Features, Pharmacological chemistry, molecular mechanism and health benefits of Lemon

2020 ◽  
Vol 16 ◽  
Author(s):  
Nitika Singh ◽  
Nagesndra Sastry Yarla ◽  
Nikhat Jamal Siddiqi ◽  
Maria de Lourdes Pereira ◽  
Bechan Sharma
Keyword(s):  
Present Article ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Antioxidant Properties ◽  
Health Benefits ◽  
Citrus Limon ◽  
Scale Production ◽  
Citrus Fruits ◽  
Medicinal Uses

Background: Citrus limon, a Mediterranean-grown citrus species of plants belonging to the Rutaceae family, occupies a place of an impressive range of food and medicinal uses with considerable value in the economy of the fruit of the country. Citrus fruits are economically important with a large-scale production of both the fresh fruits and industrially processed products. The extracts and phytochemicals obtained from all parts of C. limon have shown immense therapeutic potential because of their anticancer, anti-tumor and anti-inflammatory nature and also serve as an important ingredient in the formulation of several ethnic herbal medicines. These properties are mediated by the presence of different phytochemicals, vitamins and nutrients in the citrus fruits. Material and Methods: The methods involve in preparation of the present article included the collection of information from various scientific databases, indexed periodicals, and search engines such as Medline Scopus google scholar PubMed, PubMed central web of science, and science direct etc. Results: This communication presents an updated account of different pharmacological aspects of C. limon associated with its anti-oxidative, antiulcer, antihelmintic, insecticidal, anticancer, cytotoxic, and estrogenic activities. In addition, C. limon extracts possess hepatoprotective, anti-hyperglycemic, and antimicrobial properties. The present article includes the structure and function of different key chemical constituents from different parts of C. limon. Also, the possible molecular mechanisms of actions of bioactive compounds from C. limon are displayed. Conclusion: The traditional and ethno-medicinal literature revealed that C. limon is very effective in different pathologies. Most of these compounds possessing antioxidant properties would be implicated in offering health benefits by acting as potential nutraceuticals to humans with special reference to disease management of health and disease.

Phytochemical, Pharmacological Activities and Ayurvedic Significances of Magical Plant Mimosa pudica Linn

2020 ◽  
Vol 17 ◽  
Author(s):  
Vijay Kumar
Keyword(s):  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Chemical Constituents ◽  
Future Research ◽  
Mimosa Pudica ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Traditional Medicines ◽  
Crude Extracts ◽  
Anti Cancer

: Mimosa pudica Linn is an integrated part of Traditional Medicines Systems of India, China, Africa, Korea and America. It has been used from centuries in traditional medicines to cure different diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, and dyspepsia. It is an important ingredient of wide class of herbal formulations. To assess the scientific evidence for therapeutic potential of Mimosa pudica Linn and to identify the gaps for future research. The available information on the ethno-medicinal uses, phytochemistry, pharmacology and toxicology of Mimosa pudica Linn was collected via a library and electronic searches in Sci-Finder, Pub-Med, Science Direct, Google Scholar for the period, 1990 to 2020. In traditional medicinal systems, variety of ethno-medicinal applications of Mimosa pudica Linn has been noticed. Phytochemical investigation has resulted in identification of 40 well known chemical constituents, among which alkaloids, phenols and flavionoids are the predominant groups. The crude extracts and isolates have exhibited a wide spectrum of in vitro and in vivo pharmacological activities including anti-cancer, anti-inflammation, osteoporosis, neurological disorders, hypertension etc.. To quantify the Mimosa pudica Linn and its formulations, analytical techniques like HPLC and HPTLC has shown dominancy with good range of recovery and detection limit. Mimosa pudica Linn is the well-known herb since an ancient time. The pharmacological results supported some of the applications of Mimosa pudica Linn in traditional medicine systems. Perhaps, the predominance of alkaloids, phenols and flavionoids are responsible for the pharmacological activities the crude extracts and isolates of Mimosa pudica Linn. Further, there is need to isolate and evaluate the active chemical constituents of Mimosa pudica Linn having significant medicinal values. In future, it is important to study the exact mechanism associated with the phytochemicals of Mimosa pudica Linn especially on anti-cancer activities. Notably, toxicity studies on Mimosa pudica Linn are limited which are to be explored in future for the safe application of Mimosa pudica Linn and its formulations.

scholarly journals Biochemical Characteristics and Antioxidant Properties of Citrus Juice from Lemon (Citrus limon), Lime (Citrus aurantifolia) and Grapefruit (Citrus paradisi) as Influenced by Degree of Ripening

2021 ◽  
pp. 40-51
Author(s):  
Olusegun O. Ogundele ◽  
Mathew K. Bolade
Keyword(s):  
Free Radical ◽  
Antioxidant Properties ◽  
Antioxidant Potential ◽  
Total Phenolic ◽  
Citrus Limon ◽  
Citrus Fruits ◽  
Biochemical Characteristics ◽  
Ph Values ◽  
Juice Yield ◽  
Citrus Juices

The influence of degree of ripening (unripe, half-ripe and ripe) of citrus fruits (lemon, lime and grapefruit) on the biochemical characteristics and antioxidant potential of their juices was investigated. The juice yield from the citrus fruits was affected by the level of ripening as the highest juice yield was obtained when the fruits were at ripe stage giving 25.2 mL/100 g (lemon), 43.3 mL/100 g (lime), and 21.1 mL/100 g (grapefruit). The biochemical characteristics of the citrus juices revealed that the pH values were generally increasing with an increasing level of ripening particularly for lime and grapefruit while the pH of lemon juice was decreasing with an increase in the degree of ripening. The lowest pH values exhibited by the citrus fruits were 2.87 (ripe lemon), 2.16 (unripe lime), and 3.27 (unripe grapefruits). The total acidity of the citrus juices essentially exhibited an inverse relationship with their corresponding pH values. The highest ascorbic acid contents of the juices were 51.3 g/100mL (unripe lemon), 38.9 g/100mL (unripe lime), and 44.7 g/100mL (unripe grapefruit) while the highest total phenolic contents were 722 µg GAE/mL (unripe lemon), 207 µg GAE/mL (unripe lime), and 646 µg GAE/mL (unripe grapefruit); indicating a significant impact of degree of ripening on the parameters. The antioxidant activity of the citrus juices using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical assay revealed a significant influence of degree of ripening and juice volume on the activity. The percent inhibition of DPPH free radical by the juices was generally higher at an unripe stage of fruit maturity as well at greater juice volume. The ferric-reducing antioxidant potential (FRAP) of the citrus juices was also influenced by the level of ripening of the fruit. The FRAP values were generally higher at unripe stage which were 3.72 µ mol Fe(II)/g (unripe lemon), 4.98 µ mol Fe(II)/g (unripe lime) and 9.53 µmolFe(II)/g (unripe grapefruit).

Antioxidant Activity of Selected Chemical Constituents of Quinchamaliumchilensis

2015 ◽  
Vol 8 (1) ◽  
pp. 2775-2778
Author(s):  
Orlando Muñoz ◽  
Rita Aquino ◽  
Teresa Mencherin ◽  
Patrizia Picern ◽  
Philippe Christen ◽  
...  
Keyword(s):  
Total Phenolic Content ◽  
Phenolic Content ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Antioxidant Properties ◽  
2D Nmr ◽  
Uv Spectra ◽  
Total Phenolic ◽  
Antioxidant Compounds ◽  
Isolation And Identification

Antioxidant compounds from plant sources have been used worldwide for a variety of indications.  In this study, phytochemical investigation of the aerial parts of QuinchamaliumchilensisMol. (Santalaceae) resulted in the isolation and identification of fourflavonol glycolsides, quercetin-3-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamnopyra-nosyl-(1→6)]-β-D glucopyranoside(1), kaempferol-3-O-β-D-glucopyranosyl-(1→2)-[α-L-rhamn opyranosyl-(1→6)]-β-D-glucopyranoside(2),quercetin-3-O-xylosyl-(1→2)-[α-L-rha-mnopyranosyl-(1→6)]-β-D-glucopyranoside(3) and rutin(4), as well as one flavanone glycoside, pinocembroside(5). The compounds were identified by 1D- and 2D-NMR experiments, mass spectrometry and UV spectra by comparison with those reported in literature. These compounds were isolated for the first time from the leaves of Q. chilensis. The antioxidant properties of the extract were investigated using DPPH and ferric reducing antioxidant potential (FRAP) assays. Total phenolic content was determined by the Folin-Ciocalteau method. Significant relationship between antioxidant capacity and total phenolic content was found, indicating that phenolic compounds are the major contributors to the antioxidant properties of this plant. These active molecules have therapeutic potential in treating conditions associated with oxygen free radicals.   

scholarly journals Emodin inhibits zinc-induced neurotoxicity in neuroblastoma SH-SY5Y cells

2019 ◽  
Vol 39 (5) ◽  
Author(s):  
Wenzhou Liu ◽  
Zhen Fan ◽  
Feng Gao ◽  
Li Ou ◽  
Min Li ◽  
...  
Keyword(s):  
Cell Viability ◽  
Cell Apoptosis ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Antioxidant Properties ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma ◽  
Beneficial Effects ◽  
Lactate Dehydrogenase Release ◽  
Pathway Activation

Abstract Emodin is a natural anthraquinone derivative with numerous beneficial effects, including antioxidant properties, anti-tumor activities, and protecting the nerves. Zinc-induced neurotoxicity plays a crucial role in the pathogenesis of vascular dementia (VD) and Parkinson’s disease (PD). Here, the protective activity of emodin inhibiting zinc-induced neurotoxicity and its molecular mechanisms such as cellular Zn2+ influx and zinc-induced gene expression were examined using human neuroblastoma cells (SH-SY5Y cells). Our findings showed that emodin obviously enhanced cell viability and reduced cell apoptosis and lactate dehydrogenase release. Bedsides, we detected a decrease of intracellular Zn2+ concentration after SH-SY5Y cells were pretreated with emodin. Simultaneously, the expression of zinc transporter-1, metallothionein-1, and metallothionein-2 were weakened in emodin-pretreated SH-SY5Y cells. In addition, emodin prevented the depletion of NAD+ and ATP induced by zinc. Emodin also reduced intracellular reactive oxygen species and endoplasmic reticulum-stress levels. Strikingly, emodin elevated SH-SY5Y cell viability and inhibited cell apoptosis caused by AMP-activated protein kinase signaling pathway activation. Thus, emodin could protect against neurotoxicity induced by Zn2+ in neuroblastoma SH-SY5Y cells. It is expected to have future therapeutic potential for VD or PD and other neurodegenerative diseases.

Molecular Mechanisms and Therapeutic Potential of miR-493 in Cancer

2019 ◽  
Vol 29 (6) ◽  
pp. 521-528
Author(s):  
Lingli Huang ◽  
Lingwei Huang ◽  
Ziwei Li ◽  
Qing Wei
Keyword(s):  
Molecular Mechanisms ◽  
Therapeutic Potential

Primordial science and pioneering approaches of guggul for chronic ailments – A modernized review

2020 ◽  
Vol 7 (2) ◽  
pp. 14-20
Author(s):  
Jamal Basha D ◽  
Kumar P R ◽  
Ranganayakulu D
Keyword(s):  
Water Solubility ◽  
Therapeutic Potential ◽  
Chemical Constituents ◽  
Signs And Symptoms ◽  
Dosage Forms ◽  
The Novel ◽  
Lipids Metabolism ◽  
Clinical Conditions ◽  
Novel Drug ◽  
Conventional Dosage

An oleo gum resin guggulu is a product which obtained as a result of gummosis from the bark of Commiphora wightii (Arnott) Bhandari [syn. Commiphoramukul (Hook. Ex Stocks) Family, Burseraceae]. It has been known for its immense applicability in the Ayurveda since time immemorial for the treatment of variety of disorders such as inflammation, gout, rheumatism, impotence, leprosy, obesity, and disorders of lipids metabolism. It is a mixture of phytoconstituents like terpenoids, steroids, flavonoids, guggultetrols, lignans, sugars, and amino acids. This review is an effort to compile all the information available on all of its chemical constituents which are responsible for its therapeutic potential, limitation of guggul extracts and the necessity of novel principles for gum guggul. Nowadays, Guggul is available as the marketed formulation for curing numerous clinical conditions and is accessible in combination with various other ingredients. Though conventional dosage form shows the dominance as patient compliance and easy availability, yet it has found to pose the problems like dose fluctuation, peak-valley effect, non-adjustment of the administered drug, invasiveness etc. Guggul lacks its desired effect due to its low bioavailability and water solubility. This makes it a partial or a deficient therapy for remedy of many signs and symptoms. Novel drug delivery system (NDDS), a new approach and has excluded many of drawbacks exhibited by conventional dosage forms. Some of the novel dosage forms of guggul has been formed like nanoparticles, nanovesicles, gugglusomes and proniosomal gel. But still, the novel formulations for guggul has its less outspread in the market. Guggul can be executed as a profitable drug using NDDS. There is a need to highlight the unidentified and unexplained facts about guggul so as to make it more efficacious and effective in terms of bioavailability and aqueous insolubility.

Polyphenols of leaves of Apium graveolens inhibit in vitro protein glycation and protect RINm5F cells against methylglyoxal-induced cytotoxicity

2018 ◽  
Vol 8 (3) ◽  
pp. 193 ◽  
Author(s):  
Rosa Martha Perez Gutierrez ◽  
Alethia Muñiz-Ramirez ◽  
Abraham Heriberto Garcia Campoy ◽  
Jose Maria Mota Flores ◽  
Sergio Odin Flores
Keyword(s):  
Therapeutic Potential ◽  
Health Benefits ◽  
Protein Glycation ◽  
Apium Graveolens ◽  
Ionization Mass ◽  
Intensity Level ◽  
Edible Plants ◽  
Rinm5f Cells ◽  
Protein Carbonyl Content

Background: The health benefits of edible plants have been widely investigated and disseminated. However, only polyphenols have been found to have sufficient therapeutic potential to be considered in clinical trials. Fewer manuscripts have other applications such as prospective health benefits and disease treatment. Other components of edible plants are responsible for a range of other benefits including antimalarial, burns, flu, cancer, inflammation, diabetes, glycation, antimicrobial, prevention of neurodegeneration, analgesic, antimigraine activity, sedative activities, etc. Accordingly, the public needs to be informed of the potential edible plants have to act on different targets and maintain better control over diabetes compared to commercial drugs which can be toxic, have side effects, do not have the capacity to maintain blood glucose at normal levels, and do not protect the patient from the complications of diabetes over time. Consequently, edible plants, such as Apium graveolen, which have therapeutic targets on AGEs formation, are potentially a better alternative treatment for diabetes.Methods: The leaves of celery were extracted with methanol (CM). Polyphenols contents in CM were investigated by liquid chromatography-electrospray ionization mass. The ability of the compounds to inhibit formation of AGEs was evaluated in vitro models using formation of AGE fluorescence intensity, level of fructosamine, Nε-(carboxymethyl)lysine (CML), methylglyoxal (MG)-derived protein, and formation of amyloid cross β structure. Protein-oxidation was determined by thiol group and protein carbonyl content. Inhibition of MG-derived AGEs and MG-trapping ability were also measured. Additionally, insulin production was determined in methylglyoxal-treated pancreatic RINm5F cells assay. Results: Apigenin, kaempferol, apiin, rutin, caffeic acid, ferulic acid, chlorogenic acid, coumaroylquinic acid, and p-coumaric acid were the major polyphenols contained in CM. In all the model tests CM displayed potent AGE inhibitory activity, suggesting that CM delayed the three stages of glycation. Accordingly, the mechanisms of action of celery involving dicarbonyl trapping and breaking the crosslink structure in the AGEs formed may contribute to the protection of pancreatic RINm5F cells against MG conditions.Conclusion: These findings indicate that CM have an excellent anti-glycation effect which may be beneficial for future development of antiglycating agents for the treatment of diabetes.Keywords: Apium graveolens, anti-glycation, polyphenols methylglyoxal, insulin, pancreatic cells

Neuroprotective Effects of Ellagic Acid in Alzheimer's Disease: Focus on Underlying Molecular Mechanisms of Therapeutic Potential

2020 ◽  
Vol 26 ◽  
Author(s):  
Nimra Javaid ◽  
Muhammad Ajmal Shah ◽  
Azhar Rasul ◽  
Zunera Chauhdary ◽  
Uzma Saleem ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ellagic Acid ◽  
Molecular Mechanisms ◽  
Neurodegenerative Disorder ◽  
Therapeutic Potential ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Acetylcholinesterase Activity ◽  
Neuroprotective Effects

: Neurodegeneration is a multifactorial process involved the different cytotoxic pathways that lead towards neuronal cell death. Alzheimer’s disease (AD) is a persistent neurodegenerative disorder that normally has a steady onset yet later on it worsens. The documented evidence of AD neuropathology manifested the neuro-inflammation, increased reactive oxygen, nitrogen species and decreased antioxidant protective process; mitochondrial dysfunction as well as increased level of acetylcholinesterase activity. Moreover, enhanced action of proteins leads towards neural apoptosis which have a vital role in the degeneration of neurons. The inability of commercial therapeutic options to treat AD with targeting single mechanism leads the attraction towards organic drugs. Ellagic acid is a dimer of gallic acid, latest studies expressed that ellagic acid can initiate the numerous cell signaling transmission and decrease the progression of disorders, involved in the degeneration of neurons. The influential property of ellagic acid to protect the neurons in neurodegenerative disorders is due to its antioxidant effect, iron chelating and mitochondrial protective effect. The main goal of this review is to critically analyze the molecular mode of action of ellagic acid against neurodegeneration.

A Review of Phytochemical and Pharmacological Studies of Inula Species

2020 ◽  
Vol 16 (5) ◽  
pp. 557-567
Author(s):  
Aparoop Das ◽  
Anshul Shakya ◽  
Surajit Kumar Ghosh ◽  
Udaya P. Singh ◽  
Hans R. Bhat
Keyword(s):  
Bacterial Infections ◽  
Chemical Constituents ◽  
Valuable Insight ◽  
Important Ingredient ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
The Family ◽  
Pharmacological Studies ◽  
Perennial Herbs ◽  
Insight Into

Background: Plants of the genus Inula are perennial herbs of the family Asteraceae. This genus includes more than 100 species, widely distributed throughout Europe, Africa and Asia including India. Many of them are indicated in traditional medicine, e.g., in Ayurveda. This review explores chemical constituents, medicinal uses and pharmacological actions of Inula species. Methods: Major databases and research and review articles retrieved through Scopus, Web of Science, and Medline were consulted to obtain information on the pharmacological activities of the genus Inula published from 1994 to 2017. Results: Inula species are used either alone or as an important ingredient of various formulations to cure dysfunctions of the cardiovascular system, respiratory system, urinary system, central nervous system and digestive system, and for the treatment of asthma, diabetes, cancers, skin disorders, hepatic disease, fungal and bacterial infections. A range of phytochemicals including alkaloids, essential and volatile oils, flavonoids, terpenes, and lactones has been isolated from herbs of the genus Inula, which might possibly explain traditional uses of these plants. Conclusion: The present review is focused on chemical constituents, medicinal uses and pharmacological actions of Inula species and provides valuable insight into its medicinal potential.

The Valuable Impacts of Halophytic Genus Suaeda; Nutritional, Chemical, and Biological Values

2020 ◽  
Vol 16 (8) ◽  
pp. 1044-1057 ◽  
Author(s):  
Hamdoon A. Mohammed
Keyword(s):  
Search Engines ◽  
Scientific Literature ◽  
High Salinity ◽  
Chemical Constituents ◽  
Harsh Environment ◽  
Science Literature ◽  
Medicinal Uses ◽  
Nutritional Values ◽  
Alternative Medicines ◽  
Natural Substances

Background: Suaeda is a halophytic genus belonging to the Amaranthaceae family and can survive in the high salted marsh areas of the world. Suaeda plants can biosynthesize natural substances with powerful antioxidant activity and are considered as a renewable source of energy, food, and edible oil for a larger number of populations living in the harsh environment with high salinity and drought conditions. These plants also meet folk and alternative medicines' needs. Methods: The review encompasses available scientific literature related to folk medicinal uses of Suaeda plants, their nutritional values, and chemical constituents. In addition, the biological trials applied for the Suaeda plants are also part of the review. The review covers the researches from major science literature search engines and other sites representing scientific literature, i.e., Scifinder, Google Scholar, PubMed, ScienceDirect, Scopus, and Google. The searches were programmed on the advance options available in the search engines and are latest up to November 2019. The searches were exhaustive and rechecked for accuracy. Conclusion: The study summarizes the uses of Suaeda plants as a remedy for various ailments due to their contents from the polyphenols and flavonoids. The comparatively large amounts of fixed oils, minerals, and vitamins in Suaeda plants have also made them potential renewable sources for foods.

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