Isolation and Detection of Proteins with Nano-Particles and Microchips for Analyzing Proteomes on a Large Scale Basis

2011 ◽  
Vol 18 (4) ◽  
pp. 423-433 ◽  
Author(s):  
Ki Chan ◽  
Tzi Bun Ng
Keyword(s):  
Large Scale ◽  
Nano Particles

scholarly journals Silver Nanoparticles: Properties, Synthesis, Characterization, Applications and Future Trends

2021 ◽  
Author(s):  
Sunil T. Galatage ◽  
Aditya S. Hebalkar ◽  
Shradhey V. Dhobale ◽  
Omkar R. Mali ◽  
Pranav S. Kumbhar ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Metallic Nanoparticles ◽  
Large Scale ◽  
Cost Effective ◽  
Nano Particles ◽  
Scale Production ◽  
Green Technologies ◽  
Synthesis Of Nanoparticles ◽  
Vital Importance ◽  
Environmentally Safe

Nanotechnology is an expanding area of research where we use to deal with the materials in Nano-dimension. The conventional procedures for synthesizing metal nanoparticles need to sophisticated and costly instruments or high-priced chemicals. Moreover, the techniques may not be environmentally safe. Therefore “green” technologies for synthesis of nanoparticles are always preferred which is simple, convenient, eco-friendly and cost effective. Green synthesis of nanoparticle is a novel way to synthesis nanoparticles by using biological sources. It is gaining attention due to its cost effective, ecofriendly and large scale production possibilities. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical applications. It has vital importance in nanoscience and naomedicines to treat and prevent vital disease in human beings especially in cancer treatment. In current work we discussed different methods for synthesis of AgNPs like biological, chemical and physical along with its characterization. We have also discussed vital importance of AgNPs to cure life threatnign diseases like cancer along with antidiabetic, antifungal, antiviral and antimicrobial alog with its molecular mode of action etc. Finally we conclude by discussing future prospects and possible applications of silver nano particles.

Direct large-scale synthesis of perovskite barium strontium titanate nano-particles from solutions

2005 ◽  
Vol 178 (1) ◽  
pp. 279-284 ◽  
Author(s):  
Jian Quan Qi ◽  
Yu Wang ◽  
Wan Ping Chen ◽  
Long Tu Li ◽  
Helen Lai Wah Chan
Keyword(s):  
Strontium Titanate ◽  
Barium Strontium Titanate ◽  
Large Scale ◽  
Nano Particles ◽  
Barium Strontium ◽  
Large Scale Synthesis

Ultrasonic Milling and Dispersing Technology for Nano-Particles

2012 ◽  
Vol 1479 ◽  
pp. 21-26 ◽  
Author(s):  
Kathrin Hielscher
Keyword(s):  
Particle Size ◽  
Large Scale ◽  
Size Reduction ◽  
Nano Particles ◽  
Industrial Scale ◽  
Wet Milling ◽  
Particle Size Reduction ◽  
Ultrasonic Milling ◽  
Ultrasonic Parameters

ABSTRACTUltrasonically generated forces are well known for dispersing and deagglomeration of small volumes in laboratory and bench-top scale. By the evaluation and optimization of the most important ultrasonic parameters and the development of large scale ultrasonic machinery, ultrasound forces can be applied also for particle size reduction and wet-milling of nano-particles in industrial scale.

scholarly journals Large-Scale Fabrication of Nanostructure on Bio-Metallic Substrate for Surface Enhanced Raman and Fluorescence Scattering

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 916 ◽  
Author(s):  
Lu ◽  
Zhang ◽  
Jiao ◽  
Guan
Keyword(s):  
Large Scale ◽  
Hierarchical Structures ◽  
Metallic Substrate ◽  
Nano Particles ◽  
Fluorescence Signal ◽  
Dual Mode ◽  
Surface Enhanced Fluorescence ◽  
Relative Standard ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

The integration of surface-enhanced Raman scattering (SERS) and surface-enhanced fluorescence (SEF) has attracted increasing interest and is highly probable to improve the sensitivity and reproducibility of spectroscopic investigations in biomedical fields. In this work, dual-mode SERS and SEF hierarchical structures have been developed on a single bio-metallic substrate. The hierarchical structure was composed of micro-grooves, nano-particles, and nano-ripples. The crystal violet was selected as reporter molecule and both the intensity of Raman and fluorescence signals were enhanced because of the dual-mode SERS−SEF phenomena with enhancement factors (EFs) of 7.85 × 105 and 14.32, respectively. The Raman and fluorescence signals also exhibited good uniformity with the relative standard deviation value of 2.46% and 5.15%, respectively. Moreover, the substrate exhibited high sensitivity with the limits of detection (LOD) as low as 1 × 10−11 mol/L using Raman spectroscopy and 1 × 10−10 mol/L by fluorescence spectroscopy. The combined effect of surface plasmon resonance and “hot spots” induced by the hierarchical laser induced periodical surface structures (LIPSS) was mainly contributed to the enhancement of Raman and fluorescence signal. We propose that the integration of SERS and SEF in a single bio-metallic substrate is promising to improve the sensitivity and reproducibility of detection in biomedical investigations.

Antibacterial properties of biosynthesized silver nano particles

2020 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
Krishna Reddy BV ◽  
Avinash Kumar G ◽  
Nageswara Rao G
Keyword(s):  
Staphylococcus Aureus ◽  
Silver Nanoparticles ◽  
Large Scale ◽  
Leaf Extract ◽  
Antibacterial Agents ◽  
Uv Spectroscopy ◽  
Antibacterial Properties ◽  
Nano Particles ◽  
Lannea Coromandelica ◽  
Cost Efficacy

Nanoparticles have their demand in various fields of science and technology and their applications extend even in medical and pharmaceutical arena. They have been used as preservatives, diagnosing aids and potent antibacterial agents. But their production is a serious matter of concern when it comes to cost, efficacy and toxicity issues. Overcoming these limitations green synthesis has taken its advantage for their commercial and large scale synthesis. This research will focus on the preparation of nano particles of silver with the help of purified leaf extract from Lannea coromandelica and evaluation of the same using UV-Vis Spectrophotometry. The nanoparticles exhibited surface plasmon resonance at 420nm in UV spectroscopy. Futhermore, nanoparticles have been evaluated for their antibacterial activity on Putida vulgaris, Staphylococcus aureus, and Bacillus subtillis. The results proved the eco friendly synthesized silver nanoparticles have a good antibacterial and can be used effectively in therapies targeting infections and infectious wounds.

Classification, synthesis, characterization and biomedical application of nanoparticle: Detailed review

2020 ◽  
Vol 11 (4) ◽  
pp. 7980-7984
Author(s):  
Ranganathan K ◽  
Muruganantham V
Keyword(s):  
Large Scale ◽  
Biomedical Application ◽  
Maximum Growth ◽  
Drug Carriers ◽  
The Body ◽  
Nano Particles ◽  
Scale Production ◽  
Nano Technology ◽  
Nano Science ◽  
Nano Medicine

The branches of science like Nano medicine, Nano technology, Nano chemistry and Nano science are a few of those departments that have the word 'nano' in their name and were frequently published in books and journals and became familiar to the public and the research professionals too. It was an emerging science in the 20th century and is the trend currently. It is not a single isolated technique or method that is applicable in one field, but it is multi-dimensional and is applied in various fields considering the advantages. Its arena ranges from the synthesis, designs, large scale production and potential application of nano-sized materials. They are the systems of a matrix of drug carriers that are uniformly dispersed in the polymeric membranes. This review concentrates on the methods of preparation of nano particles, evaluation methods, advantages and applications of nano particles in medicine. Nanotechnology mostly provides better drug delivery in order to transfer into the smaller parts of the body. This is mostly implemented to enter the ultrathin areas in the body. So, the drugs such as genetic medicine can easily permeated into the cell walls to produce maximum growth within a few more years. The doctors are paid by the patients. The patients who are receiving this therapy shows better bioavailability, decreased drug toxicity, lesser cost of treatment, and extend the life of proprietary drugs.

Advantages and Limitations of Using Nano Sized Powders for Powder Injection Molding Process: A Review

2012 ◽  
Vol 59 (2) ◽  
Author(s):  
Javad Rajabi ◽  
Norhamidi Muhamad ◽  
Abu Bakar Sulong ◽  
Abdolali Fayyaz ◽  
Azizah Wahi
Keyword(s):  
Injection Molding ◽  
Large Scale ◽  
Sintering Temperature ◽  
High Surface ◽  
Volume Ratio ◽  
Powder Injection Molding ◽  
Nano Particles ◽  
Powder Injection ◽  
Injection Molding Process ◽  
Molding Process

Powder injection molding (PIM) is among the most known forming techniques that use material powders. This technique has been widely evaluated for the production of large scale and small components using metal and ceramic powders. Nano particles have larger surface-to-volume ratio compared with large-sized particles, thus they display high surface area. Some merits in the application of nano-sized particles in the PIM process includes increasing its comparative density at a low sintering temperature, decreasing sintering temperature, decreasing grain size of sintered bodies, increasing hardness value, and improving surface properties. However, it also has several disadvantages, which include increasing the viscosity behaviour of feedstock, oxidation, and agglomeration. This article reviews current studies on the effects of nano-sized particles on the PIM process and finding solutions to address its disadvantages.

Evaluation of Cytotoxic Effect of Silver Nanoparticles (AgNP) Synthesized from Phlebodium aureum (L.) J. Smith Extracts

2020 ◽  
Vol 21 ◽  
Author(s):  
Johnson Marimuthu ◽  
Shibila Thangaiah ◽  
Amutha Santhanam ◽  
Vidyarani George
Keyword(s):  
Silver Nanoparticles ◽  
Green Synthesis ◽  
Large Scale ◽  
Color Change ◽  
Nanoparticle Synthesis ◽  
Xrd Analysis ◽  
Nano Particles ◽  
Synthesis Methods ◽  
Aqueous Extracts ◽  
Ft Ir

Background:: Chemical synthesis methods are adverse in the medicinal field as they produce toxic in the surface whereas green synthesis provide advancement as well as they are cost effective, environment friendly, can be easily scaled up for large scale synthesis. Silver and silver nanoparticles have an important application in the medical industry such as tropical ointments which are used to prevent infection against burn and open wounds. There is no report on the green synthesis from Phlebodium aureum (L.) J. Smith. Objective:: The present study was aimed to synthesize silver nano-particles using Phlebodium aureum (L.) J. Smith extracts by green approach and to screen their cytotoxicity. Methods:: The synthesized AgNPs of P. aureum were characterized by FT-IR, SEM and XRD. The cytotoxicity of the aqueous extracts and AgNPs of P. aureum were determined. Results:: The silver nanoparticle synthesis was confirmed by color change from yellow to dark brown and absorption peak at 460 nm. FT-IR analysis confirmed the capping by proteins and other metabolites. XRD analysis confirmed the existence of silver nanaoparticles with a peak at 46.253°. The dose dependent cytotoxicity was observed in the aqueous and silver nanoparticles of P.aureum. Conclusion:: The present study gave a simple and cheap route to synthesize the AgNPs using aqueous extracts of P. aureum. The studied extracts of P. aureum can be considered as a promising candidate for a plant-derived anti-tumour compound.

One-Pot Synthesis of LiFePO4 Nano-Particles Dispersed in N-Containing Melamine-Formaldehyde Carbon Matrix as the Cathode Materials for Large Scale Lithium Ion Batteries

2018 ◽  
Vol 775 ◽  
pp. 342-349
Author(s):  
Supacharee Roddecha ◽  
Kantawich Jittmonkong ◽  
Malinee Sriariyana
Keyword(s):  
Ionic Conductivity ◽  
Surface Area ◽  
Large Scale ◽  
Carbon Matrix ◽  
Nano Particles ◽  
Pluronic F127 ◽  
Molar Ratio ◽  
Melamine Formaldehyde ◽  
One Pot ◽  
One Pot Synthesis

LiFePO4 is considered as the promising cathode material for a large-scale Li batteries used in electrical vehicles (EVs). However, a practical use of LiFePO4 cathode is limited by its low ionic conductivity, resulting in low battery’s power performance. This work, a facile and practical method to promote ionic conductivity and capacity of LiFePO4 was developed by dispersing LiFePO4 nanoparticles into a porous nitrogen-riched carbon matrix by employing one-pot synthesis approach. The N-containing carbon porous matrix was prepared by utilizing melamine-formaldehyde (MF) resin as the N-containing carbon precursor and Pluronic F127 as the porous template. The pseudo capacitive effect attributed from lone-pair electrons into melamine functional group was expected to support Li ion transport. After carbonization at 600 °C, uniform LiFePO4 nanocomposite clusters with an average size of about 50-300 nm were obtained. The influence of the molar ratio between pluronic F127 and melamine-formaldehyde (i.e. F127:MF molar ratio as 0:1, 0.03:1, 0.3:1) on the LiFePO4 nanocomposite’s morphology and crystalline structure was investigated by using scanning electron microscope and X-ray diffraction technique. The results show that increasing F127 concentrations support more porous structure formation, leading to a higher surface area but does not affect the LiFePO4 nanocrystalline structure. According to the highest surface area, the N-doped carbon coated LiFePO4 composite product obtained from the molar ratio of F127:MF as 0.3:1 exhibited highest discharging specific capacity of 158.1 mAh g-1, at a rate of 0.1 C and also shows high cycle stability.

The Fracture and Fatigue Behaviour of Nano-Modified SAN

2010 ◽  
Vol 118-120 ◽  
pp. 43-48 ◽  
Author(s):  
Kou Cheng Zuo ◽  
Bamber Blackman ◽  
J. Gordon Williams ◽  
Helmut Steininger
Keyword(s):  
Fracture Energy ◽  
Large Scale ◽  
Volume Fraction ◽  
Process Zone ◽  
Fatigue Behaviour ◽  
Nano Particles ◽  
Fatigue Properties ◽  
Marginal Effect ◽  
Force Microscopy ◽  
The Matrix

An amorphous styrene-acrylonitrile (SAN) copolymer has been modified by various concentrations of metal oxide (MeO) nano-particles up to 0.50 vol.%. Atomic force microscopy of the modified thermoplastics showed that the nano-particles were well dispersed in the matrix. The incorporation of the nano-particles had a marginal effect on the glass transition temperature and yield stress. However, the Young’s modulus increased with the volume fraction of the nano-particles. The fracture and fatigue properties also had a marked increase with the addition of the nano-particles. The fracture energy was increased from 316±10 J/m2 to 445±27 J/m2, and the maximum fracture energy threshold was increased from 17±1 J/m2 to 34±2 J/m2 at 23 °C. Scanning electron microscopy (SEM) studies showed that debonding of nano-partilces, subesequent plastic void growth and large scale fibril deformation initiated by mulitiple crazing were observed in the process zone of the nano-modified composites.

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