scholarly journals Bryonia Laciniosa An Ayurvedic Herbal Plant ‘Bryonia laciniosa’ with its Ethnomedicinal Significance

2021 ◽  
Vol 11 (3-S) ◽  
pp. 137-141
Author(s):  
Hemlata Kaurav ◽  
Shailja Choudhary ◽  
Gitika Chaudhary
Keyword(s):  
Infectious Diseases ◽  
Metabolic Disorders ◽  
Therapeutic Potential ◽  
Review Article ◽  
Pharmacological Properties ◽  
Important Ingredient ◽  
Snake Bites ◽  
Plant Utilization ◽  
Inflammatory Drugs ◽  
Herbal Plant

Bryonia laciniosa is one such plant that is also known by the name of shivlingi as its seeds resemble the 'shivling' icon of Lord Shiva. This plant is mainly known for its seeds and is used in various ayurvedic drug formulations as an important ingredient. In Ayurveda and the folklore culture, shivlingi plant is used to treat various types of diseases such as cholera, bronchitis, constipation, diabetes, inflammation, paralysis, snake bites, abdominal diseases and mainly used as an aphrodisiac agent. In homeopathy, the B. laciniosa plant is used as an important ingredient in the formulation of anti-inflammatory drugs. Also, the plant is used to treat gastrointestinal, rheumatic, respiratory, liver, infectious diseases and metabolic disorders Besides this, shivlingi plant is associated with therapeutic potential which includes analgesic, antidiabetic, antioxidant, androgenic, antitumor, fertility and antipyretic properties. In this review article, the reported pharmacological properties of the plant have been described along with the plant utilization in folklore and ayurvedic medicinal system. Keywords: Ayurveda, Shivlingi, Folk view, Pharmacological properties

Systematic analysis of the biological roles and pharmacological properties of D-chiro-inositol

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (3) ◽  
pp. 21-28
Author(s):  
Olga A. Gromova ◽  
Ivan Yu. Torshin ◽  
Elena V. Uvarova ◽  
Natalya I. Tapilskaya ◽  
Alla G. Kalacheva
Keyword(s):  
Metabolic Disorders ◽  
Blood Lipids ◽  
Therapeutic Potential ◽  
Polycystic Ovary ◽  
Oocyte Quality ◽  
Excess Body Weight ◽  
Therapeutic Effects ◽  
Pharmacological Properties ◽  
Ovary Syndrome ◽  
Systematic Analysis

D-chiroinositol (DCI) is one of the 9 inositol isomers that forms inositol phosphoglycans, which are mediators of the action of insulin. The metabolism of DCI and myo-inositol (MI) is impaired against the background of insulin resistance, including the patients with polycystic ovary syndrome (PCOS). Aim. Highlight the most characteristic pharmacological properties of DCI. Materials and methods. Systematic computer analysis of 45 600 publications on the biological roles of inositol by methods of the topological theory of pattern recognition and systems biology analysis of human proteome. Results. A complex of interactions between metabolic disorders of DCI, PCOS, ovulation disorders, obesity associated with numerous hormonal disorders is described. Supplements with DCI and MI increase the sensitivity of cells to insulin and normalize the metabolism of androgens. An important difference between DCI and MI is the presence of DCI in the composition of inositol phosphoglycans that mediate the action of insulin on cells, as well as its participation in the realization of the therapeutic effects of metformin. The use of the MI+DCI combination allows achieving positive dynamics in reducing excess body weight, normalizing blood lipids, glucose and insulin levels, restoring the ovulatory menstrual cycle, improving oocyte quality, and helps prevent gestational diabetes in pregnant women and macrosomia of the fetus. DCI is more effective than MI in reducing the risk of folate-resistant neural tube defects. Conclusion. The therapeutic potential of DCI in combination with MI for treating PCOS and hyperandrogenism is evident. Depending on the therapeutic expediency, various ratios of MI:DCI can be used for the treatment of PCOS and disorders of carbohydrate and lipid metabolism.A

Certain important aspects of the prevention of pathologies of labor activity in obstetric practice (Сlinical lecture)

2016 ◽  
pp. 11-18
Author(s):  
L. Nazarenko ◽  
◽  
L. Dubrova ◽  
O. Tarusмna ◽  
◽  
...  
Keyword(s):  
Key Words ◽  
Review Article ◽  
Optimal Time ◽  
Safe Method ◽  
Individual Approach ◽  
Obstetric Practice ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Time To Delivery ◽  
Ripening Of The Cervix

The question of the prevention of pathologies of the labor is currently very important, the answer to them has become the favored formation of «dominants of delivery», choice of the optimal time to delivery, effective and safe method of induction, that promotes the promptness of the female organism and ripening of the cervix, as well as the timely identification and correction of pathological prelмmмnary period. In a review article describes the modern approaches and methods of preventing the pathology of labor activity, presented by the authors ‘ own experience regarding the use of prostaglandins, non-steroidal anti-inflammatory drugs, individual approach to the management of perinatal risk. Key words: childbirth, prevention, induction, prostaglandin, non-steroidal anti-inflammatory drugs.

Synthetic Routes to 2-Iminothiazolidines: State-of-the-Art 2006-2020

2020 ◽  
Vol 24 (24) ◽  
pp. 2823-2844
Author(s):  
Aditya Bhattacharyya
Keyword(s):  
State Of The Art ◽  
Biological Significance ◽  
Review Article ◽  
Synthetic Methods ◽  
Pharmacological Properties ◽  
Cyclic Molecules ◽  
Synthetic Routes

: Multiheteroatom-containing small-sized cyclic molecules such as 2- iminothiazolidines are often found to possess beneficial pharmacological properties. In this review article, the biological significance of 2-iminothiazolidines is discussed and the literature reports published in the last 15 years spanning from 2006 to 2020 describing various preparative routes to access 2-iminothiazolidine derivatives have been categorically and chronologically described. The notable synthetic methods discussed here involve ringexpansion transformations of nonactivated and activated aziridines, thiiranes, epoxides, and other miscellaneous reactions.

Exploring the Chemistry and Therapeutic Potential of Triazoles: A Comprehensive Literature Review

2019 ◽  
Vol 19 (16) ◽  
pp. 1298-1368 ◽  
Author(s):  
Ankit Jain ◽  
Poonam Piplani
Keyword(s):  
Oxidative Stress ◽  
Drug Discovery ◽  
Literature Review ◽  
Structural Modification ◽  
Therapeutic Potential ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Triazole Derivatives ◽  
Comprehensive Literature Review ◽  
The Common

: Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.

Therapeutic perspectives of the black cumin component thymoquinone: A review

2021 ◽  
Author(s):  
Chandan Sarkar ◽  
Sarmin Jamaddar ◽  
Tawhida Islam ◽  
Milon Mondal ◽  
Muhammad Torequl Islam ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Nigella Sativa ◽  
Pharmacological Properties ◽  
Black Cumin

The dietary phytochemical thymoquinone, obtained from the black and angular seeds of Nigella sativa, is a promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties.

scholarly journals Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1609
Author(s):  
Lutfun Nahar ◽  
Shaymaa Al-Majmaie ◽  
Afaf Al-Groshi ◽  
Azhar Rasul ◽  
Satyajit D. Sarker
Keyword(s):  
Medicinal Plant ◽  
Critical Appraisal ◽  
Therapeutic Potential ◽  
Therapeutic Agents ◽  
Review Article ◽  
Natural Distribution ◽  
Antiplatelet Aggregation ◽  
Ruta Chalepensis ◽  
The Family ◽  
Novel Therapeutic

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.

scholarly journals The Abstruse Side of Type I Interferon Immunotherapy for COVID-19 Cases with Comorbidities

2021 ◽  
Vol 1 (1) ◽  
pp. 49-59
Author(s):  
Selvakumar Subbian
Keyword(s):  
Infectious Diseases ◽  
Disease Severity ◽  
Type I Interferon ◽  
Host Factors ◽  
Type I ◽  
The Novel ◽  
Inflammatory Drugs ◽  
Precautionary Measures ◽  
Inducible Genes

The Coronavirus Disease-2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has claimed 1.2 million people globally since December 2019. Although the host factors underpinning COVID-19 pathology are not fully understood, type I interferon (IFN-I) response is considered crucial for SARS-CoV-2 pathogenesis. Perturbations in IFN-I signaling and associated interferon-inducible genes (ISG) are among the primary disease severity indicators in COVID-19. Consequently, IFN-I therapy, either alone or in- combination with existing antiviral or anti-inflammatory drugs, is tested in many ongoing clinical trials to reduce COVID-19 mortality. Since signaling by the IFN-I family of molecules regulates host immune response to other infectious and non-infectious diseases, any imbalance in this family of cytokines would impact the clinical outcome of COVID-19, as well as other co-existing diseases. Therefore, it is imperative to evaluate the beneficial-versus-detrimental effects of IFN-I immunotherapy for COVID-19 patients with divergent disease severity and other co-existing conditions. This review article summarizes the role of IFN-I signaling in infectious and non-infectious diseases of humans. It highlights the precautionary measures to be considered before administering IFN-I to COVID-19 patients having other co-existing disorders. Finally, suggestions are proposed to improve IFN-I immunotherapy to COVID-19.

Role of cannabinoids in various diseases: A review

2021 ◽  
Vol 23 ◽  
Author(s):  
Simran Kaur ◽  
Nikita Sharma ◽  
Arpita Roy
Keyword(s):  
Infectious Diseases ◽  
Metabolic Disorders ◽  
Viral Infections ◽  
Cannabis Sativa ◽  
Endocannabinoid System ◽  
Psychological Disorders ◽  
Bioactive Compound ◽  
The Body ◽  
Therapeutic Aspect

Background: The plant, Cannabis sativa is heavily explored and researched with many industrial and pharmaceutical applications. The medicinal and therapeutic role of cannabis Sativa has been summarized in the paper, citing its mechanism of action and influence on the human body. Diseases like metabolic disorders, infectious diseases, and psychological disorders pose negative and long-term drastic effects on the body like neurodegeneration and other chronic system failures. Several existing literature has proved its effectiveness against such diseases. Objectives: This review aims to provide an overview of the role of cannabinoids in various diseases like metabolic disorders, infectious diseases, and psychological disorders. Method: Various e-resources like Pubmed, Science Direct, and Google Scholar were thoroughly searched and read to form a well-informed and information-heavy manuscript. Here we tried to summaries the therapeutic aspect of Cannabis sativa and its bioactive compound cannabinoids in various diseases. Result: This review highlights the various constituents which are present in Cannabis sativa, the Endocannabinoid system, and the role of cannabinoids in various diseases Conclusion: Recent research on Cannabis has suggested its role in neurodegenerative diseases, inflammation, sleep disorders, pediatric diseases, and their analgesic nature. Therefore, the authors majorly focus on the therapeutic aspect of Cannabis sativa in various diseases. The focus is also on the endocannabinoid system (ECS) and its role in fighting or preventing bacterial, parasitic, fungal, and viral infections.

scholarly journals Modified ELISA for Ultrasensitive Diagnosis

2021 ◽  
Vol 10 (21) ◽  
pp. 5197
Author(s):  
Naoko Tsurusawa ◽  
Jyunhao Chang ◽  
Mayuri Namba ◽  
Daiki Makioka ◽  
Sou Yamura ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Present Article ◽  
Immunosorbent Assay ◽  
Current Literature ◽  
Quantitative Measurement ◽  
Review Article ◽  
Detection Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Ultrasensitive Detection ◽  
Lifestyle Related Diseases

An enzyme-linked immunosorbent assay (ELISA) can be used for quantitative measurement of proteins, and improving the detection sensitivity to the ultrasensitive level would facilitate the diagnosis of various diseases. In the present review article, we first define the term ‘ultrasensitive’. We follow this with a survey and discussion of the current literature regarding modified ELISA methods with ultrasensitive detection and their application for diagnosis. Finally, we introduce our own newly devised system for ultrasensitive ELISA combined with thionicotinamide adenine dinucleotide cycling and its application for the diagnosis of infectious diseases and lifestyle-related diseases. The aim of the present article is to expand the application of ultrasensitive ELISAs in the medical and biological fields.

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