scholarly journals Engineering Electrospun Nanofibers for the Treatment of Oral Diseases

2021 ◽  
Vol 9 ◽  
Author(s):  
Yuanfei Wang ◽  
Yingnan Liu ◽  
Xiaopei Zhang ◽  
Na Liu ◽  
Xixi Yu ◽  
...  
Keyword(s):  
Dental Caries ◽  
Electrospun Nanofibers ◽  
Functional Materials ◽  
Controlled Drug Release ◽  
Biological Functions ◽  
Oral Diseases ◽  
Wide Range ◽  
Anti Cancer ◽  
Functional Nanofibers ◽  
Tissue Restoration

With the increase of consumption of high-sugar foods, beverages, tobacco, and alcohol, the incidence rate of oral diseases has been increasing year by year. Statistics showed that the prevalence of oral diseases such as dental caries, dental pulpal disease, and periodontal disease has reached as high as 97% in 2015 in China. It is thus urgent to develop functional materials or products for the treatment of oral diseases. Electrospinning has been a widely used technology that is capable of utilizing polymer solution to generate micro/nano fibers under an appropriate high voltage condition. Owing to their excellent structures and biological performances, materials prepared by electrospinning technology have been used for a wide range of oral-related applications, such as tissue restoration, controlled drug release, anti-cancer, etc. In this regard, this article reviews the application and progress of electrospun nanofibers to various oral diseases in recent years. Firstly, engineering strategies of a variety of nanofiber structures together with their resultant functions will be introduced. Then, biological functions of electrospun nanofibers as well as their applications in the treatment of oral diseases are summarized and demonstrated. Finally, the development viewpoint of functional nanofibers is prospected, which is expected to lay the foundation and propose the direction for further clinical application.

Oral Health Status in Relation to Nutritional Status among 9 years old school Children in Dewanyiah City/Iraq

2019 ◽  
Vol 14 (1) ◽  
pp. 80
Author(s):  
Dr. Zahraa Ali Al-Awadi ◽  
Dr. Baydaa Hussien Hussien
Keyword(s):  
Oral Health ◽  
Dental Caries ◽  
Nutritional Status ◽  
Oral Health Status ◽  
Health Condition ◽  
Primary Dentition ◽  
Anthropometric Measurement ◽  
Oral Diseases ◽  
Gingival Health ◽  
Significant Difference

Background: Although they are not life threatening, dental caries and periodontaldisease are the most predominant and widely spread oral diseases throughout theworld. The aims of the study included the investigation of the prevalence andseverity of dental caries, gingivitis and dental plaque in relation to gender,furthermore, nutritional status was assessed in relation to oral health condition(dental caries).Materials and Methods: This oral health survey was conducted among primaryschool children aged 9 years old in Dewanyiah city in Iraq. The total samplecomposed of 600 child (320 males and 280 females) selected randomly fromdifferent school in Dewanyiah city. Diagnosis of dental caries was according tothe criteria described by WHO (1987). Plaque index of Silness and Loe (1964)was used for plaque assessment, gingival index of Loe and Silness (1963) wasfollowed for recording gingival health condition. Nutritional status was assessedaccording to body mass index (BMI) indicator using anthropometric measurement(height and weight).Results: Results showed that the prevalence of dental caries was 85% for 9 year-oldschool children. Regarding primary and permanent dentition, dental caries washigher among females compared to males with statistically significant difference(P<0.05) for primary dentition, on the other hand, males showed higher values offilled surfaces compared to females with statistically significant difference(P<0.05) for primary dentition and highly significant difference (P<0.01) forpermanent dentition. Finding of this study revealed that 100% of the children hadgingival inflammation. Furthermore, the values of plaque and gingival indiceswere higher among males compared to females with statistically highly significantdifferences (P<0.01). In current study, the prevalence of malnutrition described bythe BMI indicator was 5.3%. For total samples no significant difference wasrecorded in dmfs /DMFS values among wasting and well nourished children(P>0.05).Conclusion: A high prevalence of dental caries and gingivitis were recorded.Improvement in the prevention educational programs is needed among schoolchildren.

Formulation and evaluation of herbal tooth powder for oral care

2020 ◽  
Vol 8 (1) ◽  
pp. 1-5
Author(s):  
Bharathi M ◽  
Rajalingam D ◽  
Vinothkumar S ◽  
Artheeswari R ◽  
Kanimozhi R ◽  
...  
Keyword(s):  
Dental Caries ◽  
Tooth Loss ◽  
Oral Care ◽  
Mustard Oil ◽  
Tooth Decay ◽  
Normal Flora ◽  
Opportunistic Bacteria ◽  
Wide Range ◽  
Acid Producing Bacteria ◽  
Streptococcus Mutants

Herbal tooth powders consisting of various ingredients that are available in the market in a wide range. Hence modern methods focusing on these aspects are useful for the standardization of herbs and their formulations. Consumers believed by using herbal-based toothpowders are safe, effective, and less toxic. This study is thus aimed to provide an alternative to the consumer and formulate herbal tooth powder using Clove, Neem Stem, Acacia Stem, Stevia Leaf, Mustard Oil, Salt, Ginger and Amla. The oral cavity infections are the most common types of infections. Dental caries is an infectious disease, causes damage and infection of enamel and dentine. If it is not treated, the infection continues and will lead to tooth loss. The mouth contains normal flora of opportunistic bacteria that are normally non-pathogenic. The imbalance of this situation causes infection and tooth decay. Streptococcus mutants are considered as the main species involved in the development of dental caries. S. mutants, acid-producing bacteria, causes fermentation of carbohydrates which results in tooth decay. Therefore, in the present work, the following aspects of Herbal tooth powders were planned for the formulation, standardization of herbal tooth powder, and anti-bacterial screening of the extracts of herbal tooth powder. 

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

Phyto-Facilitated Bimetallic ZnFe2O4 Nanoparticles via Boswellia carteri: Synthesis, Characterization and Anti-Cancer Activity.

2020 ◽  
Vol 21 ◽  
Author(s):  
Amer Imraish ◽  
Afnan Al-Hunaiti ◽  
Tuqa Abu-Thiab ◽  
Abed Al-Qader Ibrahim ◽  
Eman Hwaitat ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Metallic Nanoparticles ◽  
Bimetallic Nanoparticles ◽  
Iron Chloride ◽  
Nano Particles ◽  
Adverse Side Effect ◽  
Wide Range ◽  
Anti Cancer ◽  
Znfe2o4 Nanoparticles

Background: The growing unsatisfaction toward the available traditional chemotherapeutic agents enhanced the need to develop new methods for obtaining materials with more effective and safe anti-cancer properties. Over the past few years, usage of metallic nanoparticles has been a target for researchers of different scientific and commercial fields due to their tiny sizes, environment friendly properties and wide range applications. To overcome the obstacles of traditional physical and chemical methods for synthesis of such nanoparticles, a new less expensive and eco-friendly method has been adopted using natural existing organisms as a reducing agent to mediate synthesis of the desired metallic nanoparticles from their precursors, a process called green biosynthesis of nanoparticles. Objective: Here in the present study, zinc iron bimetallic nanoparticles (ZnFe2O4) were synthesized via an aqueous extract of Boswellia Carteri resin mixed with zinc acetate and iron chloride precursors, and they were tested for their anticancer activity. Methods: Various analytic methods were applied for the characterization of the Phyto synthesized ZnFe2O4 and they were tested for their anticancer activity against MDA-MB-231, K562, MCF-7 cancer cell lines and normal fibroblasts. Results: Our results demonstrate the synthesis of cubic structured bimetallic nanoparticles ZnFe2O4 with an average diameter 10.54 nm. MTT cytotoxicity assay demonstrate that our phyto-synthesized ZnFe2O4 nanoparticles exhibited a selective and potent anticancer activity against K562 and MDA-MB-231 cell lines with IC50 values 4.53 µM and 4.19 µM, respectively. Conclusion: In conclusion, our bio synthesized ZnFe2O4 nano particles show a promising environmentally friendly of low coast chemotherapeutic approach against selective cancers with a predicted low adverse side effect toward normal cells. Further in vivo advanced animal research should be done to execute their applicability in living organisms.

Circadian rhythms, sleep, and anti-cancer treatments

2018 ◽  
Author(s):  
Pasquale F. Innominato ◽  
David Spiegel
Keyword(s):  
Quality Of Life ◽  
Circadian Rhythms ◽  
Biological Functions ◽  
Cancer Treatments ◽  
Anti Cancer ◽  
Timing System ◽  
Physical Wellbeing ◽  
Circadian Timing System ◽  
Chemotherapy Agents

The circadian timing system temporally regulates biological functions relevant for psycho-physical wellbeing, spanning all the systems related to health. Hence, disruption of circadian rhythms, along with sleep cycles, is associated with the development of several diseases, including cancer. Moreover, altered circadian and sleep functions negatively impact on cancer patients’ quality of life and survival, above and beyond known determinants of outcome. This alteration can occur as a consequence of cancer, but also of anti-cancer treatments. Indeed, circadian rhythms govern also the ability of detoxifying chemotherapy agents across the 24 hours. Hence, adapting chemotherapy delivery to the molecular oscillations in relevant drug pathways can decrease toxicity to healthy cells, while increasing the number of cancer cells killing. This chronomodulated chemotherapy approach, together with the maintenance of proper circadian function throughtout the whole disease challenge, would finally result in safer and more active anticancer treatments, and in patients experiencing better quality and quantity of life.

Soames' & Southam's Oral Pathology

2018 ◽  
Author(s):  
Max Robinson ◽  
Keith Hunter ◽  
Michael Pemberton ◽  
Philip Sloan
Keyword(s):  
Skin Diseases ◽  
Oral Pathology ◽  
Pathological Features ◽  
Oral Diseases ◽  
Oral Medicine ◽  
Cross Sectional ◽  
Facial Region ◽  
Wide Range ◽  
Cross Sectional Imaging ◽  
Key Aspects

A sound understanding of clinical oral pathology is essential if a dental clinician is to navigate successfully through clinical guidelines, make timely referrals to specialists, and provide good care for patients. This new edition of Soames' & Southam's Oral Pathology provides a clear and friendly guide for students, practitioners, and the whole dental team. Thoroughly updated for today's clinical practice, this textbook covers 'must-know' oral pathology and integrates key aspects of oral medicine. It begins by explaining the principles of clinical assessment, the synthesis of a differential diagnosis, and the selection of further investigations including laboratory tests. Ten chapters bring this theory to life by looking at the clinical and pathological features of a wide range of common oral diseases including oral cancer, salivary gland disorders, and diseases of the jaws. Two new chapters address skin diseases affecting the oro-facial region and neck lumps. A final chapter highlights the importance of clinical oral pathology in the context of systemic human disease. New radiology content includes examples of cross-sectional imaging. Photomicrographs have been replaced with carefully selected images to illustrate key pathological features. Each chapter includes key points boxes and tables to aid learning. Written by experts in both oral pathology and oral medicine, this new edition is a must-have for dentistry students, and those working in the field, providing current and trustworthy information.

scholarly journals Virtual Screening and Biological Evaluation of Anti-Biofilm Agents Targeting LuxS in the Quorum Sensing System

2021 ◽  
Vol 16 (6) ◽  
pp. 1934578X2110196
Author(s):  
Zheng Liu ◽  
Lihua Zhang ◽  
Jincai Wang ◽  
Yanping Li ◽  
Yiqun Chang ◽  
...  
Keyword(s):  
Dental Caries ◽  
Quorum Sensing ◽  
Biofilm Formation ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Oral Diseases ◽  
Traditional Use ◽  
New Approach ◽  
Sensing System ◽  
Plaque Biofilm

Biofilm formation is considered as a crucial factor in various oral diseases, such as dental caries. The quorum sensing (QS) signaling system was proved to have a crucial role in the microbial dental plaque biofilm formation of Streptococcus mutans ( S. mutans). LuxS was critical to regulating the QS system and survival of the bacterium, and, therefore, compounds which target LuxS may be a potential therapy for dental caries. The binding activities of 37,170 natural compounds to LuxS were virtually screened in this study. Baicalein and paeonol were chosen for further research of the binding mode and ΔG values with LuxS. Both baicalein and paeonol inhibited the biofilm formation without influence on the growth of S. mutans. Baicalein also distinctly reduced the production of both rhamnolipids and acids. The results provide us with a new approach to combat dental caries instead of the traditional use of antibacterial chemicals.

scholarly journals Characterizing Bacterial Cellulose Produced byKomagataeibacter sucrofermentans H-110 on Molasses Medium and Obtaining a Biocomposite Based on It for the Adsorption of Fluoride

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1422
Author(s):  
Viktor V. Revin ◽  
Alexander V. Dolganov ◽  
Elena V. Liyaskina ◽  
Natalia B. Nazarova ◽  
Anastasia V. Balandina ◽  
...  
Keyword(s):  
Composite Material ◽  
Adsorption Capacity ◽  
Bacterial Cellulose ◽  
Functional Materials ◽  
Degree Of Crystallinity ◽  
Maximum Adsorption Capacity ◽  
Fluoride Ions ◽  
Sorption Ability ◽  
Wide Range ◽  
Biocomposite Material

Currently, there is an increased demand for biodegradable materials in society due to growing environmental problems. Special attention is paid to bacterial cellulose, which, due to its unique properties, has great prospects for obtaining functional materials for a wide range of applications, including adsorbents. In this regard, the aim of this study was to obtain a biocomposite material with adsorption properties in relation to fluoride ions based on bacterial cellulose using a highly productive strain of Komagataeibacter sucrofermentans H-110 on molasses medium. Films of bacterial cellulose were obtained. Their structure and properties were investigated by FTIR spectroscopy, NMR, atomic force microscopy, scanning electron microscopy, and X-ray structural analysis. The results show that the fiber thickness of the bacterial cellulose formed by the K. sucrofermentans H-110 strain on molasses medium was 60–90 nm. The degree of crystallinity of bacterial cellulose formed on the medium was higher than on standard Hestrin and Schramm medium and amounted to 83.02%. A new biocomposite material was obtained based on bacterial cellulose chemically immobilized on its surface using atomic-layer deposition of nanosized aluminum oxide films. The composite material has high sorption ability to remove fluoride ions from an aqueous medium. The maximum adsorption capacity of the composite is 80.1 mg/g (F/composite). The obtained composite material has the highest adsorption capacity of fluoride from water in comparison with other sorbents. The results prove the potential of bacterial cellulose-based biocomposites as highly effective sorbents for fluoride.

scholarly journals Oral health problems in high-performance athletes at 2019 Pan American Games in Lima: a descriptive study

BDJ Open ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Catalina Opazo-García ◽  
Jeel Moya-Salazar ◽  
Karina Chicoma-Flores ◽  
Hans Contreras-Pulache
Keyword(s):  
Oral Health ◽  
Dental Caries ◽  
Dental Care ◽  
Disease Surveillance ◽  
High Performance ◽  
Elite Athletes ◽  
Periodontal Diseases ◽  
Health Problems ◽  
Oral Diseases ◽  
Pan American

Abstract Introduction Dental care is provided for high-performance athletes at national and international sports events. Elite athletes may seek care for sports-related injuries and pre-existing oral diseases. Previous studies indicate an association between oral health problems and negative performance impacts in elite athletes. Objectives To determine the prevalence of the most common oral pathologies in high-performance athletes during the emergency dental care performed at the Lima 2019 Pan American Games (JPL-19). Methodology All reports of athletes (≥18 years old, of both sexes, from 41 countries) who received emergency dental care at Pan American Villas during the JPL-19 were included. Injuries and types of oral diseases were classified according to the Injury and Disease Surveillance System proposed by the International Olympic Committee. Results Of the 6680 participating athletes, 76 (1.14%) presented as dental emergencies, 90.8% (69/76) of the athletes seen presented pre-existing oral pathological conditions, the most frequent were periodontal diseases (34%, 26/76) and dental caries (29%, 22/76). Among the sports with the most cases, there were 22 (29%) in athletics, 6 (8%) in soccer, and 6 (8%) in taekwondo. The most frequent dental emergencies came from Peru, Puerto Rico, Bahamas, Grenada, and Venezuela. Conclusions Pre-existing oral diseases were more frequent than sports-related accidents. The most prevalent diseases were periodontal disease and dental caries disease. It is necessary to implement new care strategies for athletes, based on prevention, before and during sports competitions.

scholarly journals Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1125
Author(s):  
Raluca Nicu ◽  
Florin Ciolacu ◽  
Diana E. Ciolacu
Keyword(s):  
Rapid Development ◽  
Cellulose Nanofibrils ◽  
Functional Materials ◽  
Medical Applications ◽  
Bacterial Nanocellulose ◽  
Green Materials ◽  
Wide Range ◽  
In Vivo Cytotoxicity

Nanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been designed based on the most desirable properties of NCs, such as biocompatibility, biodegradability, and their special physicochemical properties. In this context and under the pressure of rapid development of this field, it is imperative to synthesize the successes and the new requirements in a comprehensive review. The first part of this work provides a brief review of the characteristics of the NCs (cellulose nanocrystals—CNC, cellulose nanofibrils—CNF, and bacterial nanocellulose—BNC), as well as of the main functional materials based on NCs (hydrogels, nanogels, and nanocomposites). The second part presents an extensive review of research over the past five years on promising pharmaceutical and medical applications of nanocellulose-based materials, which have been discussed in three important areas: drug-delivery systems, materials for wound-healing applications, as well as tissue engineering. Finally, an in-depth assessment of the in vitro and in vivo cytotoxicity of NCs-based materials, as well as the challenges related to their biodegradability, is performed.

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