Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD

Abstract The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p<0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p<0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p<0.05) and alkaline phosphatase (p<0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.

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Impact of the Level of Adherence to Mediterranean Diet on the Parameters of Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies

Nutrients ◽

10.3390/nu13051514 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1514

Author(s):

Dimitra Rafailia Bakaloudi ◽

Lydia Chrysoula ◽

Evangelia Kotzakioulafi ◽

Xenophon Theodoridis ◽

Michail Chourdakis

Keyword(s):

Metabolic Syndrome ◽

Mediterranean Diet ◽

Observational Studies ◽

Positive Impact ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Central Registry ◽

High Adherence ◽

The Impact

High adherence to the Mediterranean diet (MD) has been associated with a lower prevalence of Metabolic Syndrome (MetS). The present study aimed to investigate the impact of MD adherence on parameters of MetS. A systematic literature search was performed in PubMed, Cochrane Central Registry of Clinical Trials (CENTRAL), Scopus, EMBASE, Web of Science and Google Scholar databases. Observational studies that recorded adherence to MD and components/measures of the MetS, such as waist circumference (WC), blood pressure (BP), fasting blood glucose (FBG), high-density lipoprotein (HDL) cholesterol and triglycerides (TG), were included in this study. A total of 58 studies were included in our study. WC and TG were significantly lower in the high adherence MD group (SMD: −0.20, (95%CI: −0.40, −0.01), SMD: −0.27 (95%CI: −0.27, −0.11), respectively), while HDL cholesterol was significantly higher in the same group (SMD: −0.28 (95%CI: 0.07, 0.50). There was no difference in FBG and SBP among the two groups (SMD: −0.21 (95%CI: −0.54, 0.12) & SMD: −0.15 (95%CI: −0.38, 0.07), respectively). MD may have a positive impact on all parameters of MetS. However, further research is needed in this field.

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Association between C reactive protein and obesity: a study in a tertiary care hospital

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20194212 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1535

Author(s):

Lavanya Mandli

Keyword(s):

Blood Pressure ◽

Blood Glucose ◽

Cardiovascular Diseases ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Obese Patients ◽

Elevated Blood ◽

C Reactive Protein ◽

Reactive Protein

Background: Obesity and dyslipidemia, especially in children and adolescents coupled with impaired blood glucose metabolism and elevated blood pressure may result in atherosclerosis in the older ages. This study was conducted to assess the association between high levels of CRP with obesity.Methods: Details including height and weight for BMI and serum for C reactive protein estimation was collected for all 134 patients.Results: 60.4% were females and 49.6% were males. Among the obese patients, clinically raised CRP levels was observed in 29.2% and elevated CRP levels in 45.8% levels, while in overweight patients, 21.4% had clinically raised CRP and 46.4% has elevated CRP levels. In normal BMI patients, elevated CRP was seen in 22% and clinically raised in 1.9%.Conclusion: Detection of CRP levels in overweight and obese patients is imperative in the early stages itself to prevent cardiovascular diseases.

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Preliminary Results on the Effectiveness of a Nutrition Intervention in Lowering Diabetes Risk in Prediabetic People Living with HIV (PLWH) in MASH Cohort (OR36-06-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz035.or36-06-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Alicia Sneij Perez ◽

Adriana Campa ◽

Leslie Seminario ◽

Sabrina Martinez ◽

Fatma Huffman ◽

...

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Intervention Group ◽

Nutrition Intervention ◽

Control Group ◽

Reactive Protein ◽

Research Initiative ◽

Significant Difference ◽

Hs Crp

Abstract Objectives The objective of this study is to assess the effectiveness of a 6-month nutrition intervention to improve glycemic parameters and inflammation in prediabetic PLWH on stable ART with undetectable HIV viral load. Methods A 6-month randomized, controlled nutrition intervention was conducted in prediabetic PLWH. The study participants for the intervention were recruited from the Miami Adult Studies for HIV (MASH) cohort at the FIU-Borinquen Research Clinic. Upon their consent, the participants were randomized into the intervention group or the control group. Participants randomized in the intervention group met once a month for approximately 1 hour where they received medical nutrition therapy, nutrition counseling and nutrition education; participants randomized into the control group received educational material at baseline. Blood was drawn at baseline and at 6-month to measure fasting blood glucose (FBG) and high sensitivity C-reactive protein (hs-CRP). Results A total of 38 participants were recruited and randomized into either the intervention group (n = 20) or the control group (n = 18). We found that the FBG for the 6-month follow-up for the intervention group was significantly lower than the baseline FBG values of the same study group (paired t-test; P = 0.031). No significant difference was found in the control group between the baseline and 6-month fasting blood glucose values (P = 0.068). Moreover, no significant difference was found in pre/post C-reactive protein (CRP) levels in the intervention or control group (paired t-test; P = 0.404 and P = 0.117 respectively). There was a significant difference in CRP levels at baseline (P = 0.028) between the study groups but no difference at the 6-month follow up (Mann Whitney U test: P = 0.430). Conclusions The results from this intervention support the notion that a nutrition intervention is effective in prediabetic PLWH to lower diabetes risk by significantly lowering fasting blood glucose and may be implemented into larger scale interventions; however, no significant changes was seen in hs-CRP values between the 2 groups. Funding Sources National Institute of General Medical Sciences (NIGMS): Research Initiative for Scientific Enhancement (RISE), Biomedical Research Initiative (BRI) Grant, National Institute on Drug Abuse 5U01DA040381-03 and FIU-Dissertation Funding.

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Fasting Blood Glucose Profile among Secondary School Adolescents in Ado-Ekiti, Nigeria

Journal of Nutrition and Metabolism ◽

10.1155/2015/417859 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

I. O. Oluwayemi ◽

S. J. Brink ◽

E. E. Oyenusi ◽

O. A. Oduwole ◽

M. A. Oluwayemi

Keyword(s):

Blood Glucose ◽

Family History ◽

Secondary School ◽

Fasting Blood Glucose ◽

Positive Family History ◽

Cross Sectional ◽

Female Ratio ◽

History Of ◽

History Of Obesity ◽

The Impact

Background.Over the past two decades there has been an increase in type 2 diabetes mellitus (T2DM) in children. Baseline data is needed to assess the impact of changing lifestyles on Ado-Ekiti, a previously semiurban community in Southwest Nigeria. This study was therefore conducted to assess the fasting blood glucose (FBG) of adolescents in Ado-Ekiti, Nigeria.Methodology.This was a cross-sectional study involving 628 adolescents from three different secondary schools in Ado-Ekiti, Nigeria. With parental consent, volunteers completed a structured questionnaire, and an overnight FBG was measured.Results.There were 346 males and 282 females (male : female ratio = 1.2 : 1). Their ages ranged from 10 to 19 years (mean age:14.2±1.7years). Four hundred and forty-four (70.7%) had normal FBG, while 180 (28.7%) and 4 (0.6%) had FBG in the prediabetic and diabetic range, respectively. Female gender, age group 10–14 years, and family history of obesity were significantly associated with impaired FBG (Pvalue <0.001, <0.001, and 0.045, resp.).Conclusion.Impaired FBG is common among secondary school adolescents and it is more prevalent among younger female adolescents (10–14 years) with positive family history of obesity.

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Influence of Diversity Nursing on Patients’ Rehabilitation in Cardiology Treatment

Journal of Healthcare Engineering ◽

10.1155/2021/5606660 ◽

2021 ◽

Vol 2021 ◽

pp. 1-15

Author(s):

Changling Li ◽

Aijie He

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Blood Glucose ◽

Angina Pectoris ◽

Positive Impact ◽

Blood Glucose Control ◽

Nursing Intervention ◽

Control Group ◽

The Impact ◽

Experimental Group

With the improvement of living standards, people have more and more physical health problems. Among them, high-risk cardiovascular diseases such as hypertension, diabetes, and coronary heart disease are the most prominent. The number of cardiology patients is increasing year by year. Effectively improving the treatment of cardiology patients and speeding up the recovery of cardiology patients have become a social problem. This article aims to explore the impact of diverse nursing care on patients in cardiology treatment. This article first gives a detailed introduction to the treatment of diverse nursing and cardiology diseases, then takes 300 cardiology patients in our hospital as experimental subjects, and conducts a controlled experiment of nursing intervention, which is categorized into an experimental group of 150 cases (including 35 cases of hypertension, 46 cases of diabetes, 28 cases of coronary heart disease, 24 cases of angina pectoris, and 17 cases of multiple complications) and a control group of 150 cases (including 30 cases of hypertension, 47 cases of diabetes, 39 cases of coronary heart disease, 21 cases of angina pectoris, and 13 cases of multiple complications). The experimental results showed the following: the general information of the two groups of patients was not statistically different ( P > 0.05 ); after the nursing intervention, the blood glucose levels of the two groups of patients decreased, but the experimental group decreased more significantly and the blood glucose control effect was more obvious; after the intervention, in the experimental group that implemented diversified nursing interventions, the patient’s condition management effect was better and their scores were between 8 and 10; the mental state self-evaluation of the two groups of patients was significantly different from the domestic reference value ( P < 0.05 ), and there is a very significant statistical difference between the two groups after nursing intervention ( P < 0.01 ); after nursing intervention, compared with the control group, the quality of life of the experimental group improved more significantly and the highest score reached about 70; the overall satisfaction of the experimental group with nursing work reached 92%, while the satisfaction of the control group with nursing work was only 44.67%. Studies have shown that diversified care has a positive impact on the rehabilitation of patients in cardiology treatment.

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Hypoglycemic efficacy of Rosmarinus officinalis and/or Ocimum basilicum leaves powder as a promising clinico-nutritional management tool for diabetes mellitus in Rottweiler dogs

Veterinary World ◽

10.14202/vetworld.2020.73-79 ◽

2020 ◽

Vol 13 (1) ◽

pp. 73-79 ◽

Cited By ~ 2

Author(s):

Noha Abdelrahman ◽

Ramadan El-Banna ◽

Mahmoud M. Arafa ◽

Maha M. Hady

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Positive Impact ◽

Basal Diet ◽

Ocimum Basilicum ◽

Rosmarinus Officinalis ◽

Management Tool ◽

Nutritional Management ◽

Glucose Levels ◽

The Impact

Background and Aim: This study examined the impact of dietary fortification with rosemary (Rosmarinus officinalis) and/or basil (Ocimum basilicum) leaves powder on glycemic status of dogs. Materials and Methods: Forty-five Rottweiler dogs were assigned to five experimental groups and fed an experimentally processed extruded basal diet that was either fortified or not fortified. G1 was fed the basal diet without any fortification (negative control); G2 was consumed the basal diet supplemented with a commercially available synthetic palatant (positive control); G3 was provided with rosemary fortified (at 0.05%) basal diet; G4 was provided with a basil fortified (at 0.05%) basal diet; and G5 was offered a rosemary and basil fortified (each at 0.025%) basal diet. Results: G4 and G5 exhibited a positive impact on growth performance traits. Dogs in G3, G4, and G5 showed significant decreases in serum glucose levels in comparison to dogs of the control groups (G1 and G2). It was clear that the inclusion level of 0.05% of basil leaves powder showed the greatest hypoglycemic action. Indeed, G4 dogs showed a reduction in blood glucose at a percentage of approximately 31% followed by G5 and G3 groups (16.25% and 14%, respectively). Furthermore, basil leaves inhibited the amylase enzyme activity. Both insulin and cortisol levels in G4 dogs were increased and reduced compared to controls, respectively. In addition, dietary fortification with rosemary and/or basil significantly increased glutathione, superoxide dismutase, and catalase levels, while values for malondialdehyde and lactate dehydrogenase were decreased. Conclusion: It could be concluded that dietary fortification of dog diet with rosemary and/or basil leaves powder at 0.05% separately or 0.025% in combination might be used as promising modulators of blood glucose levels as well as clinico-nutritional management tools for the prevention and control of diabetes mellitus in dogs.

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miR1908-5p regulates energy homeostasis in hepatocyte models

Scientific Reports ◽

10.1038/s41598-021-03156-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Sébastien Soubeyrand ◽

Paulina Lau ◽

Kaitlyn Beehler ◽

Kelsey McShane ◽

Ruth McPherson

Keyword(s):

Blood Glucose ◽

Energy Homeostasis ◽

Fasting Blood Glucose ◽

Energy Regulation ◽

Primary Hepatocytes ◽

Genomic Variants ◽

Direct Target ◽

Human Primary Hepatocytes ◽

The Impact ◽

Metabolic Regulators

AbstractWe previously identified genomic variants that are quantitative trait loci for circulating miR-1908-5p and then showed this microRNA to causally associate with plasma levels of LDL-C, fasting blood glucose and HbA1c. The link to LDL-C was subsequently validated and clarified by the identification of a miR1908-5p-TGFB-LDLR regulatory axis. Here, we continue our investigations on miR1908-5p function by leveraging human primary hepatocytes and HuH-7 hepatoma models. Expression of miR1908-5p was shown to be sensitive to glucose and agents affecting glucose metabolism. Transcriptome-wide changes in primary hepatocytes and HuH-7 cells treated with a miR1908-5p mimic were investigated by enrichment approaches to identify targeted transcripts and cognate pathways. Significant pathways included autophagy and increased mitochondrial function. Reduced activation and/or levels of several key energy and metabolic regulators (AKT, mTOR, ME1, G6PD, AMPK and LKB) were subsequently confirmed in mimic treated HuH-7 cells. These effects were associated with reduced NADPH to NADP+ ratio in HuH-7 cells. LKB1 was validated as a direct target of miR1908-5p, the reintroduction of which was however insufficient to compensate for the impact of the miR1908-5p mimic on AMPK and ACC1. These findings implicate miR1908-5p in metabolic and energy regulation in hepatocyte models via multiple, independent, pathways.

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Association of physical activity on blood glucose in individuals with type 2 diabetes

Translational Behavioral Medicine ◽

10.1093/tbm/ibab159 ◽

2021 ◽

Author(s):

Yajuan Wang ◽

Eldin Dzubur ◽

Roberta James ◽

Tamer Fakhouri ◽

Scott Brunning ◽

...

Keyword(s):

Physical Activity ◽

Type 2 Diabetes ◽

Blood Glucose ◽

Fasting Blood Glucose ◽

World Population ◽

Mixed Effect ◽

Step Counts ◽

Steps Per Day ◽

The Impact

Abstract Regular physical activity (PA) has been shown to improve glycemic control in persons with type 2 diabetes. This study aimed to investigate the impact of PA on blood glucose after controlling for medication use, demographics, and week of activation using a real-world population of individuals with type 2 diabetes. A longitudinal, retrospective study was performed evaluating weekly PA of Livongo members (N = 9,509), which analyzed fasting blood glucose (FBG), step counts, and daily active minutes. Linear mixed-effect modeling technique was used to investigate within member and between member effects of input variables on average weekly FBG. Of members enrolled, 6,336 (32%) had self-reported body mass index, qualified week with diabetes medications, and FBG measures. Members’ baseline average age was 49.4 (SD 10.1) years old, 43% female, and 45,496 member weeks with an average of 7.2 qualified weeks (PA observable in ≥4 days) per member. Average weekly FBG was 140.5 mg/dL (SD 39.8), and average daily step counts were 4,833 (SD 3,266). Moving from sedentary (<5,000 steps per day) to active (≥5,000 steps per day) resulted in mean weekly FBG reduction of 13 mg/dL (95% CI: −22.6 to −3.14). One additional day of ≥8,000 steps reduced mean weekly FBG by 0.47 mg/dL (95% CI: −0.77 to −0.16). Members who completed 30 min of moderate to vigorous PA above the population average reduced mean weekly FBG by 7.7 mg/dL (95% CI: −13.4 to −2.0). PA is associated with a mean weekly FBG reduction of 13 mg/dL when changing from a sedentary to active lifestyle while participating in a remote diabetes monitoring program.

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Effect of Haemoglobin Variants on Glycemic Indices

International Blood Research & Reviews ◽

10.9734/ibrr/2021/v13i130161 ◽

2021 ◽

pp. 8-12

Author(s):

Victor Tuanwii ◽

Jonathan Nyebuchi ◽

Albert Lesere Nwibani ◽

Friday Ogidigba ◽

Felix Eedee Konne ◽

...

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Glycated Haemoglobin ◽

Spectrophotometric Analysis ◽

Electrophoretic Method ◽

Glycemic Indices ◽

The Impact

Haemoglobin genotypes have been known to be linked with groups of diseases such as diabetes. The aim of this study is to assess the impact of haemoglobin variants on glycemic indices (fasting blood glucose and glycated haemoglobin) in subjects in Bayelsa State, Nigeria. A total of 150subjects were enrolled for the study with AA group = 99 subjects and AS group = 51 subjects. 4mls of blood was collected into EDTA bottle for each subject and was assayed for Hb electrophoresis and glycated haemoglobin (HbA1C) using electrophoretic method and automated CLOVER A1c Analyser respectively. 2mls was collected into fluoride oxalate bottle for spectrophotometric analysis of fasting blood glucose (FBG). Results revealed that there were no significant differences in the FBG and HbA1C mean levels of the two studied groups (AA and AS). This study has shown that AA and AS blood genotypes may not have any impact on FBG and HbA1C glycemic parameters.

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The Impact of Intermittent Fasting (Ramadan Fasting) on Psoriatic Arthritis Disease Activity, Enthesitis, and Dactylitis: A Multicentre Study

Nutrients ◽

10.3390/nu11030601 ◽

2019 ◽

Vol 11 (3) ◽

pp. 601 ◽

Cited By ~ 15

Author(s):

Mohammad Adawi ◽

Giovanni Damiani ◽

Nicola Bragazzi ◽

Charlie Bridgewood ◽

Alessia Pacifico ◽

...

Keyword(s):

Psoriatic Arthritis ◽

Disease Activity ◽

Positive Impact ◽

Activity Index ◽

Disease Activity Index ◽

Severity Index ◽

Intermittent Fasting ◽

Psoriasis Area Severity Index ◽

Reactive Protein ◽

The Impact

Intermittent circadian fasting, namely Ramadan, is a common worldwide practice. Such fasting has a positive impact on psoriasis, but no data exist on its role in psoriatic arthritis (PsA)—a disease that is clearly linked to body mass index. We enrolled 37 patients (23 females and 14 males) with a mean age 43.32 ± 7.81 and they fasted for 17 h for one month in 2016. The baseline PsA characteristics were collected and 12 (32.4%) patients had peripheral arthritis, 13 (35.1%) had axial involvement, 24 (64.9%) had enthesitis, and 13 (35.1%) had dactylitis. Three patients (8.1%) were treated with methotrexate, 28 (75.7%) with TNF-α blockers, and 6 (16.2%) with IL-17 blockers. After a month of intermittent fasting, C-reactive protein (CRP) levels decreased from 14.08 ± 4.65 to 12.16 ± 4.46 (p < 0.0001), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) decreased from 2.83 ± 1.03 to 2.08 ± 0.67 (p = 0.0078), Psoriasis Area Severity Index (PASI) decreased from 7.46 ± 2.43 to 5.86 ± 2.37 (p < 0.0001), and Disease Activity index for PSoriatic Arthritis (DAPSA) decreased from 28.11 ± 4.51 to 25.76 ± 4.48 (p < 0.0001). Similarly, enthesitis improved after fasting, with Leeds Enthesitis Index (LEI) decreasing from 2.25 ± 1.11 to 1.71 ± 0.86 (p < 0.0001) and dactylitis severity score (DSS) decreasing from 9.92 ± 2.93 to 8.54 ± 2.79 (p = 0.0001). Fasting was found to be a predictor of a decrease in PsA disease activity scores (DAPSA, BASDAI, LEI, DSS) even after adjustment for weight loss. IL-17 therapy was found to be an independent predictor of decreases in LEI after fasting. These preliminary data may support the use of chronomedicine in the context of rheumatic diseases, namely PsA. Further studies are needed to support our findings.

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