scholarly journals The Associations of SCFA with Anthropometric Parameters and Carbohydrate Metabolism in Pregnant Women

2020 ◽  
Vol 21 (23) ◽  
pp. 9212
Author(s):  
Małgorzata Szczuko ◽  
Justyna Kikut ◽  
Dominika Maciejewska ◽  
Danuta Kulpa ◽  
Zbigniew Celewicz ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Carbohydrate Metabolism ◽  
Short Chain Fatty Acids ◽  
Caproic Acid ◽  
Normal Weight ◽  
Obese Women ◽  
Anthropometric Parameters ◽  
Metabolic Adaptations ◽  
Stool Samples ◽  
Intestinal Gluconeogenesis

Short-chain fatty acids (SCFAs) mediate the transmission of signals between the microbiome and the immune system and are responsible for maintaining balance in the anti-inflammatory reaction. Pregnancy stages alter the gut microbiota community structure, which also synthesizes SCFAs. The study involved 90 pregnant women, divided into two groups: 48 overweight/obese pregnant women (OW) and 42 pregnant women with normal BMI (CG). The blood samples for glucose, insulin, and HBA1c were analyzed as well as stool samples for SCFA isolation (C2:0; C3:0; C4:0i; C4:0n; C5:0i; C5:0n; C6:0i; C6:0n) using gas chromatography. The SCFA profile in the analyzed groups differed significantly. A significant positive correlation between C2:0, C3:0, C4:0n and anthropometric measurements, and between C2:0, C3:0, C4:0n, and C5:0n and parameters of carbohydrate metabolism was found. SCFA levels fluctuate during pregnancy and the course of pregnancy and participate in the change in carbohydrate metabolism as well. The influence of C2:0 during pregnancy on anthropometric parameters was visible in both groups (normal weight and obese). Butyrate and propionate regulate glucose metabolism by stimulating the process of intestinal gluconeogenesis. The level of propionic acid decreases with the course of pregnancy, while its increase is characteristic of obese women, which is associated with many metabolic adaptations. Propionic and linear caproic acid levels can be an important critical point in maintaining lower anthropometric parameters during pregnancy.

scholarly journals Study of the Prevalence of Obesity and Its Association with Maternal and Neonatal Characteristics and Morbidity Profile in a Population of Moroccan Pregnant Women

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Fatima Taoudi ◽  
Fatima Zahra Laamiri ◽  
Fatima Barich ◽  
Nadia Hasswane ◽  
Hassan Aguenaou ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Age Groups ◽  
Public Health Problem ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Obese Group ◽  
Obese Women ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Prevalence Of Obesity

Obesity is a real public health problem whose prevalence continues to increase throughout the world. It affects all age groups and does not spare pregnant women. This work aims to determine the prevalence of obesity and to study its association with maternal and neonatal characteristics and the morbidity profile of pregnancy. This is a descriptive and cross-sectional study carried out in the maternity ward of the prefectural hospital center called “Sidi Lahcen” in Témara, Morocco, over a 12-month period. Maternal and neonatal data are collected through a preestablished questionnaire, and anthropometric parameters were recorded. 390 participants, aged between 18 and 43 years, were included in this study, with a prevalence of overweight and obesity of 34.9% and 41%, respectively. Correlation results revealed that the prevalence of overweight and obesity was significantly elevated in women over 25 years p < 0.001 . The rate of caesarean section was four times higher in obese women compared to women of normal weight (53.8% versus 12.8%; p = 0.018 ). The over-term was significantly high in the obese group compared to the nonobese group (33.8% versus 20.2%; p = 0.013 ). A statistically significant positive correlation was found between gestational body mass index and newborn birth weight (r = 0.29; p < 0.001 ) as well as a high prevalence of macrosomia in newborns of comparatively obese women compared to newborns of nonobese women (17.6% versus 9.6%; p = 0.041 ). The correlation analysis with the morbidity profile showed a significantly high preponderance of gestational diabetes, anemia, and toxemia of pregnancy in the obese group compared to the normal group p < 0.001 . This study clearly demonstrated that obesity during pregnancy is associated with higher risks of maternal and neonatal complications, the management of which places a burden on the health system as well as families. These data reinforce the need to improve antenatal care for the prevention of obesity and its preventable complications.

scholarly journals A Higher Rate of Iron Deficiency in Obese Pregnant Sudanese Women

2017 ◽  
Vol 5 (3) ◽  
pp. 285-289 ◽  
Author(s):  
Wisal Abbas ◽  
Ishag Adam ◽  
Duria A. Rayis ◽  
Nada G. Hassan ◽  
Mohamed F. Lutfi
Keyword(s):  
Body Mass Index ◽  
Iron Deficiency ◽  
Pregnant Women ◽  
Serum Ferritin ◽  
Linear Regression Analysis ◽  
Normal Weight ◽  
Negative Association ◽  
Deficiency Anemia ◽  
Obese Women ◽  
Blood Indices

AIM: To assess the association between obesity and iron deficiency (ID).MATERIAL AND METHODS: Pregnant women were recruited from Saad Abualila Hospital, Khartoum, Sudan, during January–April 2015. Medical history (age, parity, gestational age) was gathered using questionnaire.  Weight and height were measured, and body mass index (BMI) was calculated. Women were sub-grouped based on BMI into underweight (< 18.5 kg/m^2), normal weight (18.5–24.9 kg/m^2), overweight (25–29.9 kg/m^2) and obese (≥ 30 kg/m^2). Serum ferritin and red blood indices were measured in all studied women.RESULTS: Two (0.5%), 126 (29.8%), 224 (53.0%) and 71 (16.8%) out of the 423 women were underweight, normal weight, overweight and obese, respectively. Anemia (Hb <11 g/dl), ID (ferritin <15µg/l) and iron deficiency anemia (IDA) were prevalent in 57.7%, 21.3% and 12.1%, respectively. Compared with the women with normal BMI, significantly fewer obese women were anemic [25 (35.2%) vs. 108 (85.7%), P < 0.001] and significantly higher number of obese women [25 (35.2) vs. 22 (17.5, P = 0.015] had iron deficiency. Linear regression analysis demonstrated a significant negative association between serum ferritin and BMI (– 0.010 µg/, P= 0.006).CONCLUSION: It is evident from the current findings that prevalence of anaemia and ID showed different trends about BMI of pregnant women.

scholarly journals Plasma Obestatin Levels in Normal Weight, Obese and Anorectic Women

2008 ◽  
pp. S49-S55
Author(s):  
H Zamrazilová ◽  
V Hainer ◽  
D Sedlačková ◽  
H Papežová ◽  
M Kunešová ◽  
...  
Keyword(s):  
Body Weight ◽  
Energy Homeostasis ◽  
Normal Weight ◽  
Obese Women ◽  
Lower Plasma ◽  
Anthropometric Parameters ◽  
Common Precursor ◽  
Fat Stores ◽  
The Common

Obestatin is a recently discovered peptide produced in the stomach, which was originally described to suppress food intake and decrease body weight in experimental animals. We investigated fasting plasma obestatin levels in normal weight, obese and anorectic women and associations of plasma obestatin levels with anthropometric and hormonal parameters. Hormonal (obestatin, ghrelin, leptin, insulin) and anthropometric parameters and body composition were examined in 15 normal weight, 21 obese and 15 anorectic women. Fasting obestatin levels were significantly lower in obese than in normal weight and anorectic women, whereas ghrelin to obestatin ratio was increased in anorectic women. Compared to leptin, only minor differences in plasma obestatin levels were observed in women who greatly differed in the amount of fat stores. However, a negative correlation of fasting obestatin level with body fat indexes might suggest a certain role of obestatin in the regulation of energy homeostasis. A significant relationship between plasma obestatin and ghrelin levels, independent of anthropometric parameters, supports simultaneous secretion of both hormones from the common precursor. Lower plasma obestatin levels in obese women compared to normal weight and anorectic women as well as increased ghrelin to obestatin ratio in anorectic women might play a role in body weight regulation in these pathologies.

scholarly journals Implications of SCFAs on the Parameters of the Lipid and Hepatic Profile in Pregnant Women

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1749
Author(s):  
Maciej Ziętek ◽  
Zbigniew Celewicz ◽  
Justyna Kikut ◽  
Małgorzata Szczuko
Keyword(s):  
Lipid Metabolism ◽  
Liver Function ◽  
Pregnant Women ◽  
Short Chain Fatty Acids ◽  
The Body ◽  
Control Group ◽  
Special Role ◽  
Obese Women ◽  
Plasma Parameters ◽  
Bacterial Fermentation

Short-chain fatty acids (SCFAs) are the product of the anaerobic intestinal bacterial fermentation of dietary fiber and resistant starch. An abnormal intestinal microbiota may cause a reduction in the production of SCFAs, which stimulate the development of intestinal epithelial cells, nourish enterocytes, influence their maturation and proper differentiation, reduce the pH, and are an additional source of energy for the host. There have been reports of the special role of SCFAs in the regulation of glucose and lipid metabolism during pregnancy. Aim: The aim of the study was to analyze the correlation of SCFAs with lipid and hepatic metabolism during pregnancy in relation to the body weight of pregnant women. Material and methods: This study was conducted in pregnant women divided into two groups: Obese (OW—overweight and obese women; n = 48) and lean (CG—control group; n = 48) individuals. The biochemical plasma parameters of lipid metabolism (TG, CH, LDL, HDL), inflammation (CRP), and liver function (ALT, AST, GGT) were determined in all of the subjects. SCFA analysis was performed in the stool samples to measure acetic acid (C 2:0), propionic acid (C 3:0), isobutyric acid (C 4:0 i), butyric acid (C 4:0 n), isovaleric acid (C 5:0 i) valeric acid (C 5:0 n), isocaproic acid (C 6:0 i), caproic acid (C 6:0 n), and heptanoic acid (C 7:0). Results: Statistically significant differences in the concentrations of C 3:0 and C 6:0 n were found between women in the OW group compared to the CG group. The other SCFAs tested did not differ significantly depending on BMI. The C 2:0, C 3:0, and C 4:0 n ratios showed differences in both OW and CG groups. In the OW group, no relationship was observed between the concentrations of the SCFAs tested and CRP, ALT, AST. A surprising positive relationship between C 5:0 n and all fractions of the tested lipids and branched C 5:0 with CHL, HDL, and LDL was demonstrated. In the OW group, HDL showed a positive correlation with C 3:0. However, lower GGT concentrations were accompanied by higher C 4:0 and C 5:0 values, and this tendency was statistically significant. Conclusions: The results of our research show that some SCFAs are associated with hepatic lipid metabolism and CRP concentrations, which may vary with gestational weight. Obesity in pregnancy reduces the amount of SCFAs in the stool, and a decrease in the level of butyrate reduces liver function.

scholarly journals Patterns and predictors of gestational weight gain in Addis Ababa, Central Ethiopia: a prospective cohort study

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Fekede Asefa ◽  
Allison Cummins ◽  
Yadeta Dessie ◽  
Maralyn Foureur ◽  
Andrew Hayen
Keyword(s):  
Public Health ◽  
Cohort Study ◽  
Weight Gain ◽  
Pregnant Women ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Addis Ababa ◽  
Normal Weight ◽  
Obese Women ◽  
Gestational Weight

Abstract Introduction Gaining excessive or inadequate gestational weight is associated with many adverse maternal and fetal outcomes. Inadequate gestational weight gain (GWG) increases the risk of fetal growth restriction, pre-term birth, and low birth weight. It is a public health concern in sub-Saharan Africa. The aim of this study was to assess the patterns and predictors of GWG in Addis Ababa, Ethiopia. Methods We conducted a prospective cohort study among pregnant women who attended antenatal care in health centres in Addis Ababa, from January to September 2019. Data were collected by a structured questionnaire and checklists and analysed using Stata version-14. Weight at or before 16 weeks gestation was used as a proxy for pre-pregnancy weight. Women’s height and baseline weight were measured by data collectors, and we obtained weight at the end of the 24th and 36th weeks of gestation from women’s medical records. GWG was categorized as inadequate, adequate and excessive based on the United States Institute of Medicine criteria. Predictors of GWG were identified using multinomial logistic regression. Results A total of 395 pregnant women were enrolled in the study. GWG was assessed for 369 (93%) women. The median GWG was 8.7 kg with inter quartile ranges (25th, 75th percentiles) of 7.0 kg and 11.6 kg. More than two-third of the participants, 248 (67.2% [95% CI: 62.2, 72.0%]), gained inadequate weight; 103 (27.9% [95% CI: 23.4, 32.8%]) gained adequate weight; and 18 (4.9% [95% CI: 2.9%, 7.6%]) gained excessive weight. Three quarters (75%) of underweight women gained inadequate gestational weight, whereas 43% of overweight or obese women gained inadequate gestational weight. Being underweight (AOR = 3.30 [95% CI: 1.32, 8.24]) or normal weight (AOR = 2.68 [95% CI: 1.37, 5.24]) before pregnancy increased the odds of gaining inadequate gestational weight compared to overweight or obese women. Not having paid employment was associated with higher odds of gaining inadequate gestational weight compared to women employed outside the home (AOR = 2.17 [95% CI: 1.16, 4.07]). Conclusions Most pregnant women in Addis Ababa gain inadequate gestational weight. In particular, three quarters of underweight women gained inadequate gestational weight. Being underweight, normal weight or having no paid employment were associated with higher odds of inadequate GWG. Promoting adequate GWG in Addis Ababa among underweight and normal weight women may be an important public health initiative.

scholarly journals Dietary intake assessment in women with different weight and pregnancy status using a short questionnaire

2013 ◽  
Vol 17 (9) ◽  
pp. 1939-1948 ◽  
Author(s):  
Åsa Svensson ◽  
Frida Renström ◽  
Les Bluck ◽  
Lauren Lissner ◽  
Paul W Franks ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Large Scale ◽  
Normal Weight ◽  
Group Level ◽  
Obese Women ◽  
Doubly Labelled Water ◽  
Cross Sectional ◽  
Short Questionnaire ◽  
Significant Difference ◽  
Dietary Intake Assessment

AbstractObjectiveFirst, to evaluate the ability of a short dietary questionnaire (SDQ) to estimate energy intake (EI) on group and individual levels compared with total energy expenditure (TEE) measured by the doubly labelled water method. Second, to compare the SDQ's performance in estimating energy, nutrient and food intakes with a sixty-six-item FFQ used in large-scale Swedish epidemiological research.DesignCross-sectional.SettingUmeå, Sweden.SubjectsIn total, sixty-five non-pregnant women, of whom thirty-one were overweight or obese, and twenty-five pregnant, normal-weight women completed the protocol.ResultsOn average, the SDQ captured 78 % and 79 % of absolute TEE in the non-pregnant and pregnant normal-weight women, respectively. Furthermore, the SDQ captured an average of 57 % of TEE in the overweight/obese non-pregnant women. The Spearman correlation of EI and TEE was significant in the overweight and obese women only (ρ = 0·37, 95 % CI 0·02, 0·64). There was no significant difference between the SDQ and the more extensive FFQ in the ability to assess EI when compared with TEE. Intakes of most nutrients and foods were significantly higher when assessed with the SDQ compared with the FFQ.ConclusionsA new short dietary questionnaire with an alternative design underestimated EI of non-pregnant and pregnant, overweight and obese women on a group level but was able to rank the overweight/obese women according to EI. Furthermore, the short questionnaire captured as much or more of the energy, nutrient and food intakes of non-pregnant normal-weight and overweight/obese women on the group level as a traditional, more extensive FFQ.

scholarly journals Effect of vitamin D supplementation on vitamin D status in pregnant women: findings from the MO-VITD study

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Raghad Alhomaid ◽  
Maria Mulhern ◽  
Laura Cassidy ◽  
Eamon Laird ◽  
Martin Healy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Pregnant Women ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Normal Weight ◽  
Vitamin D Status ◽  
Obese Women ◽  
Maternal Vitamin ◽  
Treatment Groups

AbstractPregnant women who are overweight/obese are particularly vulnerable to vitamin D insufficiency owing to higher physiological requirements and lower status (25(OH)D concentrations) associated with obesity. Achieving adequate maternal vitamin D status with current recommendations (10μg/d) remains controversial.This study examined supplementation effects (10μg-vs-20μg vitamin D3/d) throughout pregnancy (12 weeks gestation until delivery) on vitamin D status of normal weight, overweight and obese pregnant women and on cord blood, using a double-blind randomised vitamin D intervention study (MO-VITD). 240 pregnant women were recruited throughout the year at antenatal clinics in Northern Ireland (equal numbers of normal weight (18.5–24.9 kg/m2), overweight (25–29.9 kg/m2), and obese (> 30kg/m2)). Non-fasting maternal blood samples were collected at 12, 28 and 34–36 weeks gestation and from the umbilical cord after delivery and analysed for total serum 25(OH)D using LCMS.A high prevalence of vitamin D insufficiency (25–50nmol/L) was found in the 1st trimester in both treatment groups (41.5% and 48.8%; 10μg vs. 20μg respectively). Maternal 25(OH)D concentrations increased from the 1st to 3rd trimester in both the 10μg/d and 20μg/d groups, with a higher increase in the 20μg group (17.1 ± 24.7 and 28.8 ± 33.3nmol/L, P = 0.002). There was no difference in cord blood 25(OH)D concentrations between treatment groups.Women who started pregnancy with insufficient 25(OH)D concentrations remained insufficient throughout pregnancy in the 10μg/d group (49.9 ± 28.2nmol/L at trimester 3). In the 20μg/d group, women starting pregnancy as insufficient achieved levels of sufficiency in the 2nd (58.9 ± 30.6nmol/L) and 3rd (64.0 ± 35.9nmol/L) trimesters. Women who started pregnancy with sufficient vitamin D status (25(OH)D > 50nmol/L), maintained levels of sufficiency throughout pregnancy irrespective of treatment group (83.1 ± 24.4 and 96.7 ± 30.7 at trimester 3 in 10μg/d and 20 μg/d groups respectively); findings were similar across all BMI categories.Obese women who started pregnancy with an insufficient status were found to have deficient cord blood (25(OH)D < 25 nmol/L) in both the 10μg/d and 20μg/d groups (19.4 ± 20.2 vs. 19.5 ± 9.4nmol/L respectively), whilst obese women who started pregnancy with sufficient status (> 50nmol/L) had cord blood concentrations considered insufficient (40.2 ± 18.4 vs. 44.2 ± 15.6nmol/L; 10μg vs. 20μg groups respectively).Based on our findings of the high prevalence of vitamin D insufficiency in early pregnancy, maternal vitamin D supplementation of 20μg/d is advisable to maintain maternal vitamin D status in pregnant women in Northern Ireland.

scholarly journals Maternal Obesity and the First Birth: A Case for Targeted Contemporary Maternity Care

2014 ◽  
Vol 4 (2) ◽  
pp. 120-129
Author(s):  
Valerie J. Slavin ◽  
Jennifer Fenwick ◽  
Jenny Gamble
Keyword(s):  
Caesarean Section ◽  
Pregnant Women ◽  
Birth Outcomes ◽  
Maternity Care ◽  
Maternal Obesity ◽  
Clinical Audit ◽  
Normal Weight ◽  
Obese Women ◽  
Model Of Care ◽  
First Birth

BACKGROUND: Obesity in childbearing women is associated with poorer pregnancy and birth outcomes, particularly caesarean section, compared with normal-weight women. The high caesarean section rate may reflect care and outcomes which occur at the time surrounding the first birth.AIM: To describe the birth outcomes of extremely obese pregnant women (body mass index [BMI] of 40 or more) experiencing their first birth.METHODS: Clinical audit was used to systematically review the care and birth outcomes of all extremely obese pregnant women experiencing their birth at one study site during a 2-year period in 2009 and 2010. Fifty participants birthed during the study period. Data were collected from booking to discharge from the maternity service and included variables such as model of care, number of appointments, and obstetric and neonatal outcomes. Descriptive statistics were used to describe and synthesize the data. Inferential statistics were used to draw inferences about the population.RESULTS: Obese women rarely had contact with a midwife, except at booking, receiving a standard model of care provided by numerous caregivers, most often inexperienced medical staff. More than half of the obese women experienced a caesarean section (56%), 2.3 times that of normal-weight primiparous women who birthed at the study site during the same period (24.2%). This was despite 64% experiencing normal pregnancy free from any complication. For women who planned to labor, birth intervention including induction of labor, augmentation for slow labor, epidural, and continuous cardiotocography was high. Caesarean occurred most often for “failure to progress” and “failed induction.”CONCLUSION: Clinical audit was useful in determining information, which suggests current maternity care provision is not meeting the needs of extremely obese women experiencing their first birth.IMPLICATIONS FOR PRACTICE: The development of effective, targeted antenatal care designed to meet the needs of extremely obese women is recommended as are strategies to keep birth normal.

scholarly journals Psychological profile, dietary preferences and reproductive history of pregnant women with obesity

2013 ◽  
Vol 94 (2) ◽  
pp. 216-220
Author(s):  
O S Derdyay ◽  
S V Khlybova
Keyword(s):  
Pregnant Women ◽  
Life Quality ◽  
Reproductive Function ◽  
Class Ii ◽  
Normal Weight ◽  
High Risk Group ◽  
Class I ◽  
Psychological Profile ◽  
Obese Women ◽  
Dietary Preferences

Aim. To study the psychological profile and determine dietary preferences of pregnant women with various stages of diet-induced obesity and to evaluate the relationship between the determined features and reproductive function. Methods. 120 women who were at the 1st trimester of normal pregnancy were administered the modified Life Quality Self-Assessment Questionnaire for Overweight Patients. Women were divided into groups according to body mass index (group 1 - women with normal weight, group 2 - overweight women, group 3 - women with class I obesity, group 4 - women with class II obesity). The data from exchange cards of pregnant women were also included in the analysis. Results. Women with class I and class II obesity had higher rates of concomitant diseases, complications during pregnancy and cesarean sections. The main causes of obesity were genetic predisposition, decreased physical activity, increased dietary energy supply. Such traits as hypochondria, frequent mood changes, desire to be at the center of attention were present in obese women. They evaluate their health as poor. Conclusion. The questioning makes it possible to mark out a high risk group for complications of pregnancy and delivery. A questionnaire survey and monitoring by a psychologist and a dietary specialist are recommended for this group of patients.

scholarly journals Modification of Irisin Level in Overweight/Obese Women during Pregnancy and Its Association with Some Metabolic Risk Factors

2020 ◽  
Vol 17 (3(Suppl.)) ◽  
pp. 1124
Author(s):  
Mohammad Ahmad Hamza ◽  
Yassar Yahya Al Tamer ◽  
Omar Abdulmajeed Al habib
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
First Trimester ◽  
Normal Pregnancy ◽  
Maternity Hospital ◽  
Normal Weight ◽  
Metabolic Risk Factors ◽  
Reproductive Age ◽  
Metabolic Risk ◽  
Obese Women

Irisin is a novel myokine and adipokine, its role during pregnancy and its association with some metabolic risk factors especially pre-pregnancy body mass index (pre-BMI) need more evaluation. The aim of the study is to find whether the pre-BMI could predict irisin levels during normal pregnancy and to clarify associations of irisin with some pathological parameters. Irisin levels were estimated by ELISA in sera of 59 normal pregnant women who enrolled from December 2016 to May 2017 at Maternity Hospital, Zakho city, Kurdistan region (Iraq). Thirty-two normal-weight pregnant (pre-BMI≤24.9 kg/m2, Age=24.03 mean±3.7standard deviation) and 27 overweight/obese-pregnant (pre-BMI>25 kg/m2, Age=27.6 mean±3.9 standard deviation) were accounted for each trimester as10: 8 in first trimester, 10:10 in second trimester and12:9 in third trimester respectively. Twenty-two healthy married non-pregnant women of reproductive age served as controls, accounted as 10 normal-weight women (BMI ≤24.9 kg/m2) and 12 overweight/obese women (BMI>25 kg/m2). In pregnant women as a whole, irisin level significantly increased compared to control (p=0.003), and correlated with the pre-BMI, FBS, TP and HOMA2-IR. Pre-BMI and TP predicted irisin levels in a whole study population (p=0.011 and 0.014 respectively). In Overweight/Obese-pregnant, irisin increased significantly by 55.3% in first trimester compared with Overweight/Obese women control, then decreased progressively toward the end of gestation, correlated with TP, Albumin, FBS, HOMA2-IR and negatively correlated with gestational weight gained. TP and FBS independently predicted irisin level in Overweight/Obese-pregnant group. Conclusion: Circulating irisin levels are influenced by pre-BMI, and both of TP and FBS predict irisin levels in overweight/obese pregnant. Irisin level should be a radical factor in future studies for pathological conditions linked to hypoproteinemias such as edema and hepatic disease.

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