scholarly journals The experience of Avicenna and possibility to improve the diabetes treatment

2017 ◽  
Vol 15 (1) ◽  
pp. 58-67
Author(s):  
Mizhgona U Sharofova
Keyword(s):  
Insulin Resistance ◽  
Herbal Medicine ◽  
Modern Science ◽  
Modern Medicine ◽  
The Body ◽  
Diabetes Treatment ◽  
Ibn Sina ◽  
Metabolic Conditions ◽  
Definition Of ◽  
The Impact

This article provides an analysis of research on the impact of modern antidiabetic drugs on the patients and possible ways to improve the treatment of diabetes, based on the experience of Avicenna’s medicine. More and more doctors today practice complementary medicine, combining traditional techniques with non-traditional treatments, including herbal medicine. Studying of various side effects of hypoglycemic drugs showed that most of synthetic means cause numerous complications. Modern medicine is faced with the need to develop new approaches to diabetes treatment and medicines that help to achieve stable metabolic conditions and ensure the safety of medicines. A huge contribution to the study of diabetes has made Abu Ali ibn Sina, who cured the disease, based on the definition of “mizadzh” (nature) of human and drugs prescribed for its correction. There are many etiological factors contributing to insulin resistance and pre-diabetes and they often are interrelated. Based on the Avicenna’s theory of diabetogenezis, we subdivided prediabetes on prepankreatic and pancreatic stages. The onset of prediabetes Avicenna linked with impaired renal, liver and internal environment’s function of the body, which are based on acidosis, eventually contributing to the emergence of pre-diabetes and insulin resistance. Ibn Sina believed that the increased consumption of acidic foods causes a change of the “mizadzh” of the human body in a “cold” (sour, atsidic) diabetogenic side. Modern science has proved that the basis for the development of diabetes is a pH shift toward acidosis. Our studies have shown that the basis of Avicenna’s antidiabetic means comprise alkalizing agents of natural origin. On this basis, herbal medicine is an effective supplement to the officially accepted treatment methods based on the principles of evidence.

A Critical Review on Tamaka Shwasa (Bronchial Asthma) - An Ayurvedic View

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Sandip R. Baheti ◽  
Deepa Sharma ◽  
Saroj Devi ◽  
Amit Rai
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Critical Review ◽  
Modern Science ◽  
Modern Medicine ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Natural Immunity ◽  
Shortness Of Breath ◽  
Asthma Symptoms

Difficulty in breathing or shortness of breath may be simply termed as Shwasa (Asthma), As per Ayurveda, Shwasa is mainly caused by the Vata and Kapha Doshas. Shwasa is broadly classified into five types in Maha Shwasa (Dyspnoea major), Urdhawa Shwasa (Expiratory Dyspnoea), Chinna Shwasa (Chyne-stroke respiration), Kshudra Shwasa (Dyspnoea minor), Tamaka Shwasa (Bronchial Asthma). In modern science Tamaka Shwasa can be correlated with Asthma, Asthma which is a chronic inflammatory disease of airway. In modern medicine there is no cure for Asthma, symptoms can typically be improved. In Ayurveda, Asthma can be effectively and safely manage the condition without inducing any drug dependency where Pachakarma procedures and use of internal medication detoxifies the body, provides nutrition and increases the elasticity of lung tissue it also develops natural immunity of the body thus decreasing episodic recurrence of the disease.

scholarly journals Selecting informative biomarkers for early diagnosis of occupational neurological diseases

2021 ◽  
Vol 100 (9) ◽  
pp. 953-958
Author(s):  
Inna V. Lapko
Keyword(s):  
Insulin Resistance ◽  
Carbohydrate Metabolism ◽  
The Body ◽  
Working Environment ◽  
Total Testosterone ◽  
Physical Factors ◽  
Lumbosacral Radiculopathy ◽  
Vibration Disease ◽  
Neurohumoral Regulation ◽  
The Impact

Introduction. At present, the patterns of changes in the levels of biomarkers and the relationship of changes in their values with the pathogenesis of diseases caused by the impact of adverse factors of labour activity are not sufficiently studied. The most unresolved issues are the choice of informative laboratory indicators and diagnostic test systems in investigating the impact of physical factors on the working environment (vibration and physical overload) neurohumoral regulation: pituitary-adrenal pituitary-thyroid, pituitary-gonadal system and hormonal indicators of carbohydrate metabolism. The aim of the study was to determine diagnostic hormonal markers and integral indices to identify early changes in the neurohumoral status in the body of workers under the influence of working environment factors. Materials and methods. 330 workers of mining and machine-building enterprises were examined. Of these, 128 people with vibration disease, 45 people - with lumbosacral radiculopathy, combined pathology (vibration disease and lumbosacral radiculopathy) was detected in 60 persons. The preclinical stage (initial signs of diseases) was noted in 97 workers. Laboratory studies included hormones and integral indices of the pituitary-adrenal, pituitary-thyroid, pituitary-gonadal system, carbohydrate metabolism. To select the diagnostic significance of laboratory biomarkers, diagnostic sensitivity, prenosological value, pathognomonicity, direction, severity, and selectivity of changes in biomarker levels were evaluated. Results. The combined effect of vibration and physical overload on the body of workers was found to have a unidirectional and systemic impact on the levels of hormones of the pituitary-adrenal, pituitary-thyroid and pituitary-gonadal systems, increases insulin resistance. The severity of changes in neurohumoral regulation indicators depends on the nature and severity of the occupational neurological disease. The highest diagnostic sensitivity (Df = 72-74%) in vibration disease and its combination with lumbosacral radiculopathy was obtained for pituitary-gonadal hormones and indicators of insulin resistance. The lowest values of Dh are typical for the hormones of the pituitary-thyroid system (no more than 14%). To identify early changes in neurohumoral regulation in the body under the influence of vibration and physical exertion, it is most informative to determine the concentration of total testosterone, luteinizing hormone and insulin, as well as the integral pituitary-adrenal index, insulin resistance indices. To identify hidden disorders of the pituitary-thyroid system, the definition of the essential thyroid index can be used. Discussion. The results obtained allowed us to assess the nature of changes in the levels of hormones of the pituitary-adrenal, pituitary-thyroid and pituitary-gonadal systems and carbohydrate metabolism and to propose informative laboratory biomarkers reflecting early changes in neurohumoral regulation under the influence of physical factors of the working environment. Conclusions. To identify early changes in neurohumoral regulation in the body of workers under the influence of vibration and physical exertion, the most informative is the determination of the concentration of total testosterone, luteinizing hormone and insulin, the integral pituitary-adrenal index, and insulin resistance indices. To identify hidden disorders of the pituitary-thyroid system, the definition of the integral thyroid index can be used.

Present and future applications of enterosorbents in the prevention and treatment of adverse effects of heavy metal compounds

2020 ◽  
pp. 42-47
Author(s):  
A. V. Fomichev ◽  
A. E. Sosyukin ◽  
E. V. Malysheva ◽  
V. S. Litvinсev ◽  
N. V. Lapina ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Modern Science ◽  
The Body ◽  
Biologically Active ◽  
Toxic Substances ◽  
Metal Compounds ◽  
Medicinal Substances ◽  
Relationship Of ◽  
The Impact

Research of the last decade, which revealed the relationship of various socially significant diseases (Alzheimer’s disease, parkinsonism, multiple sclerosis, etc.) with the impact of heavy metals on the human body, stimulates modern science to create drugs that can quickly and safely remove these toxic substances from the body. The article presents a review of studies on the effectiveness of heavy metal adsorption by modern enterosorbents officially registered in the Russian Federation as drugs. The prospects of using non-starch polysaccharides, which are part of modern biologically active additives, in order to create new medicinal substances for the elimination of heavy metals that pose a threat to public health are indicated.

scholarly journals An attempt to understand the concept of PCOS w. s. r. to artavavaha sroto dusti

2018 ◽  
Vol 6 (04) ◽  
Author(s):  
Dharmaraj Nagorao Lone ◽  
Chitra Gawande ◽  
Pratibha Kulkarni ◽  
Nagorao Dattarao Lone
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Modern Medicine ◽  
The Body ◽  
Reproductive Age ◽  
Fallopian Tubes ◽  
Women Of Reproductive Age ◽  
Androgen Excess ◽  
Hormonal Imbalance ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the most common endocrine ovarian disorder affecting 5 to 10% women of reproductive age. It is also known as stein- laventhal syndrome or hyper androgenic Anovulation. The main primary character of PCOS is irregular menstrual cycle which leads to improper ovulation. Exact pathogenesis of PCOS is not understood clearly, it may be discussed under following headings: Abnormality of Hypothalamic-pituitary compartment (Hormonal imbalance), androgen excess, anovulation, obesity and insulin resistance etc. Srotas are the circulatory channels through which Dosha’s, Dhatu’s and Mala’s moves from one part to another part of the body. Each srotas has srotomoola, srotomarga and srotomukha. The moolasthana of artavavaha srotas are garbhashaya(uterus) and artavavahi dhamani’s(uterine & ovarian arteries). Artavavaha srotas may be categorized into Shonita artavavaha srotas which carries menstrual blood through blood vessels and capillaries of the uterus & Beejartavavaha srotas which carries ovum through fallopian tubes. Abnormality of Artavavaha srotas causes Vandhyatva, Maithuna Asahishnuta and Artavanasha. Vandhyatva caused due to abnormality in chaturvidha garbhottpadaka(rutu, kshetra, ambu and beeja) samagri. Maithuna Asahishnuta related to vatala, paripluta, vipluta and shandi yoniyapada, while Artavanasha related to Vandhya, Arajaska and shushka yonivyapada. All these symptoms like Vandhyatva, Maithuna Asahishnuta and Artavanasha are correlated with common symptoms of PCOS which include Infertility, Dyspareunia & Amenorrhoea respectively. As there is no curative treatment available in modern medicine, understanding of PCOS with reference to Artavavaha sroto dusti may be a ray of hope to treat PCOS with Ayurvedic remedies. KEY WORDS: Artava, Srotas, PCOS, Vandhyatva, Yonivyapada.

scholarly journals Yoga and relaxation for promoting public health: A review of the practice and supportive research

2020 ◽  
Vol 12 (1) ◽  
pp. 133-140
Author(s):  
Krzysztof Stec
Keyword(s):  
Life Stress ◽  
Holistic Approach ◽  
Well Being ◽  
Natural World ◽  
Modern Medicine ◽  
The Body ◽  
General Level ◽  
Reduced Physical Activity ◽  
Fitness Training ◽  
The Impact

SummaryThe purpose of this review is to present yoga as an important tool for both disease prevention and health care. Yoga involves a holistic approach that lacks the mechanistic fragmentation of the impact on individual organs and body systems, which arises from much of the specialization found in modern medicine. Lifestyle diseases are increasingly a problem. The incidence of diabetes, hypertension, atherosclerosis, cancer, mental illness and obesity is increasing worldwide. This is true even of countries that, until recently, followed a traditional way of life. Technology, the pace of life, stress, and reduced physical activity serve to degrade the general level of health in societies across the globe. In Western societies, these factors have raised the demand for preventive and therapeutic antidotes, leading Westerners to turn to traditional yoga, which is, however, often modified to the point of distorting its essence. In its original nature yoga is a non-religious, psychosomatic system based on natural laws, inspired by science to act on the body in a way that is integrated into the natural world. The system of Ayurvedic medicine works in parallel with yoga, aiming at the same holistic effect. Both it and the various elements of yoga, in particular asanas (postures), are the means of effecting beneficial changes in psychosomatic functioning. Yoga itself relaxes and strengthens physical movement, focusing particular attention on the mobility of the spine. It is also the perfect medium for achieving mental balance. These properties of yoga have made it useful in the treatment of cancer and other modern diseases, in slowing the body’s aging process, and in achieving general welfare and well-being. More intense forms of yoga practice, such as the ancient method of fitness training called Suryanamaskar, have demonstrated their effectiveness in preventing and treating cardiovascular diseases, respiratory ailments and other conditions.

RESULTS OF THE IMPACT OF ANTIPROTEINASE HEMOSORBENT ON THE DYNAMICS OF CLINICAL AND LABORATORY INDICATORS IN CHILDREN WITH GENERALIZED PERITONITIS

2021 ◽  
Vol 19 (4) ◽  
pp. 410-417
Author(s):  
U. K. Serhiyenka ◽  
◽  
R. E. Yakubtsevich ◽  
V. G. Vakulchik ◽  
V. A. Kazhina ◽  
...  
Keyword(s):  
Intensive Care ◽  
Comparison Group ◽  
Intensive Therapy ◽  
Randomized Study ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Blood Oxygenation ◽  
The Body ◽  
Generalized Peritonitis ◽  
The Impact

Background. Despite the undoubted success of modern medicine, peritonitis in children remains not only a surgical, but also a general pathological problem, the relevance of which is not decreasing. The use of efferent therapy methods, in particular hemosorption, imitating the natural mechanisms of detoxification of the body, are promising in the complex therapy of children with peritonitis. The aim of the study was to establish the effectiveness of the antiproteinase hemosorbent "Hemo-proteazsorb" in the complex intensive care of children with generalized peritonitis. Material and methods. A prospective randomized study of 60 children with generalized peritonitis was conducted. In the main group, there were 30 patients who underwent hemosorption in complex intensive therapy. The comparison group also included 30 patients who underwent traditional treatment. The examined groups were comparable in terms of the nature of the pathology and the severity of the condition. Results. During hemoperfusion, a significant increase in blood saturation was established – from 95.1 (93.2; 97.1)% to 97.3 (95.5; 98.7)%, with an improvement in oxygen transport (ctO2, mmol/l) from 6.9 (6.4; 7.9) to 8.8 (1.5; 9.7) and a decrease in lactate level (mmol/l) from 1.7 (1.5;2.1) to 1.1 (0.9;1.3), which indicated normalization of blood oxygenation and improvement of microcirculation. After 24 hours, there was a significant decrease in the sum of points on the pSOFA scale, from 4.5 (3.0; 6.0) to 0.5 (0; 2.0), p<0.001. Normalization of body temperature and restoration of intestinal function in 15 (50.0% СI 32.1-67.9) children were also noted, which indicated a decrease in multiple organ dysfunction and improvement of the condition. In the comparison group, the studied indicators changed much more slowly. Conclusions. The data on the positive dynamics of clinical and laboratory parameters, obtained as a result of the study, prove the high effectiveness of the Belarusian hemosorbent "Hemo-proteazsorb" in the complex intensive care for generalized peritonitis.

scholarly journals Psoralea corylifolia L. Seed Extract Attenuates Methylglyoxal-Induced Insulin Resistance by Inhibition of Advanced Glycation End Product Formation

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Cao-Sang Truong ◽  
Eunhui Seo ◽  
Hee-Sook Jun
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Hepg2 Cells ◽  
Product Formation ◽  
The Body ◽  
Psoralea Corylifolia ◽  
Advanced Glycation ◽  
Metabolic Conditions

Accumulation of advanced glycation end products (AGEs) in the body has been implicated in the pathogenesis of metabolic conditions, such as diabetes mellitus. Methylglyoxal (MGO), a major precursor of AGEs, has been reported to induce insulin resistance in both in vitro and in vivo studies. Psoralea corylifolia seeds (PCS) have been used as a traditional medicine for several diseases, but their potential application in treating insulin resistance has not yet been evaluated. This study is aimed at investigating whether PCS extract could attenuate insulin resistance induced by MGO. Male C57BL/6N mice (6 weeks old) were administered 1% MGO in their drinking water for 18 weeks, and the PCS extract (200 or 500 mg/kg) was orally administered daily from the first day of the MGO administration. We observed that both 200 and 500 mg/kg PCS extract treatment significantly improved glucose tolerance and insulin sensitivity and markedly restored p-Akt and p-IRS1/2 expression in the livers of the MGO-administered mice. Additionally, the PCS extract significantly increased the phosphorylation of Akt and IRS-1/2 and glucose uptake in MGO-treated HepG2 cells. Further studies showed that the PCS extract inhibited MGO-induced AGE formation in the HepG2 cells and in the sera of MGO-administered mice. PCS extract also increased the expression of glyoxalase 1 (GLO1) in the liver tissue of MGO-administered mice. The PCS extract significantly decreased the phosphorylation of ERK, p38, and NF-κB and suppressed the mRNA expression of proinflammatory molecules including TNF-α and IL-1β and iNOS in MGO-administered mice. Additionally, we demonstrated that the PCS extract attenuated oxidative stress, as evidenced by the reduced ROS production in the MGO-treated cells and the enhanced expression of antioxidant enzymes in the liver of MGO-administered mice. Thus, PCS extract ameliorated the MGO-induced insulin resistance in HepG2 cells and in mice by reducing oxidative stress via the inhibition of AGE formation. These findings suggest the potential of PCS extract as a candidate for the prevention and treatment of insulin resistance.

scholarly journals Body Composition, Insulin Resistance and Mediators of Appetite and Energy Homeostasis in Hyperthyroidism

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A825-A825
Author(s):  
Avinash Patil ◽  
Suresh Vaikkakara ◽  
Alok Sachan ◽  
P Varma Buddharaju
Keyword(s):  
Insulin Resistance ◽  
Body Composition ◽  
Body Weight ◽  
Fat Mass ◽  
Energy Homeostasis ◽  
The Body ◽  
Unexpected Finding ◽  
Reduced Body ◽  
Total Body ◽  
The Impact

Abstract Background: Hyperthyroidism is associated with reduced body weight despite an increase in appetite; due mainly to an increase in energy production. While appetite is regulated by the balance of orexogenic and anorexogenic peripheral signals like Ghrelin and Leptin respectively, energy expenditure is profoundly influenced by thyroxine itself as well as mediators like FGF 21 and Leptin. Hyperthyroidism offers a good model to study the impact of thyroid hormones on the above mediators. Materials & Methods: 35 adult patients with overt hyperthyroidism were evaluated for leptin, ghrelin, adiponectin, FGF21 levels & insulin resistance as well as the body composition by DEXA both at baseline and a minimum of two months following normalization of serum thyroxin on carbimazole treatment. Results: Correction of hyperthyroidism was associated with an increase in body weight including both the lean body (p&lt;0.001) and the fat mass (p&lt;0.001), but with no change in percentage of total body fat (p=0.516). Accompanying the weight gain, there was no change in adiponectin (p=0.98), while a paradoxical decrease in insulin resistance was observed (p&lt;0.001). Correction of hyperthyroidism was also associated with a decrease in FGF21 (p&lt;0.001) and leptin levels (p=0.03) and an increase in ghrelin (p=0.05). Conclusion: Thyrotoxic state is associated with high leptin & FGF21 levels - both known to be thermogenic. Despite a lower weight and fat mass, thyrotoxicosis is associated with insulin resistance- possibly a direct effect of thyroxine. Ghrelin levels are low in thyrotoxicosis; which together with raised leptin is an unexpected finding, given the increased appetite observed in this condition.

scholarly journals Does glucocorticoid exposure explain the association between metabolic dysfunction and tendinopathy?

2020 ◽  
Vol 9 (3) ◽  
pp. R36-R46
Author(s):  
Trevor Lewis ◽  
Eva Zeisig ◽  
Jamie E Gaida
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Tendon Rupture ◽  
Structure And Function ◽  
Metabolic Health ◽  
The Body ◽  
Visceral Adiposity ◽  
And Function ◽  
The Impact

Background While metabolic health is acknowledged to affect connective tissue structure and function, the mechanisms are unclear. Glucocorticoids are present in almost every cell type throughout the body and control key physiological processes such as energy homeostasis, stress response, inflammatory and immune processes, and cardiovascular function. Glucocorticoid excess manifests as visceral adiposity, dyslipidemia, insulin resistance, and type 2 diabetes. As these metabolic states are also associated with tendinopathy and tendon rupture, it may be that glucocorticoids excess is the link between metabolic health and tendinopathy. Objective To synthesise current knowledge linking glucocorticoid exposure to tendon structure and function. Methods Narrative literature review. Results We provide an overview of endogenous glucocorticoid production, regulation, and signalling. Next we review the impact that oral glucocorticoid has on risk of tendon rupture and the effect that injected glucocorticoid has on resolution of symptoms. Then we highlight the clinical and mechanistic overlap between tendinopathy and glucocorticoid excess in the areas of visceral adiposity, dyslipidemia, insulin resistance and type 2 diabetes. In these areas, we highlight the role of glucocorticoids and how these hormones might underpin the connection between metabolic health and tendon dysfunction. Conclusions There are several plausible pathways through which glucocorticoids might mediate the connection between metabolic health and tendinopathy.

Efficacy of Herbal Medicine in Treating Metabolic and Endocrine Disorders

2021 ◽  
pp. 236-255
Author(s):  
Chittipolu Ajaykumar
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Herbal Medicine ◽  
Modern Medicine ◽  
Dosage Forms ◽  
Syndrome X ◽  
Endocrine Disorders ◽  
Evidence Based ◽  
The Metabolic Syndrome ◽  
The World

Metabolic syndrome is an interrelated cluster of pathogens such as obesity, impaired glucose tolerance, cancer, and insulin resistance leading to endocrinal disorders. In the 21st century, progression of the disease is rapid increases due to change in the lifestyle of humans having a chance to develop metabolic change, and in some cases, mutations occur, which drastically affects the endocrine functionality and subsequently causes syndrome X. In modern medicine, different medications are available but only to maintain the condition lifetime. For the complete cure, WHO focused on the traditional knowledge in 2004, using the herbal medicine to cure all metabolic aliments. According to ancient medical treatment, metabolic syndromes are completely curable. They divided the disease progression stages and formulated the different dosage forms. All the data obtained from the ancient herbal medicine treatment are not evidence-based. So, the researchers all around the world focused on the evidence-based proofs to confirm whether herbal medicine shows efficacy in curing the metabolic syndrome or not.

Sign in / Sign up

Export Citation Format

Share Document