scholarly journals Value and feasibility of probiotic use

2018 ◽  
Vol 20 (87) ◽  
pp. 116-121
Author(s):  
R.P. Paraniak ◽  
B.M. Kalyn ◽  
T.B. Nahirniak

The article substantiates the importance, the principle of the action of probiotics, the purpose of their application, the mechanisms of therapeutic and prophylactic action, the effectiveness of the use of probiotic drugs and the feasibility of their application. It is known that the ideal probiotic should be of the origin of the body for which it will be used, be resistant to acids and bile, capable of adhesion and colonization in the intestinal tract or other ecosystems, to produce antibiotic substances, to prevent the development of cariogenic and pathogenic microorganisms, to be safe for use in products and clinics and have a well-defined and validated clinical trial with a positive effect on human or animal health. Positive effects of probiotics are manifested in reducing the duration of toxic effects or increasing the resistance to action of pathogens. The components of probiotics are representatives of normal microflora, and therefore the main mechanisms that determine their degree and direction of healing effect on the host organism are colonization resistance and immunomodulatory ability, regulation of metabolic processes and detoxification action, anti-carcinogenic activity. These functions are implemented through enzymatic, vitamin-synthesizing, antagonistic and adhesive activity. Strains of bacteria of probiotics produce a wide range of digestive enzymes - amylase, lipase, protease, pectinase, endoglucanose and phytase. Important impetus for the use of probiotics was the recommendations and requirements for limiting the use of antibiotics in livestock used for therapeutic purposes. The adverse effect of fodder antibiotics is the appearance of diarrhea in animals, as well as the risk of the formation and rapid reproduction of antibiotic-resistant bacteria such as Salmonella spec. Probiotic drugs are most often used in the treatment of a number of pathological conditions occurring against the background of disturbed normal microflora of the human body. Probiotic drugs can also be used for the prevention and treatment of major dental diseases: caries, chronic generalized periodontitis of catarrhal gingivitis, aphthous stomatitis. In experimental studies, it has been shown that intestinal microbiota, interacting with the host organism, can increase the number of osteoclasts, for example, in the femoral bones, and, consequently, decrease their density, which confirms the growth of catabolic activity of bones under conditions of intestinal microbiota dysbiosis. Recently, for the normalization of metabolic processes in the organism of farm animals and poultry began to use probiotic drugs, which, in essence, are a living microbial supplement to the feed and have a positive effect on the body through improving its intestinal microbial balance. Probiotics, as environmentally safe drugs, help to reduce the man-caused and microbial stress on the animals organism in conditions of intensive production of livestock products, which prevents the development of many pathologies in animals, and, consequently, in humans. Probiotic products should be characterized by a pronounced antagonistic activity to a wide range of pathogenic and opportunistic microorganisms, to be strong immunomodulators and to produce bacteriocin and enzymes. The bacteria that are part of the probiotics should remain viable when passing through the gastrointestinal tract of animals and poultry, as well as in the production of feed (for example, in granulation). At present, the effectiveness of the use of probiotics for stimulation of growth intensity and prevention of diseases of young animals, increase of productivity and quality of received products, prevention of gynecological diseases in cows, prevention of viral diseases of bees and increase of their productivity, reduction of parasitic diseases in fish and increase of efficiency of fish farming is substantiated. A promising direction for improving probiotics is the development of complex drugs, which include different types of bacterial cultures that complement each other by specific activity and the effect on opportunistic microorganisms.

2008 ◽  
Vol 52 (5) ◽  
pp. 1812-1819 ◽  
Author(s):  
Queenie C. K. Cheung ◽  
Patricia V. Turner ◽  
Cheng Song ◽  
De Wu ◽  
Hugh Y. Cai ◽  
...  

ABSTRACT Antibiotic-resistant bacteria have become a public health concern. It was suggested that one source of resistant pathogens may be food-producing animals. Alternative approaches are therefore needed to enhance the resistance of farm animals to bacterial infection. Protegrin-1 (PG-1) is a neutrophil-derived antimicrobial peptide that possesses activity against a wide range of bacteria and enveloped viruses. Here we report on the production of transgenic mice that ectopically expressed PG-1 and compare their susceptibilities to Actinobacillus suis infection with those of their wild-type (WT) littermates. Of the 126 mice that were challenged with A. suis, 87% of the transgenic mice survived, whereas 31% of their WT littermates survived. The PG-1 transgenic mice had significantly lower bacterial loads in their lungs and reduced numbers of pulmonary pathological lesions. The antimicrobial function of PG-1 was confirmed in vitro by using fibroblast cells isolated from the transgenic mice but not the WT mice. Moreover, differential blood cell counts in bronchoalveolar lavage fluid indicated greater number of neutrophils in PG-1 transgenic mice than in their WT littermates after bacterial challenge. Our data suggest that the ectopic expression of PG-1 in mice confers enhanced resistance to bacterial infection, laying the foundation for the development of livestock with improved resistance to infection.


Author(s):  
A. V. Fominykh ◽  
V. G. Chyumakov ◽  
N. A. Kovshova ◽  
D. P. Ezdin ◽  
M. N. Kostomakhin

Humic drugs have a wide range of biological activity, affecting the metabolic processes in the body of animals and humans. Humins play a vital role in protecting the intestine from infections and favorably affect its functions, have the potential to suppress mold and bacterial growth, and reduce the level of toxins. When goats received humic substances they had higher milk yields, while significantly reducing total blood cholesterol. Sodium humate administered to broiler chickens increases the live weight by an average of 5–7 % and the livability of poultry by 3–5 %. The influence of humic acid on the quality of laying and egg quality in Japanese quails has been studied. The implementation of socio-economic and environmental programs of the agro-industrial complex provides for the improvement of technologies and technical means for the production of compound feed and protein-mineral vitamin additives for farm animals and poultry. The purpose of the research was to select a vacuum evaporation plant to increase the concentration of humic gel. It has been found that to increase the concentration of humic gel, it is advisable to use a vacuum evaporation plant with an ejector and a steam condenser. Methods for calculating the parameters of the ejector and the pressure reduction process in a vacuum evaporation unit have been developed. The dependences obtained to study the correlation between the area and the diameter of the nozzle water-air ejector, mass flow inject air, water pressure before the working nozzle, pressure inject air, density of the working water, pressure after the ejector, pressure of saturated steam, working temperature of water, temperature inject air, pressure reduction time.


Author(s):  
O. I. Sobolev ◽  
S. V. Sliusarenko ◽  
A. O. Sliusarenko ◽  
R. А. Petryshak ◽  
I. P. Golodyuk ◽  
...  

According to modern classification of trace elements, which is based on their biological significance for living organisms, selenium is classified as a group of vital or biogenic elements. As a biotic element, it has unique physico-chemical and biochemical properties and, with adequate intake into the body of farm animals and poultry has a positive effect on a number of physiological processes. The discovery of biological properties of selenium became the basis for its use first in the prevention and treatment of many diseases associated with a deficiency of this trace element, and later – as a stimulator of growth and development of young animals, as well as in order to increase egg production, poultry safety, improve the incubation characteristics of eggs and several other productive qualities. Scientists who have studied the effects of selenium on poultry have paid relatively little attention to meat quality. The effect of additives of different selenium doses in compound feed on the chemical composition, energy and biological value of Ukrainian white breed ducklings’ meat was studied in the scientific and economic experiment. Four groups of ducklings with 100 heads in each groups were formed to conduct the scientific and economic experiment. The duration of the experiment was 56 days and corresponded to the period of raising ducklings for meat. The ducklings of the first control group did not receive selenium supplementation. Selenium was additionally introduced into compound feed for poultry of the experimental groups in the following amount, mg/kg: the second group – 0.2; the third – 0.4 and the fourth – 0.6. It was established that the introduction of selenium into compound feed in the studied dose did not significantly affect to the quality of ducklings’ meat, although it had a positive effect on some indicators that characterize its chemical composition, nutritional and biological value. Among the experimental groups, ducklings of the third and fourth groups, which were injected with selenium into compound feed at the rate of 0.4 and 0.6 mg/kg, stood out in terms of meat quality.


Author(s):  
N. I. Kulmakova ◽  
N.M. Kostomakhin ◽  
V. G. Semenov ◽  
R.M. Mudarisov ◽  
I.N. Khakimov ◽  
...  

Many researchers note the need to improve feed additives and the search for new promising drugs for the intensification of the pig industry. We have developed a biologically active complex drug Microlact. It is used by animals as a means aimed at correcting the disturbed metabolism of sows associated with pregnancy and lactation, to activate the growth and development of piglets as well as their viability. The purpose of the work was to develop and study the effectiveness of the biologically active drug in the diet of lactating sows. The use of the drug led to the improvement of biochemical parameters of blood of pregnant sows, indicating the activation of metabolic processes in their body, which provided the increase in milk yield of sows, average daily weight gain of piglets and their livability. The live weight of piglets for weaning increased by 8,0% (P < 0,01), the livability of suckling piglets increased to 93,1%, which is a consequence of improving the quality of colostrum and milk, and consequently the positive effect of the biologically active drug containing an optimal complex of minerals, vitamin E in the composition of malt sprouts, essential amino acids and organic form of selenium. More nutritious colostrum and milk contributed to the better development of the piglets’ body and resistance to adverse factors. Immunoglobulins have been obtained by piglets with colostrum and milk increase their resistance and contribute to higher livability. The increase in the weight of suckling pigs has a positive effect on the further development and growth of animals on fattening. Thus, the administration of the biologically active drug Microlact to sows during pregnancy leads to the activation of metabolic processes, which can only be provided by a high level of functioning of the organs and systems of the body.


2021 ◽  
Vol 9 (1) ◽  
pp. 30-34
Author(s):  
M. I. Harashchuk ◽  
L. M. Stepchenko ◽  
T. L. Spitsina ◽  
V. R. Goryaniy

The search for new natural non-toxic biologically active substances for animals used to correct and stimulate metabolic processes, and through it the ability to control the growth and animals’ productivity, the state of their natural resistance is the main task of the present. The paper presents study results on the effect of cold-pressed amaranth oil and biologically active additive of humic nature «Humilid» when used simultaneously on the general body condition, growth indicators of laboratory rats, morphofunctional and biochemical parameters of their blood. To achieve this goal, the following tasks were set: – to investigate how cold-pressed amaranth oil affects the metabolic processes in the body of laboratory rats; – to conduct research and analyze the effect of the cold-pressed amaranth oil and a humic nature biologically active substance «Humilid» simultaneous use on the indicators of their homeostasis. To accomplish the tasks, the following research methods were used: physiological, morpho-functional, and blood biochemical analysis in experimental laboratory rats. Sexually mature male white rats of 2 months age were used in the experiment. For the study, three groups of animals were formed. The experiment lasted four weeks, during which the animals of the first experimental group received daily, in addition to the main feed settled amaranth oil in the amount of 0.1 ml per rat, and free access to the drinking water. Rats of the second experimental group in addition to the main feed received settled amaranth oil in the amount of 0.1 ml, and free access to the drinking of 0.005% solution Humilid. It was found that the simultaneous use of cold-pressed amaranth oil and Humilid in laboratory rats had a positive effect on the state of erythron, erythrocytes count increased by an average of 28% (P < 0.001), hemoglobin concentration by 10% (P < 0.05). At the same time in animals the biosynthetic function of the liver improved, the total protein content in the blood significantly increased by 10% (P < 0.05), and the amount of albumin by 25% (P < 0.01). Energy processes in the body of experimental animals were increased, that pointed a decrease in blood glucose levels by 22% (P < 0.05). The obtained data obtained indicates that the simultaneous use of amaranth oil and Humilid had a positive effect on the state of homeostasis and metabolic processes in the body of laboratory rats. Thus for them synergistic action is noted.


Author(s):  
R. Temiraev ◽  
M. Farnieva

In recent decades, the quail industry has become a promising direction in industrial poultry farming in our country. The basis of full-fledged compound feed of meat poultry is grain cereals (corn, barley, sorghum, etc.) and legumes (soy, peas, castor-oil plant, etc.). However, due to the high concentration of lipids in the grain of some of these crops and compound feed in general if storage in conditions are violated, feeding them to quails in large quantities can lead to the accumulation of peroxides in them and activation of lipid peroxidation processes in the body. The mechanism of action of antioxidants is to activate the body’s anti-radical defense, because these drugs are able to effectively prevent “oxidative stress” by neutralizing free oxygen radicals. Without antioxidants due to the high activity of free radicals in the bird’s body the processes of oxidation of phospholipids of cell membranes are activated, which leads to the destruction of the structure of the DNA molecule and gene mutations. Therefore, natural and synthetic feed preparations of antioxidants, which differ in synergism of action with a wide range of dietary additives on metabolic processes, have become more actively used in poultry nutrition. The purpose of the research was to study the influence of barley-sorghum-soy-type diets enriched with antioxidant preparations Hadox and vitamin E on meat productivity, nutritional and biological value of meat, the state of metabolism in the body of quails reared for meat. Under the conditions of the North Caucasus the expediency of joint feeding of feed antioxidants vitamin E and Hadox to quails grown for meat has been experimentally proved and scientifically justified, when using diets based on barley grain, sorghum and soy of local production, to increase meat productivity, increase their nutritional and biological value of meat and intensify metabolic processes. Thus, in order to increase the economic effectiveness of quail meat production in the North Caucasus the formulation of compound feed based on barley, sorghum and soy of local production should be input together the antioxidant preparations vitamin E at the dose of 25 thousand IU/t of feed and Hadox at the dose of 150 g/t of feed.


Author(s):  
O. Sobolev ◽  
B. Gutyj ◽  
R. Petryszak ◽  
I. Golodjuk ◽  
O. Naumyuk ◽  
...  

Scientific studies of foreign and domestic scientists convincingly proved that selenium is a vitally necessary trace element for farm animals and birds with a wide range of biological effects. It performs unique multifunctional functions in the body – structural, catalytic, regulatory, possesses antioxidant, anti-carcinogenic radioprotective, immunostimulant, antiviral, anti-mutagenic, anti-toxic and adaptogenic properties, participates in the formation of mechanisms that determine the reproductive function of animals and birds, affects osteogenesis, participates in the processes of growth and development. In the scientific and economic research the influence of additives of various doses of selenium into mixed fodder on the development of the digestive system in broiler chickens was studied. As a source of selenium, selenite sodium was used. The research was conducted in the production conditions on broiler chickens of the COOB 500 cross. The duration of the experiment corresponded to the period of growing the young for meat and was 42 days. It was established that the use of selenium in the composition of mixed fodder for broiler chickens at doses of 0.3; 0.4 and 0.5 mg/kg positively influenced the development of the digestive system in young, in particular, contributed to an increase in the mass (by 4.1–11.6%) and total length (1.3–3.5%) of the intestine in general, and its thin and thick parts in particular, as well as the mass of the muscular stomach (17.3–23.2%) and liver (3.6–10.0%). The best macromorphological parameters of the digestive system development were chicken broilers, which, during the entire period of growing, mixed fodder, were enriched with selenium at a rate of 0.3 mg/kg. Comparison of the live weight of broiler chickens of experimental groups with indicators of intestinal development, muscular stomach and liver allows us to assume that the digestive systems in them have been developed better and during the growing period they function more actively.


2020 ◽  
Vol 20 (1) ◽  
pp. 36-40
Author(s):  
O. Karunskyi ◽  
О. Voietska ◽  
I. Cherneha ◽  
V. Fedoryaka

The further development of animal husbandry requires more active involvement of all factors that increase milk and meat production. The widespread use of recyclable canning production in the diets of farm animals is one of the important resources for strengthening and developing the feed base. Efforts aimed at the practical solution of the problem of the use of secondary raw materials of the food industry are rightly considered at the same level as the implementation of measures to increase the yield of fodder crops. In conditions of production, animals are not always provided with complete diets, especially for protein, vitamins and other biologically active substances. One method of balancing pigs' diets for nutrients and biologically active substances may be to feed them tomato shoots. Tomato squeezes can replace some of the forage that is included in the feed mix. Tomato shoots have a wide range of biological activity, and therefore using them as a feed additive can normalize the metabolic processes of the animal body, improve the function of the digestive system. However, there are no clear guidelines for the inclusion of tomato shoots in pig feeds today. In addition, there is still no consensus among researchers on the relatively optimal way of harvesting, preserving and storing these unconventional feeds. The purpose of the work was to justify the optimal levels of tomato shoots animals in the feed for young pigs for fattening. In the course of the research, the chemical composition and nutritional value of tomato shoots were analyzed, compound feed recipes were developed with partial replacement of grain components for tomato shoots, the effect of the developed compound feeds on feeding them on the growth of pigs and peculiarities of the influence of tomato buds were studied, their rational use in pig production is substantiated.The results of the experiment indicate the feasibility of replacing in the feed for the repair of young pigs part of the raw material for tomato shoots. Studies have shown that feeding young pigs with tomato shoots leads to a slight decrease in the digestion of nutrients. Analysis of the daily average nitrogen balance indicates better deposition of it in the body of the animals of the experimental groups, which fed 10 and 15 % of tomato shoots. At feeding of 20 % of tomato shoots nitrogen balance worsened considerably.


Author(s):  
Vera Boldyreva ◽  
Aleksandr Keyno ◽  
Mikhail Bogdanov

The Russian school of gymnastics is distinguished by the high performing skills of female athletes, a wide range of styles, the composition integrity, which is achieved with the help of choreographic training. The concept of “choreography” includes everything that relates to the art of classical, folk, historical and everyday, modern dance. Choreographic training in gymnastics is understood as a system of exercises and influence methods aimed at nurturing the motor culture of the gymnasts, at expanding their arsenal of expressive means. In addition, when practicing chore-ography, flexibility and coordination of movements develops, strengthens the musculoskeletal system, increases the density of the workout, which has a positive effect on the cardiovascular and respiratory systems of the body, contributes to the development of special endurance. Along with this, choreography lessons solve technical training problems: mastering various elements and combinations, an individual image in the composition. To create an image, expressiveness is in-dispensable, which is inextricably linked with the beauty of the movements, grace, dancing character, etc. A choreographer in rhythmic gymnastics has to work with a constant shortage of time, since choreographic training is only part of the training process. This time is not enough for the full development of the “rhythmic” gymnasts’ choreography. A characteristic feature of training in jazz gymnastics is the performing of exercises that fully activate the body’s motor system, with the participation of the greatest possible number of muscle groups. Also for those engaged in jazz gymnastics is characteristic dynamism, expression, together with wide and smooth movements. The nature of the movements is expressive. All this contributes to the development of “rhythmic” gymnasts’ choreography. Analysis of scientific literature and practical experience indicates the lack of jazz gymnastics use in the choreographic training of “rhythmic” gymnasts. Our research is related to the development of this particular direction, which determines its relevance.


2019 ◽  
pp. 33-37
Author(s):  
M.A. Verotchenko

Цель исследования изучение биохимического статуса организма телят 1 3месячного возраста при применении вермикулита. Опыт на животных проводили в течение 60 дней. Для опыта были отобраны, по принципу аналогов, 3 группы телят молочного периода выращивания по 9 голов в каждой. Телята контрольной группы получали стандартный рацион, телятам 1й опытной группы к основному рациону добавляли 2 на голову в сутки вермикулита, 2й опытной группе 3 на голову в сутки. Использовали вермикулит (ГОСТ 1286567), выпускаемый ОАО Ковдорслюда . Для изучения состояния обменных процессов в организме подопытных животных отбирали кровь из яремной вены после утреннего кормления два раза: в начале опыта и через месяц после его окончания. Исследования показали, что использование вермикулита в кормлении молочных телят, благодаря многогранным буферным, ионообменным и сорбционным свойствам положительно сказалось на белковоминеральном обмене животных и интенсивности их роста. В опытных группах уровень общего белка вырос в 1,04 1,06 раза, достоверно повысился к концу исследований уровень альбуминов. Целесообразно для нормализации обменных процессов в организме молочных телят использовать добавку вермикулита в количестве 2 и 3 к сухому веществу рациона.The purpose of the research is to study the biochemical status of the organism of calves 13 months of age with the use of vermiculite. The animal experiment was carried out for 60 days. 3 groups of calves of the dairy period of growing of 9 animals in each were selected for the experiment according to the principle of analogues. The calves of the control group received a standard diet, 2 per head per day of vermiculite was added to the main diet of the calves of the 1st experimental group, and the 2nd experimental group 3 per head per day. We used vermiculite (GOST 1286567) manufactured by OAO Kovdorslyuda. To study the state of metabolic processes in the body of experimental animals blood was taken from the jugular vein after morning feeding two times: at the beginning of the experiment and one month after its completion. Researches have shown that the use of vermiculite in the feeding of dairy calves due to its multifaceted buffering, ionexchange and sorption properties has a positive effect on the proteinmineral metabolism of animals and their growth rate. In the experimental groups the level of total protein increased in 1.04 1.06 times and the level of albumen significantly increased by the end of the research. It is advisable to normalize the metabolic processes in the body of dairy calves to use the additive of vermiculite in an amount of 2 and 3 to the dry matter of the diet.


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