scholarly journals Analysis of Hyperhomocysteinemia and Related Factors : A Case - Control Study in Northeast China

2021 ◽  
Author(s):  
Ding Ding ◽  
Ya Lin Zhang ◽  
Jing Xin Yang ◽  
Yu Fu ◽  
Ning Liu ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Uric Acid ◽  
Folic Acid ◽  
Dietary Habits ◽  
Mthfr C677t ◽  
The Body ◽  
Chi Square ◽  
Related Factors ◽  
Great Pressure ◽  
Control Study

Abstract Objectives. Hyperhomocysteinemia (HHcy) is an easily neglected disease, which can be hidden in the body for many years without signs or symptoms. We want to explore the causes of HHcy, the correlation of HHcy with micronutrients, lifestyle, dietary habits and HHcy related genes, preventing the occurrence of HHcy.Methods. 800 subjects (M/F, 403/397) were divided into normal Hcy and HHcy group according to the plasma levels of Hcy, compared essential characteristics by questionnaires, genetic polymorphism tested by Realtime PCR and micronutrients detected by mass spectrometry. The statistical analysis methods were Chi - square tests, ANOVA, logistic regression. This trial has been registered with the trial number ChiCTR1900025136. Results. 42.66% of 143 HHcy cases were aged from 10 to 18, with higher levels of zinc (Zn), vitamin A, Uric acid (P < 0.05) and a lower level of 25-OH-D3, VB12, folic acid (Fol) (P < 0.05) compared to the normal group. The multivariate logistic regression significantly predicted HHcy development containing higher level of Zinc (Exp(B) = 1.042; 95% CI, 1.000 - 1.086), higher Uric (Exp(B) = 1.014; 95% CI, 1.008 - 1.019), lower B12 (Exp(B) = 0.993; 95%CI, 0.989 - 0.997), lower Folic acid (Exp(B) = 0.772; 95% CI, 0.657 - 0.907), and polymorphism of MTHFR C677T (Exp(B) = 2.923; 95% CI, 1.399–6.107).Conclusion. Pay more attention to those students who were facing great pressure because they are very likely to be potential HHcy patients with high levels of uric acid and zinc and anxiety.

scholarly journals 745 Risk Factors of Incident Renal Stones in Indian Population: A Hospital-Based Case-Control Study

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
S Singh ◽  
S Gupta ◽  
T S Mishra ◽  
B D Banerjee ◽  
T Sharma ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heavy Metals ◽  
Case Control Study ◽  
Dietary Habits ◽  
Renal Stones ◽  
Tertiary Hospital ◽  
Case Control ◽  
The Body ◽  
Increased Risk ◽  
Control Study

Abstract Introduction Nephrolithiasis is pathological calcification in the excretory passages of the body and is prevalent among 7.6% of Indians. We aimed to study the various risk factors associated with renal stones from India. Method It was a hospital-based case-control study conducted over 18 months in a tertiary hospital in Delhi. Cases were defined as patients with renal stones diagnosed on the basis of history and radiological examination. Controls were similar to cases in all respects except for the diagnosis and selected from the hospital. A total of 18 risk factors, including age, gender, heavy metals, stress, metabolic factors, alcohol intake, dietary habits, co-morbidities, etc. were assessed. Logistic regression analysis was performed to calculate the strength of the risk associations. Results In the analysis of 60 cases and controls, we found 6 times, 5.5 times, and 2.4 times increased odds of renal stones in patients with increased arsenic, cadmium, and lead concentrations in blood, respectively. Similarly, there are 3 times increased odds of renal stones in patients suffering from stress. Conclusions Exposure to smoke, occupation dust, and contaminated water may lead to an increased ingestion/inhalation of heavy metals like cadmium, arsenic, and predisposing people to an increased risk of renal stones.

scholarly journals Prevalence and correlates of overweight and obesity among adolescents in northeastern China: a cross-sectional study

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e036820
Author(s):  
Ruixin Duan ◽  
Changgui Kou ◽  
Jing Jie ◽  
Wei Bai ◽  
Xiaoxin Lan ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Dietary Habits ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Northeastern China ◽  
Sectional Study ◽  
Multivariate Logistic Regression ◽  
Related Factors ◽  
Cross Sectional ◽  
Changchun City

ObjectivesTo estimate the prevalence of overweight/obesity among adolescents and evaluate the associated factors in this group in Changchun City in northeastern China.MethodsA cross-sectional study of 1955 adolescents aged 11–18 years was conducted in Changchun City using stratified cluster sampling. Parents and caregivers of children completed the questionnaires as requested without objection. The questionnaire included demographic characteristics and anthropometric parameters. Univariate and multivariate logistic regression analyses were performed to analyse the relationship between overweight/obesity and related factors.ResultsIn total, the prevalence of overweight was 12.7% (male 17.4%; female 10.1%) and of obesity was 4.9% (male 8.8%; female 3.1%) in Changchun, Jilin Province. The prevalence of overweight and obesity was higher in boys than in girls (p<0.001). Multivariate logistic regression showed that overweight and obesity were significantly associated with male sex (OR=1.91, 95% CI 1.48 to 2.47), eating fresh fruits more than 2 days per week (OR=1.41, 95% CI 1.09 to 1.84) and eating quickly (OR=1.37, 95% CI 1.06 to 1.78). Students who were not picky (OR=0.69, 95% CI 0.53 to 0.90) were less likely to be overweight, and adolescents whose father was overweight or obese (OR=0.67, 95% CI 0.52 to 0.86) or whose mother was overweight or obese (OR=0.72, 95% CI 0.52 to 0.99) were less likely to be overweight.ConclusionThe prevalence of overweight and obesity among adolescents in Changchun has been high in recent years, and the prevalence was higher among boys than among girls. Sex, dietary habits (weekly frequency of fruit consumption, picky eating and slowness in eating) and parental weight were important factors for overweight and obesity in adolescents. Further research should be conducted on the health of adolescents in China, and further intervention measures should be implemented to reduce the prevalence of overweight/obesity.

Effect of Genetic Polymorphisms Related to Folate and Homocysteine Metabolism In the Etiology of Recurrent Miscarriages

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 5136-5136
Author(s):  
Elvira Maria Guerra-Shinohara ◽  
Kelma Cordeiro da Silva Giusti ◽  
Nathalia Sierra Monteiro ◽  
Robson José Lazaro ◽  
Fernanda Midori Seino ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Folic Acid ◽  
Conflicts Of Interest ◽  
Conditional Logistic Regression ◽  
The Body ◽  
Methionine Synthase ◽  
Folic Acid Deficiency ◽  
Recurrent Miscarriages ◽  
History Of ◽  
Total Homocysteine

Abstract Abstract 5136 Introduction: Folic acid deficiency has been associated with obstetric complications such as preeclampsia, placental abruption and recurrent miscarriages (RM). Folic acid is a methyl group donating in various reactions. Low concentrations of 5,10-methylenetetrahydrofolate, the cofactor of enzyme thymidylate synthase, decrease the synthesis of thymidylate, which results in increased ratio deoxyuridylate monophosphate/deoxytimidylate monophosphate (dUMP/dTMP) and increased incorporation of deoxyuridylate triphosphate (dUTP) to DNA. The removal of dUTP by DNA-glycosylase can cause permanent damage to DNA, which may lead to apoptosis or increase the risk of developing cancer. Polymorphisms in genes of enzymes (MTHFR - methylene tetrahydrofolate reductase, MTR - methionine synthase and MTRR - methionine synthase reductase) and also in the gene of the reduced folate carrier (RFC1) were related to reduced folate and increased total homocysteine concentrations and have been associated as risk factors for RM. Material and Methods: 171 women with a history of three or more recurrent miscarriages and 95 healthy women with no history of abortion and having two or more normal babies were included. Weight and height of women were obtained and the body mass index (BMI) was calculated. The presence of antibodies (ANA and anti-DNA) was evaluated using immunofluorescence kits. The genotypes of the polymorphisms MTHFR c. 677C>T, MTR c. 2756A>G and RFC1 c.80G>A were obtained by PCR-RFLP, while genotyping for polymorphisms MTRR c. 66A>G and MTHFR c. 1298A>C was made by real time PCR. Multivariate logistic regression model (forward conditional) was used to obtain the odds ratio and its 95% confidence intervals of having MR (dependent variable). The independent variables were: quartiles of BMI, age range, positive ANA (titer of 1/40), positive anti-DNA (titre 1/10), genotypes for the MTHFR c. 677C>T, MTHFR c.1298A>C, MTR c. 2756A>G, MTRR c. 66A>G and RFC1 c. 80G>A. Results: No differences between the groups were observed for serum total homocysteine or allele frequencies for MTHFR c. 677C>T, MTHFR c. 1298A>C, MTR c. 2756A>G and RFC1 c.80G>A polymorphisms. In a conditional logistic regression analysis the risk of RM was significantly associated with BMI OR [95% CI] = 1.40 [1.02, 1.93] per quartile increase in BMI), positive anti-DNA OR [95% CI] = 7.24 [0.92, 57.25], positive ANA OR [95% CI] = 2.48 [1.21, 5.08], and AA genotype for MTRR c. 66A>G polymorphism (OR [95% CI] = 2.19 [1.16, 4.12]. Conclusion: The etiology of RM is multifactorial and it is associated with increasing of BMI, presence of autoantibodies and AA genotype for MTRR c. 66A>G polymorphism. Disclosures: No relevant conflicts of interest to declare.

Nonattendance of adult otolaryngology patients for scheduled appointments

2006 ◽  
Vol 121 (3) ◽  
pp. 258-261 ◽  
Author(s):  
A D Cohen ◽  
D M Kaplan ◽  
M Kraus ◽  
E Rubinshtein ◽  
D A Vardy
Keyword(s):  
Logistic Regression ◽  
Waiting Time ◽  
Female Gender ◽  
Categorical Variables ◽  
Multivariate Logistic Regression Model ◽  
Patient Scheduling ◽  
Continuous Variables ◽  
Chi Square ◽  
Related Factors ◽  
Chi Square Test

Background: Nonattendance for appointments is an impediment to otolaryngology patient care worldwide. In a previous study of children attending an otolaryngology clinic, we observed that attendance was determined by the waiting time for an appointment and the timing of the appointment within the day. However, the factors that affect nonattendance in adults have not been well studied.Objective: We aimed to investigate factors associated with nonattendance in adults visiting an otolaryngology clinic.Methods: Nonattendance was observed for a period of one year in adult patients visiting an ambulatory otolaryngology clinic. The following parameters were also noted: age, gender, treating physician, waiting time and timing of the appointment. The chi-square test was used to analyse differences between categorical variables. The t-test was used to analyse differences between continuous variables. Logistic regression was used for multivariate analyses.Results: The study assessed 8071 visits to the otolaryngology clinic. The overall proportion of nonattendance was 27.7 per cent. A multivariate logistic regression model demonstrated that nonattendance was significantly associated with the following factors: female gender, younger age, long waiting time for an appointment, timing of the appointment within the day and the treating physician.Conclusion: In adult otolaryngology patients, nonattendance was associated with patient-related factors and healthcare systems related factors alike. It is suggested that managed overbooking could be carefully introduced into otolaryngology patient scheduling.

scholarly journals Analysis of Environmental Factors with Chronic Diarrhea in Toddlers in Jambi City in 2019

2020 ◽  
Vol 2 (4) ◽  
pp. 300-310
Author(s):  
Eko Misriyanto ◽  
Rico J. Sitorus ◽  
Misnaniarti
Keyword(s):  
Logistic Regression ◽  
Diarrheal Disease ◽  
Chronic Diarrhea ◽  
Growth Failure ◽  
The Body ◽  
P Value ◽  
Multiple Logistic Regression ◽  
Chi Square ◽  
Confidence Degree ◽  
The Impact

Chronic diarrhea is defecation with a frequency of 3 or more times in infants and children lasting for 14 days. The impact of diarrheal disease in general causes loss of fluid in the body (dehydration) and chronic diarrhea can cause a child to experience poor nutritional status and experience growth failure. This study uses a case-control design using a retrospective approach. The number of samples in this study was 135 respondents. Instruments for collecting data in the form of questionnaires and observations. Data were analyzed by univariate, bivariate using the Chi-Square test, and multivariate analysis with multiple logistic regression. The statistical test results obtained p-value on the variables of clean water supply (0.007), latrine ownership (0.001), sewerage system (0.04), confidence degree 95% Confidence Interval (95% CI) and p-value ˂ 0, 05, it can be concluded that there is a significant relationship with chronic diarrheal disease in infants. The results of multiple logistic regression tests, on the variable wastewater discharge obtained OR = 3.801, meaning that sewerage is closely related to causing chronic diarrheal disease in infants.

scholarly journals Faktor ibu, pola asuh anak, dan MPASI terhadap kejadian stunting di kabupaten Gorontalo

2019 ◽  
Vol 3 (2) ◽  
pp. 74-81
Author(s):  
Siti Surya Indah Nurdin ◽  
Dwi Nur Octaviani Katili ◽  
Zul Fikar Ahmad
Keyword(s):  
Logistic Regression ◽  
Random Sampling ◽  
Case Control Study ◽  
Case Control ◽  
Chi Square ◽  
Purposive Sampling ◽  
Control Study

Latar belakang: Stunting merupakan retardasi pertumbuhan linier kurang dari standar menurut usianya. Masalah stunting masih merupakan salah satu masalah terbesar di Kabupaten Gorontalo. Tujuan penelitian: Diketahuinya pengaruh faktor ibu, pola asuh, dan variasi MPASI terhadap kejadian stunting di Kabupaten Gorontalo. Metode: Desain penelitian menggunakan Case Control Study. Seluruh balita di Kabupaten Gorontalo menjadi Populasi studi. Sampel kasus merupakan balita yang menderita stunting, dan sampel kontrol adalah balita normal. Jumlah sampel sebanyak 118 balita. Sampel kasus dipilih dengan menggunakan purposive sampling dan sampel kontrol dipilih menggunakan random sampling. Data dianalisis dengan menggunakan uji Chi Square dan Logistic Regression. Hasil: pola asuh (OR = 3,901, 95% CI 1,692 – 8,994), variasi MPASI (OR = 3,260, 95% CI 1,371 – 7,750), riwayat KEK (OR = 2,482, 95% CI 1,013 – 6,081) dan pendidikan ibu (OR = 2,345, 95% CI 1,007 – 5,456). Umur ibu, pemberianASI Ekslusif, makanan pendamping ASI (MPASI), konsumsi snak hampir tiap hari, dan konsumsi mie instan 3 kali dalam seminggu bukan merupakan faktor risiko kejadian stunting. Simpulan: Faktor ibu yaitu pendidikan ibu, riwayat KEK, pola pemberian MPASI, dan pola asuh merupakan faktor risiko kejadian stunting.

scholarly journals Syphilis Infection During Pregnancy will Increases the Risk of Hypertensive Disorders of Pregnancy- Results from A Case-Control Study in China

2021 ◽  
Author(s):  
Xiangyi Zhang ◽  
Huixin Yang ◽  
Lixin Sun ◽  
Jing Hu ◽  
Mujinyan Li ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Total Cholesterol ◽  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Related Factors ◽  
Syphilis Infection ◽  
Maternal Anemia ◽  
Hypertensive Disorders ◽  
Control Study

Abstract BackgroundThe incidence of pregnancy syphilis remains at a high level in China. Studies investigating the influencing factors of pregnancy syphilis are mainly concentrated in economically developed areas. Limited studies were conducted in northern China. This study mainly aimed to explore the related factors of pregnancy syphilis and examine the association with the risk of Hypertensive disorders of pregnancy.MethodsThis case-control study compared pregnancy syphilis cases, matched (1:1) to non-syphilitic pregnant women controls by age, which was diagnosed in Changchun between January 2014 and December 2018. Multivariable logistic regression was used to identify potential correlates of HDP in syphilis populations. Then a propensity score-matched method was conducted to match pregnancy syphilis with and without HDP, and further we explore the related factors of HDP in syphilis by multivariable logistic regression.ResultsIn our study, the median age of syphilis in the case group was 28 years (range 16-53 years). A high rate of syphilis-HDP co-infection（49/349, 12.3%）was observed in syphilis patients and further research revealed an association between syphilis and HDP. Multivariate analysis indicated HDP in syphilis was independently associated with Dysmenorrhea [adjusted odds ratio (a OR) 5.413, 95% confidence interval (CI) 2.410-12.158], Maternal anemia (a OR 3.808, 95% CI 1.833-7.911), Total cholesterol (a OR 3.144, 95% CI 1.485-6.655).ConclusionSyphilis infection in pregnancy associate with the increased risk of hypertensive disorders of pregnancy, attention should also be paid to the occurrence of HDP in the lower age group, to further prevent the occurrence of stroke, cardiovascular disease. Besides, Dysmenorrhea, Maternal anemia, Total cholesterol may be risk factors for HDP in syphilis.

scholarly journals Faktor-Faktor yang Berhubungan dengan Pernikahan Dini pada Wanita

2017 ◽  
Vol 5 (1) ◽  
pp. 68
Author(s):  
Kanella Ayu Wulanuari ◽  
Anggi Napida Anggraini ◽  
Suparman Suparman
Keyword(s):  
Logistic Regression ◽  
Case Control Study ◽  
Sampling Technique ◽  
Married Women ◽  
Early Marriage ◽  
Dominant Factor ◽  
Exclusion Criteria ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

<em>A study by UNICEF in Indonesia find that the number of early marriage for 15 years old is 11% and 18 years is 35%. Generally, early marriage is more common in women than men, it’s approximately 5% of boys get married before they are 19 years old. The purpose of this study was to determine factors relating to early marriage in women and the most significant factor relating to early marriage. The study used observational quantitative study with case-control study design. The population of the study was 132 married women, samples were selected by using total sampling technique with the inclusion and exclusion criteria. The respondents of this study were 53 women. Data were analysis by chi square test and logistic regression. The results of chi-square test showed variables that had relationship with early marriage were respondents' education (p=0.035), respondents’ income (p=0.000), and sexual pre marriage (p=0.006) whereas variables that did not have relationship with early marriage are father's education (p=0.436), mother’s education (p=0.290), parents’ income (p=0.356) and respondents’ religiosity (p=0.489). The result of logistic regression analysis showed that respondents’ income was the most dominant factor affecting early marriage in women. Conclusion the most significant factor related to early marriage was respondents’ income.</em>

scholarly journals Faktor Risiko Kejadian Diabetes Melitus Tipe Dua di RS Bhayangkara Kota Kupang

2019 ◽  
Vol 1 (1) ◽  
pp. 11-20
Author(s):  
Renata Aryndra Sukma Kabosu ◽  
Apris A. Adu ◽  
Indriati Andolita Tedju Hinga
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Control Sample ◽  
Consumption Pattern ◽  
Chi Square ◽  
Related Factors ◽  
Type 2 Dm ◽  
Control Study ◽  
Diabetes Melitus

Diabetes mellitus is a disease that causes public health problems because it is one of the causes of deaththroughout the world. This study aimed to analyze the risk factors for type 2 diabetes mellitus. The type ofresearch used is a case control study, with a retrospective approach. The location of this study is in BhayangkaraHospital on Kupang city. The sample in this study was divided into two groups, namely a case sample as muchas 37 people and a control sample as much as 37 people. Research instruments use questionnaires and medicalrecords. The data obtained were analyzed using chi square statistical test. From the results of the study it wasfound that the related factors were: age (p=0,018, OR=3,544; CI= 95%), obesity (p=0.015; OR=3.826;CI=95%), hypertension (p=0.019; OR=3,423; CI=95%), consumption pattern (p=0,017; OR=3,660; CI=95%),stress (p=0,036 OR=3,033; CI=95%). It is expected the hospital provides information through counseling orleaflets about risk and danger factors of Type 2 DM to the community and for community to be able to increaseawareness for risk factors of the Type 2 DM by diligently checking for self-detection so the treatment can bedone as early as possible.

scholarly journals A focus on homocysteine in autism.

2013 ◽  
Vol 60 (2) ◽  
Author(s):  
Joanna Kałużna-Czaplińska ◽  
Ewa Żurawicz ◽  
Monika Michalska ◽  
Jacek Rynkowski
Keyword(s):  
Human Physiology ◽  
Folic Acid ◽  
Dietary Habits ◽  
Biological Fluids ◽  
Body Fluids ◽  
The Body ◽  
Autistic Children ◽  
Pathological Conditions ◽  
Wide Range

Homocysteine is an amino acid, which plays several important roles in human physiology. A wide range of disorders, including neuropsychiatric disorders and autism, are associated with increased homocysteine levels in biological fluids. Various B vitamins: B6 (pyridoxine), B12 (cobalamin), and B9 (folic acid) are required as co-factors by the enzymes involved in homocysteine metabolism. Therefore, monitoring of homocysteine levels in body fluids of autistic children can provide information on genetic and physiological diseases, improper lifestyle (including dietary habits), as well as a variety of pathological conditions. This review presents information on homocysteine metabolism, determination of homocysteine in biological fluids, and shows abnormalities in the levels of homocysteine in the body fluids of autistic children.

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