scholarly journals Saliva and Oral Diseases

2020 ◽  
Vol 9 (2) ◽  
pp. 466 ◽  
Author(s):  
Emanuela Martina ◽  
Anna Campanati ◽  
Federico Diotallevi ◽  
Annamaria Offidani
Keyword(s):  
Therapeutic Response ◽  
Biological Fluid ◽  
Analytical Techniques ◽  
Systemic Diseases ◽  
Transport Mechanisms ◽  
Oral Diseases ◽  
Intimate Contact ◽  
New Era ◽  
Salivary Biomarkers ◽  
Crevicular Fluid

Saliva is a fascinating biological fluid which has all the features of a perfect diagnostic tool. In fact, its collection is rapid, simple, and noninvasive. Thanks to several transport mechanisms and its intimate contact with crevicular fluid, saliva contains hundreds of proteins deriving from plasma. Advances in analytical techniques have opened a new era—called “salivaomics”—that investigates the salivary proteome, transcriptome, microRNAs, metabolome, and microbiome. In recent years, researchers have tried to find salivary biomarkers for oral and systemic diseases with various protocols and technologies. The review aspires to provide an overall perspective of salivary biomarkers concerning oral diseases such as lichen planus, oral cancer, blistering diseases, and psoriasis. Saliva has proved to be a promising substrate for the early detection of oral diseases and the evaluation of therapeutic response. However, the wide variation in sampling, processing, and measuring of salivary elements still represents a limit for the application in clinical practice.

scholarly journals Salivary Biomarkers and Their Application in the Diagnosis and Monitoring of the Most Common Oral Pathologies

2020 ◽  
Vol 21 (14) ◽  
pp. 5173 ◽  
Author(s):  
Lucía Melguizo-Rodríguez ◽  
Victor J. Costela-Ruiz ◽  
Francisco Javier Manzano-Moreno ◽  
Concepción Ruiz ◽  
Rebeca Illescas-Montes
Keyword(s):  
Biological Fluid ◽  
Osteonecrosis Of The Jaw ◽  
Response To Treatment ◽  
Oral Diseases ◽  
Early Evaluation ◽  
Non Invasive ◽  
Salivary Biomarkers ◽  
Diagnosis And Prognosis ◽  
New Biomarkers

Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner—and the results of its analysis complement clinical and histopathological findings in the diagnosis of multiple diseases. The objective of this review was to offer an update on the contribution of salivary biomarkers to the diagnosis and prognosis of diseases of the oral cavity, including oral lichen planus, periodontitis, Sjögren’s syndrome, oral leukoplakia, peri-implantitis, and medication-related osteonecrosis of the jaw. Salivary biomarkers such as interleukins, growth factors, enzymes, and other biomolecules have proven useful in the diagnosis and follow-up of these diseases, facilitating the early evaluation of malignization risk and the monitoring of disease progression and response to treatment. However, further studies are required to identify new biomarkers and verify their reported role in the diagnosis and/or prognosis of oral diseases.

scholarly journals Salivary Metabolomics for Diagnosis and Monitoring Diseases: Challenges and Possibilities

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 587
Author(s):  
Eelis Hyvärinen ◽  
Minttu Savolainen ◽  
Jopi J. W. Mikkonen ◽  
Arja M. Kullaa
Keyword(s):  
Metabolic Profile ◽  
Biological Fluid ◽  
Treatment Success ◽  
Review Article ◽  
Biological Information ◽  
Systemic Diseases ◽  
Oral Diseases ◽  
Biochemical Processes ◽  
Diagnosis And Prognosis ◽  
Viable Method

Saliva is a useful biological fluid and a valuable source of biological information. Saliva contains many of the same components that can be found in blood or serum, but the components of interest tend to be at a lower concentration in saliva, and their analysis demands more sensitive techniques. Metabolomics is starting to emerge as a viable method for assessing the salivary metabolites which are generated by the biochemical processes in elucidating the pathways underlying different oral and systemic diseases. In oral diseases, salivary metabolomics has concentrated on periodontitis and oral cancer. Salivary metabolites of systemic diseases have been investigated mostly in the early diagnosis of different cancer, but also neurodegenerative diseases. This mini-review article aims to highlight the challenges and possibilities of salivary metabolomics from a clinical viewpoint. Furthermore, applications of the salivary metabolic profile in diagnosis and prognosis, monitoring the treatment success, and planning of personalized treatment of oral and systemic diseases are discussed.

scholarly journals THE EFFECTS OF PANORAMIC RADIOGRAPHY ON GINGIVAL CREVICULAR FLUID VOLUME IN GINGIVITIS

2021 ◽  
Vol 6 (2) ◽  
pp. 136
Author(s):  
Rini Rahmiyati ◽  
Didit Aspriyanto ◽  
Beta Widya Oktiani
Keyword(s):  
Filter Paper ◽  
Wistar Rats ◽  
Gingival Crevicular Fluid ◽  
Panoramic Radiography ◽  
Cell Damage ◽  
Biological Fluid ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference ◽  
Crevicular Fluid

Background: Gingival crevicular fluid (GCF) is a biological fluid derived from the gingival sulcus and can be elevated in the inflammatory state of periodontal tissue, such as gingivitis. In previous studies, the number of GCF could also increase after panoramic radiographic exposure. Increase in GCF due to panoramic radiography is a sign of cell damage. Objective: To analyze the effects of panoramic radiography on the volume of GCF in wistar rats with gingivitis. Method: This type of research was true experimental with post test only and control group design. The sampling technique used was simple random sampling. A total of 25 wistar rats were classified into two control groups without exposure (state without gingivitis and gingivitis) and three groups treatment of exposure (state of gingivitis with 1 time, 2 times, and 3 times the exposure). GCF sampling using filter paper was carried out 10 minutes after panoramic radiographic exposure. The filter paper was stained by 2% ninhydrin solution, after that the GCF volume was calculated. Results: There was a significant difference in the number of GCF (p<0.05) in the group without gingivitis and exposure compared to all other groups, the gingivitis group without exposure compared to the gingivitis group with 3 times exposure, and the gingivitis group with 1 time exposure compared to the gingivitis group 3 times with exposure. Conclusion: Panoramic radiography can cause an increase in the volume of GCF in wistar rats with gingivitis. Keywords: GCF, gingivitis, panoramic radiography

scholarly journals Evaluation of Salivary Antioxidant Enzymes among Smokers and Nonsmokers

2012 ◽  
Vol 3 (1) ◽  
pp. 18-21 ◽  
Author(s):  
KMK Masthan ◽  
Tajinder Kaur Saggu ◽  
Mahesh Pundaleek Dudanakar ◽  
Shams UI Nisa
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Glutathione Peroxidase ◽  
Cigarette Smoke ◽  
Biological Fluid ◽  
Antioxidant Defense System ◽  
Mean Value ◽  
Oral Diseases ◽  
Unstimulated Saliva ◽  
Smoking Group

ABSTRACT Background Cigarette smoke contains various oxygen-free radicals which are considered as the main causes of damage to biomolecules when exposed to cigarette smoke. Saliva is the first biological fluid that encounters inhaled cigarette smoke (CS) and has an antioxidant defense system able to counter toxic activities of free radical species. So, the aim of this study was to compare the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in saliva of smokers and nonsmokers. Materials and methods Unstimulated saliva of 200 males (100 smokers and 100 nonsmokers) was collected. The saliva was centrifuged and the activity of salivary superoxide dismutase and glutathione peroxidase was measured according to a specific assay. Results The mean value of superoxide dismutase activity was significantly higher in the smoking group than in the nonsmoker group, while the levels of GSH-Px activity was significantly higher in the nonsmoking group than in the smoking group. Conclusion Cigarette smoke leads to an alteration in salivary antioxidant activity. Evaluating the variations in the level of antioxidant enzymes (SOD and GSH-Px) in smoker's saliva might be useful for estimating the level of oxidative stress caused by cigarette smoke. Thus, it may help in patient's education regarding the ill-effects of smoking and determining the evolution and progress of various oral diseases. How to cite this article Saggu TK, Masthan KMK, Dudanakar MP, Nisa SUI, Patil S. Evaluation of Salivary Antioxidant Enzymes among Smokers and Nonsmokers. World J Dent 2012;3(1):18-21.

scholarly journals Possible interaction between visfatin, periodontal infection, and other systemic diseases: A brief review of literature

2017 ◽  
Vol 11 (03) ◽  
pp. 407-410 ◽  
Author(s):  
Mojtaba Bayani ◽  
Mohammad Pourali ◽  
Mohammad Keivan
Keyword(s):  
Periodontal Disease ◽  
Bacterial Infections ◽  
Alveolar Bone ◽  
Gingival Crevicular Fluid ◽  
Systemic Diseases ◽  
Hand Search ◽  
Periodontal Infection ◽  
Etiologic Agents ◽  
Visfatin Level ◽  
Crevicular Fluid

ABSTRACTGingivitis and periodontitis are common bacterial infections caused by a variety of microorganisms. Despite the microorganisms' roles as etiologic agents, inflammation-induced substances also have crucial parts in the loss of connective tissue and the supporting alveolar bone. Visfatin is a pleiotropic mediator, which acts as growth factor, cytokine, and pre-B-cell colony-enhancing factor. A positive correlation was detected between the serum/plasma levels of visfatin and inflammatory disorders such as diabetes mellitus and cardiovascular disease. In addition, the visfatin level was higher in saliva and the gingival crevicular fluid (GCF) of subjects with periodontal disease. This review defined current, predictable patterns of possible interaction of visfatin with periodontal infection and other systemic diseases, using PubMed and Medline databases searching for articles written in English. Peer-reviewed articles were targeted using the following keywords: “visfatin,” “periodontal disease,” “inflammatory mediator,” and “biomarker.” Available full-text articles were read, and related articles were also scrutinized, while a hand search was also performed. Search was confined to human studies, and articles written in English and published between 1985 and 2016 were selected. It was concluded that periodontal infection and other systemic diseases could be related to the levels of visfatin in GCF, saliva, and serum as a biomarker of these diseases.

Garlic: A Miraculous Herb for Oral Diseases – A Review

2014 ◽  
Vol 8 (1) ◽  
pp. 51-54
Author(s):  
S Yadav ◽  
A Ahuja ◽  
V Ahuja
Keyword(s):  
Traditional Medicine ◽  
Antifungal Agent ◽  
Antibacterial Agent ◽  
Clinical Applications ◽  
Review Article ◽  
Systemic Diseases ◽  
Oral Diseases ◽  
Dental Diseases ◽  
Pungent Odor ◽  
Antibacterial And Antifungal

ABSTRACT Garlic is a member of lily family that has been used worldwide as an incredible herb in the array of medicine. In Indian traditional medicine, garlic holds a special place and is used to cure variety of diseases. It has got the reputation of a powerful healing, antibacterial and antifungal agent. It has proved beneficial in treating systemic diseases like diabetes, hypertension etc in medicine. But it has got less importance in dentistry due to lack of clinical data assuring its safe usage in curing dental diseases. Drawback of garlic is its pungent odor which restricts its oral usage as an antibacterial agent, but now a days odor less garlic preparations are available which can be utilized in treating oral diseases. This review article throws a light on the clinical applications of garlic in the field of dentistry.

Role of Salivary Biomarkers for Early Detection of Oral Squamous Cell Carcinoma

2017 ◽  
Vol 2 (3) ◽  
pp. 155-160 ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Early Detection ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Biological Fluid ◽  
Salivary Biomarkers

ABSTRACT Introduction Oral cancer is a potentially fatal disease, which constitutes an important portion of tumors of the head and neck region. Among head and neck cancers, oral squamous cell carcinomas (OSCCs) constitute 90% of total cancers. Regardless of the fact that the oral cavity is easily accessible to the accumulation of carcinogens, most oral cancers are typically detected at an advanced stage leading to lower survival rate among subjects. Abnormal cellular products elucidated from malignant cells can be detected and measured in various body fluids including saliva, which constitute tumor markers. Saliva, an aqueous biological fluid, is in direct contact with the oral cancer lesion. Hence, the saliva in any stage of oral cancer constitutes abnormal deoxyribonucleic acid (DNA), acid (RNA), and protein molecules. Saliva, being a noninvasive diagnostic aid, can be an alternative to serum for early detection, status of chemotherapy regime, and also patient prognosis. This article aims at providing a brief overview of various salivary biomarkers and their implications in oral cancer. How to cite this article Gupta P. Role of Salivary Biomarkers for Early Detection of Oral Squamous Cell Carcinoma. Int J Adv Integ Med Sci 2017;2(3):155-160.

Investigation of potential salivary biomarkers for the diagnosis of breast cancer.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 145-145 ◽  
Author(s):  
Hiromitsu Jinno ◽  
Takeshi Murata ◽  
Makoto Sunamura ◽  
Masahiro Sugimoto
Keyword(s):  
Breast Cancer ◽  
Early Diagnosis ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Biological Fluid ◽  
Neoadjuvant Treatment ◽  
Human Saliva ◽  
Breast Cancer Patients ◽  
Operating Characteristics ◽  
Salivary Biomarkers

145 Background: Saliva is an easily accessible and informative biological fluid which has high potential for the early diagnosis of diseases. Saliva-based diagnostics, particularly those based on metabolomics technology, offer a promising clinical strategy by characterizing the association between salivary analysts and a particular disease. The aim of this study is to investigate potential biomarkers in human saliva to facilitate the early diagnosis of breast cancer. Methods: We conducted a comprehensive metabolite analysis of saliva samples obtained from 60 breast cancer patients and 20 healthy controls, using capillary electrophoresis time-of-flight mass spectrometry (CE-TOF-MS). Statistical analyses were performed by using a nonparametric Mann-Whitney U test, multiple logistic regression and the receiver operating characteristics (ROC) to evaluate the predictive power of biomarkers. Results: Forty-nine patients (81.7 %) had invasive ductal carcinoma (IDC) and 9 patients (15.0 %) had ductal carcinoma in situ. In 33 patients receiving neoadjuvant treatment, saliva samples were obtained just before surgery. After removing the concomitantly observed peaks and noise peaks, an average of 205 peaks were derived from the metabolites. Among these peaks, five potential salivary biomarkers demonstrated significantly higher concentrations in breast cancer patients comparing with healthy individuals (p < 0.05). Especially, salivary biomarkers obtained from patients with IDC before neoadjuvant treatments tended to be higher concentrations than those obtained after treatment. In these metabolites, the area under the ROC curves (AUCs) were 0.765 for substance A, 0.716 for substance B, 0.809 for substance C, 0.819 for substance D and 0.850 for substance E. Conclusions: Salivary metabolites are promising biomarkers for the early diagnosis of breast cancer.

scholarly journals Salivary Biomarkers for Detection of Systemic Diseases

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61356 ◽  
Author(s):  
Nilminie Rathnayake ◽  
Sigvard Åkerman ◽  
Björn Klinge ◽  
Nina Lundegren ◽  
Henrik Jansson ◽  
...  
Keyword(s):  
Systemic Diseases ◽  
Salivary Biomarkers

scholarly journals Periodontal Disease and COPD

2018 ◽  
Vol 2 (4) ◽  
Author(s):  
Swarga Jyoti Das
Keyword(s):  
Inflammatory Response ◽  
Periodontal Disease ◽  
Alveolar Bone ◽  
Airflow Obstruction ◽  
Well Being ◽  
The Body ◽  
Chronic Obstructive ◽  
Systemic Diseases ◽  
Oral Diseases ◽  
Increased Risk

Periodontal disease is an inflammatory disease caused predominantly by Gram-negative, anaerobic, and microaerophilic bacteria that colonise the subgingival area though modified by environment, physical, social and host stresses. It results in progressive destruction of the periodontal ligament and alveolar bone with increased probing depth, recession, or both [1]. Throughout the history of mankind, it has been believed that oral diseases and maladies including periodontal disease may have an effect on the rest of the body. Over the centuries, writings from the ancient Egyptians, Hebrews, Assyrians, Greeks and Romans, have all noted the importance of the mouth in overall health and well-being. Thus, the concept of linking periodontitis and systemic diseases could be traced back to the beginning of recorded history and medicine [2]. Periodontal disease has been linked to an increased risk of various systemic diseases, including the respiratory diseases e.g. pneumonia and chronic obstructive pulmonary disease (COPD) [3]. COPD is a generic term defined by the presence of airflow obstruction with excess production of sputum resulting from chronic bronchitis and/or emphysema. It has been recognized as one of the major causes of death and disability globally and is the fourth leading cause of death in United States [4]. The aetiology of COPD is complex and multifactorial, involving multiple genetic and environmental factors [5]. An enhanced or abnormal inflammatory response to inhaled particles or gases, beyond the normal protective inflammatory response in the lungs, is a characteristic feature of COPD and is potential to produce lung injury

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