scholarly journals Synthesis of Some Novel Chalcone Derivative Via Microwave Method & It’s Antimicrobial Activity

2017 ◽  
pp. 25-28
Author(s):  
Nilesh Pandya ◽  
Tejas Gandhi ◽  
KR Desai
Keyword(s):  
Antimicrobial Activity ◽  
Public Awareness ◽  
Microwave Method ◽  
Initial Compound ◽  
Chemical Product ◽  
Pharmacological Activities ◽  
Regulatory Policies ◽  
Chalcone Derivative ◽  
Innovative Solutions ◽  
State Of The Environment

Growing public awareness about the state of the environment, chemical product safety and new chemical regulatory policies is driving demand for leaders who are able to understand the science underlying environmental challenges and develop innovative solutions. Chalcones belong to the flavonoid family and display several pharmacological activities which are very important. They can be used as an initial compound for synthesis of a lot of compounds. In this research chalcone derivative are made via green chemistry route and analysed their physical and antimicrobial activity.

Environmental Degradation in the Ikorodu Sub-Urban Lagos - Lagoon Coastal Environment, Nigeria

2018 ◽  
Vol 10 (1) ◽  
pp. 16-33 ◽  
Author(s):  
Shakirudeen Odunuga ◽  
Samuel Udofia ◽  
Opeyemi Esther Osho ◽  
Olubunmi Adegun
Keyword(s):  
Anthropogenic Activities ◽  
Public Awareness ◽  
Biodiversity Loss ◽  
Policy Formulation ◽  
Coastal Environment ◽  
Resource Exploitation ◽  
Average Growth ◽  
Awareness Campaigns ◽  
The Government ◽  
State Of The Environment

Introduction:Human activities exert great pressures on the environment which in turn cause environmental stresses of various intensities depending on the factors involved and the sensitivity of the receiving environment.Objective:This study examines the effects of anthropogenic activities along the sub-urban lagoon fragile coastal ecosystem using DPSIR framework.Results:The results show that the study area has undergone a tremendous change between 1964 and 2015 with the built up area increasing to about 1,080 ha (17.87%) in 2015 from 224 ha (1.32%) in 1964 at an average growth rate of 16.78ha per annum. The nature of the degradation includes an increasing fragility of the ecosystem through the emergence and expansion of wetlands, flooding and erosion as well as a reduction in the benefits from the ecosystem services. Population growth, between 2006 and 2015 for Ikorodu LGA, estimated at 8.84% per annum serves as the most important driving force in reducing the quality of the environment. This is in addition to Pressures emanating from anthropogenic activities. The state of the environment shows continuous resource exploitation (fishing and sand mining) with the impacts of the pressures coming from water pollution, bank erosion, biodiversity loss and flooding. Although there has been a strong policy formulation response from the government, weak implementation is a major challenge.Recommendation:The study recommends public awareness campaigns and the implementation of existing policies to ensure a sustainable sub-urban lagoon coastal environment..

scholarly journals Characterization and Antimicrobial Activity of Silver Doped Hydroxyapatite Obtained by the Microwave Method

2016 ◽  
Vol 22 (3) ◽  
Author(s):  
Meruyert KOIZHAIGANOVA ◽  
Ihsan YAŞA ◽  
Gürbüz GÜLÜMSER
Keyword(s):  
Antimicrobial Activity ◽  
Microwave Method

scholarly journals SYNTHESIS AND SCREENING OF BENZOFURAN FUSED C-2,4,6-SUBSTITUTED PYRIMIDINE DERIVATIVES AS A NEW ANTIBACTERIAL AND ANTIFUNGAL AGENT

2017 ◽  
Vol 9 (9) ◽  
pp. 27
Author(s):  
Javarappa Rangaswamy ◽  
Nagaraja Naik
Keyword(s):  
Antimicrobial Activity ◽  
Development Program ◽  
Pyrimidine Ring ◽  
Antibacterial And Antifungal Activity ◽  
Pyrimidine Derivatives ◽  
Pharmacological Activities ◽  
Spectral Techniques ◽  
Wide Range ◽  
Antibacterial And Antifungal ◽  
Drug Development Program

Objective: Benzofuran and their heterocyclic analogs represent an important class of molecules which have a wide range of pharmacological activities. Therefore, in this study synthesis and antimicrobial activity of benzofuran fused C-2,4,6-substituted pyrimidine derivatives was extensively discussed.Methods: Benzofuran fused C-2,4,6-substituted pyrimidine derivatives (4a-k) were built by cyclo condensation, Claisen-Schmidt condensation followed by cyclization via coupling of benzoyl fragments, which include benzofuran, a pyrimidine ring and C-6 substituted phenyl residue with various substituents, connected by linker-S-band. The structures of the synthesized compounds were confirmed by analytical and spectral techniques and evaluated their antimicrobial activity.Results: The results of antibacterial and antifungal activity against various microbes, most of the compounds have shown considerable antimicrobial activity, but compounds 4g and 4e exhibits superior activity compared to standards, this may be due to presence bromo and fluro electron withdrawing substituent on the benzoyl moiety and more lipophilic nature of pyrimidine ring.Conclusion: According to the activity studies, it is observed that the synthesis and antimicrobial activity of benzofuran fused C-2,4,6-substituted pyrimidine derivatives have been shown better antimicrobial activity. The obtained results suggest that these classes of compounds can be considered as new hits for further structural optimization to obtain better antimicrobial drug development program.

scholarly journals Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Jéssica A. Jesus ◽  
João Henrique G. Lago ◽  
Márcia D. Laurenti ◽  
Eduardo S. Yamamoto ◽  
Luiz Felipe D. Passero
Keyword(s):  
Antimicrobial Activity ◽  
Animal Health ◽  
Mechanisms Of Action ◽  
Human Pathogens ◽  
Future Perspectives ◽  
Pharmacological Activities ◽  
Long Period ◽  
Wide Range ◽  
Potential Use

Triterpenoids are the most representative group of phytochemicals, as they comprise more than 20,000 recognized molecules. These compounds are biosynthesized in plants via squalene cyclization, a C30hydrocarbon that is considered to be the precursor of all steroids. Due to their low hydrophilicity, triterpenes were considered to be inactive for a long period of time; however, evidence regarding their wide range of pharmacological activities is emerging, and elegant studies have highlighted these activities. Several triterpenic skeletons have been described, including some that have presented with pentacyclic features, such as oleanolic and ursolic acids. These compounds have displayed incontestable biological activity, such as antibacterial, antiviral, and antiprotozoal effects, which were not included in a single review until now. Thus, the present review investigates the potential use of these triterpenes against human pathogens, including their mechanisms of action, viain vivostudies, and the future perspectives about the use of compounds for human or even animal health are also discussed.

scholarly journals Antimicrobial Activity of Hypericum perforatum Essential Oil

2016 ◽  
Vol 12 (3-4) ◽  
Author(s):  
Vesna Kalaba ◽  
Jovana Glušac ◽  
Milka Stijepić ◽  
Dragana Kalaba ◽  
Dragica Đurđević Milosević
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Hypericum Perforatum ◽  
Public Awareness ◽  
Multidrug Resistant ◽  
World Health ◽  
Antimicrobial Drugs ◽  
Antimicrobial Substances ◽  
Health Organization ◽  
And Control

European Centre for Disease Prevention and Control (ECDC) and World Health Organization (WHO) initiate public awareness campaign about antimicrobial substances and their rational uses due to the increasing prevalence of multidrug resistant strains of bacteria. The objective of this study was to evaluate antimicrobial activity of Hypericum perforatum essential oil and reference antimicrobial drugs against the growth of certain bacteria Staphylococcus aureus, Salmonella typhimurium i Pseudomonas aeruginosa.

scholarly journals Ethnopharmacology of the Asteraceae family in Mexico

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Virginia Gabriela Cilia-López ◽  
Raquel Cariño-Cortés ◽  
Luis Ricardo Zurita-Salinas
Keyword(s):  
Antimicrobial Activity ◽  
Traditional Medicine ◽  
Traditional Knowledge ◽  
Pharmacological Activity ◽  
Biocidal Activity ◽  
Pharmacological Activities ◽  
Cultural Importance ◽  
The World ◽  
Artemisia Ludoviciana ◽  
Asteraceae Family

Background: In Mexico, the Asteraceae are part of traditional knowledge where its members have several uses, but they are particularly remarkable in traditional medicine and are used for different purposes. Questions: What pharmacologically studies have been carried out with Asteraceae species used in Mexican traditional medicine? What pharmacological activities have been tested? What compounds are responsible for the tested activities? Species studied: Asteraceae species used in Mexican traditional medicine pharmacologically tested. Methods: A database including scientific studies on Asteraceae species which studies on pharmacological activity or phytochemical characterization was compiled and analyzed. Results: From 249 reviewed studies only 202 fulfilled the criteria for our analysis. A total of 101 species distributed in 65 genera and 16 tribes were registered. The tribes Heliantheae and Senecioneae were the most studied. Ageratina pichinchensis, Artemisia ludoviciana, Heliopsis longipes, and Heterotheca inuloides were the most studied species. In Mexico, the Asteraceae family is mainly used in the treatment of diseases or symptoms related to the digestive and respiratory systems. In 48 % of the studies some biocidal activity was evaluated but only 21.8 % included phytochemical characterizations. Conclusions: The antimicrobial activity and phytochemical characterizations are the main kind of ethnopharmacological studies for Asteraceae in Mexico. Most of the compounds responsible for the activities have not been identified yet. The uses of Asteraceae in Mexico are similar to other countries emphasizing its cultural importance in the world. Mexican Asteraceae should be prioritized in conservation and bioscreening schemes.

scholarly journals Chemical composition, antioxidant, antimicrobial activity, toxicity, genetic analysis and popular use of Eugenia luschnathiana(O. Berg) Klotzsch ex B.D.Jacks: a literature review

2021 ◽  
Vol 20 (3) ◽  
pp. 215-225
Author(s):  
Martha Quiteria Silva Henriques ◽  
◽  
David Henrique Xavier Barbosa ◽  
Danielle da Nobrega Alves ◽  
Ana Karoline Vieira Melo ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Antimicrobial Activity ◽  
Chemical Composition ◽  
Antioxidant Properties ◽  
Chemical Compounds ◽  
Pharmacological Activities ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Major Chemical ◽  
Residual Solution

This review describes the geographical distribution, botanical data, popular use, chemical composition, pharmacological activities and genetic aspects related to Eugenia luschnathiana, a native Brazilian plant popularly known as “bay pitomba”. E. luschnathianaleaves are characterized morphologically by the presence of a petiole, an attenuated base, acuminated apex, elliptical shape, and parallel venation. The major chemical compounds found in E. luschnathiana are sesquiterpenes. Literature reports showed that E. luschnathianaextracts have antioxidant properties and antimicrobial activity against Gram-negative and Gram-positive bacteria. The extractsfrom the leaf, fruit and stem, and a concentrated residual solution of its essential oil, displayed negligible toxicity. Lastly, a cytogenetic analysis indicated that some markers can be used for the study of genetic diversity, population structure, and genetic improvements. The information available on E. luschnathianasupports the hypothesis that this plant may be a source of compounds with promising pharmacological activity.

Antimicrobial activities of various thiazine based heterocyclic compounds: A mini-review

2021 ◽  
Vol 18 ◽  
Author(s):  
Mohammad Asif ◽  
Mohd. Imran ◽  
Abida
Keyword(s):  
Antimicrobial Activity ◽  
Drug Resistance ◽  
Heterocyclic Compounds ◽  
Antimicrobial Agents ◽  
Antimicrobial Activities ◽  
Vital Role ◽  
Pharmacological Activities ◽  
Natural Sources ◽  
Anti Inflammatory ◽  
Heterocyclic Moiety

: Heterocyclic compounds play a vital role in the development of novel compounds due to their diverse pharmacological activities. Thiazine is a six-membered heterocyclic moiety. Various thiazine derivatives were synthesized or isolated from natural sources like plants and animals. Thiazine derivatives have varieties of pharmacological activities such as antimicrobial, antibacterial, antifungal, antiviral, anti-inflammatory, anticoagulant, anticancer, antihypertensive, and other useful biological as well as chemical applications. In the therapy of antimicrobial infections, new antimicrobial agents are needed because current antimicrobials have developed drug resistance. So, we discussed some thiazine derivatives which exhibited antimicrobial activity.

Practitioners' experiences with the drivers and practices for implementing sustainable construction in Nigeria: a qualitative assessment

2020 ◽  
Vol 9 (4) ◽  
pp. 443-465 ◽  
Author(s):  
Patience Tunji-Olayeni ◽  
Kahilu Kajimo-Shakantu ◽  
Ewaoluwa Osunrayi
Keyword(s):  
Thematic Analysis ◽  
Public Awareness ◽  
Health And Safety ◽  
Sampling Technique ◽  
Practical Experience ◽  
Qualitative Assessment ◽  
Sustainable Construction ◽  
Content Type ◽  
Regulatory Policies ◽  
International Pressure

PurposeThe purpose of this study is to assess the drivers, practices and policies for implementing sustainable construction in Nigeria. This is with a view towards increasing the rate of implementation and diffusion of sustainable construction practice, so that more Nigerians can benefit from its environmental, social and economic dividends.Design/methodology/approachThis study adopted a qualitative research design with the use of face-to-face oral interviews. Interviewees were selected using a purposive sampling technique. Data from the interview were analysed using thematic analysis. Descriptive statistics of frequencies, percentages and rankings were also used to present the data and complement the thematic analysis.FindingsThe study identified five major drivers of sustainable construction: clients' demand, international pressure, corporate social responsibility, competitiveness and cost-effectiveness. The common sustainable practices adopted by the interviewees are compliance with health and safety regulation, waste management, energy efficiency and material reuse. The most appropriate policies for implementing sustainable construction as suggested by the interviewees were government regulations, provision of tax relief and subsidies and public awareness. A combination of regulatory policies, market-based policies and voluntary participation of stakeholders will enhance the attainment of sustainability transformations in the construction industryOriginality/valueThe study is based on the findings of construction participants who have practical experience with sustainable construction in Nigeria. The study also provides empirical evidences which could guide the design and implementation of policies that will further promote the diffusion of sustainable construction in Nigeria

scholarly journals BIOLOGICAL POTENTIAL OF BENZOXAZOLE DERIVATIVES: AN UPDATED REVIEW

2020 ◽  
pp. 28-41
Author(s):  
UDDIN KAMAL ◽  
NAIM MOHD JAVED ◽  
KUMAR ARUN
Keyword(s):  
Antimicrobial Activity ◽  
Literature Search ◽  
Therapeutic Potential ◽  
Anthelmintic Activity ◽  
Pharmacological Activities ◽  
Drug Molecules ◽  
Biological Potential ◽  
Derivatives Of ◽  
Heterocyclic Moiety

Objective: Heterocycles exhibited an extensive role in the medicinal chemistry for the development of pharmaceutically active molecules. A heterocyclic scaffold is responsible for the therapeutic potential of majority of synthesized drug molecules. Therapeutic changes in the drug molecules related to the slight changes in the heterocyclic moiety. Benzoxazole and its derivatives showed potent and significant pharmacological activities. The main objective of our study is to impart updated information about synthesized benzoxazole derivatives and their biological potential against numerous diseases. Methods: A literature search was directed on the databases, namely, in MDPI, Science direct, PubMed, Springer, Taylor, and Francis by searching different keywords “Benzoxazole,” antimicrobial activity, anticancer activity, antitubercular, anti-inflammatory, analgesic, and anthelmintic activity. Conclusion: This review may radiate the path of researchers that are working to synthesized novel benzoxazole derivatives in the prospects of effectiveness and safety. Nonetheless, further in vivo and clinical studies are warranted on the potential derivatives of benzoxazole.

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