scholarly journals Thyroid hormone responses to acute aerobic exercise

2021 ◽  
Vol 25 (6) ◽  
pp. 359-363
Author(s):  
Mustafa Ş. Akgül ◽  
Bilgehan Baydil
Keyword(s):  
Thyroid Hormone ◽  
Aerobic Exercise ◽  
Venous Blood ◽  
P Value ◽  
Free T4 ◽  
Blood Samples ◽  
The Social ◽  
Significant Difference ◽  
Hormone Responses ◽  
Shuttle Run

Background and Study Aim. Thyroid hormone responses to acute maximal aerobic exercise is still unclear, so the aim of the study is to investigate the effect of acute maximal aerobic exercise resulting in fatigue on blood thyroid levels in men and women. Material and Methods. The study included 8 male and 7 female subjects who did not actively exercise. Both group participants were students in the Kastamonu University in the period of study. The heights, weights, resting hearth rates and 5 cc. venous blood samples of subjects were taken before the exercise. The subjects warmed up for ten minutes before they had 20 m shuttle run. The purpose of this test was to tire the subjects to the exhaustion. The heart rate were measured at the end of the test in order to determine the exhaustion levels of the participants. The 5 cc. venous blood samples were taken again just after the exhaustion exercise. Statistical analysis was carried out using Statistical Package for the Social Sciences (SPSS) 23 program (SPSS Inc. Chicago. II. USA). P value was set at p<0.05. Results. When results were compared between both sexes, no significant difference was found among variables (p>0.05). There was significant change in TSH values in all group. They increased following the exercise compared to pre-exercise values. Moreover, total T3 decreased in all group. No other significant difference was found in free T3 and free T4 variables. Conclusions. In conclusion, thyroid responses to exercise emerge in a very complex way, which makes it difficult to reach a clear conclusion about its effects. The reason why the results are so contradictory is that the duration and intensity of the exercise, age, not being able to control the diet, and the timing of collection of blood samples after exercise.

Markers of Hemostatic Activation in Affected Coronary Arteries during Angioplasty

1994 ◽  
Vol 72 (05) ◽  
pp. 672-675 ◽  
Author(s):  
Nicolas W Shammas ◽  
Michael J Cunningham ◽  
Richard M Pomearntz ◽  
Charles W Francis
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Venous Blood ◽  
Balloon Inflation ◽  
Blood Samples ◽  
Hemostatic System ◽  
Significant Difference ◽  
Hemostatic Markers ◽  
Artery Disease ◽  
High Doses

SummaryTo characterize the extent of early activation of the hemostatic system following angioplasty, we obtained blood samples from the involved coronary artery of 11 stable angina patients during the procedure and measured sensitive markers of thrombin formation (fibrino-peptide A, prothrombin fragment 1.2, and soluble fibrin) and of platelet activation ((3-thromboglobulin). Levels of hemostatic markers in venous blood obtained from 14 young individuals with low pretest probability for coronary artery disease were not significantly different from levels in venous blood or intracoronary samples obtained prior to angioplasty. Also, there was no translesional (proximal and distal to the lesion) gradient in any of the hemostatic markers before or after angioplasty in samples obtained between 18 and 21 min from the onset of the first balloon inflation. Furthermore, no significant difference was noted between angioplasty and postangioplasty intracoronary concentrations. We conclude that intracoronary hemostatic activation does not occur in the majority of patients during and immediately following coronary angioplasty when high doses of heparin and aspirin are administered.

Perbedaan Penggunaan Antikoagulan K2EDTA DAN K3EDTA Terhadap Hasil Pemeriksaan Indeks Eritrosit

2018 ◽  
Vol 1 (2) ◽  
pp. 114
Author(s):  
Wahdaniah Wahdaniah ◽  
Sri Tumpuk
Keyword(s):  
Screening Test ◽  
Venous Blood ◽  
The Body ◽  
Ethylene Diamine ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference ◽  
Ethylene Diamine Tetra Acetate ◽  
The Difference ◽  
Index Value

Abstract: Routine blood examination is the earliest blood test or screening test to determine the diagnosis of an abnormality. Blood easily froze if it is outside the body and can be prevented by the addition of anticoagulants, one of which Ethylene Diamine Tetra Acetate (EDTA). Currently available vacuum tubes containing EDTA anticoagulants in the form of K2EDTA and K3EDTA. K3EDTA is usually a salt that has better stability than other EDTA salts because it shows a pH approaching a blood pH of about 6.4. The purpose of this research is to know the difference of erythrocyte index results include MCH, MCV and MCHC using K3EDTA anticoagulant with K2EDTA. This research is a cross sectional design. This study used venous blood samples mixed with K2EDTA anticoagulant and venous blood mixed with K3EDTA anticoagulants, each of 30 samples. Data were collected and analyzed using paired different test. Based on data analysis that has been done on MCH examination, p value <0,05 then there is a significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value. Then on the examination of MCV and MCHC obtained p value <0.05 then there is no significant difference between samples with K3EDTA anticoagulant with K2EDTA to erythrocyte index value.Abstrak: Pemeriksaan darah rutin merupakan pemeriksaan darah yang paling awal atau screening test untuk mengetahui diagnosis suatu kelainan. Darah mudah membeku jika berada diluar tubuh dan bisa dicegah dengan penambahan antikoagulan, salah satunya Ethylene Diamine Tetra Acetate (EDTA). Dewasa ini telah tersedia tabung vakum yang sudah berisi antikoagulan EDTA dalam bentuk  K2EDTA dan  K3EDTA. K3EDTA  biasanya berupa garam yang mempunyai stabilitas yang lebih baik dari garam EDTA yang lain karena menunjukkan pH yang mendekati pH darah yaitu sekitar 6,4. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan hasil indeks eritrosit meliputi MCH, MCV dan MCHC menggunakan antikoagulan K3EDTA dengan K2EDTA. Penelitian ini merupakan penelitian dengan desain cross sectional. Penelitian ini menggunakan sampel darah vena yang dicampur dengan antikoagulan K2EDTA dan darah vena yang dicampur dengan antikoagulan K3EDTA, masing-masing sebanyak 30 sampel. Data dikumpulkan dan dianalisis menggunakan uji beda berpasangan. Berdasarkan analisis data yang telah dilakukan pada pemeriksaan MCH didapatkan nilai p < 0,05 maka ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit. Kemudian pada pemeriksaan MCV dan MCHC didapatkan nilai p < 0,05 maka tidak ada perbedaan yang signifikan antara sampel dengan antikoagulan K3EDTA dengan K2EDTA terhadap nilai indeks eritrosit.

Effects of Different Methods Used to Take Blood Samples on Blood Glucose Measurements

2021 ◽  
pp. 105477382110247
Author(s):  
Eda Ergin ◽  
Ayten Zaybak
Keyword(s):  
Blood Glucose ◽  
Glucose Tolerance Test ◽  
Venous Blood ◽  
Tolerance Test ◽  
Capillary Blood ◽  
Oral Glucose ◽  
Blood Samples ◽  
Significant Difference ◽  
Measurement Results ◽  
Quasi Experimental

The purpose of this study is to compare whether or not there is a difference between venous and capillary blood samples in blood glucose measurements and investigate the effects of different aseptic methods used in skin cleaning before collecting blood samples on measurement results. This quasi-experimental study was conducted with 109 patients. The capillary first and second blood drop values taken from the patients after fasting and at 2 hours following 75 g oral glucose tolerance test (OGTT) and capillary and venous blood glucose values were compared. There was no significant difference between the median venous blood glucose value and the capillary second blood drop value taken after wiping the finger with alcohol. There was no significant difference between the first and second blood drop values of capillary blood glucose 2 hours after OGTT.

scholarly journals IMPACTS OF AEROBIC EXERCISE ON HDL LEVEL OF ADULTS; IT’S SOCIAL IMPLICATIONS IN EDUCATIONAL INSTITUTES

2021 ◽  
Vol 9 (4) ◽  
pp. 65-68
Author(s):  
Noor Muhammad Marwat ◽  
Shah Khalid ◽  
Pir Muhammad Abdul Aziz Shah ◽  
Fayaz ul Hasnain ◽  
Rashid Naeem Khan
Keyword(s):  
High Density Lipoprotein ◽  
Aerobic Exercise ◽  
Heart Valves ◽  
Density Lipoprotein ◽  
High Density ◽  
Social Implications ◽  
Exercise Protocol ◽  
Post Intervention ◽  
The Social ◽  
Significant Difference

Purpose: The purpose of this study to find out the impacts of a 6-weeks supervised aerobic exercise protocol on High-Density Lipoprotein among adults aged between 25-35 years was evaluated. Methodology: Researchers through a non-probability sampling procedure selected thirty (30) volunteers ranging from 25-35 untrained adults from Lakki Marwat. Researchers used a six-week aerobic exercise protocol to collect relevant information from the targeted dependent variables. The CHOD PAP method was used to measure the High-Density Lipoprotein (HDL) of adults. All the data collected from pre-and post- (HDL) tests were recorded in numerical form and analyzed by using a t-test. Main Findings: The results of the study indicate that the six-week aerobic exercise protocol program had no significant difference on pre-and post-intervention quantities of HDL of Experimental Group which is (P>0.05). The implication of the Study: The aerobic exercise programs used for this particular study may help adults to improve and maintain their health status, proper social stature, and lipid profile. An increase in the HLD is ideal as this increase in the HDL helps to prevent cardiovascular diseases particularly the heart valves from stroke and cardiac arrest and academic achievements of the participants. Novelty: So far, no particular research has been conducted on the social implications of exercise effects on adults. Future researchers may work on the social habits of physically fit adults and their input to society.

scholarly journals Significance of serum-pleural effusion albumin gradient in differentiating transudative and exudative pleural effusions in comparison to light’s criteria

2017 ◽  
Vol 4 (2) ◽  
pp. 457
Author(s):  
Sujatha G. ◽  
Vindhya P. ◽  
Kalyan Kumar K.
Keyword(s):  
Pleural Effusion ◽  
Clinical Outcome ◽  
Pleural Fluid ◽  
Venous Blood ◽  
P Value ◽  
Protein Ratio ◽  
Clinical Disorder ◽  
Significant Difference ◽  
The Difference ◽  
Sensitivity Specificity

Background: Approximately one million patients develop pleural effusion every year. It is a common clinical disorder and is either a manifestation or a complication of one or other respiratory or non-respiratory disorders. It leads to serious prognosis, if not diagnosed and treated properly. To calculate SEAG and Light’s criteria and to compare SEAG with Light’s criteria in analyzing pleural effusions.Methods: A total of hundred patients were selected for the study. Pleural fluid of patients who met the inclusion and exclusion criteria were collected, when pleural fluid is being tapped for diagnostic thoracocentesis. Venous blood sample was collected along with diagnostic thoracocentesis or within 24 hours of thoracocentesis.  Written informed consent was obtained from them for thoracocentesis.Results: In our study we compared the clinical outcome with outcome as per Pleural fluid/Serum protein ratio (p value of <0.0001), pleural fluid/serum LDH (p value of <0.0001) and pleural fluid LDH (p value of <0.0001) separately and the p values were statistically significant. The sensitivity, specificity, PPV and NPV of Light’s criteria were 77.2%, 100%, 100%, 93.9% respectively. We compared Light’s criteria outcome with clinical outcome and the difference was statistically significant (p value of <0.0001). SEAG showed 100% sensitivity, 97.43% specificity, 91.6% PPV and is 91.66% and NPV is 100%. We compared the clinical outcome with SEAG and there was statistically significant difference (p value of <0.0001). We compared SEAG with Light’s criteria and the difference was statistically significant (p <0.0001). We compared Light’s plus pleural fluid protein gradient with SEAG and the difference is statistically significant (p value of <0.0001).Conclusions: SEAG is more sensitive for classifying transudates and more specific for exudates than Light’s criteria.

scholarly journals Peningkatan Kemampuan Ketrampilan Sosial Pasien Gangguan Jiwa di Masyarakat dengan Terapi Hortikultura

2020 ◽  
Vol 4 (1) ◽  
pp. 77-82
Author(s):  
Widyo Subagyo ◽  
Dyah Wahyuningsih ◽  
Mukhadiono Mukhadiono
Keyword(s):  
Social Skills ◽  
Mental Disorders ◽  
Quantitative Research ◽  
Intervention Group ◽  
Control Group ◽  
P Value ◽  
Horticultural Therapy ◽  
The Social ◽  
Study Results ◽  
Significant Difference

This study aimed to determine the effect of the development of horticultural therapy to improve the social skills of mental disorders patients in the community. This research's method is quantitative research with a pre-posttest queasy experimental research design with a control group. The study results the social skills score before and after treatment in the intervention group given horticultural therapy was marked with a p-value of 0.01 (<0.05). In conclusion, there is a significant difference in the mean difference in social skills scores between the intervention and control groups.   Keywords: Mental Disorders, Social Skills, Horticultural Therapy

Pharmacokinetic and Pharmacodynamic Evaluation of a Biosimilar Rituximab in Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) Treated with R-CHOP (Rituximab, Cyclophosphamide, Adriamycin, Vincristine, Prednisolone).

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4491-4491 ◽  
Author(s):  
Auro Viswabandya ◽  
P.V. Prashanthi ◽  
C. Nirmala Raju ◽  
Reena Rajsekhar ◽  
Vikram Mathews ◽  
...  
Keyword(s):  
B Lymphocyte ◽  
Stage Iv ◽  
B Cell Lymphoma ◽  
Fixed Dose ◽  
P Value ◽  
Newly Diagnosed ◽  
Blood Samples ◽  
Significant Difference ◽  
Post Infusion ◽  
Multi Center Study

Abstract Addition of rituximab (375 mg/m2) to CHOP has been shown to improve survival in patients with DLBCL. However there is limited data on the pharmacokinetics (PK) and pharmacodynamics (PD) of this drug in this condition. We have evaluated the PK and PD of a biosimilar rituximab (Reditux®, Dr. Reddy’s Laboratories Ltd, Hyderabad, India) in 17 patients with newly diagnosed DLBCL treated at a single center with R-CHOP as part of a multi-center study undertaken to assess the safety and efficacy of this drug. R-CHOP (rituximab-375mg/m2; cyclophopsphamide-750mg/m2; adriamycin-50mg/m2; vincristine-1.4mg/m2 on day 1 and prednisolone-60mg/m2 on days 1 to 5) was given every 3 weeks for a total of 6 cycles. Blood samples for measurement of rituximab were collected just prior to start of infusion and 10min, 24, 72, 192 and 360 hours post-infusion for all patients during cycle 1 and in 6 patients during cycle 6 also. Additional samples were collected pre- and 10 minutes post-infusion after cycles 2, 3, 4, 5 and 6. Plasma rituximab levels were quantified using an immunoassay (sensitivity: 1ug/ml). B-lymphocyte counts were measured in peripheral blood samples taken from all patients at the beginning of each cycle. All patients were evaluated for clinical and radiological response after the 2nd, 4th and 6th cycles. Patients, mean age: 52 years (range:31–71) had disease in the following stages: stage II: 5, stage III: 7, stage IV: 5. Twelve out of 17 patients achieved complete remission while 5 had partial response (NCI criteria). At a mean follow-up of 5 months (range: 3–8), 3 patients had relapse of the disease. The arithmetic mean ±SD of PK parameters of Rituximab during cycle 1 were as follows: T½(hrs): 167±63; Cmax(ug/ml): 186±49; Cmin(ug/ml): 22.4±12.84; AUC0-∞ (ug.hrs/ml): 28162±11227) and Cl/F (ml/kg/hr): 23.8±10.8. These data are comparable with values previously reported for rituximab in other conditions. Though a 2–7 fold inter-individual variation was noted among these patients, there was no significant difference in these parameters between those in whom the disease relapsed as opposed to those who maintained remission. Among the 6 patients in whom data was available for the 1st and 6th cycles (table), there was significant reduction in Cl/F with associated increase in Cmax and AUC in the 6th cycle as compared to the 1st cycle. In 16 patients for whom the data was available, pre-treatment mean B lymphocyte count which was 121/ul (range:1.5–410.5) dropped to a mean of 9.9/ul (range:0.3–62.3) after the first cycle and remained in that range for the rest of treatment period. These data show that even with a 3-weekly regimen, therapeutic trough levels (25 μg/ml) of rituximab was observed across all cycles. In fact, the changing PK parameters of the drug with progressive cycles of R-CHOP suggest that fixed-dose regimens may not be the optimal way to administer this drug. Parameter Cycle1 (n=6) Cycle 6 (n=6) p value T ½ (hours) 200 386 0.0481 Cmax (μg/ml) 203 279 0.0556 Cmin (360Hr) 24.71 82.16 0.0028 AUC0- ∞ (μg.hrs/ml) 31167 92240 0.0049 Cl/F(ml/kg/hr) 20.5 7.6 0.0030

scholarly journals 9. Difference in cholesterol levels hunter dog (Canis familiaris) with dog house in the district of Lima Puluh Kota

2018 ◽  
Vol 12 (1) ◽  
pp. 53-56
Author(s):  
Angga Putra Adinata ◽  
Rusli Rusli ◽  
Amiruddin Amiruddin ◽  
Nuzul Asmilia ◽  
Sri Wahyuni ◽  
...  
Keyword(s):  
Venous Blood ◽  
Canis Familiaris ◽  
Blood Cholesterol ◽  
Normal Range ◽  
Chi Square ◽  
Blood Samples ◽  
Cholesterol Levels ◽  
Significant Difference ◽  
Chi Square Test ◽  
Dog Blood

The aims of this study to find out differences in cholesterol levels hunter dog and dog house in the district of Lima Puluh Kota. This study using 99 hunter dogs and 98 dogs home in a healthy condition clinically. Dog blood samples were taken on the morning at the cephalika venous. Blood samples were obtained dripped on cholesterol strip that has been put into Gluco-dr and after 10 seconds cholesterol levels can read on screen. Data were analyzed statistically using chi-square test T which were helped by SPSS 16. The results showed that the average cholesterol levels in the dogs hunt were 87.67 ± 43.49 mg / dl and 297 in the dogs house, 72 ± 94 mg / dl. The statisticresult was showed significant difference (p 0.05) between blood cholesterol levels with a hunter dogs anddogshouse blood cholesterol levels. This research can be concluded that average of cholesterol levels of hunter dogs and dogs house were still within the normal range, but showed the sicnificant differences due to the different activities of dogs.

scholarly journals Analytical performance of lateral flow immunoassay for SARS-CoV-2 exposure screening on venous and capillary blood samples

2020 ◽  
Author(s):  
Margaret A Black ◽  
Guomiao Shen ◽  
Xiaojun Feng ◽  
Wilfredo Garcia Beltran ◽  
Yang Feng ◽  
...  
Keyword(s):  
Whole Blood ◽  
Colloidal Gold ◽  
Venous Blood ◽  
Capillary Blood ◽  
Lateral Flow ◽  
Antibody Detection ◽  
Lateral Flow Immunoassay ◽  
Blood Samples ◽  
Significant Difference ◽  
Finger Stick

Objectives: Numerous serologic immunoassays have been launched to detect antibodies to SARS-CoV-2, including rapid tests. Here, we validate use of a lateral flow immunoassay (LFI) intended for rapid screening and qualitative detection of anti-SARS-CoV-2 IgM and IgG in serum, plasma, and whole blood, and compare results with ELISA. We also seek to establish the value of LFI testing on blood obtained from a capillary blood sample. Methods: Samples collected by venous blood draw and capillary finger stick were obtained from patients with SARS-CoV-2 detected by RT-qPCR and control patients negative for SARS-CoV-2. Samples were tested with the 2019-nCoV IgG/IgM Detection Kit (Colloidal Gold) lateral flow immunoassay, and antibody calls were compared with results obtained by ELISA. Results: The Biolidics LFI kit shows clinical sensitivity of 92% at 7 days after PCR diagnosis of SARS-CoV-2 on venous blood. Test specificity was 92% for IgM and 100% for IgG. There was no significant difference in detecting IgM and IgG with Biolidics LFI and ELISA at D0 and D7 (p=1.00), except for detection of IgM at D7 (p=0.04). Finger stick whole blood of SARS-CoV-2 patients showed 93% sensitivity for antibody detection. Conclusions: Clinical performance of Biolidics 2019-nCoV IgG/IgM Detection Kit (Colloidal Gold) is comparable to ELISA and showed consistent results across different sample types. Furthermore, we show that capillary blood obtained by finger stick shows similar sensitivity for detecting anti-SARS-CoV-2 IgM and IgG antibodies as venous blood samples. This provides an opportunity for decentralized rapid testing in the community and may allow point-of-care and longitudinal self-testing for the presence of anti-SARS-CoV-2 antibodies.

scholarly journals Ghrelin levels in hypertensive obese and normotensive obese subjects.

2021 ◽  
Vol 28 (08) ◽  
pp. 1142-1146
Author(s):  
Zehra Niazi ◽  
◽  
Sundus Tariq ◽  
Muhammad Azhar Saeed ◽  
Sana Akram ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
Ghrelin Level ◽  
Enzyme Linked Immunosorbent Assay ◽  
P Value ◽  
Cross Sectional ◽  
The Social ◽  
Significant Difference ◽  
Minimum Age ◽  
Obese Subjects

Objective: The purpose was to determine the ghrelin level, its effect and relationship with blood pressure levels in obese subjects. Study Design: Comparative Cross Sectional study. Settings: General OPD of Madinah Teaching Hospital (MTH) and District Head Quarter hospital Faisalabad (DHQ). Period: 2019 to 2020. Material & Methods: Blood samples were collected from hypertensive and compared with the normotensive obese (BMI >30). Ghrelin level was measured by Enzyme-linked immunosorbent assay (ELISA). Statistical analysis was done on Statistical Package for the Social Science (SPSS) 20 software. Mean ±SD has been given for quantitative variables. Independent sample t test was used for comparisons. Significance has been chosen as p ≤ 0.05. Results: Total 114 obese patients were selected for this study, of which 57 were hypertensive and 57 were normotensive. Minimum age was 30 years and maximum age was 60 years with mean age 39.35 ± 10.08 years. Mean age of hypertensive obese was 43.42 ± 10.46 years and mean age of normotensive was 35.28 ± 7.87 years. Statistically significant difference of mean fasting ghrelin levels between hypertensive obese and normotensive obese was noted with p value 0.013. Conclusion: Obese persons with elevated circulating concentration of ghrelin may be susceptible to the progression of increasing blood pressure.

Sign in / Sign up

Export Citation Format

Share Document