scholarly journals DDH Diagnosis: What do we Know so Far?

2021 ◽  
Vol 14 (1) ◽  
pp. 469-477
Author(s):  
Saeed Al-Naser ◽  
Anas A.R. Altamimi

Background: Developmental Dysplasia of the Hip (DDH) is a common disease worldwide. The success of treatment depends on making an early and accurate diagnosis using clinical examination and imaging. Diagnosis of DDH patients is challenging and controversial, and many cases still present late. There is still a lack of consensus among health care providers regarding the diagnostic methods in terms of interpretation, accuracy and appropriate timing. The clinical practice seems to widely vary between healthcare providers in different parts of the world. Aims: We aim to provide a clear pathway to help healthcare professionals from different disciplines in diagnosing DDH at the earliest age possible in order to start an effective treatment and avoid complex procedures and unnecessary complications. We also aim to provide an extensive review that will provide a standardized reference detailing the whole diagnostic process in order to improve the clinical outcome and save resources. Methods: We reviewed the relevant literature using Pubmed, Google Scholar, and the Cochrane library and looked into the references lists of all of these papers to gather all the available evidence. All papers were carefully critiqued to use the most rigorous in the conclusions of this review. We included articles discussing clinical examination and radiological diagnosis. Papers discussing the most used clinical examination tests and the timing of clinical evaluation were reviewed. Also, we looked into papers discussing radiological diagnosis using ultrasound scanning and standard radiographs in terms of sensitivity, specificity and reliability and their relation to patient’s age and other variables. Results: DDH diagnosis must start at a very young age by repeated examination using specific clinical tests looking mainly for signs of major instability. Ultrasound scanning is the investigation of choice in screening and early diagnosis, and the Graf method seems to be the most reliable method. X-rays are not reliable in early diagnosis, especially in the first four months of life, and can lead to over-diagnosis, particularly when using the Acetabular Index as the sole measurement tool. Conclusion: DDH diagnosis has many controversies, and the practice is still widely variable. This review provides an evidence-based, updated pathway for early DDH diagnosis in order to improve the clinical outcome, avoid complications, reduce the need for surgical treatment and save public resources. It highlights some malpractices that are still used in the diagnostic process. The review provides a standardized reference to doctors from different specialties and with different experience levels who are tasked with assessing children for DDH.

Author(s):  
S.S GRECHIKHIN ◽  

Diagnostics in the practice of a dentist is the key to quality treatment. However, depending on the quality of services provided, the cost of diagnostic methods is set. For a dentist working in a private office, the key to successful diagnostic measures at a high quality level is a priority. However, these methods are expensive for the patient. The purpose of this study is to study the impact of financial incentives on the quality of early diagnosis in the practice of a dentist who provides quality treatment. In the study, we studied clinical cases with full and partial study in terms of diagnostic and neglect x-ray diagnosis from the doctor and from the patient due to a misunderstanding of the importance and necessity of this manipulation. In statistical data analysis, the resulting regression models use a binary variable as a dependent variable on the level of financial costs. Thus, in the course of our research, we found that the number of x-rays significantly increases when dentists receive a fee for services, rather than a salary, and when patients are exempt from paying for additional diagnostic methods. Our results show that financial incentives significantly influence additional high-quality and complete examination of patients.


Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 5682-5682 ◽  
Author(s):  
Jan Straub ◽  
Roman Hajek ◽  
Vlastimil Scudla ◽  
Vladimir Maisnar ◽  
Evzen Gregora ◽  
...  

Abstract Introduction: Multiple myeloma is one of the most frequent hematological malignancies. The prognosis of patients has substantially improved due to new treatment options. However, the early diagnosis is still a crucial factor for prognosis. First symptoms of myeloma are different and mostly unspecific - therefore many patients are diagnosed late with serious organ and/or tissue damage. Czech Myeloma Group initiated the program for early diagnosis of MM in 2007. Program (named due to educational reasons„CRAB“) was focused on general practitioners (GPs) and key specialists responsible for recognizing the symptoms related to MM (neurology, orthopedics, nephrology). We present results of the final analysis. Methods: a/ telephonic survey for healthcare professionals, b/ written information for primary care providers, c/ brochures containing definition of clinical symptoms and recommended diagnostic methods, d/ patient questionnaire, e/ presentations at medical meetings in Czech republic, f/ presentation in non-hematological medical journals, g/ e-learning. Primary objectives were: 1) decrease risk of late diagnosis ( > 3 month after first symptoms of myeloma) from 50% to 30% , 2) reduction of irreversible deterioration at the time of diagnosis from 20% to <10%. Secondary objectives were: 3) improve knowledge of the first-contact care providers about the initial symptoms of multiple myeloma 4) inform them about diagnostic methods applicable in first-contact care 5) inform them about new treatment modalities and improving prognosis of myeloma patiens. Planned project duration was 7 years (2007-2013). The first interim analysis was done in 2010. Results: 76,4% patients was diagnosed < 3 month after first contact with healthcare professionals according to the second analysis in 2013. Probability of early diagnosed patients increased from 53,5% in 2007 to 68,8%, ,i.e. by 29% , in 2013 However, incidence of the osteolytic lesions and renal failure at time of diagnosis remained similar. Conclusion: The 7-year project leads to the increase of early diagnosis of MM by almost one third. Long-term analysis will show whether better knowledge of medical society about myeloma is transient (just during information campaign) or permanent. Project was supported by Czech Myeloma Group and Jansen-Cillag. Disclosures Hajek: Merck: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Janssen: Honoraria.


Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 429
Author(s):  
Julian Hipp ◽  
Blin Nagavci ◽  
Claudia Schmoor ◽  
Joerg Meerpohl ◽  
Jens Hoeppner ◽  
...  

Background: A substantial fraction of patients with esophageal cancer show post-neoadjuvant pathological complete response (pCR). Principal esophagectomy after neoadjuvant treatment is the standard of care for all patients, although surveillance and surgery as needed in case of local recurrence may be a treatment alternative for patients with complete response (CR). Methods: We performed a scoping review to describe key characteristics of relevant clinical studies including adults with non-metastatic esophageal cancer receiving multimodal treatment. Until September 2020, relevant studies were identified through systematic searches in the bibliographic databases Medline, Web of Science, Cochrane Library, Science Direct, ClinicalTrials, the German study register, and the WHO registry platform. Results: In total, three completed randomized controlled trials (RCTs, with 468 participants), three planned/ongoing RCTs (with a planned sample size of 752 participants), one non-randomized controlled study (NRS, with 53 participants), ten retrospective cohort studies (with 2228 participants), and one survey on patients’ preferences (with 100 participants) were identified. All studies applied neoadjuvant chemoradiation protocols. None of the studies examined neoadjuvant chemotherapeutic protocols. Studies investigated patient populations with esophageal squamous cell carcinoma, adenocarcinoma, and mixed cohorts. Important outcomes reported were overall, disease-free and local recurrence-free survival. Limitations of the currently available study pool include heterogeneous chemoradiation protocols, a lack of modern neoadjuvant treatment protocols in RCTs, short follow-up times, the use of heterogeneous diagnostic methods, and different definitions of clinical CR. Conclusion: Although post-neoadjuvant surveillance and surgery as needed compared with post-neoadjuvant surgery on principle has been investigated within different study designs, the currently available results are based on a wide variation of diagnostic tools to identify patients with pCR, short follow-up times, small sample sizes, and variations in therapeutic procedures. A thoroughly planned RCT considering the limitations in the currently available literature will be of great importance to provide patients with CR with the best and less harmful treatment.


2021 ◽  
pp. 155982762110012
Author(s):  
Fei-Chi Yang ◽  
Aishwarya B. Desai ◽  
Pelareh Esfahani ◽  
Tatiana V. Sokolovskaya ◽  
Doreen J. Bartlett

Background. Tai Chi is a form of exercise that is accessible to people from different socioeconomic backgrounds, making it a potentially valuable activity for health promotion of older adults. Purpose. The objective of this scoping review was to summarize the current knowledge about the effectiveness of Tai Chi for older adults across a range of general health outcomes from published, peer reviewed, unique meta-analyses. Methods. Meta-analyses were retrieved from Medline, Embase, AMED, CINAHL, SPORTDiscus, PsychINFO, Web of Science, PubMed Health, and the Cochrane Library from database inception to late August 2019. Multistage deduplication and screening processes identified eligible full-length meta-analyses. Two people independently appraised 27 meta-analyses based on the GRADE system and organized results into 3 appendices subsequently collated into heterogeneous, statistically significant, and statistically insignificant tables. Results. “High” and “moderate” quality evidence extracted from these meta-analyses demonstrated that practicing Tai Chi can significantly improve balance, cardiorespiratory fitness, cognition, mobility, proprioception, sleep, and strength; reduce the incidence of falls and nonfatal stroke; and decrease stroke risk factors. Conclusions. Health care providers can now recommend Tai Chi with high level of certainty for health promotion of older adults across a range of general health outcomes for improvement of overall well-being.


Author(s):  
ÖMER FARUK ELMAS ◽  
NECMETTİN AKDENİZ

Background and Aim: Verrucous epidermal nevi are cutaneous hamartomas having many clinical variants. Dermoscopic features of verrucous epidermal nevus have rarely been investigated. We aimed to identify dermoscopic findings of the entity which will facilitate the diagnostic process by reducing the use of invasive diagnostic methods. Material and Methods: The study included the patients with histopathologically approved verrucous epidermal nevus. Clinical, dermoscopic and histopathological features of the patients were retrospectively reviewed and the findings identified were recorded. Dermoscopic examination was performed with a polarized-light handheld dermoscope with 10-fold magnification. Results: The most common dermoscopic features were thick brown circles, thick brown branched lines and terminal hairs. The most common vessel pattern was dotted vessels. Branched thick brown lines, brown globules, brown dots forming lines, serpiginous brown dots, white and brown exophytic papillary structures, fine scale, thick adherent scale and cerebriform structures were the other findings. Conclusion: We observed many vascular and non-vascular dermoscopic findings which have not been described previously for the entity. Dermoscopic examination of the verrucous epidermal nevi may lead more reliable clinical interpretation and thus it may reduce the need for histopathological investigation. Keywords: dermoscopy, large brown circles, verrucous epidermal nevus


2018 ◽  
Vol 5 (2) ◽  
pp. 67-73
Author(s):  
Inês Stafin ◽  
Virgílio Ribeiro Guedes ◽  
Seyna Ueno Rabelo Mendes

RESUMO Introdução: O diagnóstico da hanseníase ainda causa grande impacto social, tanto por ser frequentemente tardio e evoluir com sequelas, quanto pelos estigmas que a envolvem. O Brasil persiste como uma área endêmica e possui o segundo lugar em número de casos da doença no mundo. Já o Tocantins é um dos estados com maior endemicidade no país, com um aumento importante no número de diagnósticos em menores de 15 anos e no número de pessoas diagnosticadas com incapacidade grau II. Metodologia: Trata-se de uma revisão de literatura do tipo narrativa, realizada por meio de publicações sobre as ações estratégicas para o diagnóstico precoce de hanseníase, entre o período de 2012 a 2017. Desenvolvimento: A situação atual da hanseníase demonstra a persistência da transmissão, a carência de ações para o seu controle efetivo, a sub detecção e um diagnóstico tardio dessa patologia. O presente artigo aborda as principais ações estratégicas para a realização do diagnóstico precoce da hanseníase, bem como os métodos diagnósticos importantes, proporcionando um maior auxílio aos profissionais de saúde da atenção primária. Considerações finais: Para que se amplie o diagnóstico precoce de forma adequada é essencial a busca e avaliação dos contatos, a qualificação adequada dos profissionais de saúde, a educação em saúde da população e a participação ativa dos gestores.   Palavras-chave: Hanseníase; diagnóstico precoce; estratégias; atenção primária. ABSTRACT Introduction: The diagnosis of leprosy still causes great social impact, both because it is often late and evolves with sequelae, and because of the stigmas that surround it. Brazil persists as an endemic area and has the second largest number of cases of the disease in the world. The state of Tocantins represents one of the areas with high endemicity in the country, with a significant increase in the number of diagnoses in children under 15 years and in the number of people diagnosed with disability grade II. Methodology: This is a literature review of the narrative type, carried out through publications on strategic actions for the early diagnosis of leprosy, between the period of 2012 to 2017. Development: The current situation of leprosy shows the persistence of transmission, lack of actions for effective control, sub detection and a late diagnosis of this pathology. This article discusses the main strategic actions for the early diagnosis of leprosy, as well as the important diagnostic methods, providing greater assistance to primary health care professionals. Final considerations: In order to increase the early diagnosis in an adequate way, it is essential the search and evaluation of contacts, the adequate qualification of health professionals, the health education of the population and the participation of managers. Keywords: Leprosy; early diagnosis; strategies; primary care.


2006 ◽  
Vol 92 (3) ◽  
pp. 118-120
Author(s):  
S. Warwick ◽  
J. E. Smith ◽  
I. Higginson

AbstractA case is presented where an incidental finding on a trauma radiograph led to early diagnosis of a potentially life-threatening tumour, highlighting the need to be vigilant when interpreting X-rays.


2015 ◽  
Vol 8 (8) ◽  
pp. 74 ◽  
Author(s):  
Maryam Kardan-Souraki ◽  
Zeinab Hamzehgardeshi ◽  
Ismail Asadpour ◽  
Reza Ali Mohammadpour ◽  
Soghra Khani

<p><strong>BACKGROUND:</strong> Lack of intimacy is currently the main concern rather than main concern of the experts in psychology and counseling. It is considered as one of the most important causes for divorce and as such to improve marital intimacy a great number of interventions have been proposed in the literature. Intimacy training and counseling make the couples take effective and successful steps to increase marital intimacy. No study has reviewed the interventions promoting marital intimacy after marriage. Thus, this review study aimed to classify the articles investigating the impact of interventional programs on marital intimacy after marriage.</p><p><strong>SEARCH METHODS:</strong> In April 2015, we performed a general search in Google Scholar search engines, and then we did an advanced search the databases of Science Direct, ProQuest, SID, Magiran, Irandoc, Pubmed, Scopus, <a href="http://www.cochranelibrary.com/">Cochrane Library</a>, and Psych info; Cumulative Index to Nursing and Allied Health Literature (CINAHL). Also, lists of the references of the relevant articles were reviewed for additional citations. Using Medical Subject Headings (MESH) keywords: Intervention (Clinical Trials, Non-Randomized Controlled Trials, Randomized Controlled Trials, Education), intimacy, marital (Marriage) and selected related articles to the study objective were from 1995 to April 2015. Clinical trials that evaluated one or more behavioral interventions to improve marital intimacy were reviewed in the study.</p><p><strong>MAIN RESULTS:</strong> 39 trials met the inclusion criteria. Eleven interventions had follow-up, and 28 interventions lacked follow-up. The quality evidence for 22 interventions was low, for 15 interventions moderate, and for one intervention was considered high. Findings from studies were categorized in 11 categories as the intimacy promoting interventions in dimensions of emotional, psychological, physical, sexual, temporal, communicational, social and recreational, aesthetic, spiritual, intellectual intimacy, and total intimacy.</p><p><strong>AUTHORS’ CONCLUSIONS:</strong> Improving and promoting communication, problem solving, self-disclosure and empathic response skills and sexual education and counseling in the form of cognitive-behavioral techniques and based on religious and cultural context of each society, an effective step can be taken to enhance marital intimacy and strengthen family bonds and stability. Health care providers should consider which interventions are appropriate to the couple characteristics and their relationships.</p>


Author(s):  
A. V. Laryukov ◽  
E. K. Laryukova ◽  
M. K. Mikhailov

Objective:сonstructive principles development of early diagnosis of bone and cerebral metastases of peripheral non-small cell lung cancer (PNSCLC), is based on the targeted preventive and personalized application of radiological and nuclear diagnostic methods.Materials and methods.There was performed the retrospective analysis of medical cards of 1473 patients with peripheral non-small cell lung cancer for the evaluation of the characteristics and frequency of bones and brain metastases. The frequency and features of bone and brain metastases depending on clinical and morphological features of the primary lung tumor were studied. 118 patients with PNSCLC with bone and brain metastases, regardless of clinical symptoms, were examined using a wide range of modern radiological and nuclear methods.Conclusion:the original algorithm has been developed on the study of the diagnostic significance of medical imaging methods. The application of this algorithm will significantly improve the early diagnosis of bone and cerebral metastases and improve the staging of PNSCLC.


Author(s):  
Hassan Boskabadi ◽  
Ali Moradi ◽  
Maryam Zakerihamidi

Background: Biochemical markers including interleukins (ILs) has been proposed for early diagnosis of asphyxia. Objective: This study has aimed to systematically review the significance of IL measurements in the diagnosis of perinatal asphyxia. Materials and Methods: PubMed, Cochrane Library, Web of Science, Embase, and Scopus databases before 2017 were searched for the following keywords: asphyxia, neonatal, interleukin, and diagnosis. A total of 13 out of 300 searched papers were finally selected for evaluation. Interleukins under study were IL6 and interleukin 1


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