scholarly journals Comparative evaluation of different extraction methods of medical plants

2021 ◽  
Vol 84 (4) ◽  
pp. 107-112
Author(s):  
V.M. Mussifulina ◽  
◽  
M.M. Omarov ◽  
Keyword(s):  
Bioactive Compounds ◽  
Large Scale ◽  
Current Knowledge ◽  
Extraction Methods ◽  
Narrative Review ◽  
Alternative Methods ◽  
High Yield ◽  
Extraction Techniques ◽  
Medical Plant ◽  
Medical Plants

The development of extraction techniques of medical plants aims to maximize the bioactive compounds production. Тechnologies in this area of industry have not high enough еfficiency factor. In some cases, it reaches only 40-50 %. Therefore, development of new methods to effectively extract different compounds from plant material and their input into large-scale industry is of great importance. The goal is to determine an effective and suitable technology for extracting bioactive compounds from medical plant. This is a narrative review paper which focuses on different extraction methods of medical plant. To find relevant articles for this narrative review, 73 articles were reviewed. Of these, 14 irrelevant documents were discarded. This review analyses various extraction processes to guide the selection of suitable methods for various types of medical plants and applications. This is done by outlining traditional and modern methods of extraction techniques, exploring the importance of solvents for extraction, and comparing novel and alternative methods of extraction. In conclusion, based on the current knowledge, solvent extraction is the most common method for medical plants extraction. Enzymatic hydrolysis and supercritical extraction are advanced techniques with high yield of compounds. However, more research is needed for some modern extraction methods

scholarly journals Processing and extraction methods of medicinal cannabis: a narrative review

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Masoumeh Pourseyed Lazarjani ◽  
Owen Young ◽  
Lidya Kebede ◽  
Ali Seyfoddin
Keyword(s):  
Convenient Method ◽  
Current Knowledge ◽  
Chemical Constituents ◽  
Extraction Methods ◽  
Narrative Review ◽  
Alternative Methods ◽  
High Yield ◽  
Cochrane Library ◽  
Hemp Seed ◽  
Medicinal Cannabis

Abstract Introduction As the cannabis industry transitions from a black market to a legal market, product development, and methods of extraction have become a focal point. To date, more than thousands of chemical constituents have been identified from the cannabis plant, all of which possess different chemical properties that require different conditions for preservation during drying and extraction. However, scientific publications that explore these areas for the cannabis plant are currently lacking. Method This is a narrative review paper which focuses on critiquing drying and extraction methods of Cannabis sativa L. plant. Relevant keywords such as medicinal cannabis, extraction, solvent, cannabinoids, and terpenes have been searched in PubMed, EMBASE, MEDLINE, Google Scholar, and Cochrane Library (Wiley) databases. Result To find relevant papers for this narrative review, 93 papers have been reviewed. Among them, 12 irrelevant papers were discarded. The excluded papers were either about hemp seed oil or hemp fiber and protein. Based on this review, solvent extraction is the most common method for cannabis plants. Although solventless and hydrodynamic extraction are known for their high yield and feasibility, more investigation is needed in these areas. Regarding the drying process, hang-drying is the most convenient method; however, it may be substituted by freeze-drying in the near future. Discussion This review analyses various drying and extraction processes to guide the selection of suitable methods for various types of cannabis products and applications. This is done by outlining traditional and modern methods of drying techniques, exploring the importance of solvents for extraction, visiting solventless extraction procedures, and finally comparing conventional and alternative methods of extraction. Conclusion In conclusion, based on the current knowledge, using organic solvents is the most convenient method for medicinal cannabis extraction. However, more research is needed for some of the drying and extraction methods. Also, developing a green and sustainable cannabis extraction method should be considered for future studies.

scholarly journals Fishery Wastes as a Yet Undiscovered Treasure from the Sea: Biomolecules Sources, Extraction Methods and Valorization

Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 622
Author(s):  
Gabriella Caruso ◽  
Rosanna Floris ◽  
Claudio Serangeli ◽  
Luisa Di Paola
Keyword(s):  
Fatty Acids ◽  
Bioactive Compounds ◽  
Large Scale ◽  
Current Knowledge ◽  
Chemical Characterization ◽  
Short Chain Fatty Acids ◽  
Economic Feasibility ◽  
Added Value ◽  
By Catch ◽  
By Products

The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products can represent an interesting source of high added value bioactive compounds, such as proteins, carbohydrates, collagen, polyunsaturated fatty acids, chitin, polyphenolic constituents, carotenoids, vitamins, alkaloids, tocopherols, tocotrienols, toxins; nevertheless, their biotechnological potential is still largely underutilized. Depending on their structural and functional characteristics, marine-derived biomolecules can find several applications in food industry, agriculture, biotechnological (chemical, industrial or environmental) fields. Fish internal organs are a rich and underexplored source of bioactive compounds; the fish gut microbiota biosynthesizes essential or short-chain fatty acids, vitamins, minerals or enzymes and is also a source of probiotic candidates, in turn producing bioactive compounds with antibiotic and biosurfactant/bioemulsifier activities. Chemical, enzymatic and/or microbial processing of fishery by-catch or processing by-products allows the production of different valuable bioactive compounds; to date, however, the lack of cost-effective extraction strategies so far has prevented their exploitation on a large scale. Standardization and optimization of extraction procedures are urgently required, as processing conditions can affect the qualitative and quantitative properties of these biomolecules. Valorization routes for such raw materials can provide a great additional value for companies involved in the field of bioprospecting. The present review aims at collecting current knowledge on fishery by-catch or by-products, exploring the valorization of their active biomolecules, in application of the circular economy paradigm applied to the fishery field. It will address specific issues from a biorefinery perspective: (i) fish tissues and organs as potential sources of metabolites, antibiotics and probiotics; (ii) screening for bioactive compounds; (iii) extraction processes and innovative technologies for purification and chemical characterization; (iv) energy production technologies for the exhausted biomass. We provide a general perspective on the techno-economic feasibility and the environmental footprint of the production process, as well as on the definition of legal constraints for the new products production and commercial use.

scholarly journals Extraction Techniques for Bioactive Compounds and Antioxidant Capacity Determination of Chilean Papaya (Vasconcellea pubescens) Fruit

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Elsa Uribe ◽  
Alvaro Delgadillo ◽  
Claudia Giovagnoli-Vicuña ◽  
Issis Quispe-Fuentes ◽  
Liliana Zura-Bravo
Keyword(s):  
Phenolic Compounds ◽  
Vitamin C ◽  
Antioxidant Capacity ◽  
Bioactive Compounds ◽  
Extraction Methods ◽  
Total Phenolic ◽  
Coumaric Acid ◽  
Extraction Techniques ◽  
Sample Extraction

The aim of this work was to assess and compare different extraction methods by using high hydrostatic pressure (HHPE), ultrasound (UE), agitation (AE), and their combinations for the extraction of bioactive compounds of Chilean papaya. Extract antioxidant capacity was evaluated by three methods (i.e., DPPH, FRAP, and Voltammetry) and phenolic compounds and vitamin C were determined by HPLC. Papaya sample extraction was performed by HHPE at 500 MPa for 10 min and UE and AE for 30 min, respectively. The combined-extractions: HHPE-UE and HHPE-AE, were carried out for 5 min and 15 min, respectively. The highest values found were total phenolic 129.1 mg GAE/100 g FW, antioxidant capacity by DPPH 20.6 mM TE/100 g FW, and voltammetry 141.0 mM TE/100 g FW for HHPE-UE method in free compound extraction. Regarding vitamin C content, its highest value was found by HHPE-UE (74 mg/100 g FW) a combined extraction method. The phenolic compounds rutin andp-coumaric acid were found in all the extracts, both in free and bound forms, respectively. Besides, the combined techniques improved the extraction of bioactive compounds.

scholarly journals Obtaining Antioxidants and Natural Preservatives from Food By-Products through Fermentation: A Review

Fermentation ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 106
Author(s):  
Francisco J. Martí-Quijal ◽  
Sucheta Khubber ◽  
Fabienne Remize ◽  
Igor Tomasevic ◽  
Elena Roselló-Soto ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Current Knowledge ◽  
Scale Up ◽  
Added Value ◽  
High Yield ◽  
Future Research ◽  
Antioxidant Compounds ◽  
Antioxidant Peptides ◽  
Natural Preservatives ◽  
By Products

Industrial food waste has potential for generating income from high-added-value compounds through fermentation. Solid-state fermentation is promising to obtain a high yield of bioactive compounds while requiring less water for the microorganism’s growth. A number of scientific studies evinced an increase in flavonoids or phenolics from fruit or vegetable waste and bioactive peptides from cereal processing residues and whey, a major waste of the dairy industry. Livestock, fish, or shellfish processing by-products (skin, viscera, fish scales, seabass colon, shrimp waste) also has the possibility of generating antioxidant peptides, hydrolysates, or compounds through fermentation. These bioactive compounds (phenolics, flavonoids, or antioxidant peptides) resulting from bacterial or fungal fermentation are also capable of inhibiting the growth of commonly occurring food spoilage fungi and can be used as natural preservatives. Despite the significant release or enhancement of antioxidant compounds through by-products fermentation, the surface areas of large-scale bioreactors and flow patterns act as constraints in designing a scale-up process for improved efficiency. An in-process purification method can also be the most significant contributing factor for raising the overall cost. Therefore, future research in modelling scale-up design can contribute towards mitigating the discard of high-added-value generating residues. Therefore, in this review, the current knowledge on the use of fermentation to obtain bioactive compounds from food by-products, emphasizing their use as natural preservatives, was evaluated.

scholarly journals Recent Advances in Supercritical Fluid Extraction of Natural Bioactive Compounds from Natural Plant Materials

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3847 ◽  
Author(s):  
Pascaline Aimee Uwineza ◽  
Agnieszka Waśkiewicz
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Bioactive Compounds ◽  
Extraction Methods ◽  
Plant Origin ◽  
Extraction Techniques ◽  
Fluid Extraction ◽  
Plant Materials ◽  
Natural Plant ◽  
Recent Advances

In this review, recent advances in greener technology for extracting natural bioactive components from plant origin sources are discussed. Bioactive compounds of plant origin have been defined as natural chemical compounds present in small amounts in plants. Researchers have shown interest in extracting bioactive compounds because of their human health benefits and characteristics of being eco-friendly and generally recognized as safe. Various new extraction methods and conventional extraction methods have been developed, however, until now, no unique approach has been presented as a benchmark for extracting natural bioactive compounds from plants. The selectivity and productivity of traditional and modern extraction techniques generally depend on selecting the critical input parameters, knowing the nature of plant-based samples, the structure of bioactive compounds, and good scientific skills. This work aims to discuss the recent advances in supercritical fluid extraction techniques, especially supercritical carbon dioxide, along with the fundamental principles for extracting bioactive compounds from natural plant materials such as herbs, spices, aromatic and medicinal plants.

scholarly journals Clinical Value of Complex Echocardiographic Left Ventricular Hypertrophy Classification Based on Concentricity, Mass, and Volume Quantification

2021 ◽  
Vol 8 ◽  
Author(s):  
Andrea Barbieri ◽  
Alessandro Albini ◽  
Anna Maisano ◽  
Gerardo De Mitri ◽  
Giovanni Camaioni ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Large Scale ◽  
Ventricular Hypertrophy ◽  
Current Knowledge ◽  
Left Ventricular ◽  
Alternative Methods ◽  
Clinical Value ◽  
Prognostic Information ◽  
Lv Mass ◽  
Wide Range

Echocardiography is the most validated, non-invasive and used approach to assess left ventricular hypertrophy (LVH). Alternative methods, specifically magnetic resonance imaging, provide high cost and practical challenges in large scale clinical application. To include a wide range of physiological and pathological conditions, LVH should be considered in conjunction with the LV remodeling assessment. The universally known 2-group classification of LVH only considers the estimation of LV mass and relative wall thickness (RWT) to be classifying variables. However, knowledge of the 2-group patterns provides particularly limited incremental prognostic information beyond LVH. Conversely, LV enlargement conveys independent prognostic utility beyond LV mass for incident heart failure. Therefore, a 4-group LVH subdivision based on LV mass, LV volume, and RWT has been recently suggested. This novel LVH classification is characterized by distinct differences in cardiac function, allowing clinicians to distinguish between different LV hemodynamic stress adaptations in various cardiovascular diseases. The new 4-group LVH classification has the advantage of optimizing the LVH diagnostic approach and the potential to improve the identification of maladaptive responses that warrant targeted therapy. In this review, we summarize the current knowledge on clinical value of this refinement of the LVH classification, emphasizing the role of echocardiography in applying contemporary proposed indexation methods and partition values.

scholarly journals Influence of extraction methods on bioactive compounds from Ngoc Linh ginseng callus

Food Research ◽  
2021 ◽  
Vol 5 (3) ◽  
pp. 334-341
Author(s):  
M.D. Lieu ◽  
T.T.L. Nguyen ◽  
T.H. Nguyen ◽  
T.K.T. Dang ◽  
D.G. Do
Keyword(s):  
Bioactive Compounds ◽  
Economic Value ◽  
Power Saving ◽  
Total Content ◽  
Extraction Methods ◽  
Recovery Efficiency ◽  
Extraction Techniques ◽  
Environmental Friendliness ◽  
Saponin Content ◽  
First Time

Panax vietnamensis Ha et Grushv or Vietnamese ginseng is a valuable medicinal herb with high economic value in the world. In this study, three target compounds were surveyed as polyphenols, polysaccharides, and saponins to evaluate the effects of factors including microwave, ultrasound, enzyme amylase, and cellulase for the first time. The results of the study showed that with different extraction conditions, the recovery efficiency of polyphenol, polysaccharide, and saponin was also different. With the addition of 1.2% of the enzyme amylase (v/v) in 8 hrs of incubation, the highest total content of polyphenol and polysaccharide was obtained, equivalent to 6.48 mg GAE/g sample and 312.48 mg Glu/g sample. While the total saponin content reached the highest value of 4.60 mg/g sample at 4 hrs of incubation using 0.8% of cellulase enzyme (v/v). The effect of microwave and ultrasound also showed a significant recovery efficiency for the three analyzed compounds. But compared to the use of two enzymes (amylase, cellulase), the efficiency was lower. The use of these extraction techniques was based on the advantages of environmental friendliness, simple operation, lower investment costs, and power saving. At the same time, it can improve the extraction and recovery efficiency as well as the activity of bioactive compounds.

A Simple Synthesis of the Anticancer Drug Altretamine

2020 ◽  
Vol 17 (8) ◽  
pp. 628-630
Author(s):  
Vu Binh Duong ◽  
Pham Van Hien ◽  
Tran Thai Ngoc ◽  
Phan Dinh Chau ◽  
Tran Khac Vu
Keyword(s):  
Aqueous Solution ◽  
Anticancer Drug ◽  
Potassium Hydroxide ◽  
Large Scale ◽  
Synthesis Method ◽  
Practical Method ◽  
Cyanuric Chloride ◽  
Simple Synthesis ◽  
High Yield ◽  
One Step

A simple and practical method for the synthesis on a large scale of altretamine (1), a wellknown antitumor drug, has been successfully developed. The synthesis method involves the conversion of cyanuric chloride (2) into altretamine (1) by dimethylamination of 2 with an aqueous solution of 40% dimethylamine and potassium hydroxide in 1, -dioxan 4in one step to give altretamine (1) in high yield.

Comparison of Bioactive Compounds of Matricaria recutita Extracted by Ultrasound and Maceration and their Effects on Preventing Sunflower Oil During Frying

2019 ◽  
Vol 15 (2) ◽  
pp. 156-164 ◽  
Author(s):  
Reza Farahmandfar ◽  
Maryam Asnaashari ◽  
Yegane Asadi ◽  
Batool Beyranvand
Keyword(s):  
Antioxidant Activity ◽  
Gallic Acid ◽  
Bioactive Compounds ◽  
Sunflower Oil ◽  
Radical Scavenging ◽  
Stability Index ◽  
Acid Value ◽  
Extraction Methods ◽  
Oil Stability Index ◽  
Matricaria Recutita

Background: It is important to study about the use of natural antioxidants as alternatives to synthetic ones due to the possibility of carcinogenic effects of synthetic antioxidants. This study is comparing the effect of the ultrasound-assisted and maceration extraction methods on antioxidant activity of Matricaria recutita. Methods: Bioactive compounds including phenolic, tocopherol, flavonoid and tannins and antioxidant activity of the extracts were evaluated. Moreover, extracts obtained from ultrasound and maceration methods were added to sunflower oil without any antioxidants at level of 200, 500 and 800 ppm, after that samples were heated at 180°C. Oxidation of the samples were evaluated after 0, 4, 8, 12, 16, 20 and 24 hours by measuring Peroxide Value (PV), Conjugated Diene (CD), Iodine Value (IV), Carbonyl Value (CV), Total Polar Compounds (TPC), Oil Stability Index (OSI), Color Index (CI) and acid value (AV). Results: The result showed total phenol (42.90 mg gallic acid/g extract), tocopherol (120.46 µg α - tocopherol/ml extract), flavonoid (2.64 mg/100 g extract) and tannins (3.89 mg gallic acid/g extract) of ultrasound extracts were higher than maceration extracts. Antioxidant activity of the extract was evaluated by DPPH assay which indicated 800 ppm of the Matricaria recutita extracted by ultrasound was the highest radical scavenging ability. Conclusion: Result indicated both ultrasound and maceration extracts could increase the oil oxidative stability but could not increase compared to BHA. In most cases, the extract samples by ultrasound had a better effect on stabilizing of sunflower oil during frying.

Classical and modern drug extraction techniques: facts and figures

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Bharti Umrethia ◽  
Bharat Kalsariya ◽  
Prof. P. U. Vaishnav
Keyword(s):  
Solvent Extraction ◽  
Dosage Forms ◽  
Herbal Extract ◽  
Alternative Methods ◽  
Extraction Techniques ◽  
Modern Drug ◽  
Novel Drugs ◽  
Wide Range ◽  
In The Mists ◽  
Heating Pattern

In present era, herbal extract succeeds inimitable place in pharmaceutical science. In view back the earliest extraction techniques are lost in the mists of history. As time went the plants have been processed by grinding, boiling or immersing. The systemic presentation of Ayurvedic extraction system has been first time familiarized by Acharya Charaka as Panchavidha Kashaya Kalpana (five basic primary dosage forms) and based upon these primary dosage forms, secondary dosage forms are developed by using different heating pattern for extraction of pharmacological active ingredients. The administration of these dosage forms is mainly dependent on the Bala (strength) of Vyadhi (disease) and Atura (patient). Due to increased demand of Ayurvedic medicines and industrialization, the transformation of classical dosage forms takes place by implanting a wide range of technologies with different methods of extraction include conventional techniques such as maceration, percolation, infusion, decoction, hot continuous extraction etc. and recently, alternative methods like ultrasound assisted solvent extraction (UASE), microwave assisted solvent extraction (MASE) and supercritical fluid extractions (SFE). The extract obtained by these procedure uses as a large source of therapeutic phyto-chemicals that may lead to the development of novel drugs. Essentially, the purpose behind this changing face in both the extraction systems are different but can say that it is a new insight from ancient essence.

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