length of hospital stay or re-admission. In the multivariable analysis, predictors of discharge home were younger age, heart failure, and higher prehospital LOF. Outcomes were similar in adults ≥ age 90. Conclusion: EM is safe in older adults in the cardiac ICU and is associated with reduced discharge to healthcare facility and in-hospital mortality.

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Early Mobilization in Older Adults with Acute Cardiovascular Disease

Age and Ageing ◽

10.1093/ageing/afaa253 ◽

2020 ◽

Author(s):

Michael Goldfarb ◽

Koorosh Semsar-kazerooni ◽

José A Morais ◽

Diana Dima

Keyword(s):

Cardiovascular Disease ◽

Older Adults ◽

Intervention Group ◽

Length Of Hospital Stay ◽

Early Mobilization ◽

Healthcare Facility ◽

Adverse Event Rate ◽

Hospital Death ◽

Critical Care Units ◽

Cardiac Intensive Care

Abstract Background Early mobilization (EM) is beneficial in critical care units and in older hospitalized patients, but little is known about EM in older adults with acute cardiovascular disease. Methods Consecutive admissions of adults ≥80 years old to a Cardiac Intensive Care Unit (CICU) prior to and following implementation of a nurse-driven EM program were reviewed. Mobility was measured using the Level of Function (LOF) Mobility Scale, which ranges from 0 (bed immobile) to 5 (able to walk >20 meters). The primary outcome was discharge home. Results There were 412 patients included (N = 234, intervention; N = 178, preintervention). There was no difference in age between groups (overall 86.3 ± 4.8 years old) or sex (overall female N = 215, 52.2%). In the intervention group, functional impairment was present in 89 patients (38.0%) prehospitalization and in 209 patients (89.3%) on admission. Nearly half of patients (N = 107; 45.7%) improved their LOF by ≥1 during admission. Mobilization occurred during nearly all opportunities (838/850; 98.6%), and most mobility activities were completed (2,207/2,553; 86.4%). Adverse events were rare (5/2,207 activities [0.2% adverse event rate]) and transient. Patients in the intervention group were more likely than patients in the preintervention group to be discharged home (74.4 vs. 65.7%, P = 0.047, respectively) and had a lower rate of in-hospital death (6.4 vs. 14.6%, P = 0.006, respectively). There was no difference in mean length of hospital stay, 30-day emergency department visit or hospital re-admission. Conclusion EM is safe in older adults in the CICU and is associated with reduced discharge to healthcare facility and in-hospital mortality.

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Prevalence, Correlates and Management of Hyperglycemia in Diabetic Non-critically Ill Patients at a Tertiary Care Center in Lebanon

Current Diabetes Reviews ◽

10.2174/1573399814666180119142254 ◽

2019 ◽

Vol 15 (2) ◽

pp. 133-140 ◽

Cited By ~ 1

Author(s):

Ghada El Khoury ◽

Hanine Mansour ◽

Wissam K. Kabbara ◽

Nibal Chamoun ◽

Nadim Atallah ◽

...

Keyword(s):

Hospital Stay ◽

Critically Ill ◽

Critically Ill Patients ◽

Care Center ◽

Descriptive Analysis ◽

Tertiary Care ◽

Multivariable Analysis ◽

Length Of Hospital Stay ◽

Retrospective Chart Review ◽

Diabetic Patients

Background: Diabetes Mellitus is a chronic metabolic disease that affects 387 million people around the world. Episodes of hyperglycemia in hospitalized diabetic patients are associated with poor clinical outcomes and increased morbidity and mortality. Therefore, prevention of hyperglycemia is critical to decrease the length of hospital stay and to reduce complications and readmissions. Objective: The study aims to examine the prevalence of hyperglycemia and assess the correlates and management of hyperglycemia in diabetic non-critically ill patients. Methods: The study was conducted on the medical wards of a tertiary care teaching hospital in Lebanon. A retrospective chart review was conducted from January 2014 until September 2015. Diabetic patients admitted to Internal Medicine floors were identified. Descriptive analysis was first carried out, followed by a multivariable analysis to study the correlates of hyperglycemia occurrence. Results: A total of 235 medical charts were reviewed. Seventy percent of participants suffered from hyperglycemia during their hospital stay. The identified significant positive correlates for inpatient hyperglycemia, were the use of insulin sliding scale alone (OR=16.438 ± 6.765-39.941, p=0.001) and the low frequency of glucose monitoring. Measuring glucose every 8 hours (OR= 3.583 ± 1.506-8.524, p=0.004) and/or every 12 hours (OR=7.647 ± 0.704-79.231, p=0.0095) was associated with hyperglycemia. The major factor perceived by nurses as a barrier to successful hyperglycemia management was the lack of knowledge about appropriate insulin use (87.5%). Conclusion: Considerable mismanagement of hyperglycemia in diabetic non-critically ill patients exists; indicating a compelling need for the development and implementation of protocol-driven insulin order forms a comprehensive education plan on the appropriate use of insulin.

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Primary cemented bipolar hemiarthroplasty by transtrochanteric approach in unstable intertrochanteric fractures

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20212362 ◽

2021 ◽

Author(s):

Thomas Angelo Skariah ◽

Koshy George ◽

Deny Mathew ◽

James C. George ◽

Samuel Chittaranjan

Keyword(s):

Elderly Patients ◽

Successful Treatment ◽

Tertiary Care ◽

Postoperative Outcome ◽

Early Mobilization ◽

Bipolar Hemiarthroplasty ◽

Intertrochanteric Fractures ◽

Tertiary Care Centre ◽

Duration Of Surgery ◽

One Year

Background: The successful treatment of unstable intertrochanteric fractures of the femur in elderly patients is a challenge. Due to complications associated with internal fixation, primary hemiarthroplasty is increasingly becoming an alternative treatment to achieve early mobilisation. A transtrochanteric approach could potentially decrease the complications associated with primary hemiarthroplasty. Aim of the study is to document the postoperative outcome and complications associated with this treatment.Methods: In this retrospective study, all elderly patients with unstable trochanteric fractures, treated by primary hemiarthroplasty through a transtrochanteric approach, in a tertiary care centre, from September 2017 to December 2019, were enrolled. Their data from hospital records were analysed and results compared to literature.Results: 48 patients underwent the procedure. Average age was 85 years. One year mortality was 31.25%. Average duration of surgery is 85 min. 58.3% were ambulant at one year. One case of dislocation secondary to surgical site infection was present.Conclusions: Primary hemiarthroplasty as a primary treatment in this group of patients enables early mobilization and prevents complications associated with prolonged immobilization. Transtrochanteric approach reduces the duration of surgery. Achieving early ambulation is the key to successful treatment.

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Spontaneous pneumomediastinum: ten years of our experience in diagnosis and outcome

Open Medicine ◽

10.2478/s11536-013-0311-1 ◽

2014 ◽

Vol 9 (5) ◽

pp. 642-647

Author(s):

Sanja Hromis ◽

Biljana Zvezdin ◽

Ivan Kopitovic ◽

Senka Milutinov ◽

Violeta Kolarov ◽

...

Keyword(s):

Chest Pain ◽

Tertiary Care ◽

Length Of Hospital Stay ◽

Sudden Onset ◽

Recurrent Event ◽

First Episode ◽

Close Monitoring ◽

Tertiary Care Centre ◽

Benign Condition ◽

Spontaneous Pneumomediastinum

AbstractSpontaneous pneumomediastinum (SPM) is a rare clinical condition that may be mild but also dramatic with sudden onset of chest pain and dyspnea accompanied by swelling and subcutaneous crepitations. The objective of this study was to analyze the clinical presentation and outcome of SPM in a specialized pulmonary tertiary care centre over a 10 years year period. In subsequent followup, we received information related to recurrence episodes of SPM by patients or their GPs physicians. Eighteen patients, 15 (83%) men, mean age 24 years (SD ±7.86) were diagnosed with SPM. Predominant symptoms were chest pain and cough (n=11) then dyspnea (n=9). Asthma was the most common predisposing condition (n=12). Pneumomediastinum was present on chest radiograph in 17 cases (94%), and in one case it was detected only by computed tomography. The mean length of hospital stay was 7 days (SD ±4.4 days). All our patients recovered and there were no complications. Recurrent event occurred in one asthma patient, 2 years after the first episode. Although, SPM is usually a self-limiting and benign condition, close monitoring is necessary. Recurrence is rare, but possible, with no evidence that routine monitoring of those patients is needed.

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Utility of the Edmonton Frail Scale (EFS) in identifying frail elderly patients during treatment of colorectal cancer (CRC).

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e14001 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e14001-e14001

Author(s):

Brandon M Meyers ◽

Radhika Yelamanchili ◽

Sara Rask ◽

Humaid Obaid Al-Shamsi ◽

Callista Maria Phillips ◽

...

Keyword(s):

Pilot Study ◽

Odds Ratio ◽

Performance Status ◽

Tertiary Care ◽

Multivariable Analysis ◽

Primary Objective ◽

Stage Ii ◽

Care Utilization ◽

Study Phase ◽

Tertiary Care Centre

e14001 Background: CRC is the second leading cause of cancer-related death, and 40-50% of patients are older than 70 years. Frailty is a concept that has been proposed by geriatricians as an indicator of functional age. The EFS is a 15 point incremental scale; it is quick (<5 min), and simple to administer. We conducted a pilot study to establish if the EFS would add utility beyond clinician’s expertise. The primary objective was to determine if there was an association between the EFS and receipt of chemotherapy. Methods: The EFS was administered to stage II-IV CRC patients ≥70 years, referred to a Medical Oncologist at a tertiary care centre. The EFS was completed by one of the investigators, with the treating oncology team blinded to results and a follow up 14 month chart review. Results: Forty-six patients were enrolled with the following characteristics: average age 76, 48% male, 78% performance status (PS) 0-1, and 21 (46%) started chemotherapy. The EFS was reproducible between visits (r = 0.81 [CI 0.64-0.9, p<0.0001]). There was no correlation between the EFS and receipt of chemotherapy for the study population as a whole. As none of the 16 stage II patients had high-risk features requiring chemotherapy, the analysis was repeated excluding these patients. There was a reduced likelihood of receiving chemotherapy for stage III/IV patients with higher EFS scores (Odds ratio 0.56 [CI 0.37-0.85, p<0.01] per unit increment). A similar effect was observed after multivariable analysis (adjusting for PS, age, stage and gender, Odds ratio 0.41 [CI 0.18-0.96, p<0.05] per unit increment). No correlation existed between EFS and upfront dose reductions, choice of less toxic regimens, or hospitalization secondary to grade 3/4 toxicities. Conclusions: This pilot study suggests the EFS can identify patients that Oncologists may have thought were too frail for chemotherapy, independent of PS. Therefore, the EFS has the potential to add a reproducible, and quantifiable measure of frailty to the clinician’s decision making armamentarium. The next study phase will employ the EFS real-time, and determine if using the EFS can minimize complications and unplanned health care utilization in elderly cancer patients.

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Abstract 13410: Patient and Family Perspectives of Early Mobilization in Acute Cardiovascular Care

Circulation ◽

10.1161/circ.142.suppl_3.13410 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Caroline Najjar ◽

Michael Goldfarb

Keyword(s):

Family Member ◽

Tertiary Care ◽

Family Members ◽

Early Mobilization ◽

Recovery Process ◽

Family Satisfaction ◽

Care Providers ◽

Tertiary Care Centre ◽

The Family ◽

Cv Disease

Introduction: Early mobilization (EM) is safe, feasible, and associated with good outcomes in people with acute CV disease. While studies have explored the perspectives of care providers on mobilization, little is known about patient and family member perspectives and experience with mobilization. Methods: Patient and family member surveys were developed using previously validated surveys (Family Satisfaction with Care in the ICU and the Patient Mobilization Attitudes & Beliefs survey). The survey assessed attitudes toward and knowledge of mobilization, the family member’s role in providing care and the mobilization care they received. Surveys were distributed to patients and their family members in an acute CV unit of a tertiary care centre in Montreal, Canada over a 4-month period. Results: 102 participants completed the survey (78 patients and 24 family members). Most patients (N=54; 69.2%) agreed or strongly agreed that EM should be routinely performed, although nearly half of the patients (N=37, 47.4%) felt that mobilization soon after admission was potentially dangerous. Out of 64 patients who underwent EM, 60 (93.8%) felt that mobilization helped their recovery (Figure). 35 patients (54.7%) felt that family member participation helped their mobilization. Family members included 12 (50.0%) spouses/partners, 10 (41.7%) children, 1 (4.2%) siblings, and 1 parent (4.2%). Most family members felt that mobilizing their relatives too soon after admission was potentially dangerous (N=17, 70.8%). However, family members were interested in being involved with mobilization (N=22; 91.7%) and only a few felt that mobilization should not be routinely performed (N=2; 8.3%). Conclusion: Patients felt that EM helped with their recovery process. Family members were interested in being involved in mobilizing their relatives. Our findings should inform efforts to overcome patient and family-related barriers to mobilization and design an EM program for acute CV care.

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A Review of 11 Years ofStenotrophomonas maltophiliaBlood Isolates at a Tertiary Care Institute in Canada

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2012/762571 ◽

2012 ◽

Vol 23 (4) ◽

pp. 165-169 ◽

Cited By ~ 6

Author(s):

Prenilla Naidu ◽

Stephanie Smith

Keyword(s):

Infection Control ◽

Tertiary Care ◽

Laboratory Data ◽

Length Of Hospital Stay ◽

Bloodstream Infections ◽

Surveillance Program ◽

Tertiary Care Centre ◽

Alberta Hospital ◽

University Of Alberta ◽

Drug Of Choice

BACKGROUND:Stenotrophomonas maltophiliahas emerged as a significant nosocomial pathogen with increasing resistance to trimethoprim/sulphamethoxazole (TMP/SMX), the current drug of choice for treatment.OBJECTIVES: To describe the microbiological and clinical characteristics ofS maltophiliabloodstream infections (BSIs) over an 11-year period at a tertiary care centre in Canada.METHODS: All adultS maltophiliaBSIs from 1999 to 2009 in a 750-bed tertiary care teaching hospital (University of Alberta Hospital, Edmonton, Alberta) were identified through the infection control nosocomial infection surveillance program. Demographic and clinical data were extracted from the infection control database and from patient charts. Microbiological data were confirmed through the laboratory information system.RESULTS: Twenty-five episodes ofS maltophiliaBSI (0.9% of all BSIs) involving 24 patients were identified between 1999 and 2009. The patient age range was 18 to 83 years (average 45.7 years). The majority were men (14 of 24 [58.3%]). The mean length of hospital stay was 83.3 days (range eight to 310 days). The rate ofS maltophiliaBSIs per 1000 admissions ranged from 0.04 to 0.22 (average 0.09). Greater than one-half of the episodes (13 of 25 [52%]) were admitted to the intensive care unit before BSI onset. Laboratory data were available for 24 of the 25 isolates. Polymicrobial infections were present in 11 of 24 (45.8%) patients. Resistance to TMP/SMX occurred in 8.3% of all infections. Fifteen per cent of isolates were resistant to ticarcillin/clavulanate. Mortality attributed to bacteremia was 16.7%.CONCLUSIONS: In the University of Alberta Hospital, the rate ofS maltophiliaBSI remains low and constant, and TMP/SMX remains the drug of choice for treatment.

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Vascular comorbidities worsen prognosis of patients with heart failure hospitalised with COVID-19

Open Heart ◽

10.1136/openhrt-2021-001668 ◽

2021 ◽

Vol 8 (1) ◽

pp. e001668

Author(s):

Jacob Mok ◽

Juan Carlos Malpartida ◽

Kimberly O'Dell ◽

Joshua Davis ◽

Cuilan Gao ◽

...

Keyword(s):

Risk Factors ◽

Heart Failure ◽

Hospital Mortality ◽

Ischaemic Stroke ◽

Tertiary Care ◽

Vascular Diseases ◽

Length Of Hospital Stay ◽

Arterial Disease ◽

Tertiary Care Centre ◽

Peripheral Arterial

BackgroundPrior diagnosis of heart failure (HF) is associated with increased length of hospital stay (LOS) and mortality from COVID-19. Associations between substance use, venous thromboembolism (VTE) or peripheral arterial disease (PAD) and its effects on LOS or mortality in patients with HF hospitalised with COVID-19 remain unknown.ObjectiveThis study identified risk factors associated with poor in-hospital outcomes among patients with HF hospitalised with COVID-19.MethodsCase–control study was conducted of patients with prior diagnosis of HF hospitalised with COVID-19 at an academic tertiary care centre from 1 January 2020 to 28 February 2021. Patients with HF hospitalised with COVID-19 with risk factors were compared with those without risk factors for clinical characteristics, LOS and mortality. Multivariate regression was conducted to identify multiple predictors of increased LOS and in-hospital mortality in patients with HF hospitalised with COVID-19.ResultsTotal of 211 patients with HF were hospitalised with COVID-19. Women had longer LOS than men (9 days vs 7 days; p<0.001). Compared with patients without PAD or ischaemic stroke, patients with PAD or ischaemic stroke had longer LOS (7 days vs 9 days; p=0.012 and 7 days vs 11 days, p<0.001, respectively). Older patients (aged 65 and above) had increased in-hospital mortality compared with younger patients (adjusted OR: 1.04; 95% CI 1.00 to 1.07; p=0.036). Prior diagnosis of VTE increased mortality more than threefold in patients with HF hospitalised with COVID-19 (adjusted OR: 3.33; 95% CI 1.29 to 8.43; p=0.011).ConclusionVascular diseases increase LOS and mortality in patients with HF hospitalised with COVID-19.

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“Urban Tertiary Care Centre Experience of Characteristics of Severe COVID-19 Pneumonia”

10.1101/2021.08.16.21262073 ◽

2021 ◽

Author(s):

Nehal M Shah ◽

Janakkumar R Khambholja ◽

Nilay Suthar ◽

Hemant Tiwari ◽

Vandit Desai ◽

...

Keyword(s):

Heart Rate ◽

Hospital Mortality ◽

Respiratory Rate ◽

Inflammatory Markers ◽

Tertiary Care ◽

Current Evidence ◽

Hospital Death ◽

Tertiary Care Centre ◽

Novel Coronavirus ◽

D Dimer

AbstractIntroductionThe global pandemic of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, in December 2019, and has since spread worldwide.[1] This study attempts to summarize current evidence regarding major inflammatory markers, severity predictors and its impact on outcome, which provide current clinical experience and treatment guidance for this novel coronavirus.MethodsThis is a retrospective observational study done at an urban teaching covid-19 designated hospital. Hospital data were analysed with aim of studying inflammatory markers, predictors and outcome. Patients were classified in Mild, Moderate, Severe & Critical categories of COVID cases. Their clinical parameters, laboratory investigations, radiological findings & Outcome measures were studied. Strength of association & correlation of those parameters with severity and in-hospital mortality were studied.ResultsA total 204 (N) patients were clinically classified into different severity groups, as per MOHFW and qCSI(quick Covid Severity Index) guidelines, as Mild (34), Moderate (56), Severe (39) and Critical (75). The mean(SD) age of the cohort was 55.1+13.2 years; 74.02% were male. Severe COVID-19 illness is seen more in patients more than 50 years of age. COVID-19 patients having IHD develop worse disease with excess early in-hospital mortality. Respiratory rate & Heart Rate on admission are correlated with severe and stormy disease. Among Inflammatory markers, on admission LDH, D-Dimer and CRP are related with severity and excess in-hospital death rate.ConclusionAdvanced age, male gender, IHD, Respiratory Rate & Heart Rate on admission were associated with severe covid-19 illness. S. Lactate Dehydrogenase & D-dimer was associated with severe covid-19 illness and early in-hospital death.

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AVALIAÇÃO DE UM PROTOCOLO DE MOBILIZAÇÃO PRECOCE EM UMA UNIDADE DE TERAPIA INTENSIVA

Revista Conhecimento Online ◽

10.25112/rco.v3i0.1844 ◽

2019 ◽

Vol 3 ◽

pp. 92

Author(s):

Cassia Cinara Costa ◽

Briane Da Silva Leite ◽

Claudia Kist Fortino ◽

Vinicius Gonçalves Bastos

Keyword(s):

Intensive Care ◽

Intervention Group ◽

Length Of Hospital Stay ◽

Early Mobilization ◽

Pulmonary Complications ◽

Control Group ◽

Strength Gain ◽

Early Ambulation ◽

Peripheral Muscle ◽

Terapia Intensiva

RESUMOAvaliar se o protocolo de mobilização precoce contribui para a redução do tempo de internação na Unidade de Terapia Intensiva (UTI) em pacientes submetidos a ventilação mecânica invasiva (VMI), analisar o tempo de assistência à VMI e os efeitos da mobilização precoce na força da musculatura periférica, através de um estudo de coorte concorrente com amostra consecutiva, realizado em 14 pacientes que estiveram internados em uma UTI de um hospital do Vale dos Sinos/RS. Os pacientes foram divididos em Grupo Controle, que realizou a fisioterapia do setor, e Grupo Intervenção, que recebeu o protocolo de mobilização precoce proposto por Morris et al. (2008). Os pacientes do Grupo Intervenção permaneceram um tempo menor no VMI e de internação na UTI, além de terem um ganho de força muscular periférica quando comparado ao Grupo Controle. O protocolo de mobilização precoce pode reduzir a incidência de complicações pulmonares, acelerar a recuperação, diminuir o tempo da VMI e o tempo de internação da UTI.Palavras-chave: Deambulação precoce. Fisioterapia. Reabilitação. Unidades de Terapia Intensiva.ABSTRACTTo evaluate whether the early mobilization protocol contributes to the reduction of the length of hospital stay in the Intensive Care Unit (ICU) in patients undergoing mechanical ventilation (NIV), to analyze the time of NIV care and the effects of early mobilization on the strength of the peripheral musculature. Through a concurrent cohort study with a consecutive sample, performed in 14 patients who were hospitalized in an ICU of a Vale dos Sinos / RS hospital. The patients were divided into a Control Group that performed the physiotherapy of the sector, and Intervention Group that received the protocol of early mobilization proposed by Morris et al. (2008). The Intervention Group patients remained shorter in the NIV and in the ICU, in addition to having a peripheral muscle strength gain when compared to the Control Group. The early mobilization protocol can reduce the incidence of pulmonary complications, accelerate recovery, decrease NIV time and ICU length of stay.Keywords: Early Ambulation. Intensive Care Units. Physical Therapy Specialty. Rehabilitation.

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