scholarly journals Nidanparivarjan in Amlapitta:Preventive as well as Curative Aspect

2021 ◽  
Vol 9 (01) ◽  
Author(s):  
Rekhatai Supaji Chendhalane
Keyword(s):  
Dietary Habits ◽  
Sedentary Lifestyle ◽  
Normal Individual ◽  
Pathological Condition ◽  
Emerging Disease ◽  
First Line ◽  
Disease Treatment ◽  
Etiological Factors ◽  
Ancient Science ◽  
Causative Factors

Abstract: Amlapitta is a disorder of Annavaha Srotas as per Ayurveda. Amlapitta (Acid Peptic Disorder) is very common emerging disease which is an abnormal pathological condition occurring due to indulgence in Ahara, Vihara, and Manasika Bhava which are of incompatible combination, faulty dietary habits, persistent intense stress, spicy and oily food and sedentary lifestyle.   This condition can be managed using medications but it get relapse as soon as the Nidana(Etiological Factors)are taken.So, an approach should be done to tackle this problem like avoidance of Nidana i.e causative factors responsible for Amlapitta Vyadhi.   Ayurveda is recognized as ancient science and it has described ways for prevention of disease. 'Nidanparivarjnan' is mentioned in Ayurvedic text which is useful for prevention of disease, treatment of disease, and to stop the recurrence of disease and hence it is mentioned as first line of treatment for any disease. So, Amlapitta Vyadhi can be prevented and managed through Nidanparivarjan along with proper following of Pathya Apathya regimens mentioned in Ayurvedic text books. In this study all the etiological factors of Amlapitta have been studied and compiled through Ayurvedic texts, various articles are referred from Ayurvedic journals and internet surfing done.Nidanparivarjan means avoidance of etiological factors of Amlapitta which helps in prevention of Amlapitta disease in normal individual and management of disease in diagnosed patient of Amlapitta taking medications.  

A Critical Review on Kaphavrutha Vata in Manyasthambha

2018 ◽  
Vol 3 (4) ◽  
Author(s):  
Dr. Unnikrishnan VS ◽  
Dr. Prashanth AS
Keyword(s):  
Critical Review ◽  
Dietary Habits ◽  
Sedentary Lifestyle ◽  
Large Population ◽  
Load Bearing ◽  
Sitting Posture ◽  
Continuous Work

Now a days due to sedentary lifestyle and lack of time, people cannot concentrate on their proper regimen and people undergo many unwanted practices like faulty dietary habits, improper sitting posture, continuous work in one posture and overexertion, load bearing movements during travelling and sports. All these factors lead to the increase in the incidents of Manyasthambha in a large population. In classics Manyasthambha is explained under Vataja Nanatmaja Vikaras and is mentioned as Kaphaavruta Vata in its Samprapthi. While explaining treatment of Manyasthambha, Acharya Susruta clearly explains about Rooksha Sweda and Nasya which helps in the Samprapti Vighatana of Avarana in Manyasthambha.

scholarly journals Use of Biologics in Pityriasis Rubra Pilaris Refractory to First-Line Systemic Therapy: A Systematic Review

2019 ◽  
Vol 24 (1) ◽  
pp. 73-78
Author(s):  
Avee Naidoo ◽  
Cathryn Sibbald ◽  
Patrick J. Fleming ◽  
Vincent Piguet
Keyword(s):  
Large Scale ◽  
Randomized Clinical Trials ◽  
Case Series ◽  
Efficacy And Safety ◽  
Inclusion Criteria ◽  
Treatment Resistant ◽  
First Line ◽  
Disease Treatment ◽  
Pityriasis Rubra Pilaris ◽  
Systemic Therapies

Pityriasis rubra pilaris (PRP) is an uncommon, inflammatory, papulosquamous skin disease. Treatment of PRP is challenging as the disease is often refractory to conventional therapies, such as retinoids and methotrexate. There has been an increasing number of studies reporting the successful use of biologic therapy in patients with PRP; however, the data on the efficacy and safety are limited. Our objective was to evaluate the existing evidence for utilizing biologics, whether alone or in combination with established systemic therapies, in patients with treatment-resistant PRP. We systematically reviewed evidence within Medline and Pubmed databases between January 1, 2000, to March 31, 2019. Articles consisted of patients diagnosed with PRP who have failed to respond sufficiently to first-line systemic therapies, or who had comorbidities that precluded their use. In total, 363 unique articles were identified, 56 of which were considered relevant to the clinical question. Of the 56 articles highlighted, 35 met the inclusion criteria and were limited to case series and case studies. Therapy with biologics was found to be successful for both monotherapy (81.1% [27/33]) and when used in combination with existing systemic therapies (87.5% [14/16]). The existing evidence suggests that biologics may be regarded as a tool for PRP treatment alone or in combination therapy with existing treatments, although large-scale randomized clinical trials are necessary to better assess their efficacy and safety.

scholarly journals Therapeutic efficacy of azathioprine in addition to prednisone-based regimens as first-line chronic graft-versus-host disease treatment

2017 ◽  
Vol 53 (3) ◽  
pp. 334-338
Author(s):  
Jieun Uhm ◽  
Elizabeth Shin ◽  
Fotios V. Michelis ◽  
Santhosh Thyagu ◽  
Auro Viswabandya ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Therapeutic Efficacy ◽  
First Line ◽  
Disease Treatment ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Clinical assessment of Sara and Blood investigations in Madhumeha (T2DM)

2020 ◽  
Vol 11 (1) ◽  
pp. 301-310
Author(s):  
Santosh Kumar Ranjan ◽  
Byadgi P S ◽  
Tripathi N.S
Keyword(s):  
Diabetes Mellitus ◽  
Psychological Factors ◽  
Dietary Habits ◽  
Sedentary Lifestyle ◽  
Medical Science ◽  
Dietary Factors ◽  
Direct Perception ◽  
Personalized Approach ◽  
Medicinal Drug

Pratyaksha (direct perception), Anumana (inference), Aptopadesha (testimony), and Yukti (reasoning) are the tools that helps for the diagnosis of the disease.  To fulfill this purpose Atura-Pariksha (examination of patients), Dravya Pariksha (examination of medicinal drug and preparations), and Roga-Rogi Pariksha (examination of the patient and disease), etc. are a very important tool. The concept of Sara is described under Dashavidha Atura Pariksha (tenfold examination), and it is an important concept in both Swastha-rakshana (maintenance of health) and Aturasya Vikara Prashamana (treatment of disease). The concept of Sara is explained by different Acharyas elaborately in their own way. In spite of tremendous success in modern medical science, the incidence of diseases are increasing enormously. A sedentary lifestyle and improper dietary habits has led to the emergence of several health problems, including Type 2 Diabetes Mellitus (T2DM), and it is emerging as a major disease affecting mankind with many complications.  Hence present study has been undertaken to understand Sara because all persons vary from one another in many ways, and a personalized approach to patient care should be adopted to plan appropriate therapeutics. Dietary factors, lifestyle, and psychological factors are involved in the aetiology of Madhumeha (T2DM). The Twak Sara, Shukra Sara, Asthi Sara, and Majja Sara persons are more prone to develop Madhumeha (T2DM). The Meda Sara and Mamsa Sara are less prone to develop Madhumeha (T2DM). We don’t find the Rakta Sara individuals in our study.

scholarly journals Medical intervention in adolescent menorrhagia

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Bushra Haq ◽  
Humaira Akram ◽  
Tabinda Rana
Keyword(s):  
Cross Sectional Study ◽  
Medical Intervention ◽  
Subjective Improvement ◽  
Sectional Study ◽  
First Line ◽  
Cross Sectional ◽  
Combined Oral Contraceptive ◽  
Causative Factors ◽  
Antifibrinolytic Drugs ◽  
Convenience Sampling

Objectives: To find out causative factors of adolescent menorrhagia and success of various treatments. Design: Descriptive cross sectional study Place & duration of study: Lady Willingdon Hospital, Lahore from May 2004 to April 2005. Subject and methods: Fifty unmarried patients at 12-19 years with menorrhagia selected by non-probability convenience sampling. Blood loss was determined by duration of bleeding extending beyond seven days, passage of clots and presence of anaemia. Results: The most common cause of menorrhagia was DUB (92%) followed by bleeding and endocrinal disorder. Non-steroidal anti-inflammatory drug and antifibrinolytic agent produced 75% subjective improvement in complaints. However, combined oral contraceptive produced 66% improvement. Conclusion: NSAIDS and antifibrinolytic drugs were found to be effective in reducing menstrual loss and should be used as first line of treatment.

scholarly journals MANAGEMENT OF STHOULYA (OBESITY) WITH APATARPANA CHIKITSA – A CASE STUDY

2020 ◽  
pp. 58-64
Author(s):  
Rohini A. Kathale ◽  
Sharmili V. Suryavanshi ◽  
Prasad V.Kulkarni
Keyword(s):  
Weight Loss ◽  
Effective Treatment ◽  
Present Article ◽  
Dietary Habits ◽  
Technology Development ◽  
Sedentary Lifestyle ◽  
Science And Technology ◽  
Current Scenario ◽  
Threat To Life

This is the era of modernization, science and technology development; resulted into more sedentary lifestyle. This era is more challenging because of lifestyle disorders which are due to change in dietary habits and mode of lifestyle. Obesity is one of the major lifestyle disorders which are a threat to life and is also a major cosmetic issue. Effective treatment for obesity is a need which is not available in the current scenario. In Ayurveda obesity can be correlated with Sthoulya or Medoroga. Acharya Charaka has prescribed Apatarpan chikitsa as the main Chikitsa for Sthoulya. The present article is about a case of Sthoulya treated by Apatarpan chikitsa mainly with Pachana, Udwartana, Swedana, Sadyavamana, Rukshana and Basti. Patients got significant relief in all the complaints and a remarkable weight loss in 21 days only.

scholarly journals Sex and Response to Cardioprotective Conditioning Maneuvers

2021 ◽  
Vol 12 ◽  
Author(s):  
Giulia Querio ◽  
Federica Geddo ◽  
Susanna Antoniotti ◽  
Maria Pia Gallo ◽  
Claudia Penna
Keyword(s):  
Health Care ◽  
Heart Disease ◽  
Mortality Rate ◽  
Pathological Condition ◽  
Physiological Responses ◽  
Molecular Pathways ◽  
First Line ◽  
Sexual Hormones ◽  
The Past ◽  
Time Of Intervention

Ischemic heart disease (IHD) is a multifactorial pathological condition strictly related to genetic, dietary, and lifestyle factors. Its morbidity and mortality rate represent one of the most important pathological issues that today involve younger people in a stronger way than in the past. IHD clinical outcomes are difficult to treat and have a high economic impact on health care. So prevention of this pathological condition through cardioprotective maneuvers represents the first line of intervention, as already underlined by several animal and human studies. Even if the time of intervention is important to prevent severe outcomes, many studies highlight that sex-dependent responses are crucial for the result of cardioprotective procedures. In this scenario sexual hormones have revealed an important role in cardioprotective approach, as women seem to be more protected toward cardiac insults when compared to male counterparts. The aim of this mini review is to show the molecular pathways involved in cardioprotective protocols and to elucidate how sexual hormones can contribute in ameliorating or worsening the physiological responses to IHD.

Concept of Airborne Infectious Disease in Ayurveda

2020 ◽  
Vol 11 (3) ◽  
pp. 4847-4856
Author(s):  
Madhura Vinay Fadanavis ◽  
Punam Sawarkar
Keyword(s):  
Infectious Disease ◽  
Communicable Disease ◽  
Exercise Stress ◽  
Treatment Modalities ◽  
Physical And Mental Health ◽  
Normal Functions ◽  
Ancient Science ◽  
Causative Factors ◽  
Clinical Conditions ◽  
Airborne Disease

Life of any living thing starts with the breath and ends with breathlessness. Health is defined as a state of equilibrium of normal functions of Dosha, Dhatu, and Agni with body, mind and soul. Health has not given importance until someone becomes sick. Due to intake of improper diet, lack of exercise, stress, & global warming, pollution the health status of an individual is decreasing day by day & they are getting easily prone to infectious disease. It comes with significant challenges & creating a burden over medical & health care system. Ayurveda is an ancient science which has already described such communicable disease with their causes, mode of transmission, prevention as well as treatment. Charak has explained about Janapadodhwansa & its four reasons(Air, water, time, and region). Sushruta has already mentioned Aupsargikarogas that are infectious diseases. By adopting Ayurvedic measures such as following proper Dincharaya, Rutucharya, Sadvritta, Panchakarma, Shaman Cikitsa & Rasayana, both physical and mental health, can be maintained. The main aim of this paper is to highlight the airborne disease mentioned in Ayurveda. This review has been done by compiling information from classic Ayurvedic texts – Charak Samhita, Sushruta Samhita, and Astanga Hirdaya. Apart from this, modern books, journals & websites on preventive & social medicine were also searched for this study. After extensive search, specific causative factors, pathology, symptoms & various treatment regime has been narrated in scattered form by our Ancient Acharyas. The different Ayurvedic Samhitas serves as a source of getting knowledge about the airborne disease and ways to prevent it and cure it. By using these basic principles in this ancient science in a rational way, we can avoid & overcome many clinical conditions described in contemporary science which has its self-limitations in treatment modalities.

Gemcitabine/nab-paclitaxel (G/A) alternating with 5-FU/leucovorin/irinotecan (FOLFIRI) in first-line metastatic pancreatic cancer (MPC): Updated results.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 314-314
Author(s):  
Vincent J. Picozzi ◽  
Bruce Shih-Li Lin ◽  
Margaret T. Mandelson
Keyword(s):  
Cancer Biology ◽  
De Novo ◽  
Median Number ◽  
First Line ◽  
Disease Treatment ◽  
Patient Decision ◽  
Disease Site ◽  
Grade 3 ◽  
Ecog Ps ◽  
Physician Patient

314 Background: Both gemcitabine- and 5-FU-based chemotherapy (chemoRx) have demonstrated efficacy in MPC. Alternating these two regimens may 1) decrease toxicity 2) slow emergence of resistant cancer biology, and 3) provide a broader platform for addition of other (non)chemotherapeutic (CT) agents to the base regimen. The strategy using alternating G/A and FOLFIRI in MPC was first tested in the SEENA-1 trial (Picozzi et.al. GI Cancer Symposium 2017) and further suggested to be of benefit both at our own institution (Picozzi et.al. ASCO 2018 ) and elsewhere (Assenat et.al. ASCO 2018). We extend and update our observations here. Methods: Eligible patients (pts) had the following characteristics: 1) bx proven de novo MPC, 2) chemoRx naive, 3) ECOG PS 0/1, and 4) bi-dimensionally measurable disease. Treatment (Rx) consisted of 1) gemcitabine 1000 mg/m2 and nab-paclitaxel 125 mg/2d 1,(8),15 alternating every 8 weeks (2 cycles) with FOLFIRI. Pts were radiographically restaged every 8 weeks. Rx was continued for up to 48 weeks, at which time additional Rx was given per physician/patient decision. Results: As of 9/2018, 61 pts have been treated at our institution via this method. Median age is 67; ECOG PS 0/1 58/42%. Disease site involvement included liver, lung, peritoneum 79%, 39%, and 23% respectively. Toxicity is less than typical with either individual regimen (e.g. no ≥ grade 3 neuropathy or diarrhea has been seen to date). Of pts followed for ≥ 4 months , 45/51 (88%) received ≥ 4 cycles Rx. Median number Rx cycles received was 9; 15/34 (44%) pts followed for > 1 year completed 48 weeks Rx. Disease control rate at 16 weeks in 45 evaluable patients is 89% (47% PR, 42% SD, 11% PD). 27/61 pts (44%) are currently on Rx (4 transferred care from region, 30 deceased). Currently, median f/u is 11.8 mo; median OS is 14.1 mo ( 95% CI 10.6-20.3 mo) 6,12, 18 and 24 mo OS are 88%,57 %, 34%, and 15% respectively. Conclusions: 1) Alternating G/A and FOLFIRI in MPC appears to have a more favorable toxicity profile than either individual regimen. 2) Median OS in MPC using this Rx is at least competitive with other reports. 3) The above method has potential to integrate other therapeutic agents/ treatment approaches.

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