Plant Feed Additives as Natural Alternatives to the Use of Synthetic Antioxidant Vitamins on Livestock Mammals’ Performances, Health, and Oxidative Status: A Review of the Literature in the Last 20 Years

In the last two decades, the interest in natural plant feed additives (PFA) as alternatives to synthetic vitamins in livestock nutrition has increased. After a systematic review, a total of 19 peer-reviewed papers published between 2000 and 2020 were retained to evaluate the antioxidant effects of PFA compared to synthetic antioxidant vitamins (mainly vitamin E; VitE) in livestock nutrition. These studies demonstrated that PFAs could be as efficient as VitE in counteracting oxidative stress in pigs, rabbits, and ruminants. However, PFAs only positively affected animals’ growth performance and feed efficiency in some monogastric studies. The PFA can affect antioxidant enzyme activity in a dose- and method of administration-dependent manner. The antioxidant capacity of both PFA and VitE were depressed in cows fed with diets rich in polyunsaturated fatty acids. Variability among studies could be related to species differences. Despite the interest of the feed industry sector in PFA, there are still very few studies evaluating their antioxidant effect in species other than poultry.

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Plant Feed Additives as Natural Alternatives to the Use of Synthetic Antioxidant Vitamins on Yield, Quality, and Oxidative Status of Poultry Products: A Review of the Literature of the Last 20 Years

Antioxidants ◽

10.3390/antiox10050757 ◽

2021 ◽

Vol 10 (5) ◽

pp. 757

Author(s):

Rosario Pitino ◽

Massimo De Marchi ◽

Carmen L. Manuelian ◽

Marion Johnson ◽

Marica Simoni ◽

...

Keyword(s):

Scientific Evidence ◽

Feed Additives ◽

Antioxidant Vitamins ◽

Biologically Active ◽

Partial Substitution ◽

Synthetic Antioxidant ◽

Poultry Products ◽

Fatty Acids Profile ◽

Organoleptic Characteristics ◽

Poultry Diets

Scientific evidence demonstrates that plant feed additives (PFA) can be a viable alternative to synthetic antioxidant vitamins in poultry nutrition. PFA are represented by plants, essential oils, plant extracts, and by-products from herbal or crop processing. The use of PFA in the feed industry has increased in recent years as their biologically active compounds (polyphenols) have demonstrated antimicrobial and antioxidant effects in food-producing animals. However, few trials have directly compared the effects of PFA with synthetic vitamins. After a systematic literature review of studies comparing the effects of PFA and synthetic vitamins on poultry products in the last 20 years (2000–2020), a total of 44 peer-reviewed articles were included in the present work. A positive effect of PFA on poultry products’ oxidative stability during storage, organoleptic characteristics, and fatty acids profile has been observed without a specific impact on their performances. The effects of PFA are variable but often similar to those of vitamin E, suggesting the opportunity for a partial substitution of the latter in poultry diets.

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Plant Feed Additives as Natural Alternatives to the Use of Synthetic Antioxidant Vitamins on Poultry Performances, Health, and Oxidative Status: A Review of the Literature in the Last 20 Years

Antioxidants ◽

10.3390/antiox10050659 ◽

2021 ◽

Vol 10 (5) ◽

pp. 659

Author(s):

Federico Righi ◽

Rosario Pitino ◽

Carmen L. Manuelian ◽

Marica Simoni ◽

Afro Quarantelli ◽

...

Keyword(s):

Positive Impact ◽

Feed Additives ◽

Antioxidant Vitamins ◽

Synthetic Antioxidant ◽

Negative Effects ◽

Nutritional Strategy ◽

Growth Performances ◽

Poultry Diets ◽

Plant Processing ◽

Dose Dependent

Plant feed additives (PFA) such as essential oils, extracts, and by-products from plant processing can be included in poultry diets. A total of 39 peer-reviewed articles were selected from the literature published in the last 20 years (2000–2020) comparing PFA antioxidant effects with synthetic antioxidant vitamins (mainly vitamin E) in poultry nutrition. The PFA can be used as an effective nutritional strategy to face poultry’s oxidative stress with positive impact also on their productivity and efficiency. They can partially or completely replace antioxidant synthetic vitamins (the latter administered at doses between 150 and 500 mg/kg) in animal diets, sometimes affecting important physiological functions or expressing synergistic effect with the synthetic antioxidants. It is crucial to take into consideration the issues related to the absorption and the metabolism of these additives and their interaction with gut microbiota. However, some form- and dose-dependent negative effects on growth performances are observed.

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SOME OBSERVATIONS ON THE USE OF FEED ADDITIVES IN CANADIAN ANIMAL PRODUCTION

Canadian Journal of Animal Science ◽

10.4141/cjas79-041 ◽

1979 ◽

Vol 59 (2) ◽

pp. 333-337

Author(s):

T. F. SHARBY

Keyword(s):

Veterinary Medicine ◽

Feed Efficiency ◽

Antibiotic Use ◽

Feed Additives ◽

Health Hazards ◽

Potential Health ◽

Animal Agriculture ◽

Animal Feeds ◽

Control Disease ◽

And Control

Antibiotics have been used in animal feeds for almost 30 yr to improve growth, enhance feed efficiency, and control disease in birds and animals. In 1974 antibiotics used in animal feeds in Canada totalled 13.31 million dollars while those used in veterinary medicine totalled 28.8 million dollars. Antibiotics, sulfonamides and antibacterials used in human application that same year equalled 77.4 million dollars. Concerns regarding potential health hazards to humans with continued low-level antibiotic supplementation of animal feeds have resulted in a number of countries implementing or proposing more rigid legislation covering antibiotic use in animal agriculture. Possible consequences of such legislation being introduced in Canada are discussed.

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Review: Peluang Pengembangan Imbuhan Pakan Fitogenik Sebagai Pengganti Antibiotika dalam Ransum Ayam Pedaging di Indonesia

Jurnal Ilmu dan Teknologi Peternakan Tropis ◽

10.33772/jitro.v6i2.7139 ◽

2019 ◽

Vol 6 (2) ◽

pp. 188

Author(s):

Cecep Hidayat ◽

Rahman Rahman

Keyword(s):

Broiler Chicken ◽

Scientific Literature ◽

Feed Additives ◽

Feed Additive ◽

Growth Promoter ◽

Literature Study ◽

The Third ◽

Feed Industry ◽

Broiler Diet ◽

Main Support

ABSTRAK Seiring dengan telah dilarangnya penggunaan antibiotic growth promotor (AGP) dalam pakan oleh pemerintah Indonesia, maka pencarian pengganti AGP mejadi penting saat ini. Imbuhan pakan fitogenik menjadi salah satu pengganti AGP potensial. Makalah ini ditulis untuk mengungkap peluang pengembangan imbuhan pakan fitogenik sebagai pengganti AGP dalam ransum ayam pedaging di Indonesia. Metode penulisan makalah dilakukan dengan beberapa tahapan. Tahapan pertama, tahap persiapan, dilakukan dengan mengumpulkan dan membaca jurnal, makalah prosiding, buku yang diperoleh dari hasil dari pencarian pada internet. Dilanjutkan dengan memilih dan menentukan jurnal hasil penelitian, makalah ilmiah pada prosiding, buku terkait dengan topik yang sudah ditentukan. Tahapan ke dua, penyusunan outline makalah yang akan ditulis, dimana pada tahapan ini untuk menentukan skema berfikir penulis terkait dengan topik yang akan di bahas. Tahapan ke tiga, mengembangkan kerangka makalah dengan menggunakan literatur ilmiah, teori, hasil penelitian yang sudah diperoleh. Tahapan ke empat, pemeriksaan terhadap isi makalah yang sudah ditulis, baik secara substansi maupun redaksional. Berdasarkan studi pustaka yang dilakukan disimpulkan bahwa imbuhan pakan fitogenik dari berbagai jenis tanaman potensial digunakan sebagai pengganti AGP dalam pakan ayam pedaging. Kebutuhan akan daging ayam nasional yang semakin tinggi setiap tahunnya, menjadi peluang betapa besarnya pasar akan kebutuhan pengganti AGP di Indonesia. Sinergisme antara lembaga penelitian-perguruan tinggi dengan pelaku industri pakan dan imbuhan pakan menjadi penopang utama dalam pengembangan imbuhan pakan fitogenik di Indonesia.Kata Kunci: imbuhan pakan fitogenik, ayam pedagingABSTRACTKeywords: pytogenic feed additive, broiler chicken The use of antibiotic growth promoter (AGP) in feed has been banned by the Indonesian government. Therefore, the search for alternative AGP continues to be carried out. The addition of phytogenic is one of the potential alternatives because it has the same ability as AGP. This paper was written to reveal the opportunities for developing phytogenic feed additives as a substitute for antibiotics in broiler diet in Indonesia. The method of writing this paper was done in several stages. The first stage, the preparation, is done by searching and reading journals, proceedings, books obtained from the internet. The second method is the preparation of the outline of the paper to be written, to determine the author's thinking scheme related to the topic to be discussed. The third method is developing a framework of thought by using scientific literature obtained and read before. Fourth method is examination of the contents of papers that have been written, both substantially and editorially. Based on the literature study, it was concluded that the phytogenic feed additives from various types of plants should be considered as a substitute for AGP in broiler diet. The need for national chicken meat which is getting higher every year becomes an opportunity for how big the market will be for AGP's replacement in Indonesia. Synergism between university-research institutions and feed industry is the main support in developing phytogenic feed additives in Indonesia.Keywords: pytogenic feed additive, broiler chicken

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Feed Additives for Fattening Cattle

Proceedings of the British Society of Animal Production (1972) ◽

10.1017/s0308229600016184 ◽

1986 ◽

Vol 1986 ◽

pp. 112-112

Author(s):

M. Kay ◽

P.J. Broadbent ◽

E.A. Hunter

Keyword(s):

Beef Cattle ◽

Feed Efficiency ◽

Production Systems ◽

Soya Bean ◽

Feed Additives ◽

Grass Silage ◽

Bean Meal ◽

Ad Libitum ◽

Soya Bean Meal ◽

Daily Gain

Feed additives are widely used in beef production systems. Two trials were made to measure the effect of feed additives on the daily gain and feed efficiency of fattening beef cattle. In the first trial 48 Friesians and 48 weaned suckled calves weighing about 390 kg were fed individually on grass silage ad libitum together with 4 kg (Friesians) and 3 kg (weaned calves) bruised barley daily. The treatments were control (C), no additive; Avotan 150 mg/d (A); Flavomycin 45 mg/d (F) and Romensin 200 mg/d (R). Minerals and vitamins were given daily on the silage. In the second trial there were 240 Friesian and Exotic x Friesian bulls. They were housed on slats in groups of 15 and offered a mixture of bruised barley and soya bean meal ad libitum. The treatments were control, no additive; Flavomycin 50 mg/d, Romensin 210 mg/d and Salinomycin 150 mg/d. In trial 1 the steers were implanted with Ralgro and the heifers with Finaplix. No implants were used in the second trial. All the animals were weighed regularly and feed intake was recorded continuously. They were slaughtered when they achieved the required conformation and fat cover.

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Alleviation of Simvastatin-Induced Myopathy in Rats by the Standardized Extract of Ginkgo Biloba (EGb761): Insights into the Mechanisms of Action

Cells Tissues Organs ◽

10.1159/000507048 ◽

2019 ◽

Vol 208 (3-4) ◽

pp. 158-176

Author(s):

Amany R. Mahmoud ◽

Esam Omar Kamel ◽

Marwa A. Ahmed ◽

Esraa A. Ahmed ◽

Tarek Hamdy Abd-Elhamid

Keyword(s):

Ginkgo Biloba ◽

Muscle Performance ◽

Vehicle Group ◽

Control Group ◽

Dependent Manner ◽

Histopathological Changes ◽

Leaf Extracts ◽

Muscle Changes ◽

Dose Dependent ◽

Antioxidant Effects

Statins are the most widely prescribed cholesterol-lowering drugs to reduce the risk of cardiovascular diseases. Statin-induced myopathy is the major side effect of this class of drugs. Here, we studied whether standardized leaf extracts of ginkgo biloba (EGb761) would improve simvastatin (SIM)-induced muscle changes. Sixty Wistar rats were allotted into six groups: control group, vehicle group receiving 0.5% carboxymethyl cellulose (CMC) for 30 days, SIM group receiving 80 mg/kg/day SIM in 0.5% CMC orally for 30 days, SIM withdrawal group treated with SIM for 16 days and sacrificed 14 days later, and EGb761-100 and EGb761-200 groups posttreated with either 100 or 200 mg/kg/day EGb761 orally. Muscle performance on the rotarod, serum creatine kinase (CK), coenzyme Q10 (CoQ10), serum and muscle nitrite, muscle malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) activities were estimated. Additionally, muscle samples were processed for histopathological evaluation. We found that SIM decreased muscle performance on the rotarod, serum CoQ10, as well as muscle SOD and CAT activities while it increased serum CK, serum and muscle nitrite, as well as muscle MDA levels. SIM also induced sarcoplasmic vacuolation, splitting of myofibers, disorganization of sarcomeres, and disintegration of myofilaments. In contrast, posttreatment with EGb761 increased muscle performance, serum CoQ10, as well as muscle SOD and CAT activities while it reduced serum CK as well as serum and muscle nitrite levels in a dose-dependent manner. Additionally, EGb761 reversed SIM-induced histopathological changes with better results obtained by its higher dose. Interestingly, SIM withdrawal increased muscle performance on the rotarod, reduce serum CK and CoQ10, and reduced serum and muscle nitrite while it reversed SIM-induced histopathological changes. However, SIM withdrawal was not effective enough to restore their normal values. Additionally, SIM withdrawal did not improve SIM-induce muscle MDA, SOD, or CAT activities during the period studied. Our results suggest that EGb761 posttreatment reversed SIM-induces muscle changes possibly through its antioxidant effects, elevation of CoQ10 levels, and antagonizing mitochondrial damage.

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Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner

Oxidative Medicine and Cellular Longevity ◽

10.1155/2020/2452848 ◽

2020 ◽

Vol 2020 ◽

pp. 1-17

Author(s):

Jingya Gu ◽

Chang Chen ◽

Jue Wang ◽

Tingting Chen ◽

Wenjuan Yao ◽

...

Keyword(s):

Oxidative Stress ◽

Liver Fibrosis ◽

Withaferin A ◽

Dependent Manner ◽

Sirtuin 3 ◽

Antifibrogenic Effect ◽

Antioxidant Effects ◽

Sirt3 Expression ◽

Bioactive Constituent

Sirtuin 3 (SIRT3) is a deacetylase involved in the development of many inflammation-related diseases including liver fibrosis. Withaferin A (WFA) is a bioactive constituent derived from the Withania somnifera plant, which has extensive pharmacological activities; however, little is known about the regulatory role of SIRT3 in the WFA-induced antifibrogenic effect. The current study is aimed at investigating the role of SIRT3 in WFA-induced antioxidant effects in liver fibrosis. Our study verified that WFA attenuated platelet-derived growth factor BB- (PDGF-BB-) induced liver fibrosis and promoted PDGF-BB-induced SIRT3 activity and expression in JS1 cells. SIRT3 silencing attenuated the antifibrogenic and antioxidant effects of WFA in activated JS1 cells. Moreover, WFA inhibited carbon tetrachloride- (CCl4-) induced liver injury, collagen deposition, and fibrosis; increased the SIRT3 expression; and suppressed the CCl4-induced oxidative stress in fibrotic livers of C57/BL6 mice. Furthermore, the antifibrogenic and antioxidant effects of WFA could be available in CCl4-induced WT (129S1/SvImJ) mice but were unavailable in CCl4-induced SIRT3 knockout (KO) mice. Our study suggested that WFA inhibited liver fibrosis through the inhibition of oxidative stress in a SIRT3-dependent manner. WFA could be a potential compound for the treatment of liver fibrosis.

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Growth performance and gut health of Escherichia coli-challenged weaned pigs fed diets supplemented with a Bacillus subtilis direct-fed microbial

Translational Animal Science ◽

10.1093/tas/txaa172 ◽

2020 ◽

Vol 4 (3) ◽

Author(s):

Sangwoo Park ◽

Jung Wook Lee ◽

Kevin Jerez Bogota ◽

David Francis ◽

Jolie Caroline González-Vega ◽

...

Keyword(s):

Escherichia Coli ◽

Bacillus Subtilis ◽

Growth Performance ◽

Feed Efficiency ◽

Basal Diet ◽

Feed Additives ◽

Growth Promoter ◽

Gut Health ◽

Weaned Pigs ◽

E Coli

Abstract This study was conducted to investigate the effects of a direct-fed microbial (DFM) product (Bacillus subtilis strain DSM 32540) in weaned pigs challenged with K88 strain of Escherichia coli on growth performance and indicators of gut health. A total of 21 weaned pigs [initial body weight (BW) = 8.19 kg] were housed individually in pens and fed three diets (seven replicates per diet) for 21 d in a completely randomized design. The three diets were a corn-soybean meal-based basal diet without feed additives, a basal diet with 0.25% antibiotics (neo-Oxy 10-10; neomycin + oxytetracycline), or a basal diet with 0.05% DFM. All pigs were orally challenged with a subclinical dose (6.7 × 108 CFU/mL) of K88 strain of E. coli on day 3 of the study (3 d after weaning). Feed intake and BW data were collected on days 0, 3, 7, 14, and 21. Fecal scores were recorded daily. On day 21, pigs were sacrificed to determine various indicators of gut health. Supplementation of the basal diet with antibiotics or DFM did not affect the overall (days 0–21) growth performance of pigs. However, antibiotics or DFM supplementation increased (P = 0.010) gain:feed (G:F) of pigs during the post-E. coli challenge period (days 3–21) by 23% and 24%, respectively. The G:F for the DFM-supplemented diet did not differ from that for the antibiotics-supplemented diet. The frequency of diarrhea for pigs fed a diet with antibiotics or DFM tended to be lower (P = 0.071) than that of pigs fed the basal diet. The jejunal villous height (VH) and the VH to crypt depth ratio (VH:CD) were increased (P < 0.001) by 33% and 35%, respectively, due to the inclusion of antibiotics in the basal diet and by 43% and 41%, respectively due to the inclusion of DFM in the basal diet. The VH and VH:CD for the DFM-supplemented diet were greater (P < 0.05) than those for the antibiotics-supplemented diet. Ileal VH was increased (P < 0.05) by 46% due to the inclusion of DFM in the basal diet. The empty weight of small intestine, cecum, or colon relative to live BW was unaffected by dietary antibiotics or DFM supplementation. In conclusion, the addition of DFM to the basal diet improved the feed efficiency of E. coli-challenged weaned pigs to a value similar to that of the antibiotics-supplemented diet and increased jejunal VH and VH:CD ratio to values greater than those for the antibiotics-supplemented diet. Thus, under E. coli challenge, the test DFM product may replace the use of antibiotics as a growth promoter in diets for weaned pigs to improve feed efficiency and gut integrity.

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Antioxidant Effects of Ocimum Gratissimum Leaf Essential Oils as a Supplement to Extender on Chilled Canine Sperm Quality

10.21203/rs.3.rs-26157/v1 ◽

2020 ◽

Author(s):

Vui Van Nguyen ◽

Samorn Ponchunchoovong ◽

Sajeera Kupittayanant ◽

Pakanit Kupittayanant

Keyword(s):

Essential Oils ◽

Sperm Quality ◽

Antioxidant Properties ◽

Quality Parameters ◽

Control Group ◽

Dependent Manner ◽

Ocimum Gratissimum ◽

Significant Difference ◽

Antioxidant Effects

Abstract Background:Oxidative stress during chilled storage is a major problem withcanine sperm. To improve the quality of chilled canine sperm during storage, many synthetic antioxidants have been examined, but different outcomes were investigated depending on antioxidant properties. The bioactive compounds of essential oils fromOcimum gratissimumleaves are known as a natural antioxidant source. This study aimed to evaluate the antioxidant effects of essential oils from Ocimum gratissimumleavesas a supplement in extender on chilled canine sperm during 12 days of storage. Results:The results showed thatlow concentrations of Ocimum gratissimum essential oils (25, 50, and 100µg/mL) have beneficial effectson sperm quality, whereasOcimum gratissimumessential oils athigh levels (above 200µg/mL) have harmful effects. Specifically, the addition of 100µg/mL ofOcimum gratissimum essential oilsto the extender had the greatestbeneficial effect in improving the quality of chilled canine sperm, and had a significant difference in all sperm quality parameters except motility when compared to the control group (p<0.05). Conclusions:Ocimum gratissimum essential oilshave an impact on chilled canine sperm quality in a dose-dependent manner, and the best results areachieved with a maximum dose ofOcimum gratissimum essential oils of 100µg/mL.

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Feed Additives and Feed Industry

Journal of Synthetic Organic Chemistry Japan ◽

10.5059/yukigoseikyokaishi.23.171 ◽

1965 ◽

Vol 23 (2) ◽

pp. 171-176

Author(s):

Tetsusaburo NISHIKAWA

Keyword(s):

Feed Additives ◽

Feed Industry

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