scholarly journals Adverse Effect of Aerosol Pesticide on Lung Dysfunction amongPaddy Farmers in Purworejo, Central Java, Indonesia

2020 ◽  
Vol 15 (2) ◽  
Author(s):  
Fajaria Nurcandra ◽  
Renti Mahkota ◽  
Tri Yunis Miko Wahyono
Keyword(s):  
Pesticide Exposure ◽  
Communicable Disease ◽  
Smoking Habit ◽  
World Health ◽  
Dust Exposure ◽  
Normal Lung ◽  
Control Group ◽  
Chronic Obstructive ◽  
Case Group ◽  
Lung Dysfunction

The World Health Organization estimated that chronic obstructive pulmonary disease (COPD) will be the highest non-communicable disease worldwide by2030, and pesticide exposure is one of major risk factors. This study aimed to determine effect of pesticide exposure on lung dysfunction among paddyfarmers. A case-control study was performed on April - May 2016 in Purworejo. The case group comprised 66 farmers suffering from lung dysfunction during2015 based on medical records, while the control group comprised 59 neighboring farmers showing normal lung function. Both case and control groups weretested using a spirometer and COPD assessment test (CAT) questionnaire. Logistic regression analysis of pesticide quantity (OR = 0.75; 95% CI = 0.317 -1.754) and duration of spraying (OR = 1.11; 95% CI = 0.430 - 2.891) adjusted for confounders showed no clear associations. Pesticide remained a potentialhealth risk for lung dysfunction due to farming duration (OR = 5.61; 95% CI = 1.124 - 27.990) adjusted by age, personal protective equipment, records of lungdisease, smoking habit, dust exposure, and indoor air pollution. The farming duration was revealed to be a risk factor, but no clear association was found between quantity and duration of spraying to lung dysfunction.

scholarly journals Applying food frequency questionnaire to evaluate the dietary pattern and life style on women with breast cancer

2018 ◽  
Vol 60 (2) ◽  
pp. 119-125
Author(s):  
Huda H. Alabbody ◽  
Ban S. Al- Nasiry ◽  
Khalida H. Kadhim
Keyword(s):  
Breast Cancer ◽  
Food Frequency Questionnaire ◽  
Life Style ◽  
Dietary Pattern ◽  
Dietary Habits ◽  
World Health ◽  
Control Group ◽  
Case Group ◽  
Food Frequency ◽  
The World

  Background: Breast cancer is the most common cancer among women and ranked number two afterlung cancer in the world. According to the World Health Organization, breast cancer accounts for22.9% among cancers in women in 2012.Objective: This study was designed to evaluate the dietary pattern particularly dairy productsconsumption and the role of lifestyle on women with breast cancer in Baghdad city and its suburbs.Subjects and Methods: The study was conducted on 100 women with breast cancer, as a case group,compared with a control group comprised of 100 healthy women. Demographic data were collectedfrom both groups. A food frequency questionnaire was used of 33 items of foods for reporting thedietary pattern and modes of life style of the participants. The statistical Chi-square test / SPSS V.22was used to analyze the data.Results: Our data show that 71% of the women in the two groups were found to be overweightwith body mass index (BMI 25-29.9). 90% of obese women represented in case group (BMI ≥30), while82% of normal weight women (BMI 18.5-24.9) were in control group. Approximately 61% of womenin both groups were in post-menopausal age. Intake of high fatty dairy products by the participantsshowed a statistically significant increase in breast cancer risk (OR=1.625, CIs 95%=0.686-3.847).Consumption of vegetables and fruits was significantly lower (P˂0.01) in case group than in the controlgroup. Furthermore, roughly 68% women in the case group used to smoke cigarettes. In addition, lackor decreased regular physical exercises (never with ≥1 practice per wk) was statistically significant(OR= 44. 809; CIs= 5.889 –340.963). Other parameters, including long period of breastfeeding, earlyage at first birth and consumption of white meat, beans and eggs were all reported to have significance.On the other hand, there was no correlation with the marital status, occupation, living area, class ofdairy products, and passive smoking.Conclusion: Unhealthy dietary habits especially high-fat dairy intake and wrong lifestyle may be riskfactors and predispose Iraqi women for breast cancer development. Therefore, eating healthy food andfollowing correct lifestyle are highly recommended as a suitable program for the prevention of breastcancer.

scholarly journals Pola makan dan hubungannya dengan kejadian stroke di RSUD dr. Doris Sylvanus Palangka Raya

2016 ◽  
Vol 2 (2) ◽  
pp. 51
Author(s):  
Perawaty Perawaty ◽  
Pernodjo Dahlan ◽  
Herni Astuti
Keyword(s):  
Physical Activity ◽  
Risk Factor ◽  
Smoking Habit ◽  
Case Control ◽  
World Health ◽  
Control Group ◽  
Chi Square ◽  
Eating Pattern ◽  
Food Frequency ◽  
And Control

<p>ABSTRACT</p><p>Background: According to WHO it is estimated that there are 15 million people having stroke annually. High prevalence of stroke happens at Kalimantan Tengah as indicated from the growing number of outpatients and inpatients of stroke every year. There is a shift in eating pattern at urban areas from traditional eating pattern to western eating pattern that has high composition of calories, protein, fat, sugar and less fibre causing nonproportional nutrient intake. This condition is a risk factor for the prevalence of degenerative diseases such as hypertension, coronary heart disease and other health problems. Efforts for primary prevention against stroke can be made through intervention in unhealthy lifestyle including eating pattern.</p><p>Objectives: To identify association between eating pattern and the prevalence of stroke at dr. Doris Sylvanus Hospital Palangka Raya.</p><p>Methods: The study was analytic observational with case control design. Subject consisted of cases and control at comparison 1:1 matched in age. Cases were stroke inpatients of dr. Doris Sylvanus Hospital and control group consisted of patients of other diseases at the same hospital. The study involved 76 patients taken concecutive. Data comprised of sample identity, waist circumference, eating pattern, hypertension, physical activity and smoking habit. Data of eating pattern were obtained through semi quantitative food frequency questionnaire. The result of the study was analyzed using chi square and logistic regression.</p><p>Results: The result of the study showed there were 5 variables significantly associated with the prevalence of stroke; ie. more consumption of processed foods (OR 7,53 CI 95% : 1,38 – 41,13), less consumption of fruits (OR 6,98 CI 95%, 1,53-31,80), less consumption of fish (OR 6,36 CI 95% : 1,15 – 34,99), hypertension (OR 10,91 CI 95%, 2,43–49,03) and less physical activities (OR 8,36 CI 95%, 1,72-40,56) while the frequency of fast foods, alcohol consumption, obesity and smoking are not statistically significant (p &gt; 0.05).</p><p>Conclusions: The presence of hypertension, less physical activity, more consumption of processes foods, less consumption of fruits and less consumption of fish a risk factor for the dominant influence on the incidence of stroke.</p><p>KEYWORDS: stroke, eating pattern, case control</p><p>ABSTRAK</p><p>Latar belakang: Laporan World Health Organization (WHO), diperkirakan setiap tahun terdapat 15 juta orang di seluruh dunia yang mengalami stroke. Tingginya prevalensi stroke di Kalimantan Tengah dilihat dari penderita rawat inap dan rawat jalan di rumah sakit yang jumlahnya meningkat setiap tahun. Terjadinya pergeseran pola makan di kota-kota besar dari pola makan tradisional ke pola makan barat yang komposisinya terlalu tinggi kalori, banyak protein, lemak, gula tetapi rendah serat menimbulkan ketidakseimbangan asupan zat gizi. Kondisi tersebut merupakan faktor risiko untuk terjadinya penyakit degeneratif seperti hipertensi, jantung koroner dan masalah kesehatan lainnya. Upaya pencegahan tingkat awal atau preventif primer pada stroke dapat dilakukan dengan intervensi pada gaya hidup yang tidak sehat termasuk pola makan.</p><p>Tujuan: Untuk mengetahui hubungan pola makan dengan kejadian stroke di RSUD dr. Doris Sylvanus Palangka Raya.</p><p>Metode: Penelitian ini merupakan penelitian observasional analitik menggunakan rancangan case control. Subjek terdiri dari kasus dan kontrol dengan perbandingan 1:1 yang telah dilakukan matching terhadap umur. Kasus adalah penderita stroke dan kontrol adalah penderita penyakit lainnya yang menjalani<br />rawat inap di RSUD dr. Doris Sylvanus Palangka Raya. Jumlah subjek adalah 76 orang yang ditentukan dengan metode consecutive sampling. Data yang dikumpulkan yaitu identitas sampel, lingkar pinggang, pola makan, hipertensi, aktifitas fisik dan merokok. Data pola makan dikumpulkan dengan formulir semi quantitatif food frequency. Hasil penelitian dianalisis dengan menggunakan Chi square dan regresi logistik.</p><p>Hasil: Hasil penelitian menunjukkan terdapat 5 variabel yang berhubungan signifikan dengan kejadian stroke yaitu lebih konsumsi makanan olahan (OR 7,53 CI 95% : 1,38 – 41,13), kurang konsumsi buah (OR 6,98 CI 95% : 1,53 – 31,80), kurang konsumsi ikan (OR 6,36 CI 95% : 1,15 – 34,99),hipertensi (OR<br />10,91 CI 95% : 2,43 – 49,03) dan kurang aktivitas fisik (OR 8,36 CI 95% : 1,72 – 40,56), sedangkan frekuensi konsumsi fast food, konsumsi sayuran berwarna, konsumsi alkohol, obesitas, dan merokok tidak signifikan secara statistik (p &gt; 0,05).</p><p><br />Kesimpulan: Adanya hipertensi, kurang aktivitas fisik, lebih konsumsi makanan olahan, kurang konsumsi buah dan kurang konsumsi ikan merupakan faktor risiko terhadap kejadian stroke.</p><p>KATA KUNCI: stroke, pola makan, case control</p>

scholarly journals Case control study of nucleated RBC’s in cord blood as a predictor of perinatal asphyxia its severity and outcome

2017 ◽  
Vol 4 (6) ◽  
pp. 2008
Author(s):  
Mandeep Singh Khurana ◽  
Sunita Arora ◽  
Supriya Malik ◽  
Jasgobind Singh Gulati
Keyword(s):  
Cord Blood ◽  
Predictive Value ◽  
Case Control Study ◽  
Perinatal Asphyxia ◽  
Case Control ◽  
World Health ◽  
Control Group ◽  
Case Group ◽  
Chi Square Analysis ◽  
Control Study

Background: Perinatal asphyxia word derived from the greek word a-spyxos, meaning born without an evident pulse, is one of the most important causes of fetal distress. Inspite of major advances in technology and knowledge of fetal and perinatal medicine, it is one of the significant causes of mortality and long-term morbidity. World health organization (WHO) has defined perinatal asphyxia as a failure to initiate and sustain breathing at birth. HIE is one of the most common complication in an asphyxiated neonate because of its serious longterm neuromotor sequalae among the survivors. A detailed classification of HIE staging in term neonate was proposed by Sarnat and Sarnat.Methods: The present study was prospective case control study conducted in neonatal intensive care unit of Department of Pediatrics at SGRD institute of medical sciences and research over a period of one year from September 2016 to august 2017. Total of 100 newborns among which 50 asphyxiated babies were designated to case group and rest 50 normal term babies to control group. The NRBC count of the case and control groups is compared. The NRBC’s of subjects belonging to different stages of HIE is then compared. The results were analysed statistically chi-square analysis for variance (qualitative analysis), t-test (compare mean NRBC’s in different stages) by SPSS version 20 software for biostatistic and p-value of <0.05 was considered statistically significant.Results: Among total 100 babies included in the study, the male and female distribution was 22 (44%) and 28 (56%) in cases and 23 (46%) and 27 (54%) in controls respectively. In our study, the NRBC /100 WBC count for normal newborn was 0.88±1.35 and in case group it was 21.40±20.Conclusions: In present study, the cord blood NRBC count was shown to be a good predictor of perinatal asphyxia with sensitivity of 86%, specificity of 100%, positive predictive value of 100% and negative predictive value of 87.72%. NRBC’s can be used for early detection of HIE and its grading in asphyxiated neonates. 

scholarly journals C-Reactive Protein Concentrations Among Crop and Dairy Farmers with Stable Chronic Obstructive Pulmonary Disease

2017 ◽  
Vol 5 (6) ◽  
pp. 724-729 ◽  
Author(s):  
Sasho Stoleski ◽  
Jordan Minov ◽  
Jovanka Karadzinska-Bislimovska ◽  
Dragan Mijakoski ◽  
Lütfiye Tutkun
Keyword(s):  
Exposure Duration ◽  
Statistical Significance ◽  
Smoking Habit ◽  
Control Group ◽  
Chronic Obstructive ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Dairy Farmers ◽  
Reactive Protein ◽  
The Mean

AIM: To assess the mean serum C-reactive protein concentrations among farmers and office controls, and further examined its relation to exposure duration, smoking habit, as well as presence or absence of COPD.METHODS: A cross-sectional survey was performed including examined group (EG), composed of agricultural workers (87 crop - EG1 and 83 dairy farmers - EG2), and control group (CG) composed by 80 office workers. Evaluation of subjects included a questionnaire on chronic respiratory symptoms, lung function tests, COPD diagnostics, and measurement of CRP serum concentrations.RESULTS: Serum CRP concentrations were raised in stable COPD patients independent of smoking habit or exposure duration. The mean CRP serum concentrations were higher in the subjects of EG1 and EG2 compared with those in CG, but without statistical significance. This count for mean CRP serum concentrations in subjects of EG1 and EG2 exposed more than 20 years and for those in smokers in all three groups as well. The mean CRP serum concentrations were significantly higher in subjects with COPD within EG1 (P=0.049) and EG2 (P=0.040), while those in CG were not.CONCLUSION: Data obtained suggest that systemic inflammation is present in farmers with COPD and CRP is an important biomarker in COPD in means of reflecting disease severity and prognosis of exposed farmers.

scholarly journals PENGARUH GAYA HIDUP MEROKOK TERHADAP KEJADIAN INFARK MIOKARD AKUT (IMA) DI RSU BETHESDA TOMOHON

e-CliniC ◽  
2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Geiby F. Kalalo
Keyword(s):  
Myocardial Infarction ◽  
Smoking Habit ◽  
Developed Countries ◽  
Case Control ◽  
Smoking Habits ◽  
Control Group ◽  
Case Group ◽  
Cause Of Deaths ◽  
Heart Center ◽  
And Control

Abstrak : Kebiasaan dan rutinitas yang merugikan memiliki kekuatan untuk merusak kesehatan seseorang seperti kebiasaan merokok yang merupakan contoh kebiasaan untuk memudahkan seseorang terkena penyakit kardiovaskuler.2 Sekitar 1,5 juta kasus infark miokard terjadi setiap tahun di Amerika Serikat dengan tingkat kejadian tahunan adalah sekitar 600 kasus per 100.000 orang.3 Data di RS Pusat Jantung Nasional Harapan Kita menunjukkan IMA pada usia muda pada tahun 2008 adalah 108 kasus dari total 1065 kasus IMA.4 Menurut prediksi WHO, pada tahun 2020 penyakit jantung dan stroke yang saat ini menjadi penyebab kematian utama di negara maju nantinya menjadi penyebab kematian pertama di dunia.2 Tujuan : Tujuan penelitian ini yaitu untuk mengidentifikasi pengaruh gaya hidup merokok terhadap kejadian infark miokard akut di RSU Bethesda Tomohon. Metode : Metode penelitian yang dilakukan bersifat case control retrospektif. Hasil : Karakteristik responden berdasarkan umur didapatkan bahwa pada kelompok kasus sebagian responden dengan gaya hidup merokok berat pada umur ≥ 50 tahun sebesar 56%, sedangkan pada kelompok kasus sebagian responden dengan gaya hidup merokok berat pada umur 30-50 tahun sebesar 36%. Untuk karakteristik berdasarkan lamanya merokok didapatkan bahwa sebagian responden yang lamanya merokok ≥ 10 tahun memiliki persentase lebih besar dibandingkan dengan lamanya merokok 5-10 tahun dimana pada kalompok kasus sebesar 76% dan kelompok kontrol sebesar 84%. Gaya hidup merokok berat yang tidak terjadi IMA dan yang terjadi IMA memiliki persentase responden lebih besar dibandingkan dengan gaya hidup merokok sedang, dimana gaya hidup merokok berat yang tidak terjadi IMA sebesar 28% sebanyak 14 responden dan yang terjadi IMA sebesar 30% sebanyak 15 responden. Kesimpulan :. Kejadian IMA pada kelompok kasus dan kelompok kontrol sebagian besar terjadi pada gaya hidup merokok berat. Pengaruh gaya hidup merokok berat dengan kejadian IMA, memiliki signifikan pengaruh yang sangat kuat.Kata Kunci : Infark Miokard Akut, Gaya Hidup MerokokAbstract : Habits and routinity that gives bad effects have the potential to ruin a persons health, just like the smoking habit as the example that make someone has cardiovascular disease. There’s about 1,5 million myocardial infarction happened every year in USA with annual incidence of 600 cases for each 100.000 person. The database of Harapan Kita Heart Center shows that IMA cases of the young people on 2008 is 108 cases from the total 1065 IMA cases. According to who prediction on 2020, heart disease and stroke which was the main cause of deaths on developed countries will be the world’s main cause of deaths too. Objective: The purpose of this research is to identify the influence of smoking habits to IMA disease at Bethesda Hospital Tomohon. Methods: The methods on this research is case control retrospective. Result: The characteristic of the respondents according to their age, most of them has severe smoking habits at the age of ≥ 50, the percentage is 56%. While the others with severe smoking habits at the age of 30-50 is at 36%. For the characteristic according to how long they’ve been smoking, ≥ 10 years has more percentage than those who have been smoking for 5-10 years, where on the case group at 76% and the control group at 84%. Severe smoking habits who didn’t had IMA and those who had IMA, had higher respondents percentage than those with medium smoking habits, with those with severe smoking habits and don’t had IMA is 14 respondents at 28% and those who had IMA is 15 respondents at 30%. Conclusion: IMA cases on case group and control group mostly happened on those with severe smoking habits. Smoking habits has a very strong and significant influence to IMA cases.Key Words: Acute Myocardial Infarction, Smoking Habits

scholarly journals ANALISIS FAKTOR RESIKO PAPARAN PESTISIDA PADA KEHAMILAN DENGAN KEJADIAN BERAT BADAN LAHIR RENDAH (BBLR) DI KOTA PADANGSIDIMPUAN TAHUN 2019

2020 ◽  
Vol 3 (1) ◽  
pp. 39-47
Author(s):  
Fithri Handayani Lubis
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Pesticide Exposure ◽  
Bivariate Analysis ◽  
Control Group ◽  
Case Group ◽  
Chi Square ◽  
History Of ◽  
Agricultural Areas ◽  
And Storage

Low birth weight (LBW) is one of the main causes of infant mortality. The problem that arises is whether there is a relationship between risk factors for pesticide exposure during pregnancy and the incidence of LBW in agricultural areas. The purpose of this study was to determine the risk factors for pesticide exposure associated with LBW incidence. This research is a case control study. Subjects were divided into two groups: a case group of 25 farmers with a history of giving birth to LBW and a control group who were neighbors of case subjects without a history of giving birth to LBW, a total of 25 farmers. This research data collection using interviews and observations. Data analysis used univariate and bivariate analysis (chi square and fisher as alternatives). Research results: risk factors for exposure to pesticides that have been shown to be associated with the incidence of LBW in Padangsidimpuan, include: occupation of pregnant women related to pesticides (OR = 6,769) completeness of personal protective equipment (PPE) while doing activities in the fields (OR = 18,857) and storage pesticides (OR = 12,667). The recommended advice is to avoid work that is directly related to pesticides during pregnancy, if you have to participate in agricultural activities, pregnant women should use complete PPE.

scholarly journals Assessment of Cytogenetic Damage and Cholinesterases’ Activity in Workers Occupationally Exposed to Pesticides in Zamora-Jacona, Michoacan, Mexico

2021 ◽  
Vol 18 (12) ◽  
pp. 6269
Author(s):  
Rafael Valencia-Quintana ◽  
Rosa María López-Durán ◽  
Mirta Milić ◽  
Stefano Bonassi ◽  
Ma. Antonieta Ochoa-Ocaña ◽  
...  
Keyword(s):  
Dna Damage ◽  
Comet Assay ◽  
Whole Blood ◽  
Pesticide Exposure ◽  
Smoking Habit ◽  
Tail Length ◽  
Exposure Period ◽  
Control Group ◽  
Tail Moment ◽  
Cholinesterase Activities

Pesticides have been considered as potential chemical mutagens; however, little is known about toxic and genotoxic effects during pesticide application in Zamora-Jacona, Michoacan State in Mexico. This study sought to determine DNA damage and cholinesterase activities inhibitions in 54 agricultural workers exposed to complex mixtures of pesticides vs. control group (26 individuals) using Comet assay in peripheral whole blood, micronucleus (MN) test in oral mucosa cells, Cytokinesis-blocked MN assay in lymphocytes (L-CBMNcyt) and measuring AChE and BChE activities in whole blood and plasma samples, respectively. Exposed subjects demonstrated significantly elevated levels of primary (Comet assay: tail intensity, tail length, tail moment, Olive tail moment) and permanent DNA damage (MN assay: in blood/buccal cells; frequencies of nuclear buds, binucleated cells, cells with condensed chromatin, karyorrhexis, pyknosis, and karyolysis). However, inhibition of cholinesterase activities (AChE and BChE) was not observed in the workers. Confounding factors including sex, age, BMI, working exposure period, protection level, smoking habit (cigarettes per day units), alcohol consumption (weekly), medication, were considered in the analysis. These combined techniques demonstrated usefulness in the health hazards risks pesticide exposure assessment and suggested the need for periodic monitoring together with the education and the training of occupational workers for the safe application of potentially harmful pesticides.

scholarly journals Chronic obstructive pulmonary disease patients and steroids: benefit or harm

2019 ◽  
Vol 8 (10) ◽  
pp. 2247
Author(s):  
Abdul Hamid Khan ◽  
Mehwish Majeed
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Pulmonary Function Tests ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Chronic Obstructive ◽  
Case Group ◽  
Obstructive Pulmonary Disease ◽  
Function Tests

Background: Corticosteroids are being widely used in conditions related to allergy and inflammation. There are great species differences in the responses to glucocorticoids that mean a “steroid resistant” species. Steroids have profound effect on inflammatory response by way of vasoconstriction, decreased chemotaxis and interference with macrophages. There still are enormous gaps in our knowledge of the action of glucocorticosteroids in patients of chronic obstructive lung disease (COPD).Methods: This study was done in the department of general medicine at SKIMS, Srinagar from December 2017 to December 2018 on patients of chronic obstructive pulmonary disease. A total number of 100 patients were enrolled for the study but 20 patients, 10 from each group lost their follow up. To see the effect of steroids on pulmonary function tests, patients were divided into case and control group. Patients in case group were given prednisolone 30 mg orally for two week (tapering dose). Patients in control group were given placebo for the same duration of two weeks. Steroid response was defined as 15% improvement in baseline forced expiratory volume (FEV).Results: Steroid response was defined as 15% increase in forced expiratory volume in one second/forced vital capacity (FEV1/FVC) after receiving tapering dose of prednisone 30 mg for 2 weeks, no patients in case group showed increase in FEV1/FVC of 15%. The change in pulmonary function tests was comparable in each group (p>0.5).Conclusions: The change in pulmonary function tests were comparable in each group (p>0.5). So, steroids in stable patients of COPD are best to be avoided.

scholarly journals Relaxation Effect of Extract Ethanol Curcuma Longa on Isolated Guine Pig Trachea

2021 ◽  
pp. 284-289
Author(s):  
Hidayati Yanita ◽  
Chrismis Novalinda Ginting ◽  
Linda Chiuman ◽  
Sahna Ferdinand
Keyword(s):  
Smooth Muscle ◽  
Curcuma Longa ◽  
Ethanol Extract ◽  
Relaxation Effect ◽  
Developed Countries ◽  
World Health ◽  
Control Group ◽  
Chronic Obstructive ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder

Aims: Asthma is a chronic obstructive pulmonary disease which is a world health problem that is not only infected in developed countries but also in developing countries. According to the National Asthma Education and Prevention Program (NAEPP), asthma can be defined as a chronic inflammatory disorder that occurs in the airways, which involves inflammatory cells. curcumin reduces allergic airway inflammation in mice through inhibition of a specific pathway aimed at investigating the anti-inflammatory effect of curcumin in acute allergic asthma and its underlying mechanisms in mice. Study Design: This study is experimental study. Methodology: The experimental animals were divided into 2 groups, each group consisting of 4 animals. Group 1 gave theophline as a positive control group and group 2 was given extracts with concentrations (1 mg / ml, 2 mg / ml, 3 mg / ml, 4 mg / ml, 5 mg / ml, 6 mg / ml, 7 mg / ml and 8 mg / ml). These animals are acclimatized for 1 (one) week with the aim of homogenizing their food and life with the same conditions so that they are considered eligible for research. Results: The ethanol extract of curcuma longa has no different ability from atropine sulfate 1 x 10-6 M in reducing the smooth muscle contraction of isolated guinea pig tracheal induced by acetylcholine, the strength of acetylcholine without incubation contraction compared to acetylcholine with EETH incubation showed statistically different results (p<0.05). Conclusion: The mechanism of the relaxing effect of curcuma longa on isolated mouse smooth muscle is mediated through inhibition of the PDE enzyme.

scholarly journals ANALYSIS OF RISK FACTORS OF CHRONIC KIDNEY DISEASE ON PATIENTS WITH HEMODIALYSIS IN TANGERANG DISTRICT HOSPITAL

2019 ◽  
Vol 10 (2) ◽  
pp. 112-125
Author(s):  
Arman Arman ◽  
Yusi Anggriani ◽  
Hesty Utami R
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Kidney Disease ◽  
District Hospital ◽  
World Health ◽  
Bivariate Analysis ◽  
Control Group ◽  
Case Group ◽  
Predisposing Factor

Chronic kidney disease (CKD) is a major world health challenge in the 21st centuries. The prevalence of CKD in Indonesia based on the doctor's diagnosis is 0.2% while for Tangerang prevalence at 0.1%. There are no clear data of the predisposing factor of CKD in Banten province, especially in Tangerang. The purpose of this study was to analyze the risk factors CKD on patients with hemodialysis in Tangerang District Hospital. This study is an observational analytic research with case-control and cross sectional approach conducted in August to September 2017 at the Tangerang District Hospital. with 70 respondents in case group and 70 respondents in control group. The result of the bivariate analysis showed that 15 of 19 risk factors significantly (p ≤ 0.05) increased the risk of CKD with OR range 2,043 to 4,235.  The result of multivariate analysis with logistic regression test showed that the most dominant risk factor for CKD was hypertension with OR 21,806 (95% C.I. 1,015- 486,554) and p = 0,049. There are 15 risk factors that could increase the risk of CKD. the most dominant risk factor for CKD was hypertension Keywords: Risk factors, chronic kidney disease, hemodialysis

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