scholarly journals Pengaruh gelling agent kombinasi karbopol dan hpmc terhadap sifat fisik sediaan gel ekstrak etanol daun bandotan (ageratum conyzoides l) The effect of gelling agent combination of carbopol and hpmc on the physical properties of the preparation of bandotan

2021 ◽  
Vol 1 ◽  
pp. 59-66
Author(s):  
Intan Siswi Saputri ◽  
Dwi Bagus Pambudi ◽  
Wirasti Wirasti ◽  
St Rahmatullah
Keyword(s):  
Physical Properties ◽  
Extraction Method ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Laboratory Research ◽  
Ageratum Conyzoides ◽  
Qualitative And Quantitative ◽  
Dispersion Test ◽  
Gel Preparation ◽  
Collection Methods

AbstractGelling agent is a base in gel preparations that are used to thicken and make drug preparations or cosmetic preparations stable. Natural ingredients have been widely used because they are efficacious as medicine. One of them is bandotan plant (Ageratum Conyzoides L). This study aims to determine the effect of the combination of gelling agent carbopol and HPMC on the physical properties of the gel preparation of bandotan leaf ethanol extract. In this study 3 formulations of gel preparations of bandotan leaf ethanol extract were made with different concentrations of carbopol and HMPC . This research is an experimental research and uses qualitative and quantitative data collection methods from laboratory research. The extraction method used in this study is the maceration method with 96% ethanol as solvent. The prepared gel preparations were tested including organoleptic tests, pH tests, adhesion tests and dispersion tests. The results of this study indicate that there is an effect on the gelling agent of the combination of carbopol and HPMC on the gel preparation of the ethanol extract of bandotan leaves (Ageratum conyzoides L) in formula III with a ratio of gelling agent carbopol and HPMC 0.5%: 6% which is the best gel seen. from pH test, dispersion test and adhesion test.Keywords: Ageratum Conyzoides L; gel; karbopol; hpmc; gelling agent AbstrakGelling agent merupakan basis dalam sediaan gel yang digunakan untuk mengentalkan dan menjadikan sediaan obat atau sediaan kosmetik tetap stabil. Bahan alam sudah banyak digunakan karenaberkhasiat sebagai obat. Salah satunya adalah tumbuhan bandotan (Ageratum Conyzoides L). Penelitian ini bertujuan untuk mengetahui adanya pengaruh kombinasi gelling agent karbopol dan HPMC terhadap sifat fisik sediaan gel ekstrak etanol daun bandotan. Dalam penelitian ini dibuat 3 formulasi sediaan gel ekstrak etanol daun bandotan dengan perbedaan konsentrasi karbopol dan HMPC. Penelitian ini merupakan penelitian experimental dan menggunakan metode pengumpulan data kualitatif dan kuantitatif dari penelitian laboratorium. Metode ekstraksi yang digunakan dalam penelitian ini adalah metode maserasi dengan pelarut etanol 96%. Sediaan gel yang telah jadi dilakukan pengujian diantaranya uji organoleptis, uji pH , uji daya lekat danuji daya sebar. Hasil dari penelitian ini menunjukkan bahwa terdapat pengaruh padagelling agentkombinasi karbopol dan HPMC terhadap sediaan gel ekstrak etanol daun bandotan (Ageratum conyzoides L) pada formula III dengan perbandingan gelling agent karbopol dan HPMC 0,5% : 6% yang merupakan gel paling baik dilihat dari uji pH , uji daya sebar dan daya lekat.Kata Kunci : Ageratum Conyzoides L; gel; karbopol; hpmc; gelling agent

scholarly journals PENGARUH VARIASI GELLING AGENT KARBOMER 934 EKSTRAK ETANOL DAUN JERUK PURUT (Citrus hystrix DC) TERHADAP SIFAT FISIK GEL DAN AKTIVITAS ANTIBAKTERI Staphylococcus aureus

2019 ◽  
Vol 4 (1) ◽  
pp. 248-259
Author(s):  
Anggun Hari Kusumawati ◽  
Siti Hufi Hutami
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Physical Properties ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Gelling Agent ◽  
Topical Product ◽  
Gel Preparation ◽  
Made In

ABSTRAK Ekstrak etanolik daun jeruk purut (Citrus hystrix D.C) mempunyai banyak zat khasiat dimana salah satu zat aktif tersebut berkhasiat sebagai antibakteri. Penggunaan ekstrak etanolik dalam bentuk kental sangat tidak efisien dalam pemakaiannya, sehingga perlu dibuat dalam bentuk sediaan topical, misalnya gel. Penggunaan Karbomer 934 sebagai gelling agent dapat meningkatkan konsistensi basis yang akan berpengaruh terhadap pelepasan zat aktif di dalam gel. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kadar basis Karbomer 934 gel ekstrak etanolik daun jeruk purut terhadap sifat fisik gel dan aktivitas antibakteri terhadap Staphylococcus aureus. Gel dibuat dalam 4 formula dengan konsentrasi basis Karbomer 934 yaitu 0,5 %, 1%, 1,5%, dan 2%. Gel diuji sifat fisik (organolepstis, homogenitas, pH, viskositas, daya lekat, daya sebar, dan uji hedonik) dan daya antibakteri terhadap Staphylococcus aureus. Data dari uji sifat fisik dan pengukuran diameter zona hambat anti bakteri dianalisis dengan statistika Uji Kruskall-Wallis dan Mann-Withney Hasil penelitian dapat disimpulkan bahwa variasi konsentrasi Karbomer 0,5 %, 1 %, 1,5 % dan 2% sebagai gelling agent gel ekstrak etanol daun jeruk purut berpengaruh terhadap sifat fisik gel dan aktifitas antibakteri terhadap Staphylococcus aureus. Semakin besar konsentrasi Karbomer 934, viskositas semakin besar dengan FI= 3079 cP.s, FII= 8135 cP.s, FIII= 13136 cP.s, FIV= 14307 cP.s, menurunkan daya sebar dengan FI= 5.14 cm, FII= 4.04 cm, FIII= 3.51 cm, FIV= 3.35 cm, meningkatakan daya lekat dengan FI= 0.79 cm, FII= 0.87 cm, FIII= 1.05 cm, FIV= 1.16 cm dan menurunkan efektivitas antibakteri dengan FI= 6.4 cm, FII= 5.1, FIII= 5.8 cm dan FIV= 4.9 cm. Kata Kunci : gel, gelling agent, Karbomer 934, Citrus hystrix D.C , Staphylococcus aureus.   ABSTRCT Ethanolic extract of kaffir lime leaves (Citrus hystrix D.C) Has many active compounds, antimicrobial activity have been reported numerously. Ethanolic extract of Kaffir Lime leaves can’t directly exposure to the human skin. It can be increased of skin rash and eritema. The extract can be formulated in topical product like gel preparation. The aim of this work was to determine the effect of variations in base levels of Karbomer 934 gel ethanolic extract of kaffir lime leaves on the physical properties of gel and antibacterial activity against Staphylococcus aureus. The gel is made in 4 formulas with a base concentration of Carbomer 934 which is 0.5%, 1%, 1.5%, and 2%. Gel was tested for physical properties (organolepstis, homogeneity, pH, viscosity, adhesion, dispersion, and hedonic test) and antibacterial power to Staphylococcus aureus. Measuring the diameter of the antibacterial inhibition zone after incubation at 37ºC for 24 hours. Data from the physical properties test and measuring the diameter of the anti-bacterial inhibitory zone were analyzed by statistical with Kruskal-Wallis test and Mann-Withney test. The results of this study concluded that variations in Carbomer 934 concentration as gelling agent gel ethanol extract of kaffir lime leaves had an effect on the physical properties of the gel and antibacterial activity against Staphylococcus aureus. The greater concentration of Carbomer 934, increase the viscosity value with FI= 3079 cP.s, FII= 8135 cP.s, FIII= 13136 cP.s, FIV= 14307 cP.s, decrease the spreadability with FI= 5.14 cm, FII= 4.04 cm, FIII= 3.51 cm, FIV= 3.35 cm, increase in adhesion with FI= 0.79 cm, FII= 0.87 cm, FIII= 1.05 cm, FIV= 1.16 cm and decrease the effectiveness of the antibacterial with FI= 6.4 cm, FII= 5.1, FIII= 5.8 cm dan FIV= 4.9 cm. Keywords: gel, gelling agent, Carbomer 934, Citrus hystrix D.C , Staphylococcus aureus.

scholarly journals Formulasi dan evaluasi karakter fisik sediaan gel ekstrak etanol daun salam (Syzygium polyanthum)

2021 ◽  
Vol 2 (1) ◽  
pp. 16-22
Author(s):  
Lalu Mukhlis Maqbul Sani ◽  
Windah Anugrah Subaidah ◽  
Yayuk Andayani
Keyword(s):  
Free Radicals ◽  
Physical Properties ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Methyl Paraben ◽  
Freeze Thaw ◽  
Gel Preparation ◽  
Antioxidant Effects

Abstrak: Bay leaves (Syzygium polyanthum) are known to have antioxidant effects that can neutralize free radicals found in the skin. The objectives of this research are to formulate the ethanol extract of bay leaves into gel formulation and evaluate the physical properties of gel formulation. Ethanol extract of bay leaves was obtained through the maceration method with 70 % ethanol as a solvent. The thick ethanol extract of bay leaves was formulated into gel formulation with CMC – Na as a gelling agent, glycerin as a humectant, methyl paraben as a preservative, and aquadest as a solvent. After the freeze-thaw test was done, there was no change found in organoleptic but there were changes in pH, spreadability, and adhesion. The pH of gel preparation before being in storage was 5 and after being in storage was 6. In the spreadability, gel formulation spread 5,5 cm before being in the storage, and 5,1 cm after being in the storage. Gel adhesion has a sticky time of 8.35 seconds before in being storage and 8.45 seconds after being in storage.

scholarly journals OPTIMIZATION OF CARBOPOL 940 AND PROPYLENE GLYCOL CONCENTRATION ON THE CHARACTERISTIC AND INHIBITORY EFFECT OF ETHANOL EXTRACT GEL OF PAPAYA (Carica papaya L.) SEEDS AGAINST Staphylococcus aureus

2021 ◽  
Vol 18 (1) ◽  
pp. 15-25
Author(s):  
Octavianus Yandri ◽  
Wahyuning Setyani
Keyword(s):  
Staphylococcus Aureus ◽  
Physical Properties ◽  
Propylene Glycol ◽  
Inhibitory Activity ◽  
Carica Papaya ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Activity Test ◽  
Carbopol 940 ◽  
Papaya Seed

Papaya (Carica papaya L.) seeds contain alkaloids, flavonoids, tannins, phenolic compounds and saponins have been proven its synergistic effect in inhibiting the growth of Staphylococcus aureus. In this research, ethanol extract of papaya seeds was formulated in gel preparations. Optimization of the composition of the gelling agent and humectant was carried out to obtain the gel preparation of papaya seed ethanol extract with good physical properties and stability. The parameters used to determine the stability of the preparation are Physical properties which include viscosity, spreadability, and percentage of viscosity shift. Data analysis was performed using Design-Expert software version 12 and SPSS. The inhibitory activity test was carried out by the disk-diffusion agar method with Staphylococcus aureus ATCC 25923 as the test bacteria. The results of the inhibitory activity test of papaya seed ethanol extract at a concentration of 20% had moderate activity and at concentrations of 40%, 60%, 80% and 100% classified as strong against the Staphylococcus aureus. Carbopol 940 is dominant factor in influencing the response of viscosity (92.504%) and spreadability (59.539%). Preparations with good physical properties and stability were obtained on the use of carbopol 940 and propylene glycol as much as 1.06604 grams and 13.2146 grams respectively.

scholarly journals Antiseptic gel formulated from ethanol extract of Citronella grass (Cymbopogon nardus) using CMC-Na, arabic gums, and gelatin as gelling agents

2021 ◽  
pp. 258-263
Author(s):  
Reynelda Juliani Sagala ◽  
Lorensia Yolanda ◽  
Michael
Keyword(s):  
Gum Arabic ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Homogeneity Test ◽  
Gelling Agents ◽  
Cymbopogon Nardus ◽  
Dispersion Test ◽  
Gel Formulations ◽  
Citronella Grass

Introduction: The ethanol extract from citronella grass (Cymbopogon nardus) has been found to contain saponins, phenolics (flavonoids), and polyphenols which have antibacterial activity. As a result, researchers developed an antiseptic gel that contains this ethanol extract. Aims: This study aims to find the optimum concentration of gelling agent required to make the gel and to use physical evaluations in order to understand whether combining gelling agents may increase the quality of the gel. Methods: The gel was made using a melting method, which mixed the base of gel with citronella ethanol extract at a temperature of 40oC to form a homogeneous phase. The gel evaluation was conducted using an organoleptic test, homogeneity test, dispersion test, pH test, and adhesion test. Results: The tests were carried out on 15 formulations respectively (R1, R2, and R3), and resulted in the production of clear, translucent yellow gel with a distinctive citronella grass odor. The homogeneity test showed that all formulations were homogeneous and contained no agglomerated particles. The gel dosage forms made with CMC-Na, gum arabic, and gelatin as gelling agents resulted in having a pH of 7 whilst gels made with a combination of gelling agents resulted in having a pH of 8. The combination of gum arabic and CMC-Na gelling agents showed an increase in spreadability of gel formulas at the same concentration of composition, of which the combinations were 1.25% gum arabic and 1.25% CMC-Na. The gel adhesion time was 0.2-2 minutes for all formula. Conclusion: Based on this test data, it can be concluded that the 15 gel formulations that resulted from this research are good and further testing can be performed to determine the most optimum and stable formula.

scholarly journals Studi Variasi Gelling Agent PVA (Propil Vinil Alkohol) pada Formulasi Masker Peel-Off Ekstrak Lidah Buaya (Aloe vera) sebagai Anti Jerawat

2019 ◽  
Vol 10 (2) ◽  
pp. 245
Author(s):  
Dias Ardini ◽  
Pudji Rahayu
Keyword(s):  
Physical Properties ◽  
Staphylococcus Epidermidis ◽  
Univariate Analysis ◽  
Aloe Vera ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Adhesive Properties ◽  
Drying Time ◽  
Study Evaluation ◽  
Ph Range

<p><span>Gel mask can increase skin moisture and enhance the effect of the main composition (Aloe vera L) as an anti-acne on the epithelial and that is the cause of occlusivity of the polymer layer formed. PVA formulation is used to give exfoliated effect because they have adhesive properties or can form films that are easily peeled off after drying. The purpose of this study was to determine the effect of polyvinyl alcohol (PVA) variations as a gelling agent (7%, 10%, 13% and 16%) on the physical properties of ethanol extract Aloe vera leaves skin gel mask included organoleptic, homogeneity, pH, dispersibility, drying time and inhibition test against Staphylococcus epidermidis. The research conducted is experimental. The design of this research is a one-shot case study. Evaluation results were analyzed using univariate analysis. For physical properties, frequency distribution and inhibitory tests were analyzed with Analysis of variance (ANOVA). Peel off gel mask is formulated with 4 treatments and 6 repetitions. The results showed that the peel-off gel mask of Aloe vera leaves ethanol extract have clear organoleptic properties, very weak alcohol flavor and 50% slightly thick and 25% thick and 25% very thick. 75% of mask preparations are homogeneous. Has a pH range of 5.95-6.2. The spreadability of 75% gel mask preparations are meet the requirements of mask masking and 75% meets the requirements of good drying time. All variations of the formula have an inhibition effect against Staphylococcus epidermidis and between training groups, no difference was understood.</span></p>

scholarly journals FORMULASI DAN UJI ANTIBAKTERI GEL EKSTRAK ETANOL DAUN KEDONDONG (Spondias dulcis) TERHADAP BAKTERI Pseudomonas aeruginosa

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 8
Author(s):  
Kevin Yosua Pakpahan ◽  
Paulina V. Y. Yamlean ◽  
Imam Jayanto
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Ethanol Extract ◽  
Homogeneity Test ◽  
Cycling Test ◽  
Physical Evaluation ◽  
Before And After ◽  
Dispersion Test ◽  
Gel Preparation ◽  
Ethanol Extracts ◽  
Weak Antibacterial Activity

ABSTRACT Kedondong leaves (Spondias dulcis) contain flavonoid compounds, saponins and tannins that inhibit bacterial activity. This study aims to formulate, evaluate, and test the antibacterial effectiveness of the ethanol extracts gel of the Kedondong leaves (Spondias dulcis) at a concentration of 6%, 8%, 10%, respectively. This study uses an experimental method by testing the physical evaluation requirements of gel preparations. Physical evaluation of preparations includes organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and cycling test, all tests are carried out before and after the cycling test. The results of the study on the gel dispersion test did not meet the physical evaluation requirements before the cycling test and after the cycling test there was a synergetic and did not meet the requirements. Antibacterial test of ethanol extracts gel of Kedondong leaves against Pseudomonas aeruginosa produced weak inhibitory properties. It can be concluded that the gel concentration of 6%, 8%, 10% of ethanol extract of Kedondong leaves cannot be formulated as a gel preparation because it is less physically stable and has weak antibacterial activity.  Keywords: Antibacterial, HPMC Gel, Kedondong (Spondias dulcis), Pseudomonas aeruginosa   ABSTRAK Daun Kedondong (Spondias dulcis) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri.  Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan gel ekstrak etanol daun Kedondong (Spondias dulcis) pada kosentrasi 6%, 8%, 10%. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik sediaan gel. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian pada uji daya sebar sediaan gel tidak memenuhi persyaratan eveluasi fisik sebelum uji cycling test dan setelah cycling test terjadi sineresis dan tidak memenuhi syarat. Penelitian uji antibakteri sediaan gel ekstrak etanol daun Kedondong pada bakteri Pseudomonas aeruginosa menghasilkan daya hambat yang lemah. Dapat disimpulkan pada gel kosentrasi 6%, 8%, 10% ekstrak etanol daun Kedondong tidak dapat diformulasi sebagai sediaan gel karena kurang stabil secara fisik dan memiliki aktivitas antibakteri yang lemah.  Kata kunci : Antibakteri, Gel HPMC, Kedondong (Spondias dulcis), Pseudomonas aeruginosa

scholarly journals Optimization Carbopol And Glycerol As Basis Of Hand Gel Antiseptics Extract Ethanol Ceremai Leaf (Phyllantus Acidus (L.) Skeels) With Simplex Lattice Design

2017 ◽  
Vol 2 (01) ◽  
pp. 35 ◽  
Author(s):  
Dwi Saryanti ◽  
Izzatun Ni'mah Zulfa
Keyword(s):  
Physical Properties ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Test Results ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Carbopol 940 ◽  
Phyllanthus Acidus ◽  
Simplex Lattice ◽  
The One

Ceremai leaf (<em>Phyllanthus acidus </em>(L.) Skeels) is the one of the potential plant which contain flavonoid that had antibacterial activity. Carbopol is a gelling agent that is easily dispersible in water and provide consistency to the gel, while the glycerin is a humectant that can improve the softness of the gel. Carbopol can provide viscosity / hardness in the gel it is necessary to combine with glycerin to soften the gel and the increase of the spread The aims of this research to know the optimum composition from carbopol and gliserol in antiseptic gel formulation of ceremai leaf ethanol extract by Simplex Lattice Design (SLD). The method of extraction used maseration method with ethanol 70 % solvent. extract made of gel with components carbopol 940(0-100%) and glycerin(0-100%) with respond criteria physical properties such as pH, spreadability, sticking and protection power. The optimum formulated based on Simplex Lattice Design<em> </em>was the combination of carbopol 50 % : glycerol 50 %. Optimum results are obtained gel has a good physical properties. The test results showed that the effectiveness of antiseptic hand gels have generated a good antiseptic. Acceptability test results showed that the gel can be accepted by society.

Assessing Triangulation Across Methodologies, Methods, and Stakeholder Groups: The Joys, Woes, and Politics of Interpreting Convergent and Divergent Data

2018 ◽  
Vol 41 (1) ◽  
pp. 125-144 ◽  
Author(s):  
Rebecca Campbell ◽  
Rachael Goodman-Williams ◽  
Hannah Feeney ◽  
Giannina Fehler-Cabral
Keyword(s):  
Large Scale ◽  
Contextual Information ◽  
Policy Makers ◽  
Specific Data ◽  
Qualitative And Quantitative ◽  
Stakeholder Groups ◽  
Data Points ◽  
Evaluation Project ◽  
Collection Methods

The purpose of this study was to develop triangulation coding methods for a large-scale action research and evaluation project and to examine how practitioners and policy makers interpreted both convergent and divergent data. We created a color-coded system that evaluated the extent of triangulation across methodologies (qualitative and quantitative), data collection methods (observations, interviews, and archival records), and stakeholder groups (five distinct disciplines/organizations). Triangulation was assessed for both specific data points (e.g., a piece of historical/contextual information or qualitative theme) and substantive findings that emanated from further analysis of those data points (e.g., a statistical model or a mechanistic qualitative assertion that links themes). We present five case study examples that explore the complexities of interpreting triangulation data and determining whether data are deemed credible and actionable if not convergent.

scholarly journals DIE EVALUERING VAN ’N LEESBEVORDERINGSPROJEK: DIE ZOË-VOORLEESPROJEK IN DIE NOORD-KAAP

Mousaion ◽  
2016 ◽  
Vol 32 (4) ◽  
pp. 55-74
Author(s):  
Maritha Snyman
Keyword(s):  
South Africa ◽  
Best Practices ◽  
Family Literacy ◽  
Reading Aloud ◽  
Detailed Data ◽  
Qualitative And Quantitative ◽  
Northern Cape ◽  
Set Up ◽  
Collection Methods ◽  
Selection Of

In view of the dire state of literacy levels in South Africa and the fact that few literacy programmes provide research reports to evaluate best practices and effectivity, this article reports on the evaluation of a literacy project. The project, inspired by two children, is referred to as the Zoë-reading aloud project and targeted children in and around Upington in the Northern Cape, South Africa. The project was set up according to acknowledged reading promotion principles and it was structured to collect detailed data. Qualitative and quantitative data collection methods were used and a selection of methods provided reliability. The findings of the analysis of a collection of data for a period of 15 months revealed the best practices of the project. It highlights, for example, the need for financial assistance and challenges the concept of family literacy in low-literate and poor communities.

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