The Role of Arginine in Disease Prevention, Gut Microbiota Modulation, Growth Performance and the Immune System of Broiler Chicken – A Review

AbstractThe effect of dietary arginine on disease prevention, immune system modulation, the gut micro-biota composition and growth of broiler chicken was reviewed. The main aim of poultry production is the maximization of profit at the least possible cost. This objective can mainly be achieved by ensuring that there is no interference in growth or disease outbreak and by feeding chicken with the best possible level of nutrients. With the ban on antibiotic growth promoters, attention is shifted towards other nutrition methods to prevent diseases and promote growth. More attention is therefore given to protein diets in animal nutrition due to their importance as essential part of active biological compounds in the body, assisting in the breakdown of body tissue and helping in the physiological processes of the animal. Arginine plays important function in serving as building blocks of proteins and polypeptides. It performs other roles during the regulation of important biochemical functions such as maintenance, growth, reproduction and immunity. Arginine cannot be synthesized by the body so it has to be supplemented in the diet. When arginine is supplemented above the recommended level, the gut mucosa is protected, immunosuppression is alleviated, diseases like necrotic enteritis, infectious bursal disease and coccidiosis in broiler chickens are prevented. There is an improvement in growth resulting from the increase in intestinal absorption, barrier function and microbiota composition.

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Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics

AMB Express ◽

10.1186/s13568-020-01153-w ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Danish Sharafat Rajput ◽

Dong Zeng ◽

Abdul Khalique ◽

Samia Sharafat Rajput ◽

Hesong Wang ◽

...

Keyword(s):

Broiler Chickens ◽

Production Systems ◽

Economic Losses ◽

Necrotic Enteritis ◽

Poultry Production ◽

Gut Health ◽

Growth Promoters ◽

Broiler Performance ◽

Antibiotic Growth Promoters ◽

Microbial Strains

AbstractNecrotic enteritis (NE) is being considered as one of the most important intestinal diseases in the recent poultry production systems, which causes huge economic losses globally. NE is caused by Clostridium perfringens, a pathogenic bacterium, and normal resident of the intestinal microflora of healthy broiler chickens. Gastrointestinal tract (GIT) of broiler chicken is considered as the most integral part of pathogen’s entrance, their production and disease prevention. Interaction between C. perfringens and other pathogens such as Escherichia coli and Salmonella present in the small intestine may contribute to the development of NE in broiler chickens. The antibiotic therapy was used to treat the NE; however European Union has imposed a strict ban due to the negative implications of drug resistance. Moreover, antibiotic growth promoters cause adverse effects on human health as results of withdrawal of antibiotic residues in the chicken meat. After restriction on use of antibiotics, numerous studies have been carried out to investigate the alternatives to antibiotics for controlling NE. Thus, possible alternatives to prevent NE are bio-therapeutic agents (Probiotics), prebiotics, organic acids and essential oils which help in nutrients digestion, immunity enhancement and overall broiler performance. Recently, probiotics are extensively used alternatives to antibiotics for improving host health status and making them efficient in production. The aim of review is to describe a replacement to antibiotics by using different microbial strains as probiotics such as bacteria and yeasts etc. having bacteriostatic properties which inhibit growth of pathogens and neutralize the toxins by different modes of action.

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Use of essential oils in broiler chicken production – a review

Annals of Animal Science ◽

10.1515/aoas-2016-0046 ◽

2017 ◽

Vol 17 (2) ◽

pp. 317-335 ◽

Cited By ~ 16

Author(s):

Michalina Adaszyńska-Skwirzyńska ◽

Danuta Szczerbińska

Keyword(s):

Essential Oils ◽

Broiler Chickens ◽

The Body ◽

Feed Consumption ◽

Poultry Production ◽

Growth Promoters ◽

Plant Metabolites ◽

Natural Substances ◽

Enhanced Production ◽

Antibiotic Growth Promoters

Abstract Biological activity of volatile plant metabolites is the property that can potentially find application in animal nutrition. Nowadays, the use of bioactive compounds is encouraged in many areas of industry and agriculture, since these substances have similar properties as withdrawn antibiotic growth promoters. Meat poultry production is focused on the maximization of performance parameters, namely rapid chicken growth with low feed consumption, and with the optimum health status of the flock. Essential oils can stimulate the growth and functioning of the body, which translates into both chicken’s health and enhanced production parameters. The substances are characterized by a range of effects, are easily biodegradable, and do not usually require a waiting period - hence they can be used in breeding broiler chickens. Given the increasing restrictions imposed on poultry production in terms of food safety and ethical aspects of husbandry, it seems appropriate to look for the use of new, natural substances to be applied in animal production. The article presents the characteristics of essential oils in this context, with a particular focus on their antimicrobial and immunostimulatory properties. The paper also describes production applications of essential oils tested in experiments on hybrid Ross 308 and Cobb 500 chickens.

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Involvement of Probiotics and Postbiotics in the Immune System Modulation

Biologics ◽

10.3390/biologics1020006 ◽

2021 ◽

Vol 1 (2) ◽

pp. 89-110

Author(s):

Neslihan Yeşilyurt ◽

Birsen Yılmaz ◽

Duygu Ağagündüz ◽

Raffaele Capasso

Keyword(s):

Immune System ◽

Pharmaceutical Industry ◽

Intestinal Microbiota ◽

Health Benefits ◽

The Body ◽

Future Research ◽

Immune Systems ◽

Advantages And Disadvantages ◽

Immune System Modulation ◽

Molecular Patterns

Intestinal microbiota interacts with other systems, especially the immune system, which is responsible for protecting the body by recognizing “stranger” (pathogen associated molecular patterns-PAMPs) and “danger” (damage-associated molecular patterns-DAMPs) molecular motifs. In this manner, it plays an important role in the pathogenesis of various diseases and health. Despite the use of probiotics that modulate the intestinal microbiota in providing health benefits and in the treatment of diseases, there are some possible concerns about the possibility of developing adverse effects, especially in people with suppressed immune systems. Since probiotics provide health benefits with bioactive compounds, studies are carried out on the use of products containing non-living probiotic microorganisms (paraprobiotics) and/or their metabolites (postbiotics) instead of probiotic products. It is even reported that these microbial compounds have more immunomodulatory activities than living microorganisms via some possible mechanism and eliminates some disadvantages of probiotics. Considering the increasing use of functional foods in health and disease, further studies are needed with respect to the benefits and advantages of parabiotic and/or postbiotic use in the food and pharmaceutical industry as well as immune system modulation. Although probiotics have been extensive studied for a long time, it seems that postbiotics are promising tools for future research and applications according to the recent literature. This review aimed to evaluate the interaction of probiotics and postbiotics with the immune systems and also their advantages and disadvantages in the area of food-pharmaceutical industry and immune system modulation.

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BIOLOGICAL EFFECTS OF SILICON OXIDE NANOPARTICLES ON BROILER CHICKEN

Bulletin Samara State Agricultural Academy ◽

10.12737/37342 ◽

2020 ◽

Vol 5 (2) ◽

pp. 63-71

Author(s):

Vladimir Nikulin ◽

Aleksandra Mustafina

Keyword(s):

Red Blood Cells ◽

Total Protein ◽

Blood Cells ◽

Broiler Chickens ◽

Broiler Chicken ◽

Silicon Oxide ◽

The Body ◽

Control Group ◽

The Third ◽

Experimental Group

The aim of the study is to increase the productive qualities of broiler chickens by including ultrafine silicon oxide into main diet. During the experiment, the biological effect of ultrafine silicon oxide on broiler chickens was estab-lished. Use of ultrafine SiO2 particles for poultry feeding contributed to an increase in the number of red blood cells and content of total protein and albumins. By the end of the experiment, the number of red blood cells in birds in-creased by 17.43% (P≤0.001) – in the blood of birds of the first experimental group, 16.51% (P≤0.01) – the second one, 20.80% (P≤0.001) – the third experimental and 21.71% (P≤0.001) – the fourth experimental group, compared with the indicator of the control group. The amount of total protein in blood serum of chickens of the first and the second experimental groups increased by 1.36-1.39 %, in the third and fourth ones there was a significant (P≤0.05) increase by 5.45 and 3.05%, respectively. The blood glucose content of chickens in the experimental groups is higher by 8.04-23.65% compared to this indicator with ones in the control group. During the experiment feed con-sumption per 1 kg gain of live weight decreased: in the first experimental group by 3.00 % in the second by – 0.50 %, the third – 6.00 % the fourth– by 4.50 %, compared to this with the control group. The chicken’s vibrancy of the first the experimental group was higher by 4.77 %, the second – by 6.20 %, the third – by 19.25 % and the fourth– by 11.59% than in the control one. Consequently, when converting the feed energy into the body energy of a broiler chicken, the energy conversion coefficient of the experimental group of poultry is higher than that of the control one by 7.16-21.76 %. Thus, the most optimal dose for further research was determined.

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Galacto-oligosaccharides modulate the juvenile gut microbiome and innate immunity to improve broiler chicken performance

10.1101/631259 ◽

2019 ◽

Cited By ~ 1

Author(s):

Philip J. Richards ◽

Geraldine M. Flaujac Lafontaine ◽

Phillippa L. Connerton ◽

Lu Liang ◽

Karishma Asiani ◽

...

Keyword(s):

Growth Rate ◽

Innate Immunity ◽

Broiler Chickens ◽

Broiler Chicken ◽

Control Diet ◽

Innate Immune ◽

Gut Health ◽

Feed Conversion ◽

Growth Promoters ◽

Key Species

ABSTRACTImprovements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides in broiler feed enhanced the growth rate and feed conversion of chickens relative to a calorie-matched control diet. Comparison of the cecal microbiota identified key differences in abundance ofLactobacillusspp. Increased levels ofL. johnsoniiin GOS-fed juvenile birds at the expense ofL. crispatuswas linked to improved performance (growth rate and market weight). Investigation of the innate immune responses highlighted increases of ileal and cecal IL-17A gene expression counterposed to a decrease in IL-10 and IL-17F. Quantification of the autochthonousLactobacillusssp. revealed a correlation between bird performance andL. johnsoniiabundance. Shifts in the cecal populations of keyLactobacillusspp. of juvenile birds primed intestinal innate immunity without harmful pathogen challenge.IMPORTANCEImprovements in the growth rate of broiler chickens can be achieved through dietary manipulation of the naturally occurring bacterial populations whilst mitigating the withdrawal of antibiotic growth promoters. Prebiotic galacto-oligosaccharides (GOS) are manufactured as a by-product of dairy cheese production, which can be incorporated in the diets of juvenile chickens to improve their health and performance. This study investigates the key mechanisms behind this progression and pin pointsL. johnsoniias a key species that facilitates the enhancements in growth rate and gut health. It also relates the role of the innate immune system in the response to the GOS diet.

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Broiler surface temperature distribution of 42 day old chickens

Scientia Agricola ◽

10.1590/s0103-90162010000500001 ◽

2010 ◽

Vol 67 (5) ◽

pp. 497-502 ◽

Cited By ~ 39

Author(s):

Irenilza de Alencar Nääs ◽

Carlos Eduardo Bites Romanini ◽

Diego Pereira Neves ◽

Guilherme Rodrigues do Nascimento ◽

Rimena do Amaral Vercellino

Keyword(s):

Temperature Distribution ◽

Surface Temperature ◽

Air Temperature ◽

Broiler Chickens ◽

Broiler Chicken ◽

Growth Period ◽

The Body ◽

Body Parts ◽

Surface Temperature Distribution ◽

Thermographic Image

Broiler chickens in Brazil are generally reared from 1 to 42 days when they are exposed to procedures such as fasting, harvesting, crating and transport to slaughter. Maintaining homeostasis is of great importance for broiler survival under harsh environment especially prior to slaughter. Heat loss varies in the distinct parts of the body during the growth period, and it is related to the air temperature of the environment and to the amount of feather covering. This research aimed to study the surface temperature distribution using infrared thermographic image processing to characterize 42 day old broiler chicken surface temperature prior to slaughter. Broilers were reared for 42 days and prior to harvest and transport to slaughter the infrared surface temperature was recorded along the day. Data from the thermograms taken in feather and featherless regions were compared during the 42nd day of growth. High correlation between featherless regions and air temperature was found showing that these areas respond fast to changes in the rearing environment. Two functions were developed for predicting both surface temperature for featherless and feather covered areas of the broiler body parts.

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An effect of anti-stress feed additives on broiler productivity and meat quality

Theory and practice of meat processing ◽

10.21323/2414-438x-2020-5-2-4-11 ◽

2020 ◽

Vol 5 (2) ◽

pp. 4-11 ◽

Cited By ~ 1

Author(s):

E. A. Miftakhutdinova ◽

S. L. Tikhonov ◽

N. V. Tikhonova ◽

R. T. Timakova

Keyword(s):

Meat Quality ◽

Broiler Chickens ◽

Average Daily Gain ◽

Feed Additives ◽

The Body ◽

Feed Additive ◽

Lithium Content ◽

Poultry Production ◽

Broiler Meat ◽

Meat Productivity

The paper presents the study on an impact of feed additives Peak anti-stress and SPAO (SPAO-complex) with different lithium content on meat productivity and meat quality of broiler chickens. The feed additives exert a pronounced metabolic effect, have adaptogen properties and allow forming a mechanism that facilitates compensation of the expenditure of the body, which significantly increases upon stress development. It was established that the average daily gain of the broiler chickens increased by 1.8% and 4.3% on the background of using SPAO-complex and Peak anti-stress, respectively, compared to the broiler chickens that did not receive the feed additives in the daily diet. It was shown that addition of feed additives with lithium into a diet led to an improvement of the indices of broiler meat productivity and meat quality: a level of yield of the carcasses of the 1st category increased up to 56.2–79.1%, high organoleptic indices of meat were ensured, the protein content in white and red chicken meat increased and functional-technological properties of minced meat improved. The use of feed additives ensured profitability of industrial poultry production; the highest indices of profitability were established upon introduction of the feed additive Peak anti-stress into a diet — up to 8.67 rubles per each ruble of expenses. The obtained results of the study should be taken into consideration in the technological processes when raising broiler chickens.

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Residu Antibiotik Serta Keberadaan Escherichia Coli Penghasil ESBL pada Daging Ayam Broiler di Pasar Kota Purwokerto

JURNAL KESEHATAN LINGKUNGAN INDONESIA ◽

10.14710/jkli.20.2.137-142 ◽

2021 ◽

Vol 20 (2) ◽

pp. 137-142

Author(s):

Anriani Puspita Karunia Ning Widhi ◽

Imam Nafi Yana Saputra

Keyword(s):

Escherichia Coli ◽

Broiler Chickens ◽

Broiler Chicken ◽

Chicken Meat ◽

Primary Data ◽

Antibiotic Residues ◽

Growth Promoters ◽

E Coli ◽

Extended Spectrum ◽

Starting Point

Latar belakang: Pemenuhan kebutuhan pangan asal ternak yang berasal dari unggas memiliki angka konsumsi yang cukup tinggi salah satunya yaitu ayam broiler. Untuk memenuhi tingginya permintaan terhadap ayam broiler pada pakandiberifeed additiveserta antibiotic growth promotor (AGP) dalam bentuk antibiotik untuk mempercepat pertumbuhan dan daya tahan tubuh. Pemanfaatan antibiotik yang tidak bijak akan menimbulkan residu antibiotik serta resistensi Escherichia coli penghasil Extended Spectrum β-lactamase (ESBL).Metode: Penelitian ini termasuk penelitian deskriptif. Data primer diperoleh dari hasil screeningtest. Data ditunjukkan dalam tabel dangambar yang dibahas secara deskriptif. Variabel yang diamati residu antibiotik tetrasiklin serta E. coli penghasil ESBL pada daging ayam broiler.Hasil: Temuan terhadap residu antibiotik tetrasiklin pada daging ayam broiler yaitu sebesar 7,14% dengan rerata zona hambat 12,13 mm, sedangkan hasil identifikasi E. coli penghasil ESBL pada daging ayam broiler diperoleh hasil sebesar 71,4%.Simpulan:Residu antibiotik tetrasiklin dalam daging ayam broiler masih tergolong aman dapat dikonsumsi namun, temuanE. coli penghasil ESBL pada daging ayam broiler menimbulkan masalah kesehatan, baik bagi kesehatan hewan maupun manusia, serta dapat menimbulkan resistensi terhadap antibiotik. ABSTRACT Title: Broiler Chicken Meat Sold at Purwokerto's Market Has Antibiotic Residues and Escherichia Coli That Produces EsblBackground: Poultry, of which broiler chickens are one example, is a food source with a relatively high consumption rate.Feed additives and antibiotic growth promoters (AGP) in the form of antibiotics in the ration are given to increase broilers’ growth and endurance to meet the high demand for them. It is important to note that unwise antibiotic use results in the buildup of antibiotic residues and resistance to the Extended Spectrum Beta-lactamase(ESBL)produced by Escherichia coli bacterium.Method: To collect primary data for this descriptive study, the screening test results were employed as a starting point. Next, the information was presented in the form of tables and figures.Result: According to this study, broiler chickens had a tetracycline residue of 7.14 percent, with an inhibitory zone mean of 12.13 mm, and 71.4 percent of ESBL-producing E. coli.Conclusion:According to the study, broiler chicken meat with tetracycline residue is still safe to consume. E. coli, which is known to develop an antibiotic-resistant strain of E. coli ESBL) can cause serious health problems in both humans and animals.

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Dietary resin acid composition as a performance enhancer for broiler chickens

Journal of Applied Animal Nutrition ◽

10.1017/jan.2016.10 ◽

2017 ◽

Vol 5 ◽

Cited By ~ 9

Author(s):

H. Kettunen ◽

E. van Eerden ◽

K. Lipiński ◽

T. Rinttilä ◽

E. Valkonen ◽

...

Keyword(s):

Weight Gain ◽

Acid Composition ◽

Broiler Chickens ◽

Body Weight Gain ◽

Bacterial Species ◽

Resin Acid ◽

The Body ◽

Necrotic Enteritis ◽

Feed Conversion

SummaryResin acid composition (RAC) has previously been shown to inhibit the growth of the Gram-positive bacterial species Clostridium perfringens in vitro and to modulate the ileal microbiota of broiler chickens. The following trials examined the effect of RAC on broiler chickens in two experiments. In experiment 1, 1400 one-day-old Ross 308 broilers were divided into two coccidiostat treatments: chemical (CC) and ionophore (IC), which were further divided into two RAC dosages: 0 and 0.5 g/kg. All diets were supplemented with xylanase, β-glucanase and phytase feed enzymes. The birds were raised in a commercial-type environment without additional microbial challenge during the 42-day trial. RAC improved the body weight gain by 3.3% and feed conversion ratio by 5.7% with CC, and improved footpad lesion scores with IC but had no effect on the litter quality. Experiment 2 was a 35-day subclinical necrotic enteritis (NE) challenge trial with 510 male Ross 308 chickens. The dietary treatments included a non-challenged, non-supplemented control and four NE challenged treatments with dietary RAC supplementation at 0, 1, 2, and 3 g/kg. The birds were challenged with Eimeria maxima on day nine and C. perfringens on day 14. While RAC at 1 g/kg significantly increased bird weight gain during the challenge, it did not affect the microbial or short chain fatty acid (SCFA) profiles. In contrast, RAC at 3 g/kg reduced the abundance of the Lactobacillus group and tended to reduce the abundance of genus Bifidobacterium and the total numbers of eubacteria. These experiments suggest that dietary RAC at a moderate dose positively affected broiler performance. However, changes in caecal microbiota populations may not have influenced the observed performance effects of RAC.

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Natural resin acid –enriched composition as a modulator of intestinal microbiota and performance enhancer in broiler chicken

Journal of Applied Animal Nutrition ◽

10.1017/jan.2014.11 ◽

2015 ◽

Vol 3 ◽

Cited By ~ 8

Author(s):

H. Kettunen ◽

J. Vuorenmaa ◽

T. Rinttilä ◽

H. Grönberg ◽

E. Valkonen ◽

...

Keyword(s):

Lactic Acid ◽

Intestinal Microbiota ◽

Pure Culture ◽

Broiler Chickens ◽

Broiler Chicken ◽

Resin Acid ◽

Necrotic Enteritis ◽

Dependent Manner ◽

Natural Resin ◽

Enriched Composition

SummaryResin acids extracted from coniferous trees are known for their antimicrobial and antifungal effects. This trial investigated the effect of a natural resin acid-enriched composition (RAC) on the gastrointestinal microbiota and productive performance of broiler chicken. The results demonstrated that at or above 5 mg/l, RAC prevented the growth of a pure culture ofClostridium perfringens, a causative agent of necrotic enteritis in poultry. Next, the effects of RAC on the microbial community were studied in a fermentation model with both the microbial inoculum and substrate for the microbes isolated from the ileum of broiler chickens. RAC was included at 0, 0.1 and 1 g/kg digesta, and supplementation decreased the relative proportion of lactic acid and increased that of acetic acid produced during the fermentation in a dose-dependent manner. At 1 g/kg inclusion, RAC decreased the density of lactobacilli. The final part of the experiment investigated the influence of RAC on the performance and intestinal microbiota of necrotic enteritis (NE)-challenged broiler chickens. A wheat and soy -based diet was supplemented with RAC at 0, 0.5, 1 and 3 g/kg. The chickens were challenged withEimeria maximaoocysts on day 11, and a pure culture ofC. perfringenson day 14. On day 17, the final day of the trial, RAC inclusion at 1 and 3 g/kg of feed significantly increased body weight. At 3 g/kg RAC numerically decreased the daily mortality seen during the challenge period. In the ileum, RAC at 1 g/kg reduced the NE-associated peak of microbial lactic acid production. Overall, the data suggested that the dietary ingredient RAC has the potential to act as a performance-enhancer and microbial modulator in broiler chickens.

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